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Pau d’Arco: Wondrous Rainforest Herb Photo credit: © 2006 Joseph Dougherty/ecology.org TM FORMULAS NutriPlex Formulas’ DetoxFormula Contains Pau d’arco from the Costa Rican Rainforest, along with other important immunebuilding and detoxifying plant foods. PROSTATE INFLAMMATION • DETOXING INFECTION • CANCER • SKIN CONDITIONS Pau d’arco is a tree found in the rainforests of Central and South America. Its common names include lapacho, taheebo and trumpet tree. The inner bark of pau d’arco is used by native tribes to treat cancer, lupus, infectious diseases, wounds, backache, toothache and sexually transmitted diseases. “The medicinal value of pau d’arco is thought to reside in certain compounds, called naphthaquinones, in the inner bark. Proponents claim that naphthaquinones enhance the immune system, cleanse the body and stimulate the production of red blood cells, which can increase the amount of oxygen the blood can carry contributing to healing.” * The heartwood of Pau d’arco — Tabebuia avellanedae — contains chemical compounds called naphthoquinones such as lapachol, as well as significant amounts of the antioxidant quercetin. “Pau d'arco, or the inner bark of the Tabebuia avellanedae tree, is native to Brazil, where it is used traditionally to treat a wide range of conditions including pain, arthritis, inflammation of the prostate gland (prostatitis), fever, dysentery, boils and ulcers, and various cancers. Preliminary laboratory research examining the properties of pau d'arco is beginning to suggest that the traditional uses may have scientific merit. Such laboratory studies have shown that pau d'arco has pain killing, diuretic, anti-inflammatory, anti-infectious, anti-psoriatic, and anti-cancer abilities.” Other uses include for candidiasis (a yeast infection of the vaginal or oral areas), herpes simplex virus, influenza, parasitic diseases such as schistosomiasis, bacterial infections such as brucellosis, and inflammation of the cervix (cervicitis) or the vagina (vaginitis). Pau d'arco may also reduce inflammation of the joints associated with arthritis. (University of Maryland Medical Center; http://www.umm.edu/altmed/ConsHerbs/PaudArcoch.html) Traditional uses also include for cancer, lupus, infectious diseases, wounds, backache, toothache and sexually transmitted diseases. Proponents claim that naphthaquinones enhance the immune system, cleanse the body and stimulate the production of red blood cells, which can increase the amount of oxygen the blood can carry contributing to healing. In large doses, Pau d’arco has killed lung cancer cells grown in the laboratory and reduced the rate of lung tumor growth in mice. The whole bark has no known side effects. The unrefined bark is much safer than taking extracts of the active ingredients. High doses of naphthaquinones can cause uncontrolled bleeding, nausea and vomiting. (University of California Medical Center, San Diego; Moores Cancer Center) For this reason, it is safer to consume the plant in its whole, natural form (as found in Nutriplex Formulas’ Detox Complex) rather than as preparation that infuses isolated naphthaquinones into the formula. “In addition to its reported antitumor activities, Pau d’arco clearly has demonstrated broad clinical actions against a number of disease-causing organisms, which supports its wide uses in herbal medicine. Antimicrobial properties of many active phytochemicals were demonstrated in several trials, in which they exhibited strong in vitro activity against various gram-positive and gram-negative bacteria, fungi, and yeast (including Candida albicans, Candida tropicalis, cryptococcus neoformans). ”Lapachol has been stated to be active against certain viral strains including herpes virus types I and II. Naphthoquinones have been documented to show effectiveness against four strains of the flu, polio and vesicular stomatitis virus. The mechanism of action of these quinolones is supposed to be via DNA and RNA polymerase inhibition and retrovirus reveres transcriptase. Further Beta- lapachone is presumed to interfere with the replication of HIV-1 virus via transcriptase inhibition. Pau d’arco and its chemicals also have demonstrated in vitro antiviral properties against various viruses, including Herpes I and II, influenza, poliovirus, and vesicular stomatitis virus. It is reported that lapachol decreases the replication of viruses in human subjects however there is no available clinical data. (Rahel Woldu; Reviewed 5/14/03 Susan Paulsen Pharm D; University of Colorado at Denver and Health Sciences Center) IMPORTANT NOTE ON QUALITY: “Most of the commercially-available pau d’arco contain the inner and outer bark of the tree—which is stripped off at sawmills when the heartwood is milled into lumber for construction materials. At least 10 species of Tabebuia are logged commercially in South America for lumber purposes alone. When these logs arrive at lumber mills, the identifying leaves and flowers (which distinguish the tree species) are long gone—it’s all just “pau d’arco.” This may explain varying species of pau d’arco bark being sold as herbal products—and their resulting (diminished) quality.” FOR THIS REASON, NutriPlex Formulas uses a guaranteed pure source of Pau D’arco from the Costa Rican Rainforest. * A Cancer Patient's Guide toComplementary and Alternative Medicine, 2nd Edition; Editor: Kerry Harwood, RN, MSN; Duke University DetoxFormula Medical Center NutriPlex Formulas, Inc.