Download Prof.ssa Maria Giovanna Trivella

Curriculum vitae
M. Giovanna Trivella
Italian citizen
Office address
Telephone
Telefax
Position
born: November 24, 1951
Pisa, Italy
CNR (Italian National Research Council),
Clinical Physiology Institute
Via Moruzzi 1, 56124, Pisa Italy
+39 050 3152730
+39 050 3152166
CNR Senior Investigator,
Head of Experimental Laboratory of
Clinical Physiology Institute, (since February 1989)
Education
Undergraduate
Medical
Medical Doctor Degree
(Full honours)
Liceo Classico Pisa, Italy, 1970
University of Pisa, Italy 1970-1976
University of Pisa, Italy, October 1976
Post doctoral training
Practical training in Cardiology
School of Cardiology
(Final exam: full honours)
Istituto di Patologia Medica, University of Pisa, 1977
University of Pisa, Italy, 1977-1981
Fellowships
AR.MED fellowship (Association of Research in Medicine, Pisa, Italy),
Engineering Department, University of Pisa, Italy, 1981, with a program on biomedical devices.
AR.MED fellowship, Engineering Department, University of Pisa, Italy, 1982, with an experimental program
on coronary resistances.
Fogarty fellowship of NIH, October 1986-November 1987, Department of Physiology and Biophysics,
University of Washington, Seattle, USA, with a research program on coronary receptors.
Duties and experiences
Care of patients in Coronary Care Unit and in cardiological department. (since 1981).
Catheterization laboratory and interventional cardiology (since 1981).
Member of a Control Committee for Research Contracts, National Program on “Sensors, Actuators,
Transducers”, 1984-1986.
Participant in the Programs of validation of physical and chemical sensors and coronary catheters for
angioplasty (National Research Program of Technologies in Cardiology, 1989-1992).
Italian and European patent as inventor of an automatic device for the monitoring of coronary angioplasty
catheter, 1992: Apparecchiatura sensorizzata per il gonfiaggio dei palloncini dei cateteri per la procedura di
angioplastica coronarica, BO91A 000180, Italia; Apparatus provided with sensors for inflating the balloon of
catheters used for performing coronary angioplasty, 92830248.8, European patent) .
Responsible of a research project on “Acute myocardial Infarction: neuropsychic risk factors”, subproject on
Stress and Cardiovascular Diseases, CNR Program, 1990-1996.
Head of Unità Comune di Chirurgia Sperimentale, S. Piero a Grado, Pisa, since 1994 until present
(experimental surgery laboratory based on agreement and cooperation with the University of Pisa)
Responsible of Research Unit, CNR “Icaros” Strategic Project on Artificial Heart, 1992-1993.
Member of Working Group on “In vivo testing of Mechanical Circulatory Support Systems”, Concerted
Action on Heart Assist and Replacement, EC, BIOMED I, 1993-1996 (TRIVELLA M.G., DEL CANIZO J.F.,
CHIECO S., FLAMENG W., MELI M., MEYNS B., MONTIES J.R., WALDENBERGER F., RAKHORST G.:
Guidelines for in-vivo testing of mechanical circulatory support systems. Report Concerted Action Heart
Assist and Replacement, Section III - ISBN 88 - 86219.05.09, pp III-1 - III-40, 1996).
Partner of the research program on “Shape memory alloy microactuators for medical applications”, BriteEuRam II, 1993-1996.
Member of the Commission (Ministry of Health and Ministry of University and Scientific and Technological
Research of Italy) for the application problems on animal use in experiments, 1994.
Responsible of research unit and education project on “Autonomic factors in myocardial infarction”, National
Drug Program, 1997-1999.
Participant in the Clinical Validation Unit of MUSIC project (Biomed) for the study of a robotic endoscope,
1997-2000.
Participant in Microcard Project, Esprit IV-Reactive LTR, for microsensors of flow and chemical variables,
1996-2000.
Cooperation with the Robotic Group, Scuola Superiore S.Anna, Pisa, in the project EMIL (Endoscopic
Microcapsule Locomotion), financially supported by Intelligent Microsystem Center, KIST-Seoul, South
Chorea, 2000-2001.
Project leader for the construction of the Experimental Biomedicine Centre, CNR Research Area, Pisa, in
collaboration with Scuola Superiore S. Anna (facilities definition and opening steps, 1999-2002).
Biomedicine expert in SABA network (Tuscany, Italy) (Interdisciplinary regional network studying sensors for
applications in agriculture, foods, environment and biomedicine), October 2003-until present.
Member of Scientific Committee, Cancer Institute of Tuscany Region, October 2004-until present.
Responsible of Research Units for national projects of the Strategic Program “New Medical Engineering” for
the following studies: 1- Thermoablation devices (radiofrequency) on oncological and hypertrophic diseases;
2- Biotechnologies applied to solid cancers (plasmafiltration pumps);
3- Endovascular devices and minimal invasive surgery, laser assisted surgery; 2002-2006.
Experimental testing of cardiopulmonary assist devices on models of acute myocardial infarction, 2002-2006.
Partner of the European network Himnet "Microsystems, nanodevices and material for human-implantable
sensors and actuators" (application in Sixth Framework Program)”.
Collaboration in the European project Net MED “Virtual Institute on Micromechatronics for Biomedical
Industry”.
Application specialist for the European project “Biosensing textile for health management”, FP6-Joint Call
IST-NMP Biotex Project Contract 016789.
Preclinical validation of centrifugal pumps for extracorporeal circulation, 2006.
Experimental validation of new coronary stents based on genetic therapy, 2005-2009.
Participant in the bilateral project FIRB Italy–Canada, IFC-CNR e IBD-NRC, “New imaging techniques for the
understanding of cardiac disease mechanisms and their management”, 2007-2009
Awarded by the European Science Foundation for the Exploratory Workshop “Molecular signaling in
cardiovascular and oncological disease: similar and shared pathways”, Pisa July 2008 (selected for funding
within the 2007 call for proposals).
Member of National Advisory Board, Scuola Superiore Sant’Anna, Pisa, 2007-2010.
European Science Foundation peer reviewer for 2008-2009, 2009-2010,2011-2012.
Ethical Committee external member of MIBISOC Project, Medical Imaging Using Bio-inspired and Soft
Computing (no. 238819, Marie Curie Initial Training Networks ITN), 2009-2013.
Member of Ethical Commission Clinical Physiology Institute, from 2010.
Participant to the ARTreat Project, Information and Communication Technologies (ICT)
FP7-224297 for Large-scale Integrating Project (IP), “Multi-level patient-specific artery and atherogenesis
model for outcome prediction, decision support treatment, and virtual hand-on training”, 2008-2010
Coordinator of a Large-scale Integrating Project (IP): “SensorART - A remote controlled Sensorized Artificial
heart enabling patients empowerment and new therapy approaches ( FP7-ICT-248763), 2010-2014
Research activity: fields of interest
Clinical field:
Pathophysiology of myocardial ischemia and infarction
Hemodynamics monitoring (clinical evaluation and computerized analysis)
Physical and psychological stress test in cardiovascular diseases
Data bank of patient characterization (multimedial archives)
Personality and psychological characterizations in cardiovascular diseases
Personality and psychological characterizations in patients waiting for organ transplantation
Breath and sweat as disease markers.
Experimental field:
Coronary blood flow (transmural distribution, coronary reserve)
Myocardial function and coronary blood flow (interplay between mechanics and perfusion)
Neural control of myocardial blood flow and metabolism
Coronary receptors
Intracoronary thrombosis and reperfusion
Hepatic microcirculation in transplanted liver
Encephalopathy post surgical hepatectomy
Lung transplantation
Neonatal and intrauterine cardiosurgery
Therapeutic approaches in vascular surgery
Coronary restenosis
Myocardial infarction
Bioengineering:
Multisensor devices
New catheters
Computerized maps of cardiac metabolism and flow
Mathematical models of coronary vasculature
Fractal analysis of flow heterogeneity
Fractal models in nuclear magnetic resonance images
Artificial heart
Ventricular assist devices
Shape memory alloy actuators
Support devices in experimental liver failure models
Robotic endoscopes
Flow and chemical variables microsensors
Radiofrequency thermoablation devices
Laser surgical devices
Publications
Author of more than 270 scientific works, published as articles in national and international Journals, as
proceedings of national and international meetings, as chapters of books and as abstracts.
Editor of 2 books.
Recent Publications
1. Crucean A., Murzi B., Giorgi A., Burchielli S., Trivella M.G., Coceani F.: Cardiopulmonary bypass in
Ewe’s fetus: advances and setbacks in our learning curve. Asaio Journal, 51: 649-653, 2005.
2. Clara Carpeggiani, Michele Emdin, Franco Bonaguidi, Patrizia Landi, Claudio Michelassi, Maria
Giovanna Trivella, Alberto Macerata And Antonio L’abbate: Personality traits and heart rate
variability predict longterm cardiac mortality after myocardial infarction. European Heart Journal 26:
1612–1617, 2005.
3.
Di Francesco F., Fuoco R., Trivella M.G., Ceccarini A.: Breath analysis: trends in techniques
and clinical applications. Microchemical Journal 79: 405-410, 2005.
4.
M. Giovanna Trivella, Silvia Burchielli, Alessandra Piersigilli, Fabio Bernini, Luigi Taddei,
Doretta Magnozzi, Graziano Barsotti, Vittorio Gattai, Gualtiero Pelosi: Il ruolo del laboratorio
sperimentale nel percorso di validazione dei dispositivi. In Terapie termoablative: dai principi fisici
alle applicazioni cliniche, MG Trivella ed, pp 47-51, Primula Multimedia SrL Pisa, 2006
5.
Edoardo Scarcello, Md, Phd, Giuseppe Triggiani, Msc, Mario Arispici, Dvm, Leonardo Bertini,
Phd, Filippo Bosi, Fabio Bernini, Claudia Salvadori, Dvm, Phd, M.Giovanna Trivella, Md:
Experimental Study of a New Vascular Anastomotic Technique in a Swine Model: Short and MidTerm Results. Annals of Vascular Surgery, 21:346-351, 2007.
6. Trivella MG: Cardiovascular Physiology / Circulation. In Modelling cardiovascular system and
mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 3-31, ISBN 978-88-8080-081-1,
2007.
7. Trivella MG, De Lazzari C: Mechanical circulatory support system (MCSS) . In Modelling
cardiovascular system and mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 167187, ISBN 978-88-8080-081-1, 2007.
8. De Lazzari C, Trivella MG: Coronary blood flow: comparison between in vivo and numerical
simulation data. In Modelling cardiovascular system and mechanical circulatory support, C. De
Lazzari Ed, CNR Roma, pp 233-237, ISBN 978-88-8080-081-1, 2007.
9. M. Giovanna Trivella, Gualtiero Pelosi, Danilo Neglia, Antonio L’abbate: Interaction between left
ventricle mechanics and myocardial blood flow. Biocybernetics and Biomedical Engineering ,
Volume 28, Number 1, pp 3-16, 2008.
10. M. Giovanna Trivella, Giuseppe Rainaldi: SCIENTIFIC REPORT ESF Exploratory Workshop on
Molecular Signaling in Cardiovascular and Oncological Diseases: Similar and Shared Pathways.
EW07-013 – EMRC n.30, 2008.
11. C De Lazzari, D Neglia, G Ferrari, F Bernini, M Micalizzi, R Massari, A L'
abbate, MG Trivella:
Computer Simulation of Coronary Flow Waveforms during Caval Occlusion, Methods of Information
in Medicine, 48-(2): 113-122, 2009.
12. Vera Srebot, Emilio AL Gianicolo, Giuseppe Rainaldi, Maria Giovanna Trivella and Rosa Sicari:
Ozone and cardiovascular injury, Cardiovascular Ultrasound 2009, doi:10.1186/1476-7120-7-30
13. Shirley Coyle, Deirdre Morris, King-Tong Lau, Dermot Diamond, Nicola Taccini, Daniele Costanzo,
Pietro Salvo, Fabio Di Francesco, Maria Giovanna Trivella, Jacque-André Porchet, Jean Luprano:
Textile sensors to measure sweat pH and sweat-rate during exercise. BIOTEX project FP6,
http://doras.dcu.ie/3636/1/Coyle_pervasive2009.pdf
14. A Di Molfetta, C De Lazzari, G Ferrari, F Moscariello, G Aguzzi, L Fresiello, M Darowski, MG Trivella
and N Alessandri: Biventricular Pacemaker Synchronization: A Numerical Cardiocirculatory Model
Application To Reproduce In Vivo Data. Biocybernetics and Biomedical Engineering, 2010, Volume
30, Number 1, pp. 3–15
15. Shirley Coyle, King-Tong Lau, Niall Moyna, Donal O’Gorman, Dermot Diamond, Fabio Di Francesco,
Daniele Costanzo, Pietro Salvo, Maria Giovanna Trivella, Danilo Emilio De Rossi, Nicola Taccini,
Rita Paradiso, Jacque-André Porchet, Andrea Ridolfi, Jean Luprano, Cyril Chuzel, Thierry Lanier,
Frederic Revol-Cavalier, Sebastien Schoumacker, Veronique Mourier, Isabelle Chartier, Reynald
Convert, Henri De-Moncuit, and Christina Bini: BIOTEX—Biosensing Textiles for Personalised
Healthcare Management. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN
BIOMEDICINE, VOL. 14, NO. 2, MARCH 2010
16. Rocchiccioli, S; Citti, L; Boccardi, C; Ucciferri, N; Tedeschi, L; Lande, C; Trivella, MG; Cecchettini, A.
(2010) “A gel-free approach in vascular smooth muscle cell proteome: perspectives for a better
insight into activation” PMID: 20334645 Proteome Science 2010, 8:15
17. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. Optical Society of
America OCIS codes: (170.1470), 2010
18. Maria Giovanna Trivella, Federico Vozzi, Mariarita Puntoni, Nicoletta Vesentini, Claudia Kusmic,
Paolo Marraccini, Gualtiero Pelosi, Oberdan Parodi: Predizione di crescita della placca
aterosclerotica e supporto decisionale: il progetto ARTreat. Atti 44° CONVEGNO CARDIOLOGIA
2010, 443-447.
19. Maria Frigerio, Raffaele Caruso, Andrea Garascia, Luigi Martinelli, Oberdan Parodi, Maria Giovanna
Trivella: SENSORISTICA ED ASSISTENZA REMOTA DEL CUORE ARTIFICIALE:IL PROGETTO
SENSORART. Atti 44° CONVEGNO CARDIOLOGIA 2010, 448-454
20. P. Salvo, 1, F. Di Francesco, D. Costanzo, C. Ferrari, M.G. Trivella, D. De Rossi: A wearable sensor
for measuring sweat rate IEEE SENSORS JOURNAL, VOL. 10, NO. 10, OCTOBER 2010
21. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. 2010 Optical Society of
America OCIS codes: (170.1470)
22. L. Fresiello, C. De Lazzari , M.G. Trivella, A. Di Molfetta and G. Ferrari: INFLUENCE OF PULSATILE
CATHETER PUMP SYNCHRONIZATION ON HAEMODYNAMIC VARIABLES: NUMERICAL
SIMULATION Proceeding of the 7th IASTED International Conference of Biomedical Engineering
(BioMED 2010)
Curriculum vitae
M. Giovanna Trivella
Italian citizen
Office address
Telephone
Telefax
Position
born: November 24, 1951
Pisa, Italy
CNR (Italian National Research Council),
Clinical Physiology Institute
Via Moruzzi 1, 56124, Pisa Italy
+39 050 3152730
+39 050 3152166
CNR Senior Investigator,
Head of Experimental Laboratory of
Clinical Physiology Institute, (since February 1989)
Education
Undergraduate
Medical
Medical Doctor Degree
(Full honours)
Liceo Classico Pisa, Italy, 1970
University of Pisa, Italy 1970-1976
University of Pisa, Italy, October 1976
Post doctoral training
Practical training in Cardiology
School of Cardiology
(Final exam: full honours)
Istituto di Patologia Medica, University of Pisa, 1977
University of Pisa, Italy, 1977-1981
Fellowships
AR.MED fellowship (Association of Research in Medicine, Pisa, Italy),
Engineering Department, University of Pisa, Italy, 1981, with a program on biomedical devices.
AR.MED fellowship, Engineering Department, University of Pisa, Italy, 1982, with an experimental program
on coronary resistances.
Fogarty fellowship of NIH, October 1986-November 1987, Department of Physiology and Biophysics,
University of Washington, Seattle, USA, with a research program on coronary receptors.
Duties and experiences
Care of patients in Coronary Care Unit and in cardiological department. (since 1981).
Catheterization laboratory and interventional cardiology (since 1981).
Member of a Control Committee for Research Contracts, National Program on “Sensors, Actuators,
Transducers”, 1984-1986.
Participant in the Programs of validation of physical and chemical sensors and coronary catheters for
angioplasty (National Research Program of Technologies in Cardiology, 1989-1992).
Italian and European patent as inventor of an automatic device for the monitoring of coronary angioplasty
catheter, 1992: Apparecchiatura sensorizzata per il gonfiaggio dei palloncini dei cateteri per la procedura di
angioplastica coronarica, BO91A 000180, Italia; Apparatus provided with sensors for inflating the balloon of
catheters used for performing coronary angioplasty, 92830248.8, European patent) .
Responsible of a research project on “Acute myocardial Infarction: neuropsychic risk factors”, subproject on
Stress and Cardiovascular Diseases, CNR Program, 1990-1996.
Head of Unità Comune di Chirurgia Sperimentale, S. Piero a Grado, Pisa, since 1994 until present
(experimental surgery laboratory based on agreement and cooperation with the University of Pisa)
Responsible of Research Unit, CNR “Icaros” Strategic Project on Artificial Heart, 1992-1993.
Member of Working Group on “In vivo testing of Mechanical Circulatory Support Systems”, Concerted
Action on Heart Assist and Replacement, EC, BIOMED I, 1993-1996 (TRIVELLA M.G., DEL CANIZO J.F.,
CHIECO S., FLAMENG W., MELI M., MEYNS B., MONTIES J.R., WALDENBERGER F., RAKHORST G.:
Guidelines for in-vivo testing of mechanical circulatory support systems. Report Concerted Action Heart
Assist and Replacement, Section III - ISBN 88 - 86219.05.09, pp III-1 - III-40, 1996).
Partner of the research program on “Shape memory alloy microactuators for medical applications”, BriteEuRam II, 1993-1996.
Member of the Commission (Ministry of Health and Ministry of University and Scientific and Technological
Research of Italy) for the application problems on animal use in experiments, 1994.
Responsible of research unit and education project on “Autonomic factors in myocardial infarction”, National
Drug Program, 1997-1999.
Participant in the Clinical Validation Unit of MUSIC project (Biomed) for the study of a robotic endoscope,
1997-2000.
Participant in Microcard Project, Esprit IV-Reactive LTR, for microsensors of flow and chemical variables,
1996-2000.
Cooperation with the Robotic Group, Scuola Superiore S.Anna, Pisa, in the project EMIL (Endoscopic
Microcapsule Locomotion), financially supported by Intelligent Microsystem Center, KIST-Seoul, South
Chorea, 2000-2001.
Project leader for the construction of the Experimental Biomedicine Centre, CNR Research Area, Pisa, in
collaboration with Scuola Superiore S. Anna (facilities definition and opening steps, 1999-2002).
Biomedicine expert in SABA network (Tuscany, Italy) (Interdisciplinary regional network studying sensors for
applications in agriculture, foods, environment and biomedicine), October 2003-until present.
Member of Scientific Committee, Cancer Institute of Tuscany Region, October 2004-until present.
Responsible of Research Units for national projects of the Strategic Program “New Medical Engineering” for
the following studies: 1- Thermoablation devices (radiofrequency) on oncological and hypertrophic diseases;
2- Biotechnologies applied to solid cancers (plasmafiltration pumps);
3- Endovascular devices and minimal invasive surgery, laser assisted surgery; 2002-2006.
Experimental testing of cardiopulmonary assist devices on models of acute myocardial infarction, 2002-2006.
Partner of the European network Himnet "Microsystems, nanodevices and material for human-implantable
sensors and actuators" (application in Sixth Framework Program)”.
Collaboration in the European project Net MED “Virtual Institute on Micromechatronics for Biomedical
Industry”.
Application specialist for the European project “Biosensing textile for health management”, FP6-Joint Call
IST-NMP Biotex Project Contract 016789.
Preclinical validation of centrifugal pumps for extracorporeal circulation, 2006.
Experimental validation of new coronary stents based on genetic therapy, 2005-2009.
Participant in the bilateral project FIRB Italy–Canada, IFC-CNR e IBD-NRC, “New imaging techniques for the
understanding of cardiac disease mechanisms and their management”, 2007-2009
Awarded by the European Science Foundation for the Exploratory Workshop “Molecular signaling in
cardiovascular and oncological disease: similar and shared pathways”, Pisa July 2008 (selected for funding
within the 2007 call for proposals).
Member of National Advisory Board, Scuola Superiore Sant’Anna, Pisa, 2007-2010.
European Science Foundation peer reviewer for 2008-2009, 2009-2010,2011-2012.
Ethical Committee external member of MIBISOC Project, Medical Imaging Using Bio-inspired and Soft
Computing (no. 238819, Marie Curie Initial Training Networks ITN), 2009-2013.
Member of Ethical Commission Clinical Physiology Institute, from 2010.
Participant to the ARTreat Project, Information and Communication Technologies (ICT)
FP7-224297 for Large-scale Integrating Project (IP), “Multi-level patient-specific artery and atherogenesis
model for outcome prediction, decision support treatment, and virtual hand-on training”, 2008-2010
Coordinator of a Large-scale Integrating Project (IP): “SensorART - A remote controlled Sensorized Artificial
heart enabling patients empowerment and new therapy approaches ( FP7-ICT-248763), 2010-2014
Research activity: fields of interest
Clinical field:
Pathophysiology of myocardial ischemia and infarction
Hemodynamics monitoring (clinical evaluation and computerized analysis)
Physical and psychological stress test in cardiovascular diseases
Data bank of patient characterization (multimedial archives)
Personality and psychological characterizations in cardiovascular diseases
Personality and psychological characterizations in patients waiting for organ transplantation
Breath and sweat as disease markers.
Experimental field:
Coronary blood flow (transmural distribution, coronary reserve)
Myocardial function and coronary blood flow (interplay between mechanics and perfusion)
Neural control of myocardial blood flow and metabolism
Coronary receptors
Intracoronary thrombosis and reperfusion
Hepatic microcirculation in transplanted liver
Encephalopathy post surgical hepatectomy
Lung transplantation
Neonatal and intrauterine cardiosurgery
Therapeutic approaches in vascular surgery
Coronary restenosis
Myocardial infarction
Bioengineering:
Multisensor devices
New catheters
Computerized maps of cardiac metabolism and flow
Mathematical models of coronary vasculature
Fractal analysis of flow heterogeneity
Fractal models in nuclear magnetic resonance images
Artificial heart
Ventricular assist devices
Shape memory alloy actuators
Support devices in experimental liver failure models
Robotic endoscopes
Flow and chemical variables microsensors
Radiofrequency thermoablation devices
Laser surgical devices
Publications
Author of more than 270 scientific works, published as articles in national and international Journals, as
proceedings of national and international meetings, as chapters of books and as abstracts.
Editor of 2 books.
Recent Publications
1. Crucean A., Murzi B., Giorgi A., Burchielli S., Trivella M.G., Coceani F.: Cardiopulmonary bypass in
Ewe’s fetus: advances and setbacks in our learning curve. Asaio Journal, 51: 649-653, 2005.
2. Clara Carpeggiani, Michele Emdin, Franco Bonaguidi, Patrizia Landi, Claudio Michelassi, Maria
Giovanna Trivella, Alberto Macerata And Antonio L’abbate: Personality traits and heart rate
variability predict longterm cardiac mortality after myocardial infarction. European Heart Journal 26:
1612–1617, 2005.
3.
Di Francesco F., Fuoco R., Trivella M.G., Ceccarini A.: Breath analysis: trends in techniques
and clinical applications. Microchemical Journal 79: 405-410, 2005.
4.
M. Giovanna Trivella, Silvia Burchielli, Alessandra Piersigilli, Fabio Bernini, Luigi Taddei,
Doretta Magnozzi, Graziano Barsotti, Vittorio Gattai, Gualtiero Pelosi: Il ruolo del laboratorio
sperimentale nel percorso di validazione dei dispositivi. In Terapie termoablative: dai principi fisici
alle applicazioni cliniche, MG Trivella ed, pp 47-51, Primula Multimedia SrL Pisa, 2006
5.
Edoardo Scarcello, Md, Phd, Giuseppe Triggiani, Msc, Mario Arispici, Dvm, Leonardo Bertini,
Phd, Filippo Bosi, Fabio Bernini, Claudia Salvadori, Dvm, Phd, M.Giovanna Trivella, Md:
Experimental Study of a New Vascular Anastomotic Technique in a Swine Model: Short and MidTerm Results. Annals of Vascular Surgery, 21:346-351, 2007.
6. Trivella MG: Cardiovascular Physiology / Circulation. In Modelling cardiovascular system and
mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 3-31, ISBN 978-88-8080-081-1,
2007.
7. Trivella MG, De Lazzari C: Mechanical circulatory support system (MCSS) . In Modelling
cardiovascular system and mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 167187, ISBN 978-88-8080-081-1, 2007.
8. De Lazzari C, Trivella MG: Coronary blood flow: comparison between in vivo and numerical
simulation data. In Modelling cardiovascular system and mechanical circulatory support, C. De
Lazzari Ed, CNR Roma, pp 233-237, ISBN 978-88-8080-081-1, 2007.
9. M. Giovanna Trivella, Gualtiero Pelosi, Danilo Neglia, Antonio L’abbate: Interaction between left
ventricle mechanics and myocardial blood flow. Biocybernetics and Biomedical Engineering ,
Volume 28, Number 1, pp 3-16, 2008.
10. M. Giovanna Trivella, Giuseppe Rainaldi: SCIENTIFIC REPORT ESF Exploratory Workshop on
Molecular Signaling in Cardiovascular and Oncological Diseases: Similar and Shared Pathways.
EW07-013 – EMRC n.30, 2008.
11. C De Lazzari, D Neglia, G Ferrari, F Bernini, M Micalizzi, R Massari, A L'
abbate, MG Trivella:
Computer Simulation of Coronary Flow Waveforms during Caval Occlusion, Methods of Information
in Medicine, 48-(2): 113-122, 2009.
12. Vera Srebot, Emilio AL Gianicolo, Giuseppe Rainaldi, Maria Giovanna Trivella and Rosa Sicari:
Ozone and cardiovascular injury, Cardiovascular Ultrasound 2009, doi:10.1186/1476-7120-7-30
13. Shirley Coyle, Deirdre Morris, King-Tong Lau, Dermot Diamond, Nicola Taccini, Daniele Costanzo,
Pietro Salvo, Fabio Di Francesco, Maria Giovanna Trivella, Jacque-André Porchet, Jean Luprano:
Textile sensors to measure sweat pH and sweat-rate during exercise. BIOTEX project FP6,
http://doras.dcu.ie/3636/1/Coyle_pervasive2009.pdf
14. A Di Molfetta, C De Lazzari, G Ferrari, F Moscariello, G Aguzzi, L Fresiello, M Darowski, MG Trivella
and N Alessandri: Biventricular Pacemaker Synchronization: A Numerical Cardiocirculatory Model
Application To Reproduce In Vivo Data. Biocybernetics and Biomedical Engineering, 2010, Volume
30, Number 1, pp. 3–15
15. Shirley Coyle, King-Tong Lau, Niall Moyna, Donal O’Gorman, Dermot Diamond, Fabio Di Francesco,
Daniele Costanzo, Pietro Salvo, Maria Giovanna Trivella, Danilo Emilio De Rossi, Nicola Taccini,
Rita Paradiso, Jacque-André Porchet, Andrea Ridolfi, Jean Luprano, Cyril Chuzel, Thierry Lanier,
Frederic Revol-Cavalier, Sebastien Schoumacker, Veronique Mourier, Isabelle Chartier, Reynald
Convert, Henri De-Moncuit, and Christina Bini: BIOTEX—Biosensing Textiles for Personalised
Healthcare Management. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN
BIOMEDICINE, VOL. 14, NO. 2, MARCH 2010
16. Rocchiccioli, S; Citti, L; Boccardi, C; Ucciferri, N; Tedeschi, L; Lande, C; Trivella, MG; Cecchettini, A.
(2010) “A gel-free approach in vascular smooth muscle cell proteome: perspectives for a better
insight into activation” PMID: 20334645 Proteome Science 2010, 8:15
17. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. Optical Society of
America OCIS codes: (170.1470), 2010
18. Maria Giovanna Trivella, Federico Vozzi, Mariarita Puntoni, Nicoletta Vesentini, Claudia Kusmic,
Paolo Marraccini, Gualtiero Pelosi, Oberdan Parodi: Predizione di crescita della placca
aterosclerotica e supporto decisionale: il progetto ARTreat. Atti 44° CONVEGNO CARDIOLOGIA
2010, 443-447.
19. Maria Frigerio, Raffaele Caruso, Andrea Garascia, Luigi Martinelli, Oberdan Parodi, Maria Giovanna
Trivella: SENSORISTICA ED ASSISTENZA REMOTA DEL CUORE ARTIFICIALE:IL PROGETTO
SENSORART. Atti 44° CONVEGNO CARDIOLOGIA 2010, 448-454
20. P. Salvo, 1, F. Di Francesco, D. Costanzo, C. Ferrari, M.G. Trivella, D. De Rossi: A wearable sensor
for measuring sweat rate IEEE SENSORS JOURNAL, VOL. 10, NO. 10, OCTOBER 2010
21. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. 2010 Optical Society of
America OCIS codes: (170.1470)
22. L. Fresiello, C. De Lazzari , M.G. Trivella, A. Di Molfetta and G. Ferrari: INFLUENCE OF PULSATILE
CATHETER PUMP SYNCHRONIZATION ON HAEMODYNAMIC VARIABLES: NUMERICAL
SIMULATION Proceeding of the 7th IASTED International Conference of Biomedical Engineering
(BioMED 2010)
Curriculum vitae
M. Giovanna Trivella
Italian citizen
Office address
Telephone
Telefax
Position
born: November 24, 1951
Pisa, Italy
CNR (Italian National Research Council),
Clinical Physiology Institute
Via Moruzzi 1, 56124, Pisa Italy
+39 050 3152730
+39 050 3152166
CNR Senior Investigator,
Head of Experimental Laboratory of
Clinical Physiology Institute, (since February 1989)
Education
Undergraduate
Medical
Medical Doctor Degree
(Full honours)
Liceo Classico Pisa, Italy, 1970
University of Pisa, Italy 1970-1976
University of Pisa, Italy, October 1976
Post doctoral training
Practical training in Cardiology
School of Cardiology
(Final exam: full honours)
Istituto di Patologia Medica, University of Pisa, 1977
University of Pisa, Italy, 1977-1981
Fellowships
AR.MED fellowship (Association of Research in Medicine, Pisa, Italy),
Engineering Department, University of Pisa, Italy, 1981, with a program on biomedical devices.
AR.MED fellowship, Engineering Department, University of Pisa, Italy, 1982, with an experimental program
on coronary resistances.
Fogarty fellowship of NIH, October 1986-November 1987, Department of Physiology and Biophysics,
University of Washington, Seattle, USA, with a research program on coronary receptors.
Duties and experiences
Care of patients in Coronary Care Unit and in cardiological department. (since 1981).
Catheterization laboratory and interventional cardiology (since 1981).
Member of a Control Committee for Research Contracts, National Program on “Sensors, Actuators,
Transducers”, 1984-1986.
Participant in the Programs of validation of physical and chemical sensors and coronary catheters for
angioplasty (National Research Program of Technologies in Cardiology, 1989-1992).
Italian and European patent as inventor of an automatic device for the monitoring of coronary angioplasty
catheter, 1992: Apparecchiatura sensorizzata per il gonfiaggio dei palloncini dei cateteri per la procedura di
angioplastica coronarica, BO91A 000180, Italia; Apparatus provided with sensors for inflating the balloon of
catheters used for performing coronary angioplasty, 92830248.8, European patent) .
Responsible of a research project on “Acute myocardial Infarction: neuropsychic risk factors”, subproject on
Stress and Cardiovascular Diseases, CNR Program, 1990-1996.
Head of Unità Comune di Chirurgia Sperimentale, S. Piero a Grado, Pisa, since 1994 until present
(experimental surgery laboratory based on agreement and cooperation with the University of Pisa)
Responsible of Research Unit, CNR “Icaros” Strategic Project on Artificial Heart, 1992-1993.
Member of Working Group on “In vivo testing of Mechanical Circulatory Support Systems”, Concerted
Action on Heart Assist and Replacement, EC, BIOMED I, 1993-1996 (TRIVELLA M.G., DEL CANIZO J.F.,
CHIECO S., FLAMENG W., MELI M., MEYNS B., MONTIES J.R., WALDENBERGER F., RAKHORST G.:
Guidelines for in-vivo testing of mechanical circulatory support systems. Report Concerted Action Heart
Assist and Replacement, Section III - ISBN 88 - 86219.05.09, pp III-1 - III-40, 1996).
Partner of the research program on “Shape memory alloy microactuators for medical applications”, BriteEuRam II, 1993-1996.
Member of the Commission (Ministry of Health and Ministry of University and Scientific and Technological
Research of Italy) for the application problems on animal use in experiments, 1994.
Responsible of research unit and education project on “Autonomic factors in myocardial infarction”, National
Drug Program, 1997-1999.
Participant in the Clinical Validation Unit of MUSIC project (Biomed) for the study of a robotic endoscope,
1997-2000.
Participant in Microcard Project, Esprit IV-Reactive LTR, for microsensors of flow and chemical variables,
1996-2000.
Cooperation with the Robotic Group, Scuola Superiore S.Anna, Pisa, in the project EMIL (Endoscopic
Microcapsule Locomotion), financially supported by Intelligent Microsystem Center, KIST-Seoul, South
Chorea, 2000-2001.
Project leader for the construction of the Experimental Biomedicine Centre, CNR Research Area, Pisa, in
collaboration with Scuola Superiore S. Anna (facilities definition and opening steps, 1999-2002).
Biomedicine expert in SABA network (Tuscany, Italy) (Interdisciplinary regional network studying sensors for
applications in agriculture, foods, environment and biomedicine), October 2003-until present.
Member of Scientific Committee, Cancer Institute of Tuscany Region, October 2004-until present.
Responsible of Research Units for national projects of the Strategic Program “New Medical Engineering” for
the following studies: 1- Thermoablation devices (radiofrequency) on oncological and hypertrophic diseases;
2- Biotechnologies applied to solid cancers (plasmafiltration pumps);
3- Endovascular devices and minimal invasive surgery, laser assisted surgery; 2002-2006.
Experimental testing of cardiopulmonary assist devices on models of acute myocardial infarction, 2002-2006.
Partner of the European network Himnet "Microsystems, nanodevices and material for human-implantable
sensors and actuators" (application in Sixth Framework Program)”.
Collaboration in the European project Net MED “Virtual Institute on Micromechatronics for Biomedical
Industry”.
Application specialist for the European project “Biosensing textile for health management”, FP6-Joint Call
IST-NMP Biotex Project Contract 016789.
Preclinical validation of centrifugal pumps for extracorporeal circulation, 2006.
Experimental validation of new coronary stents based on genetic therapy, 2005-2009.
Participant in the bilateral project FIRB Italy–Canada, IFC-CNR e IBD-NRC, “New imaging techniques for the
understanding of cardiac disease mechanisms and their management”, 2007-2009
Awarded by the European Science Foundation for the Exploratory Workshop “Molecular signaling in
cardiovascular and oncological disease: similar and shared pathways”, Pisa July 2008 (selected for funding
within the 2007 call for proposals).
Member of National Advisory Board, Scuola Superiore Sant’Anna, Pisa, 2007-2010.
European Science Foundation peer reviewer for 2008-2009, 2009-2010,2011-2012.
Ethical Committee external member of MIBISOC Project, Medical Imaging Using Bio-inspired and Soft
Computing (no. 238819, Marie Curie Initial Training Networks ITN), 2009-2013.
Member of Ethical Commission Clinical Physiology Institute, from 2010.
Participant to the ARTreat Project, Information and Communication Technologies (ICT)
FP7-224297 for Large-scale Integrating Project (IP), “Multi-level patient-specific artery and atherogenesis
model for outcome prediction, decision support treatment, and virtual hand-on training”, 2008-2010
Coordinator of a Large-scale Integrating Project (IP): “SensorART - A remote controlled Sensorized Artificial
heart enabling patients empowerment and new therapy approaches ( FP7-ICT-248763), 2010-2014
Research activity: fields of interest
Clinical field:
Pathophysiology of myocardial ischemia and infarction
Hemodynamics monitoring (clinical evaluation and computerized analysis)
Physical and psychological stress test in cardiovascular diseases
Data bank of patient characterization (multimedial archives)
Personality and psychological characterizations in cardiovascular diseases
Personality and psychological characterizations in patients waiting for organ transplantation
Breath and sweat as disease markers.
Experimental field:
Coronary blood flow (transmural distribution, coronary reserve)
Myocardial function and coronary blood flow (interplay between mechanics and perfusion)
Neural control of myocardial blood flow and metabolism
Coronary receptors
Intracoronary thrombosis and reperfusion
Hepatic microcirculation in transplanted liver
Encephalopathy post surgical hepatectomy
Lung transplantation
Neonatal and intrauterine cardiosurgery
Therapeutic approaches in vascular surgery
Coronary restenosis
Myocardial infarction
Bioengineering:
Multisensor devices
New catheters
Computerized maps of cardiac metabolism and flow
Mathematical models of coronary vasculature
Fractal analysis of flow heterogeneity
Fractal models in nuclear magnetic resonance images
Artificial heart
Ventricular assist devices
Shape memory alloy actuators
Support devices in experimental liver failure models
Robotic endoscopes
Flow and chemical variables microsensors
Radiofrequency thermoablation devices
Laser surgical devices
Publications
Author of more than 270 scientific works, published as articles in national and international Journals, as
proceedings of national and international meetings, as chapters of books and as abstracts.
Editor of 2 books.
Recent Publications
1. Crucean A., Murzi B., Giorgi A., Burchielli S., Trivella M.G., Coceani F.: Cardiopulmonary bypass in
Ewe’s fetus: advances and setbacks in our learning curve. Asaio Journal, 51: 649-653, 2005.
2. Clara Carpeggiani, Michele Emdin, Franco Bonaguidi, Patrizia Landi, Claudio Michelassi, Maria
Giovanna Trivella, Alberto Macerata And Antonio L’abbate: Personality traits and heart rate
variability predict longterm cardiac mortality after myocardial infarction. European Heart Journal 26:
1612–1617, 2005.
3.
Di Francesco F., Fuoco R., Trivella M.G., Ceccarini A.: Breath analysis: trends in techniques
and clinical applications. Microchemical Journal 79: 405-410, 2005.
4.
M. Giovanna Trivella, Silvia Burchielli, Alessandra Piersigilli, Fabio Bernini, Luigi Taddei,
Doretta Magnozzi, Graziano Barsotti, Vittorio Gattai, Gualtiero Pelosi: Il ruolo del laboratorio
sperimentale nel percorso di validazione dei dispositivi. In Terapie termoablative: dai principi fisici
alle applicazioni cliniche, MG Trivella ed, pp 47-51, Primula Multimedia SrL Pisa, 2006
5.
Edoardo Scarcello, Md, Phd, Giuseppe Triggiani, Msc, Mario Arispici, Dvm, Leonardo Bertini,
Phd, Filippo Bosi, Fabio Bernini, Claudia Salvadori, Dvm, Phd, M.Giovanna Trivella, Md:
Experimental Study of a New Vascular Anastomotic Technique in a Swine Model: Short and MidTerm Results. Annals of Vascular Surgery, 21:346-351, 2007.
6. Trivella MG: Cardiovascular Physiology / Circulation. In Modelling cardiovascular system and
mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 3-31, ISBN 978-88-8080-081-1,
2007.
7. Trivella MG, De Lazzari C: Mechanical circulatory support system (MCSS) . In Modelling
cardiovascular system and mechanical circulatory support, C. De Lazzari Ed, CNR Roma, pp 167187, ISBN 978-88-8080-081-1, 2007.
8. De Lazzari C, Trivella MG: Coronary blood flow: comparison between in vivo and numerical
simulation data. In Modelling cardiovascular system and mechanical circulatory support, C. De
Lazzari Ed, CNR Roma, pp 233-237, ISBN 978-88-8080-081-1, 2007.
9. M. Giovanna Trivella, Gualtiero Pelosi, Danilo Neglia, Antonio L’abbate: Interaction between left
ventricle mechanics and myocardial blood flow. Biocybernetics and Biomedical Engineering ,
Volume 28, Number 1, pp 3-16, 2008.
10. M. Giovanna Trivella, Giuseppe Rainaldi: SCIENTIFIC REPORT ESF Exploratory Workshop on
Molecular Signaling in Cardiovascular and Oncological Diseases: Similar and Shared Pathways.
EW07-013 – EMRC n.30, 2008.
11. C De Lazzari, D Neglia, G Ferrari, F Bernini, M Micalizzi, R Massari, A L'
abbate, MG Trivella:
Computer Simulation of Coronary Flow Waveforms during Caval Occlusion, Methods of Information
in Medicine, 48-(2): 113-122, 2009.
12. Vera Srebot, Emilio AL Gianicolo, Giuseppe Rainaldi, Maria Giovanna Trivella and Rosa Sicari:
Ozone and cardiovascular injury, Cardiovascular Ultrasound 2009, doi:10.1186/1476-7120-7-30
13. Shirley Coyle, Deirdre Morris, King-Tong Lau, Dermot Diamond, Nicola Taccini, Daniele Costanzo,
Pietro Salvo, Fabio Di Francesco, Maria Giovanna Trivella, Jacque-André Porchet, Jean Luprano:
Textile sensors to measure sweat pH and sweat-rate during exercise. BIOTEX project FP6,
http://doras.dcu.ie/3636/1/Coyle_pervasive2009.pdf
14. A Di Molfetta, C De Lazzari, G Ferrari, F Moscariello, G Aguzzi, L Fresiello, M Darowski, MG Trivella
and N Alessandri: Biventricular Pacemaker Synchronization: A Numerical Cardiocirculatory Model
Application To Reproduce In Vivo Data. Biocybernetics and Biomedical Engineering, 2010, Volume
30, Number 1, pp. 3–15
15. Shirley Coyle, King-Tong Lau, Niall Moyna, Donal O’Gorman, Dermot Diamond, Fabio Di Francesco,
Daniele Costanzo, Pietro Salvo, Maria Giovanna Trivella, Danilo Emilio De Rossi, Nicola Taccini,
Rita Paradiso, Jacque-André Porchet, Andrea Ridolfi, Jean Luprano, Cyril Chuzel, Thierry Lanier,
Frederic Revol-Cavalier, Sebastien Schoumacker, Veronique Mourier, Isabelle Chartier, Reynald
Convert, Henri De-Moncuit, and Christina Bini: BIOTEX—Biosensing Textiles for Personalised
Healthcare Management. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN
BIOMEDICINE, VOL. 14, NO. 2, MARCH 2010
16. Rocchiccioli, S; Citti, L; Boccardi, C; Ucciferri, N; Tedeschi, L; Lande, C; Trivella, MG; Cecchettini, A.
(2010) “A gel-free approach in vascular smooth muscle cell proteome: perspectives for a better
insight into activation” PMID: 20334645 Proteome Science 2010, 8:15
17. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. Optical Society of
America OCIS codes: (170.1470), 2010
18. Maria Giovanna Trivella, Federico Vozzi, Mariarita Puntoni, Nicoletta Vesentini, Claudia Kusmic,
Paolo Marraccini, Gualtiero Pelosi, Oberdan Parodi: Predizione di crescita della placca
aterosclerotica e supporto decisionale: il progetto ARTreat. Atti 44° CONVEGNO CARDIOLOGIA
2010, 443-447.
19. Maria Frigerio, Raffaele Caruso, Andrea Garascia, Luigi Martinelli, Oberdan Parodi, Maria Giovanna
Trivella: SENSORISTICA ED ASSISTENZA REMOTA DEL CUORE ARTIFICIALE:IL PROGETTO
SENSORART. Atti 44° CONVEGNO CARDIOLOGIA 2010, 448-454
20. P. Salvo, 1, F. Di Francesco, D. Costanzo, C. Ferrari, M.G. Trivella, D. De Rossi: A wearable sensor
for measuring sweat rate IEEE SENSORS JOURNAL, VOL. 10, NO. 10, OCTOBER 2010
21. Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca
Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L’Abbate: Monitoring Myocardial Tissue
Hemodynamics During Open Chest Surgery in Pig by Time-Resolved NIRS. 2010 Optical Society of
America OCIS codes: (170.1470)
22. L. Fresiello, C. De Lazzari , M.G. Trivella, A. Di Molfetta and G. Ferrari: INFLUENCE OF PULSATILE
CATHETER PUMP SYNCHRONIZATION ON HAEMODYNAMIC VARIABLES: NUMERICAL
SIMULATION Proceeding of the 7th IASTED International Conference of Biomedical Engineering
(BioMED 2010)