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GRUPO DE TRABAJO ENFERMEDADES INFECCIOSAS (GTEI)
Memoria de actividades
A.- Actividades que se encuentran en realización
1) Estudio TAVeM: Estudio Internacional sobre Traqueobronquitis Asociada a la Ventilación Mecánica: 90
Centros de España, 140 Centros de Latinoamérica y Portugal
2) Estudio MICAFEM: Dra. Mercedes Nieto - 30 centros de España
3) ENVIN-HELICS
4) Estudio CAVATREM : Dr. Cristóbal León – 20 Centros
B.- Actividades desarrolladas
1.- Estudio sobre la Gripe A Grave. C. León (2009-2011)
2.- Estudio de bacteriemia asociada a catéter. Leo Lorente (Finalizado)
3.- Estudio Neumonía asociada a la asistencia sanitaria. Jordi Vallés (Finalizado)
4.- Neumonía ZERO. Dr. F. Álvarez Lerma (Finalizado)
5.- Bacteriemia ZERO. Dra. Mercedes Palomar (Finalizado)
6.- CAPUCI – Neumonía Comunitaria en UCI . Dr. Rello J (Finalizado)
7.- Estudio PROCAS – Dr. Cristóbal León (Finalizado)
8.- Estudio EPCAN – Dr. Cristóbal León (Finalizado)
9.- Estudio CAVA – Dr. Cristóbal León (Finalizado)
C.- Listado de Publicaciones
2004
1.- C. León, J. Ariza : Guías para el tratamiento de las infecciones relacionadas con catéteres
intravasculares de corta permanencia en adultos: conferencia de consenso SEIMC-SEMICYUC. Enferm
Infecc Microbiol Clin 2004;22:92-101
2005
1.- M. Bodı,A. Rodríguez, J. Solé -Violán, et al for the Community-Acquired Pneumonia Intensive Care
Units (CAPUCI) Study Investigators. Antibiotic Prescription for Community-Acquired Pneumonia in the
Intensive Care Unit: Impact of Adherence to Infectious Diseases Society of America Guidelines on Survival
CID 2005; 41:1709-16
2006
1.- Rello J, Rodríguez A, Torres A et al. for the CAPUCI study investigators. Implications of COPD in patients
admitted to the intensive care unit by community-acquired pneumonia.
Eur Respir J 2006; 27: 1210–1216
2.- Shorr AF, Bodi M, Rodríguez A et al. for the CAPUCI Study. Impact of Antibiotic Guideline Compliance
on Duration of Mechanical Ventilation in Critically Ill Patients With Community-Acquired Pneumonia*.
CHEST 2006; 130:93–100
3.- Alvarez Lerma F, Palomar M, Insausti J et al . Grupo de Estudio Nacional de Vigilancia de Infección
Nosocomial en UCI.
Staphylococcus aureus nosocomial infections in critically ill patients admitted in intensive care units.
Med Clin (Barc). 2006;126:641-6.
4.- León C, Ruiz-Santana S, Saavedra P et al. EPCAN Study Group
A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill
patients with Candida colonization.
Crit Care Med 2006;34:730-7.
2007
1.- Blot SI, Rodríguez A, Solé-Violán J et al. for the Community-Acquired Pneumonia Intensive Care Units
(CAPUCI) Study Investigators. Effects of delayed oxygenation assessment on time to antibiotic delivery
and mortality in patients with severe community-acquired pneumonia.
Crit Care Med 2007; 35:2509–2514
2.- Rodríguez A, Mendia A, Sirvent JM et al. for the CAPUCI Study Group. Combination antibiotic therapy
improves survival in patients with community-acquired pneumonia and shock.
Crit Care Med 2007; 35:1493–1498
3.- Olaechea Astigarraga PM, Garnacho Montero J, Grau Cerrato S et al. Study Group on Infections in
Critical Patients; Infectious Diseases Working Group.
Summary of the GEIPC-SEIMC and GTEI-SEMICYUC recommendations for the treatment of infections
caused by gram positive cocci in critical patients.
Farm Hosp. 2007;31:353-69
4.- Olaechea Astigarraga PM, Garnacho Montero J, Grau Cerrato S y col.
GEIPC-SEIMC and GTEI-SEMICYUC recommendations for antibiotic treatment of gram positive coccal
infections in the critical patient.
Med Intensiva 2007;31:294-317.
5.- Jordà-Marcos R, Alvarez-Lerma F, Jurado M et al. EPCAN Study Group
Risk factors for candidaemia in critically ill patients: a prospective surveillance study.
Mycoses. 2007;50:302-10.
6.- Alvarez-Lerma F, Palomar M, Olaechea P et al. Grupo de Estudio de Vigilacia de Infección Nosocomial
en UCI.
National Study of Control of Nosocomial Infection in Intensive Care Units. Evolutive report of the years
2003-2005.
Med Intensiva. 2007;31:6-17
2008
1.- Mensa J, Barberán J, Llinares P, Picazo J, Bouza E, Alvarez-Lerma F et al. Sociedad Española de
Quimioterapia; Sociedad Española de Medicina Interna; Sociedad Española de Medicina Interna; Sociedad
Española de Medicina Intensiva, Critica y Unidades Coronarias; Asociacion Española de Cirujanos;
Asociacion Española de Hematologia y Hemoterapia.
Guidelines for the treatment on infections caused by methicillin-resistant Staphylococcus aureus
Rev Esp Quimioter 2008; 21:234-58
2009
1.- Lisboa T, Blot S, Waterer GW et al for the Community-Acquired Pneumonia Intensive Care Units Study
Investigators. Radiologic progression of pulmonary infiltrates predicts a worse prognosis in severe
community-acquired pneumonia than bacteremia.
Chest. 2009;135:165-72.
2.- Rodríguez A, Lisboa T, Díaz E. De la seguridad a la prevención: gripe A (H1N1), un nuevo desafío para
los intensivistas.
Medicina intensiva 2009;33:265-266
3.- Rello J,Rodríguez A, Ibañez P et al. for the H1N1 SEMICYUC working group. Intensive care adult
patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.
Crit Care. 2009;13(5):R148
4.- Rodríguez A, Lisboa T, Blot SI et al. for the Community-Acquired Pneumonia Intensive Care Units
(CAPUCI) Study Investigators. Mortality in ICU patients with bacterial community-acquired pneumonia:
when antibiotics are not enough.
Intensive Care Med. 2009;35:430-8.
5.- Olaechea PM, Alvarez-Lerma F, Sánchez M y col . Spanish Society for Infectious Diseases and Clinical
Microbiology and Spanish Society of Intensive and Critical Medicine and Coronary Units.
Evaluation of the status of patients with severe infection, criteria for intensive care unit admittance.
Enferm Infecc Microbiol Clin. 2009;27:342-52.
6.- León C, Alvarez-Lerma F, Ruiz-Santana S et al. EPCAN Study Group.
Fungal colonization and/or infection in non-neutropenic critically ill patients: results of the EPCAN
observational study.
Eur J Clin Microbiol Infect Dis. 2009;28:233-42.
7.- León C, Ruiz-Santana S, Saavedra P et al. Cava Study Group .
Usefulness of the "Candida score" for discriminating between Candida colonization and invasive
candidiasis in non-neutropenic critically ill patients: a prospective multicenter study.
Crit Care Med. 2009;37:1624-33.
2010
1.- Rodríguez A, Lisboa T, Rello J y el GETGAG/SEMICYUC (Grupo Español de Trabajo de Gripe A Grave/
SEMICYUC). Gripe A (H1N1)v pandémica en UCI: ¿qué hemos aprendido?
Arch Bronconeumol. 2010;46(Supl 2):24-31
2.- A. Rodríguez A, Socías L,Guerrero JE et al. y Grupo Español de Trabajo de Gripe A Grave/ Sociedad
Española de Medicina Intensiva, Crítica y Unidades Coronarias. Gripe A pandémica en una unidad de
cuidados intensivos: experiencia en España y Latinoamérica (Grupo Español de Trabajo de Gripe A Grave/
Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias).
Med Intensiva. 2010;34:87-94
3.- Palomar Martínez M, Alvarez Lerma F, Riera Badía MA et al. Grupo de Trabajo del Estudio Piloto
«Bacteriemia Zero».
Prevention of bacteriema related with ICU catheters by multifactorial intervention: a report of the pilot
study.
Med Intensiva. 2010 ;34:581-9.
4.- Alvarez Lerma F, Olaechea Astigarraga P, Palomar Martínez M et al. Grupo de Estudio ENVIN-HELICS.
Epidemiology of the primary and vascular catheter-related bacteriemias in critical patients admitted to an
Intensive Medicine Department.
Med Intensiva 2010;34:437-45
2011
1.- Díaz E, Rodríguez A, Martin-Loeches I et al. for the H1N1 SEMICYUC Working Group.
Impact of obesity in patients infected with 2009 influenza A(H1N1).
Chest. 2011 ;139:382-6.
2.- Martín-Loeches I, Sanchez-Corral A, Diaz E et al. for the H1N1 SEMICYUC Working Group Communityacquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus.
Chest. 2011;139:555-62.
3.- Martin-Loeches I, Rodriguez A, Bonastre J for the H1N1 SEMICYUC Working Group. Severe pandemic
(H1N1)v influenza A infection: report on the first deaths in Spain. Respirology. 2011;16:78-85
4.- Maraví-Poma E, Martin-Loeches I, Regidor E et al.Grupo Español de Trabajo de Gripe Grave A
(SEMICYUC). Severe 2009 A/H1N1v influenza in pregnant women in Spain.
Crit Care Med. 2011;39:945-51.
5.- Martin-Loeches I, Papiol E, Rodríguez A, et al. H1N1 SEMICYUC Working Group. Acute kidney injury in
critical ill patients affected by influenza A (H1N1) virus infection.
Crit Care. 2011 ;15:R66.
6.- Rodríguez A, Díaz E, Martín-Loeches I, et al. H1N1 SEMICYUC Working Group. Impact of early
oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A.
J Antimicrob Chemother. 2011 May;66(5):1140-9.
7.- Rodríguez A, Martin-Loeches I, Bonastre J, et al. SEMICYUC-CIBERES-REIPI working group. First
influenza season after the 2009 pandemic influenza: report of the first 300 ICU admissions in Spain.
Med Intensiva. 2011;35:208-16.
8.- Martin-Loeches I, Díaz E, Vidaur L et al. H1N1 SEMICYUC/REIPI/CIBERES Working group. Pandemic and
post-pandemic influenza A (H1N1) infection in critically ill patients.
Crit Care. 2011;15(6):R286.
9.- Rodríguez A, Pozo F, León C. First influenza season outbreak after 2009 pandemic influenza A(H1N1) in
Spain.
Chest. 2011;140:1102-3.
10.- Vallés J, Alvarez-Lerma F, Palomar M et al. Study Group of Infectious Diseases of the Spanish Society
of Critical Care Medicine.
Health-care-associated bloodstream infections at admission to the ICU.
Chest. 2011 Apr;139(4):810-5
11.- Olaechea PM, Alvarez-Lerma F, Palomar M et al. Grupo ENVIN-HELICS
Impact of primary and intravascular catheter-related bacteremia due to coagulase-negative staphylococci
in critically ill patients.
Med Intensiva. 2011;35:217-25.
2012
1.- Diaz E, Martin-Loeches I, Canadell L et al for the H1N1 SEMICYUC-CIBERES-REIPI Working Group
(GETGAG).
Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza.
J Infect. 2012;64:311-8.
2.- Picazo JJ, Alonso LM, Arístegui J y col. Consenso sobre la vacunación frente a la gripe en el personal
sanitario.
Rev Esp Quimioter 2012;25: 226-239
3.- Rodríguez A, Alvarez-Rocha L, Sirvent JM et al. GETGAG; Infectious Diseases Work Group (GTEI) of
Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC); Infections in
Critically Ill Patients Study Group (GEIPC) of Spanish Society of Infectious Diseases and Clinical
Microbiology.
Recommendations of the Infectious Diseases Work Group (GTEI) of the Spanish Society of Intensive and
Critical Care Medicine and Coronary Units (SEMICYUC) and the Infections in Critically Ill Patients Study
Group (GEIPC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) for the
diagnosis and treatment of influenza A/H1N1 in seriously ill adults admitted to the Intensive Care Unit].
Med Intensiva. 2012 Mar;36(2):103-37.
4.- Bonastre J, Suberviola B, Pozo JC et al. SEMICYUC-CIBERES-REIPI working group.
Extracorporeal lung support in patients with severe respiratory failure secondary to the 2010-2011 winter
seasonal outbreak of influenza A (H1N1) in Spain.
Med Intensiva. 2012;36:193-9
5.- León-Gil C, Ubeda-Iglesias A, Loza-Vázquez A et al. ProCAS Study Group
Efficacy and safety of caspofungin in critically ill patients. ProCAS Study.
Rev Esp Quimioter. 2012;25:274-82.
6.- Olaechea-Astigarraga PM, Alvarez-Lerma F, Palomar-Martínez M et al. Grupo ENVIN-HELICS.
Trends in systemic antifungal use in critically ill patients. Multicenter observational study, 2006-2010.
Enferm Infecc Microbiol Clin. 2012 Oct;30(8):435-40.
7.- González de Molina FJ, León C, Ruiz-Santana S, Saavedra P; the CAVA I Study Group.
Assessment of candidemia-attributable mortality in critically ill patients using propensity score matching
analysis.
Crit Care. 2012 ;16:R105.
2013
1.- Masclans JR, Pérez M, Almirall J et al H1N1 GTEI/SEMICYUC Investigators. Early non-invasive
ventilation treatment for severe influenza pneumonia.
Clin Microbiol Infect. 2013 Mar;19(3):249-56.
2.- Martín-Loeches I, Bermejo-Martin JF, Vallés J et al. SEMICYUC/REIPI/CIBERES H1N1 Working Group
Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary
viral pneumonia.
Intensive Care Med. 2013;39:693-702.
3.- Garnacho-Montero J, Gutiérrez-Pizarraya A, Màrquez JA, et al. Spanish Society of Intensive Care
Medicine and Coronary Units Working Group. Epidemiology, clinical features, and prognosis of elderly
adults with severe forms of influenza A (H1N1)
J Am Geriatr Soc. 2013;61: 350-6.
4.- Vallés J, Palomar M, Alvárez-Lerma F et al. GTEI/SEMICYUC Working Group on Bacteremia.
Evolution over a 15-year period of clinical characteristics and outcomes of critically ill patients with
community-acquired bacteremia.
Crit Care Med. 2013;41:76-83
5.- Olaechea PM, Palomar M, Alvarez-Lerma F et al. ENVIN-HELICS Group.
Morbidity and mortality associated with primary and catheter-related bloodstream infections in critically
ill patients.
Rev Esp Quimioter. 2013;26:21-9.
6.- Alvarez Lerma F, Carrasco M, Otal JJ et al Grupo de Estudio ENVIN-HELICS.
Invasive device-related infections after heart surgery.
Med Intensiva. 2013 Mar 6. doi:pii: S0210-5691(12)00376-2. 10.1016/j.medin.2012.12.005.
7.- Alvarez-Lerma F, Gracia-Arnillas MP, Palomar M et al. Grupo de Investigadores del Estudio Nacional de
Vigilancia de Infección Nosocomial en UCI.
Urethral catheter-related urinary infection in critical patients admitted to the ICU. Descriptive data of the
ENVIN-UCI STUDY.
Med Intensiva. 2013;37:75-82.