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CURRICULUM VITAE ALEXANDER G.G. TURPIE MB, FRCP (Glasg., Lond.), FACP, FACC, FRCPC Professor of Medicine McMaster University Hamilton, Ontario, Canada and Internist Hamilton Health Sciences - General Hospital Hamilton, Ontario, Canada Business Address: Hamilton Health Sciences, General Hospital 237 Barton Street East Hamilton, Ontario, Canada L8L 2X2 Telephone: (905) 528-9946 Fax: (905) 521-1551 e-mail: [email protected] 2 CURRICULUM VITAE NAME: Alexander Graham Grierson Turpie HOME ADDRESS: 1127 Sulphur Springs Road, Dundas, ON, Canada L9H 5R3 TELEPHONE: (905) 628-4534 BUSINESS ADDRESS: McMaster Clinic, Hamilton Health Sciences General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2 BUSINESS TELEPHONE: (905) 527-1710/(905) 528-9946 (905) 527-0271 extension 4484, 4486 (905) 521-1551 - Fax machine [email protected] - email DATE OF BIRTH: February 23, l939. NATIONALITY: British, Canadian Citizen CIVIL STATUS: Married with three children EDUCATION: University of Glasgow; Glasgow, Scotland 1956-1962 UNDERGRADUATE Glasgow, Scotland Prize, HONOURS:Ure Systematic Medicine, 1959 West of Scotland R.A.M.C. Memorial Prize, 1962 Macewan Medical, 1962 Herkless Prize for Clinical Surgery, 1962 Final Examination: in Surgery, 1962 Distinctions in Medicine William UNDERGRADUATE BURSARIES: Gardiner Bursary, 1961 John McFarlane Bursary, 1962 QUALIFICATIONS: M.B., Ch.B. (with Honours) University of Glasgow, 1962 E.C.F.M.G. Certificate, 1964 M.R.C.P. (Glasg.) Royal College of Physicians Glasgow, 1967 M.R.C.P. (Lond.) Royal College of Physicians London, 1969 F.R.C.P. (C) Royal College of Physicians and Surgeons of Canada, 1972 and Surgeons 3 F.A.C.P. American College of Physicians, 1975 F.R.C.P. (Glasg.) Royal College of Physicians and Surgeons Glasgow, 1976 Licentiate Medical Council of Canada, 1976 F.R.C.P. (Lond.) Royal College of Physicians London, 1981 F.A.C.C. American College of Cardiology, 1990. F.A.H.A. Fellow of the American Heart Association APPOINTMENTS: RESIDENT HOUSE SURGEON Royal Infirmary, Glasgow, Scotland August 1962 - January 1963 RESIDENT HOUSE PHYSICIAN Stobhill General Hospital, Glasgow, Scotland February 1963 - July 1963 University Medical REGISTRAR FAULDS CLINICAL RESEARCH Department of Materia Medica FELLOW AND MEDICAL University of Glasgow and Unit, Stobhill General Hospital Glasgow, Scotland August 1963 - February 1965. HONORARY CLINIC University of East Africa Medical School LECTURER Extension. Kenyatta National Hospital SENIOR REGISTRAR IN Nairobi, Kenya MEDICINE March 1965 - March 1966 (On secondment from University of Glasgow) LECTURER Department of Materia Medica and Therapeutics University of Glasgow and University Medical Unit, Stobhill General Hospital May 1967 - June 1968 MEDICAL REGISTRAR Department of Medicine, Royal Infirmary Glasgow, Scotland July 1968 - August 1969 SENIOR MEDICAL REGISTRAR Department of Medicine, Royal Infirmary Glasgow, Scotland August 1969 - February 1972 3 4 (From October 1970 - on leave of absence) POST DOCTORAL FELLOW Canadian Medical Research Council Department of Pathology, McMaster University Hamilton, Ontario October 1970 - December 1972 ASSISTANT PROFESSOR Department of Medicine, McMaster University Hamilton, Ontario January 1973 - June 1978 ASSOCIATE CLINICAL Hamilton General Hospital TEACHING UNIT January 1974 - June 198l DIRECTOR ASSOCIATE PROFESSOR Department of Medicine McMaster University, Hamilton, Ontario July 1978 - June 1983 (Acting Chief of Medicine) Hamilton General Hospital January 1981 - September 1981 MCFARLANE VISITING University of Glasgow PROFESSOR Royal Infirmary Glasgow, Scotland January 1988 - March 1988. PRESENT APPOINTMENT PROFESSOR Department of Medicine McMaster University Hamilton, Ontario July 1983 - present. INTERNIST Active Staff Hamilton Civic Hospitals Hamilton, Ontario January 1973 - present. CHIEF OF MEDICINE Hamilton General Hospital January 1985 - 1993. EXTERNAL EXAMINER MD Examination MB, BS Examination University of the West Indies June 1990 - present LEARNED SOCIETIES U.K. Medical Research Society, London, Canadian Society for Clinical Investigation International Society on Thrombosis and 4 5 Hemostasis Central Society for Clinical Research American Federation for Clinical Research Canadian Cardiovascular Society COMMITTEES Member, Scientific Review Committee Canadian Heart Foundation 1978 - 1983 Member, Examination Board in Internal Medicine Royal College of Physicians and Surgeons 1982 - 1988 Chairman, Hamilton Civic Hospitals Research and Ethics Committee 1982 - 1987 Member, Hamilton Civic Hospitals Institutional Review Board 1973 - present Member, Hamilton Civic Hospitals Education Committee 1976 - 1982 Member, Department of Medicine Education Committee McMaster University 1975 - 1982 Member, Department of Medicine Resident Appointments Committee 1975 - present Member, Hamilton Civic Hospitals Redevelopment Committee 1977 - present Member, Committee for Scientific Development McMaster University 1981 - 1986 Member, Presidents Ethics Committee McMaster University 1976 - 1987 Elected Member, Board of Management Regional Medical Associates 1977 - 1978 Elected Member, Department of Medicine Executive Committee, McMaster University 1976 - 1978 5 6 Elected Member, Promotions and Tenure Committee, Department of Medicine McMaster University 1978 - 1980. Member, Department of Medicine Executive Committee 1981 - 1989 Elected Member, Faculty of Health Sciences Appointments Committee 1984 - 1986 Elected Member, Faculty of Health Sciences Promotions and Tenure Committee 1984 - 1988 Member, Hamilton General Hospital Planning Subcommittee l982 - present Member, Medical Staff Advisory Committee Hamilton General Hospital 1982-present Member, Special Review Committee NIH 1988 - present Elected Member, Senate McMaster University 1988 - present Member, Editorial Advisory Committee Touchstone - Journal of the Hamilton Civic Hospitals 1986 - present Elected Member The Committee of Honorary Degrees 1991 Appointed Member Senate Committee on Honorary Degrees 1992 Member Thrombosis Interest Group (Canada) 1990 - present Member Thrombosis Forum 1990 - present Member Anticoagulation Forum 1990 - present 6 7 Member Asociacion Colombiana de Angiologia y Cirugia Vascular 2002 Honorary Member Korean Society of Phlebology 2002 JOURNAL REVIEWER Annals of Internal Medicine Circulation Thrombosis Research Canadian Medical Association Journal New England Journal of Medicine Clinical and Investigative Medicine Atherosclerosis Thrombosis and Haemostasis Drugs EDITORIAL BOARD Vascular Medicine Review Blood Coagulation and Fibrinolysis Acute Coronary Syndromes HeartDrug (Co-editor) 7 8 PUBLICATIONS 1. Turpie AGG, Thomson TJ: Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side effects. Gut 6:591-594, 1965. 2. Forbes CD, Turpie AGG, McNicol GP: The anticoagulant action of puff adder (B. Arietans) venom. East African Medical Journal 42:566-574, 1965. 3. Forbes CD, Turpie AGG, McNicol GP: Enhancement of the activity of optimum concentrations of urokinase by the venom of Echis Carinata. Nature 211:989-990, 1966. 4. Forbes CD, Turpie AGG, McNicol GP, Douglas AS: Studies on East African Snakes: mode of action of Echis Carinatus venom. Scottish Medical Journal 11:168-175, 1966. 5. Forbes CD, Turpie AGG: Journal 44:163-168, 1967. A simple method of urea estimation. 6. Turpie AGG, Forbes CD, McNicol GP: British Medical Journal 3:646-648, 1967. 7. Turpie AGG: East Africa Medical Idiopathic gangrene in African children. Platelets and Thrombosis. Scottish Medical Journal 13:430-433, 1968. 8. Forbes CD, Turpie AGG, Ferguson JG, McNicol GP, Douglas AS: The effect of gaboon viper (Bitis Gabonica) venom on blood coagulation, platelets and the fibrinolytic enzyme system. Journal of Clinical Pathology 22:312-316, 1969. 9. Prentice CRM, Turpie AGG, Hassanein AA, McNicol GP, Douglas AS: platelet behaviour during Arvin therapy. Lancet i:644-647, 1969. Changes in 10. Turpie AGG, Runcie J, Thomson TJ: Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Gut 10:299-302, 1969. 11. Hassanein AA, Turpie AGG, McNicol GP, Douglas AS: Effect of RA 233 on platelet function in vitro. British Medical Journal 2:83-86, 1970. 12. McDougall AI, Addis GJ, Turpie AGG, MacArthur JG: Clonidine. British Medical Journal 3:440-442, 1970. Treatment of hypertension with 13. Turpie AGG, Prentice CRM, McNicol GP, Douglas AS: In vitro studies with Ancrod (Arvin). British Journal of Hematology 20:217-224, 1971. 14. Hassanein AA, Turpie AGG, McNicol GP, Forbes CD, Douglas AS: Action of pyrimidopyrimidine compounds on platelet behaviour in vitro. Platelet adhesion and aggregation in thrombosis. Countermeasures. FK Shattauer, Verlag-Stuttgart, New York, 1971. 15. Turpie AGG, McNicol GP, Douglas AS: Platelet electrophoresis: effect of defibrination by Ancrod (Arvin). Cardiovascular Research 6:101-108, 1972. 16. Slater SD, Turpie AGG, Douglas AS, McNicol GP: Effect in vitro on platelet function on two compounds developed from the pyrimido-pyrimidines. Journal of Clinical Pathology 25:427-432, 1972. 17. Prentice CRM, Turpie AGG, McNicol GP, Douglas AS: Urokinase therapy: dosage schedules and coagulant side effects. British Journal of Hematology 22:567-577, 1972. 8 9 18. Turpie AGG, Chernesky MA, Larke RPB, Packham MA, Mustard JF: Effect of Newcastle disease virus on human or rabbit platelets. Aggregation and loss of constituents. Laboratory Investigation 28:575-583, 1973. 19. Chernesky MA, Larke RPB, Turpie AGG: Interaction between viruses and platelets. Requirement of haemolytic activity for platelet aggregation induced by paramyxoviruses. Journal of General Virology 21:205-213, 1973. 20. Gallus AS, Hirsh J, Cade JF, Turpie AGG, Walker IR, Gent M: Thrombolysis with a combination of small doses of streptokinase and small doses of heparin. Seminars in Thrombosis and Haemostasis 2:14-32, 1975. 21. Hull R, vanAken WG, Hirsh J, Gallus AS, Hoicka G, Turpie AGG, Walker IR, Gent M: Impedance plethysmography using the occlusive cuff technique in the diagnosis of venous thrombosis. Circulation 53:696-700, 1976. 22. Turpie AGG, Gallus AS, Beattie WS, Hirsh J: Prevention of venous thrombosis in patients with intracranial disease by intermittent pneumatic compression of the calf. Neurology 5:435-438, 1977. 23. Hull R, Hirsh J, Sackett DL, Powers P, Turpie AGG, Walker I: Combined use of leg scanning and impedance plethysmography in suspected venous thrombosis. The New England Journal of Medicine 296:1497-1500, 1977. 24. Larke RPB, Turpie AGG, Scott S, Chernesky MA: Paramyxovirus-induced platelet aggregation. Requirement for neuraminic acid receptors on platelets. Laboratory Investigation 37:150-157, 1977. 25. Turpie AGG, Hirsh J: Antiplatelet drugs: atherosclerosis. Modern Medicine 50-57, 1977. 26. Turpie AGG: 161, 1978. La Pathogenie des Thromboses. Their role in prevention of L`Union Medicale du Canada, 107:151- 27. Turpie AGG: Les Methodes Physiques de Prevention des Thrombo-Embolies Veineuses. L`Union Medicale du Canada 107:227-231, 1978. 28. Turpie AGG, Hirsh J: 34:183-190, 1978. Platelet suppressant therapy. British Medical Bulletin 29. Hull R. Taylor DW, Hirsh J, Sackett DL, Powers P, Turpie AGG, Walker I: plethysmography. The relationship between venous filling and sensitivity and specificity for proximal vein thrombosis. Circulation 58:898-902, 1978. Impedance 30. Turpie AGG, Hirsh J: Prophylaxis and therapy of venous thromboembolism. Reviews in Clinical Laboratory Science 10:247-274, 1979. Critical 31. Hull R, Hirsh J, Sackett DL, Powers P, Turpie AGG, Walker I, McBride J: The value of adding impedance plethysmography to 125I-fibrinogen leg scanning for the detection of deep vein thrombosis in high risk surgical patients: A comparative study between patients undergoing general surgery and hip surgery. Thrombosis Research 15:227-234, 1979. 32. Turpie AGG, Hirsh J: Geriatrics 34:59-70, 1979. When and how to use heparin prophylaxis and treatment. 33. Heparin. Turpie AGG, Hirsh J: Nova Scotia Medical Bulletin, 58:25-29, 1979. 9 10 34. Turpie AGG, Delmore T, Hirsh J, Hull R, Genton E, Hiscoe C, Gent M: Prevention of venous thrombosis by intermittent sequential calf compression in patients with intracranial disease. Thrombosis Research 15:611-616, 1979. 35. Han P, Turpie AGG, Genton E: Plasma B-thromboglobulin: Differentiation between intravascular and extravascular platelet destruction. Blood 54:1192-1196, 1979. 36. Turpie AGG, Hirsh J: Venous thrombosis and pulmonary embolism: detection and prevention. (Part I) Hospital Medicine 1:32-47, 1980. Guide to 37. Turpie AGG, Hirsh J: Venous thrombosis and pulmonary embolism: Guide to detection and prevention. (Part II) Hospital Medicine 2:22-34, 1980. 38. Han P, Butt RW, Turpie AGG, Walker WHC, Genton E: B-thromboglobulin radioimmunoassay - A laboratory characterization and evaluation. The Journal of Radioimmunoassay 1 (2):211-227, 1980. 39. deBoer AC, Butt R, Turpie AGG, Genton E: The use of the evacuated blood collection tube in the determination of plasma betathromboglobulin. Thrombosis Research 20:693-695, 1980. 40. Hull R, Hirsh J. Sackett DL, Taylor DW, Carter C, Turpie AGG, Zielinsky A, Powers P, Gent M: Replacement of venography in suspected venous thrombosis with impedance plethysmography and 125I-fibrinogen leg scanning: A less invasive approach. Annals of Internal Medicine 94:12-15, 1981. 41. Turpie AGG: The effectiveness of drugs that modify platelet function in peripheral venous thrombosis and pulmonary embolism. (Proceedings of the First World Conference) Clinical Pharmacology and Therapeutics 224-233, 1981. 42. Hirsh J, Turpie AGG, Kelton J, Hull R, Carter C: Unresolved issue in the use of heparin for management of venous thromboembolism. Chemistry and Biology of Heparin. Lundblat RL, Brown WV, Mann KG, Roberts HR (eds) Elsevier North Holland Inc. New York 513-528, 1981. 43. deBoer AC, Han P, Turpie AGG, Butt R, Zielinsky A, Genton E: Plasma and urine betathromboglobulin concentration in patients with deep vein thrombosis. Blood 58:693698, 1981. 44. Zielinsky A, Hirsh J, Straumanis A, Carter C, Gent M, Sackett DL, Hull R, Kelton JG, Powers P, Turpie AGG: The diagnostic value of fibrinogen/fibrin Fragment E assay in clinically suspected deep vein thrombosis. Blood 59:346-350, 1982. 45. Turpie AGG: Antiplatelet therapy. Clinics in Haematology 10 (2):497-520, 1981. 46. Hull R, Hirsh J, Sackett DL, Taylor DW, Carter C, Turpie AGG, Powers P, Gent M: Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis. Circulation 64 (3):622-625, 1981. 47. Hull R, Delmore T, Carter C, Hirsh J, Genton E, Gent M, Turpie AGG, McLaughlin D: Adjusted subcutaneous heparin versus warfarin sodium in the long term treatment of venous thrombosis. New England Journal of Medicine 306 (4):189-234, 1982. 48. deBoer AC, Turpie AGG, Butt RW, Duke RJ, Bloch RF, Genton E: Plasma betathromboglobulin and serum Fragment E in acute partial stroke. British Journal of Haematology 50:327-334, 1982. 49. deBoer AC, Genton E, Turpie AGG: Chemistry, measurement and clinical significance of platelet specific proteins. C.R.C. Critical Reviews 18 (2):183-211, 1982. 10 11 50. deBoer AC, Turpie AGG, Butt RW, Johnston RV, Genton E: Platelet release and thromboxane synthesis in symptomatic coronary artery disease. Circulation 66:327-333, 1982. 51. Turpie AGG, deBoer AC, Genton E: Platelet consumption in cardiovascular disease. Seminars in Thrombosis and Hemostasis 8:157-181, 1982. 52. Rosenfeld J, Devereaux D, Buchanan MR, Turpie AGG, High-performance liquid chromatographic determination of dipyridamole. Journal of Chromatography 231:216-221, 1982. 53. Hull R, Hirsh J, Jay R, Carter C, England C, Gent M, Turpie AGG, McLoughlin D, Dodd P, Thomas M, Raskob G, Ockelford P: Different intensities of oral anticoagulant therapy in the treatment of proximal vein thrombosis. New England Journal of Medicine 307:1676-1681, 1982. 54. Buchanan MR, Rischke JA, Butt RW, Turpie AGG, Hirsh J, Rosenfeld J: The sex related differences in platelet function and aspirin pharmacokinetics in rabbits and man. Thrombosis Research 29:125-129, 1983. 55. deBoer AC, Han P, Turpie AGG, Butt RW, Gent M, Genton E: Platelet tests and antiplatelet drugs in coronary artery disease. Circulation 67:500-504, 1983. 56. Hull R, Carter C, Jay R, Ockelford P, Hirsh J, Turpie AGG, Zielinsky A, Gent M, Powers P: The diagnosis of acute recurrent deep vein thrombosis. A diagnostic challenge. Circulation 67:901-906, 1983. 57. Duke RJ, Turpie AGG, Bloch RF, Trebilcock RG: Natural history of acute partial stroke and stroke-in-evolution: A clinical trial of low-dose subcutaneous heparin for the prevention of stroke progression. Cerebrovascular Diseases 399-405, 1983. 58. Hull RD, Hirsh J, Carter CJ, Jay RM, Dodd PE, Ockelford PA, Coates G, Gill GJ, Turpie AGG, Doyle DJ, Buller HR, Raskob GE: Pulmonary angiography, ventilation lung scanning and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Annals of Internal Medicine 98:891-899, 1983. 59. Rosenfeld J, Buchanan MR, Reilly PA, Turpie AGG: Dipyridamole disposition after chronic administration: Effect of aspirin. Thrombosis Research (Supp 14):137-143, 1983. 60. Genton E, Turpie AGG: Anticoagulant therapy following acute myocardial infarction. Modern Concepts of Cardiovascular Disease 52 (9):45-48, 1983 September (Part I). 61. Genton E, Turpie AGG: Anticoagulant therapy following acute myocardial infarction. Modern Concepts of Cardiovascular Disease 52 (10):49-51, 1983 October (Part II). 62. Kelton JG, Brain H, Sheridan D, Powers PJ, Turpie AGG, Carter CJ: The clinical usefulness of testing for a heparin-dependent platelet aggregating factor in patients with suspected heparin-associated thrombocytopenia. Journal of Laboratory and Clinical Medcine 103 (4):607-612, 1984. 63. Turpie AGG, Gent M, deBoer AC, Giroux M, Kinch D, Butt R, Gunstensen J, Saerens E, Genton E: Effect of suloctidil on platelet function in patients with shortened platelet survival time. Thrombosis Research 35:397-406, 1984. 11 12 64. Jay R, Hull R, Carter C, Ockelford P, Buller H, Turpie AGG, Hirsh J: Outcome of abnormal impedance plethysmography results in patients with proximal vein thrombosis. Frequency of return to normal. Thrombosis Research 36:259-263, 1984. 65. Turpie AGG, Hirsh J: Venous thromboembolism: Medicine 151-166, October 1984. Current Concepts (Part I) Hospital 66. Turpie AGG, Hirsh J: Venous thromboembolism: Medicine 13-41, November 1984. Current Concepts (Part II) Hospital 67. Butt RW, deBoer AC, Turpie AGG, Evaluation of a commercial kit for the radioimmunoassay of fibrinopeptide A. Journal of Immunoassay 5 (3 & 4):245-266, 1984. 68. Turpie AGG, Gent M, Doyle DJ, Saerens E, deBoer AC, Talbot C, McNamee J, Hirsh J: An evaluation of suloctidil in the prevention of deep vein thrombosis in neurosurgical patients. Thrombosis Research 39:173-181, 1985. 69. Gent M, Blakely JA, Hachinski V, Roberts RS, Barnett HJM, Bayer NH, Carruthers SG, Collins SM, Gowel MG, Giroux-Klimek M, Hopkins MB, Jain P, Lamy M, Meloche JP, Saerens E, Sicurella J, Turpie AGG: A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke. Stroke 16 (3):4l6-424, 1985. 70. Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford P, Buller H, Turpie AGG, Powers P, Kinch D, Dodd P, Gill GJ, LeClerc JR, Gent M: Diagnostic efficacy of impedance plethysmography for clinically suspected deep vein thrombosis. Annals of Internal Medicine 102 (1):21-28, 1985. 71. Turpie AGG: Platelet release proteins. Laboratory Management 23 (8):43-51, 1985. 72. Turpie AGG: Thrombolytic therapy in myocardial infarction. Cardiology 2 (2):46-51, 1986. Perspectives in 73. Turpie AGG, Levine MN, Hirsh J, Carter CJ, Jay R, Powers P, Andrew M, Hull R, Gent M: A randomized controlled trial of PK 10169 low-molecular weight heparin (Enoxaparin) for the prevention of deep vein thrombosis in patients undergoing elective hip surgery. New England Journal of Medicine 315 (15):925-929, 1986. 74. Turpie AGG, Levine MN, Hirsh J: Response to "Letter to the Editor" New England Journal of Medicine 316 (15):pp 949, 1987. 75. Duke RJ, Bloch RF, Turpie AGG, Trebilcock R, Bayer N: Intravenous heparin for the prevention of stroke progression in acute partial stable stroke: A randomized controlled trial. Annals of Internal Medicine 105:825-828, 1986. 76. Duke RJ, Bloch RF, Turpie AGG: Internal Medicine 106:781-782, 1987. 77. Turpie AGG, HN, Hull RD, Gent heparinoid in the Lancet i:523-526, Response to "Letter to the Editor", Annals of Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Magnani M: A double-blind randomized trial of Org 10172 low molecular weight prevention of deep vein thrombosis in patients with thrombotic stroke. 1987. 78. Buchanan MR, Butt RW, Turpie AGG: Effect of Nafazatrom on platelet function and release: Relationship to symptomatic episodes in patients with peripheral vascular disease. American Heart Journal 113 (5):1033-1137, 1987. 79. Doyle DJ, Turpie AGG, Hirsh J, Best C, Kinch D, Levine MN, Gent M: A randomized trial of adjusted subcutaneous heparin versus continuous intravenous heparin in patients with acute deep vein thrombosis. Annals of Internal Medicine 107 (4):441-445, 1987. 12 13 80. Turpie AGG: Clinical Studies: Evidence for intervention with specific antiplatelet drugs in arterial thromboembolism. Seminars in Thrombosis and Hemostasis 14 (1)41-49, 1988. 81. Turpie AGG: February 1988. Recent advances in thrombolytic therapy. Ontario Medicine, pp. 8, 82. Turpie, AGG: Subcutaneous versus continuous intravenous heparin for deep vein thrombosis. Cardiology Board Review, 5 (7) 103-114, 1988. 83. Turpie AGG: The relationship between ex-vivo anti-Factor Xa levels and efficacy/safety of low molecular weight heparin. Br J of Clin Practice 43 (1) Supp 65:18-25, 1988. 84. Turpie AGG, Hirsh J, Gent M, Julian D, Johnson J: Prevention of deep vein thrombosis in potential neurosurgical patients: A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control. Archives of Internal Medicine 149:679-681, 1989. 85. Turpie AGG, Gunstensen J, Hirsh J, Nelson H, Gent M: A randomized trial comparing two intensities of oral anticoagulant therapy following tissue heart valve replacement. Lancet i:1242-1245, 1988 86. ISIS-2 Collaborative Group: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Journal of the American College of Cardiology 12 (6): 3A-12A, 1988. 87. Turpie AGG: Low molecular weight heparins: Deep vein thrombosis prophylaxis in elective hip surgery and thrombotic stroke. Acta Chir Scand Suppl 543:85-86, 1988. 88. ISIS-2 Collaborative Group: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet ii:349-360, 1988. 89. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group: Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Streptokinase for Acute Myocardial Infarction: Results and Implications of the Major Clinical Studies. Proceedings of a satellite symposium held in Vienna, Austria, P. Sleight (ed) August 31, 1988. pp 51-73. 90. M. Gent, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW, Panak E, Roberts RS, J. Sicurella J, Turpie AGG: The Canadian American Ticlopidine Study (CATS) in Thromboembolic Stroke. Stroke 19 (10):1203-1210, 1988 91. Turpie AGG, Robinson JG, Doyle DJ, Mulji AS, Mishkel GJ, Sealey BJ, Cairns JA, Hirsh J, Skingley L, Gent M: Prevention of left ventricular mural thrombosis in acute transmural anterior myocardial infarction: A double blind trial comparing high dose with low dose subcutaneous calcium heparin. N Engl J Med 320 (6):352-357, 1989. 92. Turpie AGG, Gent M, Hirsh J: Letter to the Editor, N Engl J Med 321:259-260, 1989. 93. Powers PJ, Gent M, Jay R, Julian D, Turpie AGG, Levine MN, Hirsh J: A randomized trial of post-operative less-intense warfarin or acetylsalicylic acid in the prevention of venous thromboembolism after surgery for fractured hip. Archives of Internal Medicine, 149 (4):771-774, 1989. 13 14 94. Turpie AGG, Bloch R, Duke R: Heparin in the treatment of thromboembolic stroke. Annals of New York Academy of Sciences 556:406-415, 1989. 95. Dormandy J, Mahir M, Ascady G, Balsano F, DeLeeuw P, Blombery P, Bousser MG, Clement D, Coffman J, Deutshinoff A, Bletry O, Hampton J, Mahler F, Ohlin P, Rieger H, Stranden E, Turpie AGG, Urai L, Verstraete M: Fate of the patient with chronic leg ischaemia. A review article. J of Cardiovasc Surg 30 (2): 50-57, 1989. 96. Prevention of Atherosclerotic Complications with Ketanserin Trial Group: Prevention of atherosclerotic complications: controlled trial of ketanserin. Brit J Med 298:424-430, 1989. 97. Turpie AGG: Thrombolytic therapy. Medicine, North America 30: 5549-5554, 1989. 98. Gent M, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW, Panak E, Roberts RS, Sicurella J, Turpie AGG and the CATS Group. The Canadian American Ticlopidine Study (CATS) in Thromboembolic Stroke. Lancet i:1215-1220, 1989. 99. Turpie AGG: Examining the role of anticoagulants in post-AMI. Cardiology 5 (5):31-41, 1989. 100. Turpie AGG: Therapy of deep vein thrombosis. 14 (6) 341-347, 1989. Perspectives in Herz (Kardiovaskulare Erkankungen) 101. Ginsberg JS, Shin A, Turpie AGG, Hirsh J: Detection of previous proximal venous thrombosis with doppler ultrasonography and photoplethysmography. Archives of Internal Medicine 149:2255-2257, 1989. 102. Cruickshank MK, Levine MN, Hirsh J, Turpie AGG, Powers P, Jay R, Gent M: An evaluation of impedance plethysmography and 125 I-fibrinogen leg scanning in patients following hip surgery. Thrombosis and Haemostasis 62 (3) 830-834, 1989. 103. Turpie AGG, Robinson JG, Doyle DD, Mulji AS, Mishkel GJ, Sealey BJ, Cairns JA, Skingley L, Hirsh J, Gent M: Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med 320:352-357, 1989. 104. Turpie AGG, Hirsh J, Gent M, Julian D, Johnson J: Prevention of deep vein thrombosis in potential neurosurgical patients. Arch of Int Med 149:679-681, 1989. 105. Turpie AGG: 64:41B-43B, 1989. Prevention of left ventricular mural thrombosis. Am J Cardiol 106. Turpie AGG: Anticoagulant therapy after acute myocardial infarction. Cardiol 65:20C-23C, 1990. Am J of 107. Turpie AGG, Levine MN, Hirsh J, Ginsberg JS, Cruickshank M, Jay R, Gent M: Tissue plasminogen activator (rt-PA) versus heparin in deep vein thrombosis: results of a randomized trial. Chest 97: 172S-175S, 1990. 108. Levine MN, Weitz J, Turpie AGG, Andrew M, Cruickshank M, Hirsh J: A new short infusion dosage regimen of recombinant tissue plasminogen activator in patients with venous thromboembolic disease. Chest 97: 168S-171S, 1990. 109. Turpie AGG: Thrombolytic agents in venous thrombosis. J of Vasc Surg August: 196-197, 1990. 14 15 110. Turpie AGG: Enoxaparin prophylaxis in elective hip surgery. Scandinivica 156 (Supp 556) 1990. Acta Chirurgica 111. Turpie AGG: Low-dose or high-dose heparin to prevent left ventricular mural thrombosis. LeMonde Medical Magazine 25-29, 1990. 112. Levine M, Hirsh J, Weitz J, Cruickshank M, Neemeh J, Turpie AGG, Gent M: A randomized trial of a single bolus dosage regimen of recombinant tissue plasminogen activator in patients with acute pulmonary embolism. Chest 98 (6) 1473-1479, 1990. 113. Hirsh J, Turpie AGG: of Surg 14: 688-693, 1990. 114. Turpie AGG: 197, 1990. Use of plasminogen activators in venous thrombosis. Thrombolytic agents in venous thrombosis. World J J of Vasc Surg 12: 196- 115. Levine MN, Hirsh J, Gent M, Turpie AGG et al: Prevention of deep vein thrombosis in patients undergoing elective hip surgery: A randomized trial comparing Enoxaparine low molecular weight heparin with standard unfractionated heparin. Annals of Int Med 114 (7) 545-551, 1991. 116. Turpie AGG: Efficacy of a postoperative regimen of enoxaparin in deep vein thrombosis prophylaxis. Am J of Surg 161:532-536, 1991. 117. Prins MH, Turpie AGG: Clinical and laboratory diagnosis of deep vein thrombosis: current status. Current Medical Literature - Thrombosis (Scientific and Clinical Perspectives) 1: (3) 67-74, 1991. 118. Turpie AGG: Atrial Fibrillation: Helping patients get into the rhythm of life. Perspectives in Cardiology March: 41-48, 1991. 119. Connolly S, Laupacis A, Gent M (for the CAFA Study Coinvestigators): Canadian Atrial Fibrillation Anticoagulation (CAFA Study). JACC 18 (2):349-355, 1991. 120. ISIS-4 Collaborative Group: Fourth International Study of Infarct Survival: Protocol for a large simple study of the effects of oral mononitrate, of oral captopril and of intravenous magnesium. Am J of Cardiol 68:87D-100D, 1991. 121. ISIS-3: Third International Study of Infarct Survival Collaborative Group. 3: A randomized comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction. The Lancet 339:753-781, 1992. ISIS- 122. Turpie AGG: Orgaran in the prevention of deep vein thrombosis in stroke patients. Haemostasis 22:92-98, 1992. 123. Turpie AGG, Gent M, Cote R, Levine MN, Ginsberg JS, Powers PJ, Leclerc J, Geerts W, Jay R, Neemeh J, Klimek M, Hirsh J. A low-molecular weight heparinoid compared with unfractionated heparin in the prevention of deep vein thrombosis in patients with acute ischemic stroke. Annals of Internal Medicine 117 (5):353-357, 1992. 124. European Consensus Group. Angiology 11 (3)151:159, 1992. Prevention of venous thromboembolism. International 125. Stein PD, Alpert JS, Copeland J, Dalen JE, Goldman S, Turpie AGG: Antithrombotic therapy in patients with mechanical and biological prosthetic heart valves. Chest (Suppl) 102 (4):445S455S, 1992. 15 16 126. Stein PD, Dalen JE, Goldman S, Schwartz L, Turpie AGG, Theroux P: Antithrombotic therapy in patients with saphenous vein and internal mammary artery bypass grafts following percutaneous transluminal coronary angioplasty. Chest (Suppl) 102 (4):508S515S, 1992. 127. Turpie A. Graham G, Rosenbloom David: Ticlopidine: stroke prevention. Pharmacy Times 69-79, September 1992. A new antiplatelet agent for 128. Turpie AGG: Heparin alternative called efficacious to stop thrombosis. Anesthesiology News, pp 1 and 26, 1992. 129. Turpie AGG: 4719-4724, 1992. Ischemic heart disease and anticoagulants. Medicine, North America 130. Turpie AGG: Thromboprophylaxis in orthopedic surgery. Practice and Perspectives 5:1-16, 1992. Thrombosis-Clinical 131. Turpie AGG: Long-term warfarin RX safe for elderly with atrial fibrillation. Medical Post March 23, 1993. 132. Turpie AGG, Gent M, Laupacis A, Latour Y, Gunstensen J, Basile F, Klimek M, Hirsh J. A comparison of aspirin with placebo in patients treated with warfarin after heartvalve replacement. N Engl J Med 329:524-529, 1993. 133. Turpie AGG: 661, 1993. Acknowledgement of Scientific Reviewers. Cdn Med Assoc J 149(5) pp 134. Heijboer H, Buller HR, Lensing AWA, Turpie AGG, Colly LP, ten Cate, JW: A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients. New Eng J Med 329 (19) 1365-1369, 1993. 135. Turpie AGG: Thromboprophylaxis in orthopaedic surgery. International Edition 1 (5):396-401, 1993. Orthopaedics 136. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Brit Med J 308:81-106, 1994. 137. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy - II: Maintenance of vascular graft of arterial patency by antiplatelet therapy. Brit Med J 308:159-168, 1994. 138. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Brit Med J 308:235-246, 1994. 139. Levine MN, Hirsh J, Gent M, Turpie AGG, Cruickshank M, Weitz J, Anderson D, Johnson M. A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Int Med 154:49-56, 1994. 140. Turpie AGG, Gent M, Laupacis A, Latour Y, Gunstensen J, Basile F, Klimek M, Hirsh J. Aspirin and warfarin after heart-valve replacement. ACP Journal Club, Jan/Feb, 1994. 16 17 141. Turpie AGG, Gent M, Laupacis A, Hirsh J: Warfarin and aspirin after heart-valve replacement (Letter to the Editor) N Engl J Med 330 (7)507-509, 1994. 142. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: Collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. The Lancet 343:311-322, 1994. 143. Turpie AGG: Preventing thromboembolism in patients with prosthetic heart valves. Cardiology Clinics 12 (3), 487-493, 1994. 144. Turpie AGG: Thrombolytic therapy in venous thrombosis and pulmonary embolism. Fibrinolysis 8 (1):237-244, 1994. 145. The Stile Investigators: Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. Annals of Surgery 220 (3) 251-268, 1994. 146. Bolus Alteplase Pulmonary Group: Reduced dose bolus Alteplase vs conventional Alteplase infusion for pulmonary embolism thrombolysis. Chest 106:718-724, 1994. 147. Ginsberg J, Nurmohamed MT, Gent M, MacKinnon B, Sicurella J, Brill-Edwards P, Levine MN, Panju AA, Powers P, Stevens P, Turpie AGG et al: Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery. Circulation 90 (5):2385-2389, 1994. 148. Turpie AGG: 1995, pp 552. Acknowledgement of Scientific Reviews. Cdn Med Assoc J Februrary 15, 149. Turpie AGG: Ticlopidine in cardiovascular and peripheral vascular conditions. Does it have a role in event prevention. A Special Report. Proceedings of a Symposium. February 1995, 49:52. 150. Turpie AGG. Pathogenesis, diagnosis and treatment of deep vein thrombosis. Current Concepts in Venous Thromboembolic Disorder 1:4-7, 1994. 151. Andrew M, Brigden M, Bormanis J, Cruickshank M, Geerts W, Giles A, Hirsh J, Hull R, Johnson J, Johnston M, Leclerc J, Mant M, Pineo G, Robinson S, Robitaille D, Rutledge Harding S, Scully MF, Turpie AG et al: INR reporting in Canadian Medical Laboratories. Am J of Hematol 48:237-239, 1995. 152. Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Archives of Internal Medicine 154:14491457, 1994. 153. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 345 (8951):669-685, 1995. 154. Turpie AGG. The role of antiplatelet agents in cerebrovascular disease. Consultation on Stroke 4:1, 1995. 155. Turpie AGG. Management of deep vein thrombosis: Prevention and treatment. (Excerpta Medica) June Supplement, 1995. 156. Turpie AGG. Anticoagulation in cardiovascular disease. European Heart Journal 16 (Supp D):38-39, 1995. 17 P & T Concluding remarks. 18 157. Turpie AGG. DVT prophylaxis in the outpatient setting: following hospital discharge. Orthopedics 18, July 1995. Preventing complications 158. Turpie AGG. Antithrombotic therapy in acute coronary ischaemia. Progress 8:49-51, 1995. Biomedical 159. Levine MN, Hirsh J, Gent M, Turpie AGG, Weitz J, Ginsberg J, Geerts W, LeClerc J, Neemen J, Powers P, Piovella F. Optimal duration of oral anticoagulant therapy: A randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis. Thrombosis and Haemostasis 74 (2):606-611, 1995. 160. The STILE Investigators. Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischaemia of the lower extremity. Annals of Surgery 220 (3):251-268, 1995. 161. Parish S, Collins R, Peto R, Youngman L, Barton J, Jayne K, Clarke R, Appleby P, Lyon V, Cederholm-Williams S, Marshall J, Sleight P for the International Studies of Infarct Survival (ISIS) Collaborators. British Medical Journal 311:471-477, 1995. 162. Turpie AGG: 1995. Danger of using antithrombotics postoperatively. Vessels 1 (3)25-29, 163. Turpie AGG: Terapeutica antiplaquetaria en la prevencion primaria y secundaria del accidente cerebrovascular. Revista Argentina de Cardiologia, Noviember-Diciembre 63 6):597, 1995. 164. Turpie AGG: Heparina en el accidente cerebrovascular isquemico. Argentina de Cardiologia, Noviember-Diciembre 63 6):601, 1995. Revista 165. Turpie AGG, Weitz JI, Hirsh J. Advances in antithrombotic therapy: Thromb & Haemost 74 (1):565-571, 1995. Novel agents. 166. Connolly SJ, Turpie AGG. Antithrombotic therapy in atrial fibrillation. Canadian Journal of Cardiology 12 A:17A-20A, 1996. The 167. Gent M, Hirsh J, Ginsberg JS, Powers PJ, Levine MN, Geerts WH, Jay RM, Leclerc J, Neemeh JA, Turpie AGG. Low-molecular-weight heparinoid Orgaran is more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture. Circulation 93 (1):80-84, 1996. 168. Levine M, Gent M, Hirsh J, Leclerc J, Anderson D, Weitz J, Ginsberg J, Turpie AGG. A comparison of low-molecular weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep vein thrombosis. New England Journal of Medicine 334 (11):677-681, 1996. 169. Turpie AGG. Hirudin and thrombosis prophylaxis. The Lancet 347:632-633, 1996. 170. Nurmohamed MT, van Riel AM, Henkens CMA, Koopman MMW, Que GTH, d'Azemar P, Buller HR, ten Cate JW, Hoek JA, van der Meer J, van der Heul C, Turpie AGG, Haley S, Sicurella J, Gent M. Low molecular-weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb & Haemost 75 (2):233-238, 1996. 171. Levine MN, Gent M, Hirsh J, Weitz J, Turpie AG et al. Ardeparin (Low molecular weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism. Arch Intern Med 156:851-856, 1996. 18 19 172. Turpie AGG. New therapeutic opportunities for heparins: What does low molecular weight heparin offer? Journal of Thrombosis and Thrombolysis 3:145-149, 1996. 173. Turpie AGG, Connolly SJ. Antithrombotic therapy in atrial fibrillation. Family Physician 42:1341-1345, 1996. Canadian 175. Altman R, Rouvier J, Gurfinkel E, Scazziota A, Turpie AGG. Comparison of highdose with low-dose aspirin in patients with mechanical heart valve replacement treated with oral anticoagulants. Circulation 94 (9) 2113-2116, 1996. 176. Kearon C, Turpie AGG. Diagnosis of deep venous thrombosis. Thrombosis Scientific and Clinical Perspectives. Current Medical Literature, 6 (4):95-98 1996. 177. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). The Lancet 348:1329-1339, 1996. 178. Turpie AGG. Prevention and treatment of venous thromboembolism. (Special Edition) 2 (2):22-25, 1996. Orthopedic 178a. Tirone ED, Gott VL, Harker LA, Miler GE, Naftel DC, Turpie AGG. Letter to the Editor. Mechanical Valves. Annals of Thoracic Surgery 62:1565-1570, 1996. 179. Turpie AGG. Diagnosis and treatment of deep vein thrombosis. International V, pg 377-381, 1997. Surgical Technology 180. Turpie AGG. Low molecular weight heparin: From the bench to the orthopaedic patient. Orthopedics (February supplement) 10-13, 1997. 181. Turpie AGG. Safer anticoagulant therapy heart valve replacement. for less intense regimens. Postgraduate Medicine 101 (3):85-94, 1997. Recommendations 182. Lensing AWA, Doris CI, MNcGrath FP, Cogo A, Sabine MJ, Ginsberg J, Prandoni P, Turpie AGG, Hirsh J. A comparison of compression ultrasound with color Doppler ultrasound for the diagnosis of symptomless postoperative deep vein thrombosis. Archives of Internal Medicine 157 (7):765-768, 1997. 183. Turpie AGG. Prophylaxis of venous thromboembolism in stroke patients. in Thrombosis and Hemostasis 23:155-157, 1997. Seminars 184. Klein W, Buchwald A, Hillis SE, Monrad S, Sanz G, Turpie AGG, van der Meer J, Olaisson E, Undeland S, Ludwig K for the FRIC Investigators. Comparison of lowmolecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Circulation 96 (1):61-68, 1997. 185. Cohen M, Demers C, Gurfinkel EP, Turpie AGG, Fromell GJ, Goodman S, Langer A, Califf RM, Fox KAA, Premmereur J, Bigonzi F. A comparison of low molecular weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med 337 (7):447-452, 1997. 186. Turpie AGG. New frontiers in the management of unstable coronary artery disease. Am J of Cardiol 89 (5A):21E-24E, 1997. 187. Klein W, Buchwald A, Hillis SE, Monrad S, Sanz G, Turpie AGG, van der Meer J, Olaisson E, Undeland S, Ludwig K for the FRIC Investigators. Comparison of lowmolecular-weight heparin with unfractionated heparin acutely and with placebo for 6 19 20 weeks in the management of unstable coronary artery disease. (5A):21E-24E, 1997. Am J of Cardiol 89 188. Ginsberg JS, Kearon C, Douketis J, Turpie AGG et al. The use of D-dimer and impedance plethysmographic examinations in patients with clinical indications for deep vein thrombosis. Arch of Intern Med 157:1077-1081, 1997. 189. The COLUMBUS Investigators. Low molecular weight heparin in the treatment of patients with venous thromboembolism. N Engl J Med 337 (10):657-662, 1997. 190. Lengyel M, Fuster V, Keltai M, Roudaut R, Schulte HD, Seward JB, Chesebro JH, Turpie AGG. Guidelines for management of left-sided prosthetic valve thrombosis: A role for thrombolytic therapy. JACC 30 (6):1521-1526, 1997. 191. Ray JG, Turpie AGG. Survey of cardiac surgeons' perceptions of the addition of ASA to warfarin for patients with mechanical heart valves. Canadian Journal of Cardiology 13 (12):1162-1165, 1997. 192. Turpie AGG. Antithrombotic therapy: The expanding role of low molecular weight heparin. Indian Heart J 49:489-492, 1997. 193. Cogo A, Lensing AWA, Koopman MMW, Piovella F, Siragusa S, Wells PS, Villalta S, Buller HR, Turpie AGG, Prandoni P. Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ 316:17-20, 1998. 194. Turpie AGG. Thrombolysis in prosthetic valve thrombosis: When - and for which patients? Clinical Update. J of Critical Illness 13 (2):132-133, 1998. 195. Turpie AGG. Antithrombotic therapy in acute non-ST segment elevation coronary ischaemia. Cardiology Today II (1):46-48, Jan-Feb 1998. 196. Kearon C, Julian JA, Math M et al. Noninvasive diagnosis of deep thrombosis. Annals of Internal Medicine 128 (8) 663-677, 1998. 197. Turpie AGG, Weart CW, White R. Care April 106-125, 1998 venous Anticoagulation; Promises and Pitfalls, Patient 198. Caprini JA, Barie PS, Comerota AJ, Turpie AGG. Symposium: DVT pro- phylaxis in high risk general surgery patients. Contemporary Surgery 52 (4):279-298, 1998 199. ISIS-3 Collaborative Group. Comparisons of early mortality and major morbidity among 26,480 men and 9,600 women with suspected acute myocardial infarction treated with fibrinolytic therapy in the ISIS-3 study. N Engl J Med (accepted for publication) 1997. 200. Mark DB, Cowper PA, Berkowitz SD, Davidson-Ray L, DeLong ER, Turpie AGG et al. Economic assessment of low-molecular-weight heparin (Enoxaparin) versus unfractionated heparin in acute coronary syndrome patients. Results from the ESSENCE Randomized trial. Circulation 1998; 97:1702-1707. 201. Leclerc JR, Gent M, Hirsh J, Geerts WH, Ginsberg JS for the Canadian Collaborative Group. The incidence of symptomatic venous thromboembolism during and after prophylaxis with enoxaparin. Arch of Intern Med 158:873, 1998. 202. Brigden M, Johnston MJ (for the Thrombosis Interest Group). INR reporting in Canadian Medical Laboratories. Am J of Clin Path 109 (5):589-594, 1998. 20 21 203. Campbell RWF, Walletin L, Verheugt FWA, Turpie AGG, Maseri A, Klein W, Cleland JGF, Bode C, Becker R, Anderson J, Bertrand ME, Conti CR. Management strategies for a better outcome in unstable coronary artery disease. Clin Cardiol 21:314-322, 1998. 204. Baigent C, Collins R, Appleby P, Parish S, Sleight P, Peto R.on behalf of the ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both or neither. Br Med J 316:1337-1343, 1998. 205. Ageno W, Turpie AGG. Paulo 7 (3):406-417, 1997. Aspirin and ticlopidine. Rev Soc Cardiol Estado de Sao 206. Ageno W, Turpie AGG. Anticoagulation in surgical patients. Estado de Sao Paulo 7 (3):372-382, 1997. Rev Soc Cardiol 207. Turpie AGG. Clinical potential of antithrombotic drugs in coronary syndromes. J Cardiol 1998; 82:11L-14L. Am 208. Cohen M, Demers C, Gurfinkel EP, Turpie AGG, Fromell GJ, Goodman S, Langer A, Califf RM, Fox KAA, Premmereur J, Bigonzi F for the ESSENCE Study Group. Low-molecularweight heparins in non-ST-segment elevation ischaemia: The ESSENCE Trial. Am J Cardiol 1998; 82:19S-24L. 209. Kearon C, Julian JA, Math M et al (for the McMaster Diagnostic imaging Practice Guidelines Initiative). Noninvasive diagnosis of deep venous thrombosis. Annals of Intern Med 128:663-677, 1998. 210. Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie Alexander G, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Annals of Intern Med 129:997-1005, 1998. 211. Johnston M, Brigden M (for the Thrombosis Interest Group of Canada). A crossCanada survey of prothrombin time testing. Am J Clin Path 110:683-690, 1998. 212. Ginsberg JS, Wells P, Kearon C, Anderson D, Crowther M, Weitz JI, Bormanis J, Brill-Edwards P, Turpie AG, MacKinnon B, Gent M, Hirsh J. Sensitivity and specificity of a rapid whole-blood assay for D-Dimer in the diagnosis of pulmonary embolism. Ann Intern Med 129:1006-1011, 1998. 213. Turpie AGG. Antithrombotic therapy in coronary ischaemia: The expanding role of low molecular weight heparin. Haemostasis 1998; 28 (Suppl 3):35-42. 214. Ageno W, Turpie AGG. A randomized comparison of a computer-based dosing program with a manual system to monitor oral anticoagulant therapy. Thrombosis Research 91:237240, 1998. 215. Kearon C, Gent M, Hirsh J, Weitz J, Kovacs MJ, Anderson DR, Turpie AGG, Green D, Ginsberg JS, Wells P, MacKinnon B, Julian JA. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med 340 (12)901-907, 1999. 216. Turpie AGG, Kher A. Prevention of venous thrombosis after elective hip surgery. Orthopaedics Review pp 1275-1281, 1999 217. Turpie AGG. Orthopaedics (Letter to the Editor):477-478, 1999 21 22 218. Lowe GDO, Haverkate F, Thompson SG, Turner RM, Bertina RM, Turpie AGG, Mannucci PM. Prediction of deep vein thrombosis fter elective hip replacement surgery by preoperative clinical and haemostatic variables: The ECAT DVT Study. Thromb Haemost 81:879-886, 1999. 219. Turpie AGG. The ten most commonly asked questions about chronic anticoagulant use in cardiology. Cardiology in Review 7 (3):125-126, 1999. 220. Samama MM, Cohen AT, Darmon JY, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Nguyen H, Olsson CG, Turpie AGG, Weisslinger N for the prophlaxis in medical patients with enoxaparin study group. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med 341:793-800, 1999. 221. Haas S, Turpie AGG. Introduction. Fibrinolysis 10 (suppl 2):S1-S3, 1999. Blood Coagulation and 222. Turpie AGG. Customizing our approach in deep vein thrombosis and pulmonary embolism treatment: overview of our clinical experience. Blood Coagulation and Fibrinolysis 10 (suppl 2):S107-S115, 1999. 223. Turpie AGG. Antithrombotic therapy in the new millennium - the role of low molecular weight heparin. South African Medical Journal 89: (Cardiovascular suppl 3):C151-C155. 224. Turpie AGG. Anticoagulants in acute coronary syndromes. Cardiol 84:2M-6M, 1999. Am J Card 225. Antman EM, McCabe CH, Gurfinkle EP, Turpie AGG, Bernink PJLM, Salein D, Bayes de luna A, Fox K, Lablanche J-M, Radley D, Premmereur J, Braunwald for the TIMI 11B Investigators. Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction (TIMI) 11B trial. Circulation 100:1593-1601, 1999. 226. Antman EM, Cohen M, Radley D, McCabe C, Rush J, Premmereur J, Braunwald E for the TIMI 11B (Thrombolysis in myocardial infarction) and ESSENCE (Efficacy and safety of subcutaneous enoxaparin in non-Q-wave coronary events) Investigators Assessment o the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction. TIMI 11B-ESSENCE Meta-analysis. Circulation 199: 1602-1608, 1999. 227. Verheugt FW, Becker RC, Bertrand ME, Bode C, Chesebro JH, Cleland JG, Conti R, Hillis WS, Klein W, Maqseri A, Turpie AGG, Wallentin L, Waters DD. Management strategies in unstable coronary artery disease – current problems and future directions. The UCAD Council. Clin Cardiol Sept 22 (9): 551-553, 1999. 228. Haas S, Turpie AG. Building a new era in DVT management. Coagul Fi8brinolysisl Aug: 10 Suppl 2:S1-S3, 1999. Introduction. Blood 229. Toal CB, Motr M, Baird MG, Klinke P, Sclarowski S, Zilberman A, Marmor A, Kostuk WJ, Lotan C, Weiss A, Erne P, Palant A, Stolero, Belanger L, Turpie AGG. Effectiveness of nifedipine GITS I combination with atenolol in chronic stable angina. Can J Cardiol 15 (10):1103-1109, 1999. 230. Ageno W, Turpie AGG. Exaggerated initial response to warfarin following heart valve replacement. Am J Cardiol 84: 905-908, 1999. 231. Turpie AGG. Clinical trials of low molecular weight heparins. (Suppl R); 418-427, 1999. 22 Europ Heart J 1 23 232. Ageno W, Turpie AGG. Prevention and treatment of venous thromboembolism. Surgery News June 13-16, 1999. General 233. Ageno W, Turpie AGG. Prevention and treatment of venous thromboembolism. Pharmacy Practice News June 11-14, 1999. 234. Ageno W, Turpie AGG. The use of antiplatelet agents in the secondary prevention of stroke. Leading Article. Stroke, 1999. 235. Sosis MB. Enoxaparin for the prevention of venous thromboembolism. N Engl J Med 342: 136, 2000 (Correspondence). 236. Turpie, AGG. Low molecular weight heparins in acute unstable coronary artery disease. An update. Haemostasis 29 (Suppl 1):72-75, 1999. 237. Ageno W, Turpie AGG. The use of glycoprotein IIb/IIIa receptor inhibitors in unstable angina. G Ital Cardiol 29:1357-1365, 1999. 238. Turpie AGG. Is lung scanning necessary in all patients with confirmed DVT? Critical Illness 15: (2): 2000 239. Turpie AGG. Can we differentiate the low-molecular weight heparins? (Suppl I):I-4-I-7, 2000. J of Clin Card 23 240. Antman EM, Fox KM for the International Cardiology Forum. Guidelines for the diagnosis and management of unstable angina and non-Q-wave myocardial infarction: Proposed revisions. Am Heart J 2000; 139:461-475. 241. Huber K, Gaul G, Glogar D, Kaliman J und Miczoch J for the International Cardiology Forum. Richtlinien zur Diagnostik und Therapie der instabilen Angina pectoris und des Non-Q-Wave-Myokardinfarktes: vorgeschlagene Revisionen. J Kardiol 2000; 7:60-72. 242. Turpie AGG. 2000; 45:40-42. Management of deep vein thrombosis and pulmonary embolism. Scot Med J 243. Turpie AGG. Prophylaxis for venous thromboembolism in medical patients. Critical Illness (Supplement) July 2000:S24-S30. J 244. Turpie AGG, Elliot G, Fernandez B. Suspicions and subtleties in venous thromboembolism. Are clinical models and strategies effective? Medical Crossfire 2(8):35-46, 2000. 245. Wells PS, Anderson DR, Rodger M, Ginsbert JS, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-Dimer. Thromb Haemost Mar 83 (3):416-420m 2000. 246. Ageno W, Turpie AGG. Low molecular weight heparin in the treatment of pulmonary embolism. Seminars in Vasc Surg 13 (3):189-193, 2000. 247. Turpie AGG. Deep vein thrombosis (DVT) and pulmonary embolism (PE) post significant diagnostic and management challenges to clinicians. “DVT often arises in primary-care settings and crosses many subspecialty borders” noted Victor Tapson MD, Associate Professor of Medicine in the Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, in Durham, North Carolina. “We need to emphasize that, whatever the setting, there is much to consider in treating venous thrombosis and pulmonary embolism. Medical Crossfire 2 (8):35-45, 2000. 23 24 248. Cohen M, Elliot EM, Gurfinkel E, Turpie AGG, Furst J, Bigonzi F, Radley D. of enoxaparin low molecular weight heparin in patients with Q-wave myocardial infarction. Am J Cardiol 86: 553-556, 2000. 249. Turpie AGG. Prevention of venous thromboembolism is medical patients. Journal of Haematology (Suppl) 17 (3):96-101, 2000. Impact Turkish 250. Cohen M, Turpie AGG. Management of unstable angina and myocardial infarction. (letter). Lancet 356: 119, 2000. 251. Cohen M, Antman EM, Gurfinkel E, Turpie AGG, Furst J, Bigonzi F and Radley D. of enoxaparin low molecular weight heparin in patients with Q-wave myocardial infarction. Am J Cardiol 86; Sept 1; p553-556, 2000. Impact 252. Samama MM, Cohen AT, Darmon J-Y, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Nguyen H, Olsson C-G, Turpie AG, Weisslinger N. Hastalarda Enoksaparin Ile profilaksi Calisma Grubu. Akut Meeical Hastalarda Venoiz Tromboemboli Profilaksisinde Enoksaparin Ile Plasebonun Karsilastirilmasi. N Engl J med 341:793-800, 1999. 253. Ageno W, Johnson J, Nowacki B, Turpie AGG. A computer generated induction system for hospitalised patients starting on oral anticoagulant therapy. Thromb Haemost 83: 849-852, 2000. 254. Turpie AGG. Antithrombotics and anticoagulants in coronary syndromes and stroke. Seminars in Thromb and Hemost 26 (Suppl 1) 79-83, 2000. 256. Cohen M, Turpie AGG. Management of unstable angina and myocardial infarction. Lancet (Correspondence) 356:1193-1194, 2000. The 257. Goodman SG, Cohen M. Bigonzi F, Gurfinkel EP, Radley DR, LeIouer V, Fromell GJ, Demers C, Turpie AGG, Califf RM, Fox KAA, Langer A for the Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events (ESSENCE) Study Group. Randomized trial of low molecular weight heparin (Enoxaparin) versus unfractionated heparin for unstable coronary artery disease. JACC 36 (3):693-698, 2000. 258. Buchanan MR, Schwartz L, Bourassa MG, Brister SJ, Peniston CM on behalf of the BRAT Investigators. Results of the BRAT Study – A pilot study investigating the possible significance of ASA nonresponsiveness on the benefits and risks of ASA on thrombosis in patients undergoing coronary artery bypass surgery. Can J Cardiol 16 (11):1385-1390, 2000. 259. Turpie AGG. Pentasaccharide Org31540/SR90107A clinical trials update: Lessons for practice. Am Heart J 142S9-S15, 2001. 260. Turpie AGG. Thrombosis prophylaxis in the acutely ill medical patient: Insights from the prophylaxis in MEDical patients with ENOXaparin (Medenox) Trial. Am J Cardiol 86 (Suppl) 48M-52M, 2000. 261. Ageno W, Turpie AGG. Therapy of unstable angina with the low molecular weight heparins. Vascular Medicine 5:217-223, 2000 262. Ageno Walter, Turpie Alexander GG. Glycoprotein IIb/IIIa receptor antagonists in the treatment of unstable angina. JICC 1 (1): 26-31, 2000. 24 25 263. Turpie AGG, Gallus AS, Hoek JA for the Pentasaccharide Investigators. A synthetic pentasaccharide for the prevention of deep vein thrombosis after total hip replacement. N Engl J Med 334 (9):619-625, 2001. 264. Ageno W, Turpie AGG. Outpatient treatment of deep vein thrombosis. Medicine April 74-81, 2001. Emergency 265. Stein PD, Alpert JS, Bussey HI, Dalen JE, Turpie AGG. Antithrombotic therapy in patients with mechanical and biological prosthetic heart valves. Chest 119:220S-227S, 2001. 266. Turpie AGG. Looking forward in the treatment of deep vein thrombosis. Hematol 38 2 (5): 49-57, 2001. Sem in 267. Turpie AGG, Antman EM. Low-molecular-weight heparins in the treatment of acute coronary syndromes. Arch Intern Med 161:1484-1490, 2001. 268. Ageno W, Turpie AGG, Steidl L, Ambrosini F, Cattaneo R, Codari RL, Nardo B, Venco A. Comparison of a daily fixed 2.5 mg warfarin dose with a 5 mg, International Normalized Ratio adjusted, warfarin dose initially following heart valve replacement. Am J of Cardiol 88:40-44, 2001. 269. Bath PMW, Lindenstrom E, Goysen G, De Deyn Peter, Friis P, Leys D, Marttila R, Olsson J-E, O’Neill D, Orgogozo J-M, Ringelstein B, van der Sande J-J, Turpie AGG for the TAIST Investigators. Tinzaparin in acute ischaemic stroke (TAIST): a randomixed aspirin-controlled trial. The Lancet 358:702-710, 2001. 270. Holper EM, Antman EM, McCabe CH, Premmereur J, Gurfinkel E, Bernink PJ, Turpie AG Bayes de Luna A, Lablanche JM, Fox KM, Salein D, Radley DR, Braunwald E. A simple readily available method for risk stratification of patients with unstable angina and non-ST elevation myocardial infarction. Am J Cardiol April 15; 87 (8): 1008-1010, 2001, 271. Becker RC, Eisenberg P, Turie AG. Pathobiologic features and prevention of thrombotic complications associated with prosthetic heart valves: fundamental principles and the contribution of platelets and thrombin. Am Heart J 14 (6):1025-1037, 2001. 272. Ginsberg JS, Turpie AG. 2001. Thromboembolism and pregnancy. Int Angiol 20 (2):103-109, 273. Turpie AG. Setting a standard for venous thromboembolism prophylaxis. Syst Pharm 58 (Suppl 2)S18-S23m 2991, 274. Turpie AGG. Pentasaccharide Org31540/SR90107A clinical trials update practice. American Heart Journal (Supplement) 142 (2):S9-S15, 2001 Am j Health Lessons for 275. Bauer KA, Eriksson BI, Lassen MR, Turpie AG. A new antithrombotic strategy, the selective inhibition of coagulation factors, and its importance to the orthopedic specialist. J South Orthop Assoc 11 (4):197-202, 2002. 276. Eriksson BI, Bauer KA, Lassen MR, Turpie AGG for the Steering Committee of the Pentasaccharide in hip fracture surgery study. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 345: 1298-1304, 2002. 277. Bauer KA, Eriksson BI, Lassen MR. Turpie AGG for the Steering Committee of the Pentasaccharide in Major Knee Surgery Study. Fondaparinux compared with enoxaparin for 25 26 the prevention of venous thromboembolism after elective major knee surgery. Med 345: 1305-1310, 2002. N Engl J 278. Turpie AG. Overview of the clinical results of pentasaccharide in major orthopedic surgery. Haematologica 86 (Supp 2):59-62, 2001. 279. Ageno W, Turpie AG. New advances in the management of acute coronary syndromes: Low-molecular weight heparins. CMAJ 166 (7):919-924, 2002. 280. Turpie AGG. 2001. New data on long-term antiplatelet therapy. Hematologia 5 (2):47-48, 281. Turpie AGG. New strategies in the prevention and treatment of venous thromboemblism. Hematologia 5 (2): 45-46, 2001. 282. Bath PMW, Linderstrom E, J-E, O’Neill D, Orgogozo J-M, investigators. Tinzaparin in controlled trial. Lancet 358 Boysen G, De Deyn P, Friis P, Leys D, Marttila R, Olsson Ringelstein B, van der Sande J-J, Turpie AGG for the TAIST acute ischaemic stroke (TAIST): A randomised aspirin(983):703-710, 2001. 283. Mohr JP, Thompson JLP, Lazar RM, Levin B, Sacco RL, Furie KL et al. of warfarin and aspirin for the prevention of recurrent ischemic stroke. 345: 1444-1451, 2001. 284. Turpie AGG. pp59. Is new antithrombotic agent superior? A comparison N Engl J Med The Medical Post January 2002, 285. Antman EM, Cohen M, McCabe C, Goodman SG, Murphy SA and Braunwald E for the TIMI11B and ESSENCE Investigators. Enoxaparin is superior to unfractionated heparin for preventing clinical events at 1 year follow-up of TIMI 11B and ESSENCE. European Heart Journal 23:308-314, 2002. 286. Turpie AGG, Mason JA. Review of enoxaparin and its clinical applications in venous and arterial thromboembolism. Expert Opin Pharmacother 3 (5):575-598, 2002. 287. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR for the PENTATHLON 2000 Study Steering Committee. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venouis thromboembolism after elective hip replacement surgery: a randomised doubleblind trial. The Lancet 359:1721-1726, 2002. 288. Lassen MR, Bauer KA, Eriksson BI, Turpie AGG for the European Pentasaccaride Hip Elective Surgery Study (EPHESUS) Steering Committee. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hipreplacement surgery: a randomised double-blind comparison. The Lancet 359:1715-1720, 2002. 289. Turpie AGG, Bauer KA, Eriksson BI, Lassen. Major Ortopedik Cerrahide Venoz Tromboembolinin Onlenmesinde Fondaparinuks ile Enoksaparinin Karsilastirilmasi: Randomize, Cift-kor 4 Calismanin Metaanalizi. Arch Intern Med 162: 1833-1840, 2002. 290. Turpie AGG, Buller HR. evidence, and applications. New standards in antithrombotic therapy: concepts, clinical Semin in Thromb and Hemost 28 (Supp 2):1 2002. 26 27 291. Turpie AGG: Optimizing prophylaxis of venous thromboembolism. Hemost 28 (Supp 2):25-32, 2002. 292. Turpie AGG, Buller HR. Benefit of selective factor inhibition. and Hemost 28 (Supp 2):49-50, 2002. Semin in Thromb and Semin in Thromb 293.Turpie AGG. Introduction: unstable angina- its pathogenesis and management. in Thromb and Hemost 28 (Suppl 2) 1-3, 2002. Semin 294.Antithrombotic Trialis’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Brit Med J 324;71-86, 2002. 295. Turpie AGG. 171. Pentasaccharides. Seminars in Hematology 39 (3):July, 2002 pp 158- 296. Turpie AG, Eriksson BI, Lassen MR, Bauer KA. A meta-analysis of fondaparinux versus enoxaparin in the prevention of venous thromboembolism after major orthopaedic surgery. J South Orthop Assoc 11 (4):182-188, 2006. 297. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopaedic surgery. Arch Intern Med 162:1833-1840,2002. 298. Lassen MR, Bauer KA, Eriksson BI, Turpie AGG for the Euopean Pentasaccharide Hip Elective Surgery Study (EPHESUS) Committee. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip replacement surgery: a randomised double-blind comparison. The Lancet 359 (9319):17151720,2002. 299. Simoons ML, Krzeminska-Pakula M, Alonso A, Goodman SG, Kali A, Loos U, Gosset F, Louer V, Bigonzi F for the AMI-SK Investigators. Improved reperfusion and clinical outcome with enoxaparin as an adjunct to streptokinase thrombolysis in acute myocardial infarction.Eur HeartJ 23:1282-1290,2002 . 300. Turpie AGG, Buller HR. New standards in antithrombotic therapy: clinical evidence and applications. Introduction. Seminars in Thromb and (Suppl2), 2002 concepts, Hemost 28 301. Turpie AGG. State of the Art – A Journey through the world of antithrombotic therapy. Thromb and Hemost 28 (Suppl 2):3-11, 2002. 302. Turpie AGG, Lassen MR, Eriksson BI, Bauer KA. Factor Xa inhibitors in the prevention and treatment of venous thromboembolism – The role of fondaparinux, first of a new class of antithrombotic agents. Today’s Therapeutic Trends. 253-267. 2002. 303. Turpie AGG, Chin BSP, Lip GYH. ABC of antithrombotic therapy. Venous thromboembolism: pathophysiology, clinical features, and prevention. Brit Med J 325: 887-890, 2002. 304. Turpie AG, Chin BS, Lip GY. Venous thromboembolism: pathophysiology, clinical features and prevention. BMJ 325: 887-890, 2002 305. Ageno W, Turpie AG. low molecular weight heparins in the treatment of unstable angina. Minerva Cardioangiol 50 (6):643-651, 2002. 27 28 306. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR for the Steering Committee of the Pentasaccharide Orthopedic Prophylaxis Studies Fondaparinux vs enoxaparin for the prevention of venous thromoembolism in major orthopedic surgery. Arch Intern Med 162:1833-1840, 2002. 307. Turpie AGG. Use of selective factor Xa inhibitors in special Supplement to American Journal of Orthopedics. XXXI (11S) November 2002. 308. Goldsmith I, Turpie AGG, Lip GYH. ABC of antithrombotic therapy. disease and prosthetic heart valves. Brit Med J 325:1228-1231, 2002. populations. Valvular heart 309. Turpie AGG, Eriksson BI, Lassen MR, Bauer KA. A meta-analysis of fondaparinux versus enoxaparin in the prevention of venous thromboembolilsm after major orthopaedic surgery. JSOA 11 (4):182-188, 2002. 310. Ageno W, Turpie AGG. Deep venous thrombosis in the medically ill. Hematology Reports 1:73-78, 2002. Current 311. Lee AYY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M. for the Randomized comparison of low-molecular-weight heparin versus oral anticoagulant therapy for the prevention of recurrent venous thromboembolism in patients with cancer (CLOT) investigators. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 349 (2):146-153, July 2003. 312. Turpie AG, Eriksson BI, Lassen MR, Bauer KA. Fondaparinux, the first selective factor Xa inhibitor. Curr Opin Hematol 10 (5):327-332, 2003. 313. Cannon CP, Turpie AGG. Unstable angina and non-ST-elevation myocardial infarction. Circulation 107:2640-2645, 2003. 314. Kearon C, Ginsberg JS, Kovacs MJ, Anderson DR, Wells P, Julian JA, MacKinnon B, Weitz JI, Crowther MA, Dolan S, Turpie AGG et al. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med 349:631-639, 2003. 315. Turpie AGG, Bauer K, Eriksson B, Lassen M on behalf of the Steering Committees of the Pentasaccharide Orthopedic Prophylaxis Studies. Thromb Haemost 90:364-366, 2003. 316. Eriksson BI, Lassen MR for the PENTasaccharide in Hip-FRActure Surgery Plus (PENTHIFRA Plus) Investigators. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery. Arch Intern Med 163337-1342, 2003. 317. Ageno W, Turpie AGG. Breathing life into pulmonary embolism. Cardiology 19 (10):36-39, 2003. Perspectives in 318. Kearon C, Ginsberg JS, Kovacs MJ, Anderson DR Wells P, Julian JA, MacKinnon B, Weitz JI, Crowther MA, Dolan S, Turpie AG, Geerts W, Solymoss S, van Nguyen P, Demers C, Kahn SR, Kassis J, Rodger M, Hambleton J, Gent M. Extended low-intensity anticoagulation for Thrombo-Embolism Investigators. Comparison of low intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl JMed 349 (7):631-639, 2003. 319. Alikhan R, Cohen AT, Combe S, Samama MM, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Olsson CG, Turpie AG. Prevention of venous thromboembolism in medical 28 29 patients with enoxaparin: a subgroup analysis of the MEDENOX Study. Fibrinolysis 14 (4):341-346, 2003. Blood Coagul 320. The MATISSE Investigators. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med 349:1695-1702, 2003. 321. Topol EJ for the APPCR panel. Arch Intern Med 163:3251-3252, 2003. Amtocpagi;atopm wotj [rpstjetoc cardiac va;ves/ 322. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. 362: 1582-1583. 2003. Letter to the Editor, The Lancet 323. Turpie AGG. Future therapeutic directions for factor Xa inhibiton in the prophylaxis and treatment of thrombotic disorders. Am J Health-Syst Pharm, 60 (Suppl) S20-S24, 2003. 324. Data Safety Monitoring Board – Member – Colwell CW, Berkowitz D, Davidson BL, Lotke PA, Ginsberg G, Lieberman JR, Naubauer J, mcElhattan JL, Peters GR and Francis CW. Comparison of Ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomised, double-blind study. Journal of Thrombosis and Haemostasis 1:2119-2130, 2003. 325. Turpie A, Bauer K, Eriksson B, Lassen M on behalf of the Steering Committee of the Pentasaccharide Orthopedic Prophylaxis Studies. Efficacy and safety of fondaparinux in major orthopedic surgery according to the timing of its first administration. Thromb Haemost 90:364-366, 2003. 326. Turpie AG. 2003. Choice of low molecular weight heparins. J Thromb Haemost 2 (3):598, 327. Dunn AS, Turpie AG. Perioperative management of patients receiving anticoagulants: a systemic review. Arch Interjn Med 163 (8):901-908, 2003 oral 328. Turpie AG, Bauer kA, Eriksson BI, Lassen MR. Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery. Lancet 362:1582-1583, 2003. 329. Turpie Alexander G.G.: Fondaparinux (Arixtra) in the future: horizons. Thromb & Haemost (Suppl) Sept 13-14, 2004, Prague. exploring new 330. Turpie AGG. Proven strategies for preventing thromboembolism in heart failure. Cardiology Special Edition (based on the American Heart Association Scientific sessions, 2003), March 2004. 331. Kearon C, Ginsberg JS, Anderson DR, Kovacs MJ, Wells P, Julian JA, MacKinnon B, Demers C, Douketis J, Turpie AG, Van Nguyen P, Green D, Kassis J, Kahn R, Solymoss S, Desjardins L, Geerts W, Johnston M, Weitz JI, Hirsh J, Gent M and the SOFAST Investigators. Comparison of 1 month with 3 months of anticoagulation for a firwt episode of venous thromboembolism associated with a transient risk factor. J Thromb and Haemo 2:743-749, 2004. 332. Turpie AG. Venous thromboembolism prophylaxis: role of factor Xa inhibition by fondaparinux. Surg Technol Int 13:261-267, 2004 29 30 333. Turpie AGG. The design of venous thromboembolism prophylaxis trials: Fondaparinux is definitely more effective than enoxaparin in orthopaedic surgery. Int J Clin Pract 58:483-493, May 2004. 334. Turpie AGG. Fondaparinux: a Factor Xa inhibitor for antithrombotic therapy. Expert Opin Pharmacother 5 (6): 1373-1384, 2004. 335.Douketis JD, Johnson JA, Turpie AG. Low molecular weight heparin as briding anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med 164:1319-1326, 2004. 336. Ageno W, Crotti S, Turpie AG. The safety of pregnancy. Expert Opin Drug Saf 3 (2):113-118, 2004. antithrombotic therapy during 337. Turpie AGG, Norris TM. Thromboprophylaxis in medical patients: the role of lowmolecular weight heparin. Thromb Haemost 92:3-12, 2004. 338. Leizorovicz A, Cohen AT, Turpie AGG, Olsson C-G, Vitkus PT, Goldhaber SZ for the PREVENT Medical Thromboprophylaxis Study Group. Randomised, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation 110:874-879, 2004. 339. Lee, AYY, Gent M, Julian J, Bauer KA, Eriksson BI, Lassen MR, Turpie AGG. Bilateral vs ipsilateral venography as the primary efficacy outcome measure in thromboprophylaxis clinical trials: a systematic review. J Thromb and Haemost 2:1-8, 2004. 340. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Superiority of fondaparinux over enoxaparin in preventing venous thromboembolism in major orthopedic surgery using different efficacy endpoints. Chest 126:501-508, 2004. 341. Alikhan R, Cohen AT, Combe S, Samama MM, Desjardins L, Eldor , Janbon C, Leizorovicz A, Olsson CG, Turpie AG: MEDENOX Study. Arch intern Med 164 (9):963-968, 2004 342. Kearon C, Ginsberg JS, Anderson DR, Kovacs MJ, Wells P, Julian JA Mackinnon B, Demers C, Douketis J, Turpie AG, Van Nguyen P, Green D, Kassis J, Kayhn SR, Solymoss S, Desjardins L, Geerts W, Johnston M, Weitz JI, Hirsh J, Gent M; SOFAST Investigators. Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor. J Thromb Haemost 2 (5):743749, 2004. 343. Desjardins L, Bara I, Boutitie F, Samama MM, Cohen AT, Combe S, Janbon C, Leizorovicz A, Olsson CG, Turpie AG. Correlation of plasma coagulation parameters with thromboprophylaxis, ptient characteristics and outcome in the MEDENOX Study. Arch Pathol lb Med 128 (5):519-526, 2004. 344. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C. Csiba L, Kaste M, Leys D, matias-Guiu J, Rupprecht HJ on behalf of the MATCH Investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebocontrolled trial. The Lancet 394 (9431):331-337, 2004. 345. Leizorovicz A, Turpie AGG, Cohen AT, Wong W, Yoos MC, Dans A for the SMART Study Group. Epidemiology of venous thromboembolism in Asian patients undergoing major 30 31 orthopedic surgery without thromboprophylaxis. 7, 2004. The SMART Study. J Thromb Haemost 2:1- 346. Vaitkus PT, Leizorovicz A, Cohen AT, Turpie AGG, Olsson C-G, Goldhaber for the PREVENT Medical Thromboprophylaxis Study Group. Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients. Thromb Haemost 93: 76-79, 2005. 347. Turpie AGG, Eriksson BI, Bauer KA, Lassen MR. 12:371-375, 2004. Fondaparinux. J Am Acad Orthop Surg 348. Kovacs MJ, Kearon C, Rodger m, Anderson DR, Turpie AG, Bates SM, Desjardins L, Douketis J, Kahn SR, Solymoss S, Wells PS. Single-arm study of bridging therapy with low molecular weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation 10 (12):1658-1663, 2004. 349. O’Donnell M, Turpie AGG. Heart/Drug 4:111-118, 2004. Low-molecular-weight heparin in acute coronary syndromes. 350. Leizorovicz A, Turpie AGG, cohen AT, Dhillon KS, Angchaisuksiri P, Wang C-J for the SMART Study Group. Epidemiology of post-operative venous thromboembolism in Asian Countries. Int’l J of Angiology 13:101-108, 2004. 351. Turpie AGG, Norris TM. Thromboprophylaxis in medical patients: molecular weight heparin. Thromb Haemost 92: 3-12, 2004, the role of low 352. Leizorovicz A, Turpie AGG, Cohen AT, Wong L, Yoo MC, Dans A for the SMART Study Group. Epidemiology of venous thromboembolism in Asian patients undergoing major orthopedic surgery without thromboprophylaxis. J Thromb Haemost 3:28-34, 2005. 353. Turpie AGG. Venous thromboembolism prophylaxis: Role of Factor Xa inhibition by fondaparinux. Surg Tech Int’l XIII:261-267, 2005. 354. Kearon C, Ginsbert JS, Douketis J, Crowther MA, Turpie AG, Bates SM, Lee A, BrillEdwards P, Finch T, Gent M. A randomised trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography. Ann Intern med 142:490-496, 2005. 355. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Major Ortopedik Cerrahie Venoz Tromboembolinin Onlenmesinde Fonaparinuks ile Enoksaparinin Karsilastirilmasi. Archives of Internal Medicine (Turkce tipkibasim) 162:1883-1840, 2005. 356. Abramson BL, Huckell V, Anand S, Forbes T, Gupta A, Harris K, Junaid A, Lindsay T, McAlister F, Roussin A, Sar J, Teo KK, Turpie AG, Verma S. Canadian Cardiovascular Society Consensus Conference: peripheral arterial disease – executive summary. Can J Cardiol 21 (12):997-1006, 2005. 357. Spyropoulos AC, Turpie AG. Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation. Curr Opin Pulm Med 11 (5)373-379, 2005. 358. Turpie AG. thromboembolism. The safety of fondaparinux for the prevention and treatment of venous Expert Opin Drug Saf 4 (4)707-721, 2005 359. Douketis JD, Julian JA, Kearon C, Anderson DR, Crowther MA, Bates SM, Barone M, Piovella F, Turpie AG, Middeldorp S, van Nguyen P, Prandoni P, Wells PS, Kovacs MJ, MacGillavry MR, Constantini L, Ginsberg. Does the type of hormone replacement therapy 31 32 influence the risk of deep vein thrombosis? Haemost 3 (5):943-948, 2005. A prospective case-control study. J Thromb 360. Kovacs MJ, Kearon C, Julian JA, Douketis jD, Demers C, Wells PS, turpie AG, Anderson DR, Kahn SR, Nguyen PV, Green D, Kassis J, Geerts W, Mackinnon B, Ginsberg JS. Influence of warfarin on symptoms of fatigue: findings of a randomised trial. Ann Pharmacother 39 (5):840-842, 2005. 361. Antman EM, Morrow DA, McCabe CH, Jiang F, White HD, Fox KAA, Sharma , Chew P, Braunwald E for the EXTRACT-TIMI 25 Investigators. Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction: Design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction treatment-thrombolysis in Myocardial Infarction study 25 (ExTRACT-TIMI 25). American Heart Journal 149:217-226, 2005. 362. Turpie AGG. Fondaparinux: a Factor Expert Opinion Pharmacother 5:1-12, 2004. Xa inhibitor for antithrombotic therapy. 363. Ageno W, Turpie AGG. What’s new for DVT prophylaxis for the medically ill. Disease of the Month 51:194-199, 2005. 364.Turpie AGG. The safety of fondaparinux for the prevention and treatment of venous thromboembolism. Expert Opinion. Drug Safety. 4 (4):707-721, 2005. 365. Turpie AG. Multidetector-row computed tomography in suspected pulmonary embolism. N Engl j Med 353 (6):630-631. 2005. 366. Kucher N, Leizorovicz A, Vaitkus PT Cohen AT, Turpie AG et al. Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or eoderly hospitalised patients: a subgroup analysis of the PREVENT trial. Arch Intern Med 165 (3):341-345, 2005. 367. Goldhaber SZ, Turpie AGG. Prevention of venous Thromboembolism among hospitalised medical patients. Circulation 111:e1-e3, 2005. 368. Leizorovicz A, Turpie AG, Cohen AT Wong L, Yoo MC, Dans A. Haemost 3 (1) 28-34, 2005. SMART study. J Thromb 369. Vaitkus PT, Leizorovicz A, Cohen AT, Turpie AG, Olsson CG, Goldhaber SZ. PREVENT Medical Thromboprophylaxis Study Group. Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients. Thromb Haemostst 93 (1):76-79, 2005. 370. Cohen, AT, Alikhan R, Arcelus I, bergmann J-F, Haas S, Merli GJ, Spyropolous AC, Tapson VP, Turpie AGG. Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medicalpatients. Thromb Haemost 94:750-759, 2005. 371. Turpie AGG, Fisher WD, Bauer KA, kwong M, Irwin MW, Kalebo P, Misselwitz F, Gent M for the ODIXa-Knee Study Group. BAY 59-7939: an oral, direct Factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study. J Thromb & Haemost 3: 2479-2486, 2005. 372. Turpie AGG, Fisher WD, Bauer KA, Kwong LM, Irwin MW, Kalebo P, Misselwitz F, Gent M for the ODIXa-Knee Study Group. Bay 59-7939: an oral, direct Factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study. J Thromb & Haemost 3:2479-2486, 2005. 32 33 373. Anand SS, Turpie AGG. Medical Treatment. Can J Cardiol 21 (12)1002-1003, 2005. 374. Piovella F, Wang CJ, Lu H, Lee K, Lee LH, Lee WC, Turpie AGG, Gallus AS, Planes A, Passera R. Rouillon A for the AIDA investigators. Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography. J Thromb Haemost 3:26642670, 2005. 375. Eikelboom JW, Quinlan DJ, Mehta SR, Turpie AG, Menown IB, Yusuf S. Unfractionated and low molecular weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction. A meta-analysis of the randomised trials. Circulation 112:3855-3867, 2005. 376. Seshadri N, Goldhaber SZ, Elkayam U, Grimm RA, Groce JB, Heit JA, Spinler SA, Turpie AG, Bosker G, Klein AL. The clinical challenge of bridging anticoagulation with low molecular weight heparin in patients with mechanical prosthetic heart valves: an evidence-based comparative review focusing on anticoagulation options in pregnant and nonpregnant patients. Am Heart J 50 (s):27-34, 2005. 377. Ageno W, Turpie AG. Clinical trials of deep vein thrombosis prophylaxis in medical patients. Clin Cornerstone 7 (4):16-22, 2005. 378. Kahn SR, Panju A, Geerts W, Pineo GF, Desjardins l, Turpie AGG, Glezer S, Thabane L, Sebaldt for the CURVE Study Investigators. Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada. Thromb Res March 1; 2006. 379. Natarajan MK, Velianou JL, Turpie AG, Mehta SR, Raco D, Goodhart DM, Afzal R, Ginsberg JS. A randomised pilot study of dalteparin versus unfractionated heparin during percutaneous coronary interventions. Am Heart J 151 (1)175, 2006 380. Gray LJ, Sprigg N, Bath PMW, Sorensen P, Lindenstrom E, Boysen G, De Deyn PP, Frils P, Leys D, Marttila R, Olsson J-E, O’Neill D, Ringelstein B, van der Sande J-J, Turpie AGG for the TAIST Investigators. J Neurol Neurosurg Psychiatry 77:327-333, 2006. 381. Colwell CW, Kwong LM, Turpie AGG, Davidson B. Flexibility in administration of fondaparinux for prevention of symptomatic venous thromboembolism in orthopaedic surgery. J of Arthroplasty 21 (1) 36-45, 2006. 382. Cohen AT, Davidson BI, Gallus AS, Lassen MR, Prins MH, Tomkowski W, Turpie AGG, Egberts JFM, Lensing AWA for the ARTEMIS Investigators. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ 10:1-5, 2006. 383. Antman EM, Morrow DA, McCabe CH, Murphy SA, Ruda M, Sadowski Z, Budaj A, LopezSendon JL, Guneri S, Jiang F, White HD, Fox KAA, Braunwald E for the ExTRACT-TIMI 25 Investigators. Enoxaparin versus unfractionated heparin with fibrinolysis for STelevation myocardial infarction. N Eng J Med 354:1477-1488, 2006 384. Spyropoulos AC, Turpie AGG, Dunn AS, Spandorfer j, Douketis J, Jacobson A, Frost Fj for the REGIMEN Investigators. Clinical outcomes with unfractionated heparin or low molecular weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN Registry. J Thromb Haemost; 2006; 4:1246-1252. 385. Kearon C, Ginsberg Js, Douketis J, Turpie AG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson D, Kovacs MJ, Linkins L-A. Julian JA, Bonilla LR, 33 34 386. Gent M for the Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group. evaluation of D-Dimer in the Diagnosis of Pulmonary Embolism. A Randomized Trial. Intern Med 144:812-821, 2006. An Ann 387. Turpie AGG. Clinical efficacy and safety of fondaparinux: an emphasis on results in the elderly. Aging Health 2 (5) 1-13, 2006. 388. Kearon C Ginsberg JS Julian JA, Douketis J, Solymoss S, Ockelford P, Jackson S, Turpie AG MacKinnon B, Hirsh J, Gent M. Comparison of fixed-dose weight-adjusted unfractionated heparin and low molecular weight heparin for acute treatment of venous thromboembolism. JAMA 296:935-942, 2006. 389. Hull RD, Schellong SM, Tapson VF, Monreal M, Samama MM, Turpie AG, Wildgoose P, Yusen RD. Extended-duration thromboprophylaxis in acutely ill medical patients with recent reduced mobility: Methodology for the EXCLAIM study. J Thromb Thrombolysis 22 (1):31-38, 2006. 390. Shellong SM, Beyer J, Kakkar AK, Schmidt B, Halbritter K, Eriksson B, Turpie AGG, Misselwitz F, Kalebo P. Validierung von zentral befundetem venosen Ultraschall bei Patienten eine Woche nach orthopadischem Gelenkersatz: Die VENUS-Studie. VASA 35 (Suppl 69: 18, 2006. 391. Turpie AGG, Leizorovicz A. Prevention of venous thromboembolism in medically ill patients: a clinical update. Postgraduate Medical Journal (Accepted for publication). 34 35 ABSTRACTS AND COMMUNICATIONS 1. The anticoagulant action of puff adder (B. arientans) venom. (Jointly) Association of Physicians of East Africa, Nairobi, July 1965. 2. Mode of action of Echis Carinatus venom. (Jointly) Physicians of East Africa, Kampala, April 1966. 3. The role of the fibrinolytic enzyme in spontaneous gangrene in African children. (Jointly) Royal Medico-Chirurgical Society, Glasgow, November 1966. 4. Snake venom - friend of foe? Glasgow, November 1966. 5. Spontaneous gangrene in African children. February 1967. 6. Effect of gaboon viper (Bitis Gabonica) venom on blood coagulation, platelet aggregation and the fibrinolytic enzyme. (Jointly) Scotish Society for Experimental Medicine, Glasgow, June 1967. 7. Trial of deglycyrrhizinised liquorice in gastric ulcer. Society of Gastroenterology, Prague, July 1968. 8. Changes in platelet behaviour associated with Arvin therapy. Research Society, March, 1969. 9. Action of pyrimido-pyrimidine compounds on platelet behaviour in vitro. (Jointly) Vth Congress of Asian and Pacific Society of Haematology, Istanbul, September, 1969. (Jointly) Association of the Royal Medico-Chirurgical Society, Medical Research Society, London, (Jointly) European (Jointly) Medical 10. Platelets. Vascular Surgical Society of Great Britain and Ireland. November, 1969. 11. Action of pyrimido-pyrimidine compounds on platelet behaviour in vitro. (Jointly) 18th Annual Symposium on Blood. Wayne State University School of Medicine, Detroit, 1970. 12. Platelets. Association of Surgeons of Great Britain and Ireland. April, 1970. 13. Platelet electrophoresis: Effect of defibrination by ancrod. International Congress of Haematology, Munich, August, 1970. 14. The effect of cigarette smoking on blood coagulation, platelet aggregation and fibrinolysis. (Jointly) Scottish Society for Experimental Medicine, Dundee, January, 1971. 15. Interaction of Newcastle Disease Virus (NDV) with blood platelets. (Jointly) American Society of Microbiology, Minneapolis, May, 1971. Interaction of Newcastle Disease Virus (NDV) with platelets. (Jointly) Federation of American Societies of Experimental Biology, Atlantic City, April, 1972. 16. 17. Glasgow, Glasgow, Thirteenth Contrasting effects of human and rabbit platelets in Chikungunya Virus (CV) infectivity. (Jointly) American Society for Microbiology, Philadelphia, April, 1972. 35 36 18. Requirement for hemolytic activity in virus-induced platelet aggregation. (Jointly) Canadian Federation of Biological Societies, Quebec City, June, 1972. 19. Thrombocytopenia and vasculitis induced in rabbits by Newcastle Disease Virus. (Jointly) III Congress, International Society on Thrombosis and Hemostasis, Washington, D.C., August, 1972. 20. Effect of bacteria on platelet aggregation and the platelet release reaction. (Jointly) Federation of American Societies of Experimental Biology, Atlantic City, April, 1973. 21. Haematological and vascular changes in rabbits inoculated with Newcastle Disease Virus. (Jointly) American Society for Microbiology, May, 1973. 22. Thrombolysis with a combination of small doses of subcutaneous heparin. (Jointly) IV Congress, International Society on Thrombosis and Hemostasis, Vienna, June, 1973. 23. Prevention of venous thrombosis with small doses of subcutaneous heparin. (Jointly) IV Congress, International Society on Thrombosis and Hemostasis, Vienna, June, 1973. 24. Virus-induced platelet aggregation: Requirement for sialic acid receptors. (Jointly) Canadian Society of Microbiologists, Edmonton, June 1973. 25. 125 26. Prevention of venous thrombosis in neurosurgical patients by intermittent calf compression. (Jointly) Vth Congress, International Society on Thrombosis and Hemostasis, Paris, July 1975. 27. Failure of aspirin and dipyridamole to influence the incidence of leg scandetected venous thrombosis after elective hip surgery. (Jointly) Vth Congress, International Society on Thrombosis and Hemostasis, Paris, July 1975. 28. The role of the platelet in thrombosis. Symposium on the Detection and Treatment of Thromboembolism. Royal College of Physicians and Surgeons of Glasgow, April, 1976. Impedance Plethysmography. Symposium on the Detection and Treatment of Thromboembolism. Royal College of Physicians and Surgeons of Glasgow, April, 1976. 29. I-fibrinogen leg scanning after cardiac revascularization surgery. Meeting, Toronto, June, 1974. OMA Tri-City 30. Diagnosis of venous thrombosis. Invited participant. Physicians, Atlanta, October, 1976. 31. Physical methods of venbous thrombosis prophylaxis. Heart Association, Miami Beach, November, 1976. 32. Pathogenesis of Thrombosis. Symposium on the Prevention and Treatment of Human Thromboembolism. Laval University School of Medicine, Quebec City, March, 1976. 33. Venous Thromboembolism. Prevention by physical methods. Symposium on the Prevention and Treatment. Symposium on the Prevention and Treatment of Human Thromboembolism. Laval University School of Medicine, Quebec City, March, 1977. 36 American College of Chest Plenary session. American 37 34. Prevention of venous thrombosis by intermittent sequential calf compression in neurological and neurosurgical patients. International Society of Haematology, Paris, July, 1978. 35. Platelet Suppressant Therapy. Interstate Postgraduate Medical Association, Washington, D.C., October, 1978. 36. Turpie AGG, Hirsh J, Genton E, Han P, Gent M: Comparative effects of sodium and calcium heparin on plasma heparin concentration, partial thromboplastin time, platelet count and bleeding. Circulation II 58, #801, l978. 37. Han P, Turpie AGG, Genton E, Hirsh J, Gent M: Negative correlation between platelet survival, B-thromboglobulin and platelet aggregate ratio in patients with coronary artery disease. Circulation II 58, #451, 1978. 38. Zielinsky A, Hirsh J, Hull R, Powers P, Turpie AGG, Han P: Evaluation of radioimmunoassay for Fragment E (FgE) in the diagnosis of venous thrombosis. Thrombosis and Hemostasis 42, #0054, 1979. 39. Kelton J, Neame PB, Walker I, Turpie AGG, McBride J, Han P, Nicholson W, Hirsh J: Thrombotic thrombocytopenic purpura: Mechanism for effectiveness of plasmapheresis. Thrombosis and Hemostasis 42, #0264, 1979. 40. Han P, Turpie AGG, Genton E, Gent M: The effect of antiplatelet drugs on plasma B-thromboglobulin in coronary artery disease. Thrombosis and Hemostasis 42, #0131, 1979. 41. Han P, Turpie AGG, Genton E: Plasma B-thromboglobulin measurement to differentiate types of thrombocytopenia. Thrombosis and Hemostasis 42, #6010, 1979. 42. Turpie AGG, Han P, Genton E, Butt RW, Zielinsky A: The effect of contrast media, 125-Iodine labelled fibrinogen, heparin and aspirin on plasma BTG concentration. Thrombosis and Hemostasis 42, #0721, 1979. 43. Turpie AGG: Intermittent pneumatic compression prophylaxis in neurosurgery. Third Annual Symposium on Vascular Surgery, New York, New York, November, 1979. 44. Turpie AGG: Diagnosis of venous thromboembolism. Third Annual Symposium on Vascular Surgery, New York, New York, November, 1979. 45. Turpie AGG: Treatment of venous thromboembolism. Third Annual Symposium on Vascular Surgery, New York, New York, November, 1979. 46. Han P, Turpie AGG, Butt RW, LeBlanc P: The use of B-thromboglobulin release to assess platelet damage during cardiopulmonary bypass. Hematology Society of Australia, Hobart, Tasmania, February, 1980. 47. Turpie AGG: Clinical effectiveness of drugs in venous occlusion and pulmonary embolism. Haematologist's point of view. Conference on Clinical Pharmacology and Therapeutics, London, England, August, 1980. 48. deBoer AC, Stewart A, Butt R, Turpie AGG, Genton E: 125I-fibrinogen dilute whole blood clot lysis time: the effect of intermittent pneumatic compression of the calves. Joint Meeting of the 18th Congress of the International Society of Blood Transfusion, Montreal, Canada, August, 1980. 37 38 49. Turpie AGG, Neame PB, Kelton JG, deBoer AC: Plasma betathromboglobulin concentration in thrombocytopenia and thrombocytosis. Joint Meeting of the 18th Congress of the International Society of Haematology and the 16th Congress of the International Society of Blood Transfusion, Montreal, Canada, August, 1980. 50. Duke RJ, Turpie AGG, Bloch RF, Devine EE, Derby IR, Kronby MH, Bayer NH: Clinical trial of low-dose heparin for the prevention of stroke progression. Circulation II 62: #56, November, 1980. 51. Turpie AGG, Genton E, Han P, deBoer AC, Gent M: Evaluation of gamma function calculation of platelet survival time (PST). Circulation II 62: #1060, November, 1980. 52. Turpie AGG, Genton E, Hull R, Hirsh J, deBoer AC, Hiscoe C. Johnston M, Gent M: Calf and thigh compression to prevent venous thrombosis (VT) in intracranial disease (ICD). Circulation II 62: #1300, November, 1980. 53. Turpie AGG, deBoer AC, Genton E, Duke RJ, Bloch RF, Devine EE, Zielinsky A: Plasma betathromboglobulin (BTG) and serum fragment E (FgE) in acute partial stroke. Circulation II 62: #447, November, 1980. 54. Zielinsky A, Hirsh J, Carter C, Hull R, Powers P, Turpie AGG, Straumanis G: An evaluation of the radioimmunoassay for Fragment E in the diagnosis of venous thrombosis in clinically symptomatic patients. Circulation II 62: #634, November, 1980. 55. Hull R, Hirsh J, Sackett DL, Taylor W, Carter C, Turpie AGG, Zielinsky A, Powers P, Gent M: Replacement of venography in suspected venous thrombosis by impedance plethysmography and 125I-fibrinogen leg scanning. Circulation II 62: #1298, November, 1980. 56. Turpie AGG, deBoer AC, Genton E, Butt R, Han P, Gunstensen J: Platelet survival time and betathromboglobulin in cardiac valve replacement. Am J of Cardiology 47, #498, 1981. 57. deBoer AC, Han P, Turpie AGG, Butt R, Gent M: The effect of antiplatelet drugs on platelet survival time and betathromboglobulin in coronary artery disease. Thrombosis and Hemostasis 46, #60l, July, 1981. 58. Turpie AGG, deBoer AC, Sealey BJ, Butt R, Genton E: Betathromboglobulin and fibrinopeptide A in exercise-induced myocardial ischemia. Thrombosis and Hemostasis 46, #618, July, 1981. 59. deBoer AC, Turpie AGG, Butt RW, Genton E: The contribution of increased fibrinolysis induced by intermittent pneumatic compression of the legs in the prevention of deep vein thrombosis. Thrombosis and Hemostasis 46 #596, July, 1981. 60. Turpie AGG, deBoer AC, Han P, Butt R, Genton E: Plasma and urine betathromboglobulin concentration in deep vein thrombosis. Thrombosis and Hemostasis 46, #515, July, 1981. 61. deBoer AC, Turpie AGG, Butt R, Genton E: Thromboxane B2 and betathromboglobulin in symptomatic coronary artery disease. Thrombosis and Hemostasis 46, #844, July, 1981. 38 39 62. Kelton JG, Powers PJ, Turpie AGG, Carter CJ: Heparin associated thrombocytopenia is not a typical drug induced thrombocytopenia. Thrombosis and Hemostasis 46, #678, July, 1981. 63. Hull R, Carter CJ, Ockelford P, Hirsh J, Zielinsky A, Turpie AGG, Powers P: The use of non-invasive testing and venography for the diagnosis of acute recurrent deep vein thrombosis. International Vascular Symposium, London, October, 1981. 64. Turpie AGG, deBoer AC, Johnston RV, Butt R, Sealey BJ, Genton E: Plasma thromboxane B2 and urine betathromboglobulin in exercise-induced myocardial ischemia. Canadian Cardiovascular Society, Montreal, 1981. 65. Turpie AGG, Treatment of cerebrovascular disorders. Microsymposium Nieuwe ontwikkelinger in de diagnostiek en behandeling van arteriele en veneuze thrombose. Bergwegziekenhuis Rotterdam, Holland, March, 1982. 66. Hull R, Carter C, Ockelford P, Hirsh J, Turpie AGG, Powers P: Objective diagnosis of acute recurrent deep vein thrombosis by combined non-invasive testing and venography. Annals of the Royal College of Physicians and Surgeons of Canada 15, #132, 1982. 67. Turpie AGG, deBoer AC, Butt R, Genton E: Activation of platelets and blood coagulation in exercise-induced myocardial ischemia. Annals of the Royal College of Physicians and Surgeons of Canada 15, #134, 1982. 68. Turpie AGG, deBoer AC, Giroux M, Kinch D, Butt R, Gunstensen J, Gent M, E. Genton: Platelet survival and betathromboglobulin after heterograft mitral valve replacement. thrombosis and Hemostasis 50 (1), #63, 1983. 69. Doyle DJ, Turpie AGG, deBoer AC, Talbot C, McNamee J, Hirsh J, Gent M: Failure of suloctidil to prevent deep venous thrombosis in neurosurgical patients. Thrombosis and Hemostasis 50 (1), #248, 1983. 70. Turpie AGG, Butt R, Evaluation of a radioimmunoassay kit for fibrinopeptide A. Blood 62 (5) Suppl. 1, #1018, 1982. 71. Doyle DJ, Belbeck LW, McDonald S, Turpie AGG, Gunstensen J; Comparison of lowmolecular weight heparin (Choay 222) with standard heparin for cardiopulmonary bypass in dogs. Blood 62 (5) Suppl 1, #1102, 1983. 72. Buchanan MR, Butt RW, Nazir D, Turpie AGG, Hirsh J: The regulation of platelet/endothelial cell adhesion by two arachidonic acid metabolites. Thrombosis and Hemostasis 50 (1), #190, 1983. 73. Hull R, Carter C, Turpie AGG, Jay R, Hirsh J, Kinch D, Raskob G: A randomized trial of sequential pneumatic limb compression in the prevention of venous thromboembolism following elective hip surgery. Thrombosis and Hemostasis 50 (1), #66, 1983. 74. Hull R, Carter C, Turpie AGG, Hirsh J, Jay R, Powers P, Raskob G, Dodd P: A randomized trial of diagnostic strategies for symptomatic deep vein thrombosis. Blood 62 (5) Suppl. 1, #1114, 1983. 75. Hull RD, Carter C, Turpie AGG, Hirsh J, Jay R, Powers P, Kinch D, Raskob G, Dodd P: A randomized trial of diagnostic strategies for symptomatic deep vein thrombosis. Clinical and Investigative Medicine 6 (Suppl 1), #117, 1983. 39 40 76. Jay R, Hull R, Carter C, Ockelford P, Buller H, Turpie AGG, Hirsh J: Outcome of abnormal impedance plethysmography results in patients with proximal vein thrombosis: frequency of return to normal. Thrombosis and Hemostasis 50 (1), #152, 1983. 77. Hull R, Carter C, Turpie AGG, Hirsh J, Jay R, Kinch D, Raskob G: A randomized trial of diagnostic strategies for symptomatic deep vein thrombosis. Thrombosis and Hemostasis 50 (1), #160, 1983. 78. Hull RD, Hirsh J, Carter C, Jay R, Coates G, Gill J, Turpie AGG: Pulmonary angiography, ventilation scanning and venography in patients with clinically suspected pulmonary embolism and abnormal perfusion scans. Thrombosis and Hemostasis 50 (1), #328, 1983. 79. Hull R, Carter C, Turpie AGG, Hirsh J, Jay R, Powers P, Dodd P, Gent M: A randomized trial of diagnostic strategies for symptomatic deep vein thrombosis. Annals of the Royal College of PHysicians and Surgeons 16, #353, 1983. 80. Gent M (on behalf of the Study Group): An evaluation of suloctidil in the secondary prevention of cardiovascular events in patients surviving a thromboembolic stroke. Ninth International Joint Conference on Stroke and Cerebral Circulation, Tampa, February, 1984. 81. Doyle DJ, Cairns JA, Turpie AGG, McEwan P, Holder D, Steele M: Systemic urokinase in acute myocardial infarction: Dose schedules, lytic effect and correlation with peak creatine kinase. Clinical and Investigative Medicine 6 (Suppl 1), #71, 1983. 82. Doyle DJ, Cairns JA, Turpie AGG, Holder DA, McEwan MP: Intravenous urokinase (UK) and streptokinase (SK) in acute myocardial infarction (AMI). Evaluation by CK evolution and angiography. Hemostasis 14, #8, 1984. 83. Turpie AGG: The diagnosis and prevention of venous thromboembolism. Education Programme, XX Congress of the INternational Society of Hematology, Buenos Aires, Argentina, September, 1984. 84. Turpie AGG: Antiplatelet drugs in the prevention of postoperative deep vein thrombosis. Symposium - Drugs, Present and Future. XX Congress of the International Society of Hematology, Buenos Aires, Argentina, September, 1984. 85. Turpie AGG: Non-invasive diagnostic methods in thrombotic occlusive diseases. XX Congress of the International Society of Hematology, Buenos Aires, Argentina, September, 1984. 86. Turpie AGG: EnFermedad Thromboembolica. XXXII Anniversario Del Hospital, Buenos Aires, Interzonal de Agudos Buenos Aires, Argentina, September, 1984. 87. Raskob G, Hull R, Leclerc J, Jay R, Hirsh J, Rosenbloom D, Johnston M, David M, Turpie AG, Gent M: Sustained therapeutic heparinization by subcutaneous administration for the primary treatment of acute venous thrombosis. Circulation 70 (Suppl II) #36l, 1984. 88. Raskob G, Hull R, Leclerc J, Jay R, Hirsh J, Rosenbloom D, Johnston M, David M, Turpie AG, Gent M: Sustained therapeutic heparinization by subcutaneous administration for the primary treatment of venous thrombosis. Clinical and Investigative Medicine (Suppl 10) #40, 1984. 40 41 89. Raskob G, Hull R, Rosenbloom D, Leclerc J, Jay R, David M, Thomas M, Johnston M, Turpie AG, Gent M, Hirsh J: Lostistics of double-blinding a randomized trial of intravenous venous subcutaneous heparin for the treatment of venous thrombosis. Controlled Clinical Trials, 5:300, 1984. 90. Raskob G, Doyle D, Hull R, Turpie AGG, Hirsh J, David M, Jay R, Leclerc J, Gent M, Rosenbloom D. Sustained therapeutic anticoagulation with subcutaneous heparin for the primary treatment of venous thrombosis. Clinical Pharmacology and Therapeutics 35:268, 1984. 91. Turpie AGG: Antiplatelet drugs in ischemic heart disease, coronary artery bypass or peripheral arterial surgery. XVIIth International Congress of Internal Medicine, Kyoto, Japan, October, 1984. 92. Jay RM, Turpie AGG, Carter CJ, Hirsh J: Systemic fibrinolysis in venous thrombosis patients treated with recombinant tisue-type plasminogen activator. Thrombosis and Hemostasis 54, #01031, 1985. 93. Turpie AGG, Butt RW, Buchanan MR: The role of the lipoxygenase pathway in the mechanism of action of Nafazatrom. Thrombosis and Hemostasis 43, #1436, 1985. 94. Turpie AGG: Venous anatomy: Deep vein thrombosis and misconception about the disease. Third Annual Seminar on Peripheral Vascular Disease and Hypertension. Toronto, August, 1985. 95. Turpie AGG, Jay RM, Carter CJ, Hirsh J: Systemic fibrinolysis in venous thrombosis patients treated with recombinant tissue-type plasminogen activator. Clinical and Investigative Medicine 8 (4), #166, 1985. 96. Turpie AGG, Jay RM, Carter CJ, Hirsh J: A randomized trial of recombinant tissue plasminogen activator for the treatment of proximal deep vein thrombosis. Circulation II: 72 (4), #770, 1985. 97. Turpie AGG, Duke RJ, Bloch RF, Trebilcock RG, Bayer N: A randomized controlled trial of intravenous heparin for the prevention of stroke progression in acute thrombotic stroke. Circulation ii: 72 (4) #536, 1985. 98. Turpie AGG: Thrombolytic therapy in venous and arterial diseases. Clinic Day in Internal Medicine, Essex Medical Society, Windsor, Ontario, November 20, 1985. 99. Duke RJ, Turpie AGG, Bloch RF, Trebilcock RG, Bayer NH: A randomized controlled trial of heparin in acute partial thrombotic stroke. 11th International Joint Conference on Stroke and Cerebral Circulation. San Francisco, February, 1986. 100. Turpie AGG: Current trends in treating thromboembolic disorders. County Medical Socity, February 19, 1986. Wellington 101. Turpie AGG: Treatment of deep venous thrombosis. Medical College of Ohio, Department of Surgery, Toledo, Ohio, April 19, 1986. 102. Turpie AGG: thrombosis. 103. Turpie AGG, Levine MN, Hirsh J, CArter CJ, Jay RM, Powers PJ, Andrew M, Hull RD, Gent M: Randomized controlled trial of PK 10169 low molecular weight heparin (LMWH) for venous thrombosis prophylaxis after elective hip surgery. Circulation 74 (Supp II) #941, October, 1986. Clinical trials with low-molecular weight heparin in venous Thrombosis Research (Suppl VI) #132, 1986. 41 42 104. Turpie AGG, Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Magnani HN, Hull RD, Gent M: A double blind randomized trial of Org 10172 low molecular weight heparinoid in the prevention of deep vein thrombosis in patients with thrombotic stroke. Blood 68 (Supp 1) #342, November, 1986. 105. Turpie AGG: Current uses of thrombolytic therapy. Presented at the American College of Physicians/Royal College of Physicians of Canada at the Ontario Annual Meeting, Toronto, March 7, 1987. 106. Turpie AGG: Current status of prophylactic anticoagulation: valve replacement, hip and knee surgery. 59th Annual Scientific Session, The New York Cardiological Society, April 25, 1987. 107. Turpie AGG: Anticoagulation in venous and arterial thromboembolism. for Dupont, Kitchener, Ontario, May 12, 1987. 108. Turpie AGG: Thrombolytic therapy. Canadian Society of Laboratory Technologists. Hamilton, Ontario, June 21-26, 1987. 109. Turpie AGG, Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Magnani HN, Hull RD, Gent M: A double blind randomized trial of Org 10172 low molecular weight heparinoid in the prevention of deep vein thrombosis in patients with thrombotic stroke. XIth International Congress on Thrombosis and Haemostasis, Brussels, Belgium, July 6-10, 1987. 110. Powers PJ, Gent M, Jay R, Hirsh J, Levine M, Turpie G: Deep vein thrombosis prophylaxis in surgically treated fractured hip patients. XIth International Congress on Thrombosis and Haemostasis, Brussels, Belgium, July 6-10, 1987. 111. Turpie AGG, Gunstensen J, Hirsh J, Gent M: Optimal level of anticoagulation following tissue valve replacement: A randomized trial. Circulation 76 (Supp IV) #2061, October, 1987. 112. Turpie AGG, Bloch R, Duke R: Heparin in the treatment of thromboembolic stroke. New York Academy of Sciences, November 3-5, 1987. 113. Tratamiento Antitrombotico. Curso Educacional de Avances en Hemostasia Y Trombosis. Barcelona, Spain, March 3-5, 1988. 114. Turpie AGG: Current trends in antithrombotic therapy. 33rd Annual Scientific Assemby of the College of Family Physicians of Canada, Alberta Chapter, Banff, Alberta, March 6-11, 1988. 115. Turpie AGG, Robinson J, Mulji AS, Mishkel GJ, Sealey BJ, Doyle DJ, Cairns JA, Hirsh J, Gent M: Prevention of left ventricular mural thrombosis in acute myocardial infarction: A double-blind trial comparing high dose with low dose subcutaneous heparin. Journal of the American College of Cardiology 11 (2) Suppl A, 26A, 1988. 116. ISIS Collaborative Group: Results of a large randomised trial of intravenous streptokinase and oral aspirin in acute myocardial infarction. Journal of the American College of Cardiology 11 (2) Suppl A, 232A, 1988. 117. Turpie AGG: Antithrombotic effects of aspirin. Annual Towsley Lecture, Midland Hospital Centre, Midland, Michigan, April 11, l988. 118. Turpie AGG: Current trends in thromboembolic disorders: prophylaxis and treatment. Halton Medical Society Presentation, Oakville, May 18, 1988. 42 Presented 43 119. Turpie AGG, Levine MN: The relationship between ex-vivo anti-factor Xa levels and efficacy and safety of low molecular weight heparin. Satellite Symposium Xth International Congress on Thrombosis, Athens, Greece, May 22-27, 1988. 120. Turpie AGG, Hirsh J, Gent M, Julian D, Johnson J: A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control in the prevention of deep vein thrombosis in neurosurgical patients. Xth International Congress on Thrombosis, Athens, Greece, #269, 1988. 121. Turpie AGG: A randomized study of two intensities of warfarin for prosthetic heart valve surgery. Xth International Congress on Thrombosis, Athens, Greece, #77, 1988. 122. Turpie AGG: Current trends in anticoagulation. "One Day in Hematology 88", The College of Family Physicians of Canada, Saskatchewan Chapter, May 28, 1988. 123. Turpie AGG, Robinson JG, Doyle DJ, Mulji AS, Mishkel GJ, Sealey BJ, Cairns JA, Hirsh J, Gent M: Prevention of left ventricular mural thrombosis in acute transmural anterior myocardial infarction: A double blind trial comparing high dose with low dose subcutaneous calcium heparin. XXII Congress of the International Society of Hematology, Milan, Italy, August 28-September 2, 1988. 124. Turpie AGG: Platelet involvement in the pathogenesis of atherothrombotic disease. XXII Congress of the International Society of Hematology, La Ticlopidina Nella Prevenzione Degli Eventi Trombotici Maggiori Nella Malattia Vascolare Ischemica Symposium, Milan, Italy, August 28-September 2, 1988. 125. Turpie AGG: Recombinant tissue plasminogen activator (rt-PA) in pulmonary embolism and deep venous thrombosis. Special Symposium on Thrombolytic Therapy, Cardiology Symposium, Section of Cardiology and Department of Continuing Medical Education, University of Manitoba, September 9, 1988. 126. Turpie AGG: Premier Symposium Suisse sur l'heparine a bas poids moleculaire. Etude comparative contre Placebo de l'efficacite de l'Enoxaparine dans a prevention des thromboses veineuses profondes dans la chirurgie de la hanche. Berne, Switzerland, December 1, 1988. 127. Turpie AGG: What is thrombolytic therapy and why do we use it? Contemporary Management of Cardiovascular Disease - Heart and Stroke Foundation of Ontario, Toronto, December 15-16, 1988. 128. Turpie AGG: Thrombolytic therapy in venous thromboembolism. Joint Meeting of the Forum on Angiology of the Royal Society of Medicine and the British Society for Haemostasis and Thrombosis. London, England, March 21, 1989. 129. Turpie AGG: Profilaxis de la thrombosis venosa profunda con heparinas bajo peso molecular, en pacientes traumatologicos. Academia Nacional de Medicina, Buenos Aires, Argentina, April 4, 1989. 130. Turpie AGG: Prevencion de la thrombosis mural ventricular en pacientes con IAM anterior trasmural: un estudio doble ciego comparando heparina calcica en dosis altas o bajas. Academia Nacional de Medicina, Buenos Aires, Argentina, April 4, 1989. 43 44 131. Turpie AGG: Comparacion randomizada de dos intensidades de anticoagulacion oral luego del reemplazo valvular con protesis biologicas. Academia Nacional de Medicina, Buenos Aires, Argentina, April 4, 1989. 132. Turpie AGG: El uso en terapeutica de TVP de las heparinas de bajo peso molecular. Academia Nacional de Medicina, Buenos Aires, Argentina, April 5, 1989. 133. Turpie AGG: Nuevas drogas fibrinoliticas en el tratamiento de la embolia pulmonar. Academia Nacional de Medicina, Buenos Aires, Argentina, April 5, 1989. 134. Turpie AGG: CATS: Estudio Americano Canadiense sobre Ticlopidina. TASS: Estudio Ticlopidina-Aspirina en accidente cerebro vascular isquemico. 2o Simposio Educacional Reunion Satelite Grupo CAHT, Buenos Aires, Argentina, April 6, 1989. 135. Turpie AGG: Comparacion randomizada de dos intensidades de anticoagulacion oral luego del reemplazo valvular con protesis biologicas. 2o Simposio Educacional en Profilaxis Y Terapeutica Antitrombotica Reunion Cientifica Del Grupo Caht. Chateau Carreras, Cordoba, Argentina, April 7, 1989. 136. Turpie AGG: The Anti-Clotters in Heart Disease and Stroke. Education - Telemedicine, April 19, 1989. 137. Turpie AGG: Anticoagulant therapy after acute myocardial infarction. Thrombosis and Antithrombotic Therapy: Direction for the '90s" symposium, Fort Lauderdale, Florida, April 13, 1989. 138. Turpie AGG: Prevention of post-operative venous thrombosis with low molecular weight heparin. V Congreso Nacional de la Sociedad Espanola de Trombosis y Hemostasia. Bilbao, Spain, May 4, 1989. 139. Turpie AGG: When time is muscle. Critically Speaking, Current Issues. Henderson General Hospital, Hamilton, June 1, 1989. 140. Turpie AGG: The Canadian American Stroke Study (CATS). Simposio Internacional Sobre Terapeutica Antiagregante Plaquetaria Nas Isquemias Cerebrovasculares. Academia Brasileira de Neurologia, Rio de Janeiro, Brazil, July 25, 1989. 141. Turpie AGG: The Ticlopidine Aspirin Stroke Study (TASS). Simposio Internacional Sobre Terapeutica Antiagregante Plaquetaria Nas Isquemias Cerebrovasculares. Academia Brasileira de Neurologia, Rio de Janeiro, Brazil, July 25, 1989. 142. Turpie AGG: The Canadian American Stroke Study (CATS). XII Congreso Interamericano de Cardiologia, Rio de Janeiro, Brazil, July 26, 1989. 143. Turpie AGG: Prevencion del Accidente Cerebrovascular Isquemico. Resultado de los Estudios CATS (The Canadian American Ticlodipine Aspirin Study). Symposium Internacional Sobre Terapeutica Antiplaquetaria, Socieded Argentina Para el Estudio de la Trombosis. Buenos Aires, Argentina, July 28, 1989. 144. Levine MN, Planes A, Hirsh J, Goodyear M, Vochelle N, Gent M, Turpie AGG: Relationship between anti-factor Xa level and clinical outcome in patients receiving enoxaparine to prevent deep vein thrombosis after hip replacement. XIIth Congress of the International Society on Thrombosis and Haemostasis. Tokyo, Japan, August 1989. 44 Continuing Medical 45 145. Turpie AGG: Clinical evaluation of International Normalized Ratio (INR) for control of oral anticoagulants. XIIth Congress of the International Society on Thrombosis and Haemostasis, Tokyo, Japan, August 1989. 146. Turpie AGG: Significance of CATS and TASS studies from USA and Canada in prevention of secondary cardiac and cerebral infarction. Academy of Medicine of Manila, Manila, Philippines, August 1989. 147. Turpie AGG: Significance of CATS and TASS studies from USA and Canada in prevention of secondary cardiac and cerebral infarction. Neurological Society of Thailand, Bangkok, Thailand, September 1, 1989. 148. Turpie AGG: Enoxaparin prophylaxis in elective hip surgery. Venous Thromboembolism: Managing the Risk. Rhone-Poulenc Symposium, Berlin, West Germany, October 5, 1989. Turpie AGG: The Canadian American Ticloipdine Study (CATS) in thromboembolic stroke. Prevention and treatment of arterial thromboembolism: New aspects of Ticlopidine. Lancet (German Supplement) October 6, 1989. 149. 150. Turpie AGG: TPA vs Heparin in deep venous thrombosis: results of a randomized controlled trial. American College of Chest Physicians, 55th Annual Scientific Assembly and XVI World Congress on Diseases of the Chest, Boston, Massachusetts, October 29, 1989. 151. Massel D, Turpie AGG, Gill JB, Cairns JA, Russett J: Development of neutralizing antibodies after 1.5 million units of streptokinase in the treatment of acute myocardial infarction. Clin and Invest Medicine 12 (5) #120, 1989. 152. Turpie AGG: Anticoagulant therapy in cardiac disease. Continuing Medical Education - Day in Medicine, Hamilton Convention Centre, November 1, 1989. 153. Massel D, Turpie AGG, Gill JB, Cairns JA, Russett J: Development of neutralizing antibodies after 1.5 million units of streptokinase in the treatment of acute myocardial infarction. Circulation 80 (4) Suppl, #1398 Abst 1989. 154. Turpie AGG: Side effects of antithrombotic therapy - optimal dosage. Stroke Prevention; A symposium. Montreal, Toronto, Halifax, Nov 27-30, 1989. 155. Turpie AGG: Deep vein thrombosis. Contemporary Management of Cardiovascular Disease. Heart and Stroke Foundation of Ontario. Toronto, Ontario, December 1415, 1989. 156. Turpie AGG: The efficacy and tolerance of high-dose or low-dose heparin in the prevention of mural thrombosis. Prospects and Strategies in Cardiovascular Research II - Heparins in Cardiology Workshop, Second International Symposium, Antwerp, Belgium, February 19, 1990. 157. Turpie AGG: Prevention of cerebral emboli. Telemedicine Canada, March 2, 1990. 158. Turpie AGG: Ticlopidine in Recent Thromboembolic Stroke: The Canadian American Ticlopidine Study (CATS). J of Neurol 237:(2): 161, 1990. 159. Turpie AGG. Thrombolytic therapy in acute myocardial infarction. County Medical Society, Guelph, Ontario May 16, 1990. 160. Turpie AGG. New concepts in antithrombotic therapy. Residents Evening in Anticoagulant Therapy. DuPont Pharmaceuticals, Hamilton May 24, 1990. 45 Continuing Medical Education - Wellington 46 161. Turpie AGG. Update in Thromboembolic Diseases. Barcelona June 18-19, 1990. 162. Turpie AGG. Dilemma of the 90's - Stroke Prevention - When to Anticoagulate. Chinese Canadian Medical Society, Toronto, August 22, 1990. 163. Connolly SJ. Canadian Atrial Fibrillation Anticoagulation (CAFA) Study. Clinical and Investigative Medicine 13 (5): #251 Abst 1990. 164. Massel D, Turpie AGG, Cairns JA, et al. Persistence of neutralizing antibodies at one year following IV streptokinase for acute myocardial infarction. Clinical and Investigative Medicine 13 (5). #224 Abst 1990. 165. Massel D, Gill JB, Turpie AGG, Cairns JA. Thrombolysis does not increase the rate of cardiac catheterization in the first year post-MI. Clinical and Investigative Medicine 13 (5) #119 Abst 1990. 166. Turpie AGG: A symposium on modern anticoagulant therapy. Foundation of Ontario. Hamilton October 24, 1990. 167. Connolly SJ (CAFA Study Group) Canadian Atrial Fibrillation Anticoagulation Study. Circulation 82 Suppl III, #0426, 1990. 168. Massel D, Turpie AGG, Cairns JA, Gill JB, O'Dell C, Russett, J: Persistence of neutralizing antibodies at 1 year following IV streptokinase for acute myocardial infarction. Circulation 82 (4) Suppl, #1007 Abst 1990. 169. Turpie AGG: Atrial fibrillation revisited. Hamilton, October 31, 1990. 170. Turpie AGG: Continuing Medical Education. Valvular Heart Disease -Its thromboembolic complications and their prevention. "Issues in Thromboembolism in the 1990's". Tampa, Florida, November 3, 1990. 171. Levine M, Hirsh J, Gent M, Turpie A et al: A randomized trial comparing Enoxaparine low molecular weight heparin with standard unfractionated heparin in patients undergoing elective hip surgery. Blood 76 (10):Suppl 1:513a #2043, Nov 15, 1990. 172. Turpie AGG: Continuing Medical Education. Prevention of thromboembolic stroke in non-valvular atrial fibrillation. Lambton County Medical Society, Sarnia, November 21, 1990. 173. Turpie AGG: Continuing Medical Education. Indications for Anticoagulation. Dept. of General Practice Rounds, November 27, 1990 174. Turpie AGG: Visiting Professor, Medical Grand Rounds, University of California, San Diego, November 30, 1990. 175. Turpie AGG: Review of Canadian Atrial Fibrillation Anticoagulation Study. University of California, San Diego, December 1, 1990. 176. Turpie AGG: Anticoagulation in prosthetic and natural valve disease. Contemporary management of Cardiovascular Disease 1990. Heart and Stroke Foundation of Ontario, Toronto, December 6, 1990. 46 Kabi Pfrimmer S.A. Laboratories. The Heart and Stroke 17th Annual Day in Medicine, 47 177. Turpie AGG: The prevention of stroke in non-valvular atrial fibrillation. Lincoln County Academy of Medicine, St. Catharines, January 12, 1991. 178. Turpie AGG: The use of heparin in cardiology. Cardiology, Brussels, Feb 1-2, 1991. 179. Turpie AGG: Current issues in Anticoagulation. Society, Brockville, February 13, 1991. 180. Turpie AGG: Anticoagulant Therapy for Valve Disease. All Heart Symposium '91, UBC-Continuing Medical Education, Vancouver, February 22, 1991. 181. Turpie AGG: Fragmin in Australia. Australia, March 24, 1991. 182. Turpie AGG: Resultados del estudio ISIS 3. 4 Simposium Internacional, Nuevas Perspectivas Terapeuticas en Trombosis. Academia Nacional de Medicina, Buenos Aires, Argentina, April 9, 1991. 183. Turpie AGG: Terapeutica anticoagulante en la enfermedad coronaria isquemica. 4 Simposium Internacional, Nuevas Perspectivas Terapeuticas en Trombosis. Academia Nacional de Medicina, Buenos Aires, Argentina, April 10, 1991. 184. Turpie AGG: Trombosis mural ventricular en el IAM. 4 Simposium Internacional, Nuevas Perspectivas Terapeuticas en Trombosis. Academia Nacional de Medicina, Buenos Aires, Argentina, April 11, 1991. 185. Turpie AGG: Fibrilacion auricular: reduccion de riesgo de stroke. 4 Simposium Internacional, Nuevas Perspectivas Terapeuticas en Trombosis. Academia Nacional de Medicina, Buenos Aires, Argentina, April 11, 1991. 186. Turpie AGG: Estudios en prevencion de TVP y EP traumatologica con heparina y heparinas de bajo Internacional, Nuevas Perspectivas Terapeuticas de Medicina, Buenos Aires, Argentina, April 11, 187. Turpie AGG: Anticoagulant therapy for valvular heart disease. Directions for the "90's. Heart and Stroke Foundation of Ontario, May 1, 1991. 188. Turpie AGG: Atrial fibrillation - Strategies to reduce the rate of stroke. The Hong Kong Neurological Society and Australian Association of Neurologists Joint Scientific Meeting, Hong Kong, May 6-8, 1991. 189. Turpie AGG: Thrombolysis for acute non-myocardial conditions. 7th World Congress on Emergency and Disaster Medicine. Montreal, May 15, 1991. 190. Turpie AGG: Heparin and thrombolysis - ISIS-3 and other trials. Thrombolysis Symposium. Toronto May 24-25, 1991. 191. Turpie AGG: How to use anticoagulant and fibrinolytic therapy in stroke. Toronto Neurology Update 1991, Toronto, May 31, 1991. 192. Turpie AGG: Prevention of stroke in atrial fibrillation. Continuing Medical Education - Health Care for the Elderly. Hamilton, June 5, 1991. 193. Turpie AGG: Results and implications of ISIS-3. Issues in reperfusion for the 1990's. The University of Calgary, Banff, June 9, 1991. Belgian Association for The Leeds and Grenville Medical Fragmin Symposium, Hayman Island, Queensland, 47 en el postoperatorio de cirugia peso molecular. 4 Simposium en Trombosis. Academia Nacional 1991. Canadian ISIS-3 48 194. Turpie AGG: An evening in Thrombolytics. 195. Turpie AGG, Levine MN, Powers P, Ginsberg JS, Jay R, Klimek M: A double blind randomized trial of ORG 10172 low molecular weight heparinoid versus unfractionated heparin in the prevention of deep vein thrombosis. Thrombosis and Haemostasis 65 (6) #303, 1991. 196. Turpie AGG: Lomoparan in the prevention of deep vein thrombosis in stroke patients. Satellite Symposium, ISTH, Amsterdam, Netherlands, July 6, 1991. 197. Turpie AGG: Risk factors and prophylaxis of DVT with a LMWH, Fraxiparine. Satellite Symposium, ISTH, Amsterdam, Netherlands, July 6, 1991. 198. Turpie AGG: Non-valvular atrial fibrillation: Risks and benefits of anticoagulant therapy. Essex County Medical Society, Windsor Ontario, July 10, 1991. 199. Turpie AGG: ISIS III: Resultados de SK vs APSAC vs TPA. XLVII Congresso da Sociedade Brasileira de Cardiologia. Sao Paulo, Brazil, September 15-19, 1991. 200. Turpie AGG: Update in Heparin Therapy. Bangkok, Thailand, September 27, 1991. 201. Turpie AGG: Advancement in heparin therapy - Singapore Haematological Society, Singapore, September 29, 1991. 202. Turpie AGG: Strategies in risk reduction for stroke in patients with ischaemic heart disease. Singapore Haematological Society, Singapore, September 29, 1991. 203. Turpie AGG: Role of low molecular weight heparin (Fraxiparine) in cardiology. An International Symposium. Hypertension and Coronary Heart Disease Beijing, China, October 1, 1991. 204. Turpie AGG: Ticlopidine in prevention of major ischemic vascular event. An International Symposium. Hypertension and Coronary Heart Disease, Beijing, China, October 1, 1991. 205. Turpie AGG: Strategies for the prevention of cardioembolic stroke. Society of Cardiology. Beijing, China, October 2, 1991 206. Turpie AGG: Advances in heparin therapy. Kong, October 4, 1991. 207. Turpie AGG, Gent M, Laupacis A, Latour Y, Wright D, Hoffman J, Gunstensen J, Basile F, Klimek M, Hirsh J: Reduction in mortality by adding acetylsalicylic acid (100 mg) to oral anticoagulants in patients with heart valve replacement. Can J Cardiol 7:95A (Suppl A): August 1991. 208. Turpie AG: La ticlopidina en la prevencion de accidentes vasculares isquemicos graves. XXIV Congreso Nacional Sociedad Venezolana de Cardiologia. Caracas, Venezuela, October 21, 1991. 209. Turpie AGG: Antithrombotic therapy in rheumatic heart disease. Foundation of Ontario Symposium, Hamilton, November 6, 1991. 210. Turpie AGG: Prevention of stroke in atrial fibrillation. Clinical Geriatric Traineeship. Continuing Medical Education. Hamilton, November 7, 1991. 48 Port Colborne, June 12, 1991. Haematological Association of Thailand, Chinese Hong Kong Haematological Society, Hong Heart and Stroke 49 211. Massel D, Turpie AGG, Cairns JA, Ofosu F, Buchanan M: Previous streptokinase (SK) therapy inhibits subsequent SK thrombolysis. Circulation 84 (4) Abstract #1858, 1991. 212. Turpie AGG: Ticlopidine in recent thromboembolic stroke (CATS) and after stroke precursors (TASS). XII International Congress on Haemostasis and Thrombosis, Buenos Aires, Argentina, November 19, 1991. 213. Turpie AGG: Risk factors of DVT. Clinical experience with Fraxiparine in the prophylaxis and treatment of DVT. XII International Congress on Haemostasis and Thrombosis, Buenos Aires, Argentina, November 21, 1991. 214. Turpie AGG: Anticoagulation update - What's new in the 90's. Cambridge Memorial Hospital Conjoint Clinical Meeting, Cambridge, November 28, 1991. 215. Turpie AGG: Thrombolysis in acute myocardial infarction: Preliminary Results of ISIS-3. X Biennial Cardiology Conference, Pakistan Cardiac Society, December 57, 1991. 216. Turpie AGG: Thrombolytic therapy in acute venous thrombosis. Department of Surgery, Northwestern University Medical School, Chicago, December 14, 1991. 217. Turpie AGG: Should I anticoagulate my patient with atrial fibrillation? Peterborough County Medical Society, Peterborough, Ontario, January 31, 1992. 218. Turpie AGG: Cardiology. 219. Turpie AGG: The role of heparin. Newfoundland Society of Cardiology. Cornerbrook, Newfoundland, February 1, 1992. 220. Turpie AGG: Different indications for heparins in cardiology. Third International Congress in Cardiovascular Research. Antwerp, Belgium, February 17, 1992. 221. Turpie AGG: Modern anticoagulant therapy. Brantford, February 26, 1992. 222. Turpie AGG: Recent advances in antithrombotic therapy. Toronto, March 3, 1992. 223. Turpie AGG: Coumadin: Use in patients undergoing hip surgery. Rounds, Scarborough General Hospital, March 4, 1992. 224. Turpie AGG: Non-valvular atrial fibrillation. Who to anticoagulate? anticoagulate? Scarborough Grace General, March 4, 1992. 225. Turpie AGG: 5, 1992. Post-MI Anticoagulation. Jewish General Hospital, Montreal, March 226. Turpie AGG: 5, 1992. Post-MI Anticoagulation. Institute of Cardiology, Montreal, March 227. Turpie AGG: 1992. Post-MI Anticoagulation. Sacre Coeur Hospital, Montreal, March 6, Expanded Criteria for Thrombolysis. Newfoundland Society of Cornerbrook, Newfoundland, February 1, 1992. 49 Brantford General Hospital, St. Michael's Hospital, Medical/Surgical How to 50 228. Turpie AGG: The risk of stroke and the role of antithrombotic therapy. "A Closeup on the Evidence". York County Hospital, Medical Education Committee, Bradford, Ontario, March 11, 1992. 229. Turpie AGG: Antithrombotic therapy - Direction for the 90's. Medical Grand Rounds, Sunnybrook Health Science Centre, Toronto, March 24, 1992. 230. Turpie AGG: Antithrombotic therapy following heart valve replacement. Valve Surgery Programme, Lake Louise, Alberta, March 27-29, 1992. 231. Turpie AGG, Gent M, Laupacis A, Latour Y, Gunstensen J, Basile F, Klimek M, Hirsh J. Reduction in mortality by adding aspirin (100 mg) to oral anticoagulants in patients with heart valve replacement. JACC 19 (3):103A, 1992. 232. Turpie AGG. Antiplatelet therapy in Cardiovascular disease. Joint Board for Postgraduate Medical Education, Riyadh, Saudi Arabia, April 26, 1992. 233. Turpie AGG. Antithrombotic therapy in ischaemic heart disease. Joint Board for Postgraduate Medical Education, Riyadh, Saudi Arabia, April 27, 1992. 234. Turpie AGG. Low molecular weight heparin, mode of action and clinical evaluation. Joint Board for Postgraduate Medical Education, Riyadh, Saudi Arabia, April 27, 1992. 235. Turpie AGG. Antithrombotic therapy in stroke. Joint Board for Postgraduate Medical Education, Riyadh, Saudi Arabia, April 27, 1992. 236. Turpie AGG. The prevention of systemic embolism in mechanical heart valve replacement. Thrombosis and Its Management. Leon Poller Retirement Symposium, Manchester, England, May 7-8, 1992. 237. Turpie AGG: New approach in the management of stroke. Asian/Pacific Congress on Bleeding Disorders and Transfusion Medicine, Bangkok Thailand, May 10-15, 1992. 238. 239. Turpie AGG. Thrombosis update. Asian Pacific Congress on Bleeding Disorders and Transfusion Medicine. Bangkok Thailand, May 10-15, 1992. Turpie AGG: Risk factors and management of deep vein thrombosis in surgery - New approach with low molecular weight heparin. Kuala Lumpur Medical Society, Kuala Lumpur, Malaysia, May 16, 1992. 240. Turpie AGG: Recent advances in antithrombotic therapy. Medicine, Manila Philippines, May 18, 1992. Manila Academy of 241. Turpie AGG: Recent advances in antithrombotic therapy. Society, Cebu City Philippines, May 18, 1992. Cebu City Medical 242. Turpie AGG: Recent advances in antithrombotic therapy. Society, Davao City Philippines, May 19, 1992. Davao City Medical 243. Turpie AGG. Antiplatelets/Antithrombins/Antibodies. Reperfusion 1992: Emergency. Univ. of British Columbia, May 23-24, 1992. 244. Turpie AGG. Final results of the ISIS-3 Study. Aires, Argentina, June 19, 1992. 245. Turpie AGG. New advances in ischemic cardiopathy with antiplatelet drugs and LMWH. Instituto de Cardiologia, Buenos Aires, Argentina, June 19, 1992. 50 Heart Instituto de Cardiologia, Buenos 51 246. Turpie AGG. Aspirin, the ageless remedy: Comparison with oral anticoagulants. Rounds in Emostasi E Trombosi, Instituto di Clinica Medica 2, Pavia Italy, September 7, 1992. 247. Turpie AGG. Anticoagulant Therapy - Directions for the 90's. di Bergamo, Bergamo Italy, September 8, 1992. 248. Samama MM, Forbes C, Turpie AGG, Lowe G: Treatment of venous thromboembolism. 16th World Congress of the International Union of Angiology, Paris September 16, 1992. 249. Turpie AGG: Antithrombotic therapy following heart valve replacement. Tenon, Service de Cardiologie, September 17, 1992. 250. Turpie AGG: Anticoagulant Therapy. Update on Drugs - Coumadin. Geriatric Medicine for the Practising Physician. Ontario Association of Medical Directors of Homes for Senior Citizens. Toronto, September 21, 1992. 251. Turpie AGG: Anticoagulation: How I would do it. 3rd Annual Cardiovascular therapeutics related to anticoagulant therapy. The Heart and Stroke Foundation. Hamilton, October 14, 1992. Turpie AGG: Thromboembolism - Diagnosis and Treatment. Grey-Bruce Medical Society, October 15, 1992. 252. Ospedali Riuniti Hopital 253. Gill JB, Fondevila CG, Brister SJ, Turpie AGG et al: Contrast media induces thrombin generation during PTCA. Canadian Cardiovascular Society, Ottawa, October 22, 1992. 254. Turpie AGG: Antithrombotic therapy following heart valve replacement. Cardiovascular Society, Ottawa, October 23, 1992. 255. Turpie AGG: Antithrombotic therapy following heart valve replacement. Controversies in Antithrombotic Therapy. The Thrombosis Interest Group, Ottawa, October 23, 1992. 256. Turpie AGG: Physicians. 257. Turpie AGG: Anticoagulation. November 4, 1992. 258. Turpie AGG: Physicians. 259. Turpie AGG: Interchange Forum: Developments in prophylactic therapy for venous thromboembolic disease. Dallas, November 13, 1992. 260. Turpie AGG: Clinical update on antithrombotic therapy. The University of Arizona College of Medicine, New Orleans, November 14, 1992. 261. Ginsberg JS, Hirsh J, Gent M, McKinnon B, Turpie AGG et al. A phase II study of Hirulog in the prevention of venous thrombosis after major hip or knee surgery. Circulation 86 (4) ppI-409, 1992. 262. Turpie AGG: Combined antiplatelet therapy and full dose anticoagulation in patients with artificial heart valves. American Heart Association, New Orleans, November 1992. Canadian Thrombophlebitis - Long term treatment. American College of Chest 58th Scientific Assembly, Chicago, October 26, 1992. 19th Annual Day in Medicine, CME, Hamilton, Therapeutic anticoagulation. Toronto, November 12, 1992. 51 The Ontario College of Family 52 263. Turpie AGG: V.T.E.D. Diagnosis: Which investigations? Congress, San Diego, November 23, 1992. 264. Turpie AGG: V.T.E.D. Treatment: Treatment in the 90's? Congress, San Diego, November 24, 1992. 265. Turpie AGG: Pulmonary thromboembolism. Contemporary Management of cardiovascular disease. Toronto, December 11, 1992. 266. Turpie AGG: Low molecular weight heparin and heparinoids and anticoagulation. American College of Physicians, Indiana Chapter, Indianapolis, Indiana Feb. 20, 1993. 267. Turpie AGG: DVT and PE in trauma patients. Hamilton, Feb. 23, 1993. 268. Turpie AGG: Should I anticoagulate my patient with atrial fibrillation. Special Education Seminar, Huronia Medical Association, Midland, February 24, 1993. 269. Turpie AGG: Antithrombotic Update: Direction for the 90's. Continuing Medical Education, North York Branson Hospital, Toronto, March 4, 1993. 270. Turpie AGG: Thrombin Inhibitors. ISIS Collaborators Meeting; American College of Cardiology, Anaheim, California, March 16, 1993. 271. Turpie AGG: Anticoagulation in the 90's. Rounds, March 25, 1993. 272. Turpie AGG, Stanton E: The use of heparin in ischemic heart disease "Unanswered Questions", Medical Grand Rounds, St. Joseph's Hospital, Hamilton, April 14, 1993. 273. Turpie AGG: The use of low molecular weight heparins in orthopaedic surgery. University of Manitoba, Faculty of Medicine, April 19, 1993. 274. Turpie AGG: The use of low molecular weight heparins in Cardiology. Visiting Professor, Department of Cardiology, University of Manitoba, April 20, 1993. 275. Turpie AGG: Short and long-term management of lower extremity venous thrombosis. The Anticoagulation Forum. Monterey, California, April 23, 1993. 275. Turpie AGG: Prevention of recurrent Stroke. York, April 24, 1993. 276. Turpie AGG: Clinical experience with Orgaran in deep vein thrombosis prophylaxis in high risk patients. "Clinical use of the new antithrombotic Orgaran in high risk situations" Symposium, Oss, The Netherlands, April 29, 1993. 277. Turpie AGG: Prevention of stroke in atrial fibrillation. Continuing Medical Education, McMaster University, Burlington, Ontario, May 5, 1993. 278. Turpie AGG: Update on thrombolytic therapy in acute myocardial infarction. Ontario College of Pharmacists, Toronto, Ontario, May 6, 1993. 279. Turpie AGG: Oral anticoagulation: New indications and old indications revisited. Anticoagulation for the 90's Symposium. Springfield, Illinois May 8, 1993. 52 I.S.E.R.V.D. 1st I.S.E.R.V.D. 1st Multi-disciplinary Trauma Series, Belleville General Hospital, Grand Columbia University, New York, New 53 280. 281. 282. Turpie AGG: Chairman - New Concepts in Stroke, Pathophysiology anhd Prevention. 2nd International Conference on Stroke, Geneva, Switzerland, May 12-15, 1993. Turpie AGG: Venous Thromboembolism. Clinical Advances in Venous Thrombo-Embolic Disease Symposium, McMaster University Faculty of Health Sciences Symposium, Queen's Landing Inn, Niagara on the Lake, May 15, 1993. Turpie AGG: Trials with Heparin. European Atherosclerosis Society Meeting, Capri, Italy, May 16-19, 1993. 283. Turpie AGG: DVT - Diagnosis, Prevention and Treatment. General Hospital, Kitchener, Ontario, May 27, 1993. 284. Turpie AGG: Thromboembolic disease in joint replacement. 48th Annual Meeting of the Canadian Orthopaedic Association, 27th Annual Meeting of the Canadian Orthopaedic Research Society, Montreal, Quebec, June 1, 1993. 285. Turpie AGG: Prevention of deep vein thrombosis after orthopedic surgery. Orthopedic Rounds, Buffalo General Hospital, June 2, 1993. 286. Turpie AGG: Platelet dysfunction during cardiopulmonary bypass. Blood Conservation '93. Department of Anaesthesia of the University of Ottawa. Halifax, Nova Scotia, June 8, 1993. 287. Turpie AGG: Diagnosis of venous thromboembolism and pulmonary embolism. Thrombosis Forum, XVII World Congress on Diseases of the Chest, Amsterdam, June 15, 1993. 288. Turpie AGG: Controversies in the diagnosis and treatment of venous thromboembolism. Thrombosis Forum, XVII World Congress on Diseases of the Chest, Amsterdam, June 17, 1993. 289. Turpie AGG: Prophylaxis and treatment of DVT and pulmonary embolism with heparin/Coumadin, and update on usage of low molecular weight heparin. The Credit Valley Hospital, Medicine Rounds, Mississauga, June 29, 1993. 290. Turpie AGG (on behalf of the Thrombosis Interest Group). Control of anticoagulant therapy: A cross Canada survey. Thromb Haemost 69 (6):667, 1993. 291. Levine MN, Hirsh J, Gent M, Turpie AG, Weitz J, Ginsburg J, Geerts W, Neemeh J, Leclerc J, Powers P, Piovella F, Skingley P. Optimal duration of oral anticoagulant therapy: A randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis (DVT). Thromb Haemost 69 (6):982, 1993. 292. Fondevila CG, Gill JB, Brister SJ, Turpie AGG, Holder DA, Ofosu FA, Buchanan MR. Contrast media induces thrombin generation during PTCA. Thromb Haemost 69 (6):1014, 1993. 293. Powers P, Gent M, Klimek M, Levine M, Geerts W, Neemeh J, Turpie AGG, Jay R, Leclerc J, Ginsberg J, Hirsh J. A randomized double-blind trial comparing a lowmolecular weight heparinoid, Orgaran, with aspirin in the prevention of venous thromboembolism following surgery for hip fracture. Thromb Haemost 69 (6):1116, 1993. 294. Levine MN, Hirsh J, Gent M, Turpie AGG, Cruickshank M, Weitz J, Anderson D, Johnson M. A randomized trial comparing the activated thromboplastin time with the heparin assay to monitor heparin therapy in patients with acute venous 53 Grand Rounds, St. Mary's 54 thromboembolism requiring large daily doses of heparin. (6):1122, 1993. Thromb Haemost 69 295. Lensing AWA, Doris I, McGrath F, Prandoni P, Ginsberg J, Turpie A, Hirsh J. Color doppler vs real-time ultrasonography in the diagnosis of postoperataive asymptomatic DVT. Thrombosis and Haemostasis 69 (6):1361, 1993. 296. Oberhardt BJ, Gresalfi J, Fearrington T, Goslen G, Turpie AG, Massel D. Rapid determination of resistance to SK in thrombolytic therapy patients using a simple in vitro dry chemistry test. Thromb Haemost 69 (6):1654, 1993. 297. Turpie AGG: Hirulog: A new direct thrombin inhibitor. Potential role in the prevention of deep vein thrombosis. ISTH Satellite Symposium, New York City, N.Y. July 10, 1993. 298. Turpie AGG: Stroke and Cardiac Patients: Preventing vascular events and MI's. Consultation on Stroke. Kommunicom Publications, 1993. 299. Turpie AGG: Anticoagulation in the 90's. Pittsburg PA, July 27, 1993. Grand Rounds, Jefferson Hospital, 300. Turpie AGG: Anticoagulation in the 90's. Pittsburg, PA, July 28, 1993. Grand Rounds, St. Frances Hospital, 301. Turpie AGG: The clinical use of low molecular weight heparin. Rounds, McMaster University, August 5, 1993. 302. Turpie AGG: Preventing thromboembolic complications from prosthetic heart valves. 4th Annual Thrombosis, Thromboembolism and Thrombolysis Symposium, Yale University, August 20, 1993. 303. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Detroit Medical Society, Detroit Michigan, August 25, 1993. 304. Turpie AGG: Venous thromboembolism prophylaxis in orthopaedic surgery. '93, Seoul Korea, August 30, 1993. 305. Turpie AGG: Prophylaxis and treatment of DVT and Pulmonary Embolism: Update on low molecular weight heparin. Grand Rounds, Peel Memorial Hospital, September 17, 1993. 306. Massel D, Turpie AGG, Oberhardt BJ, Gresalfi NJ, Fearrington T, Goslen G: Estimation of resistance of streptokinase: A preliminary report of a rapid bedside test. The Canadian Journal of Cardiology 9 (Suppl E) Abstract #279, 1993. 307. Turpie AGG: Deep vein thrombosis: Diagnosis and Treatment. Thrombosis: New Perspectives in Diagnosis and Treatment Symposium, Robert Wood Johnson Medical School, New Brunswick, New Jersey, October 1, 1993. 308. Turpie AGG: Diagnosis and treatment of deep vein thrombosis. Current Concepts in Venous Thromboembolic Disorders Symposium, Episcopal Hospital, Philadelphia, PA, October 2, 1993. 309. Turpie AGG: Valvular Heart Disease. "Thrombosis and its Management" Triennial Symposium, McMaster University, Hamilton, Ontario, October 6, 1993. 54 Medical Grand SICOT 55 310. Turpie AGG: Heparin in acute coronary ischaemia. Medical Grand Rounds, Hamilton Civic Hospitals, Hamilton, Ontario, October 8, 1993. 311. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Pulmonology Conference, Kansas University Medical Centre, Kansas City, MO, October 12, 1993. 312. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Noon Conference, Kansas University Medical Centre, Kansas City, MO, October 12, 1993. 313. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Orthopaedic Conference, Research Hospital, Kansas City, MO, October 12, 1993. 314. Turpie AGG: Low molecular weight heparin; advancement in antithrombotic therapy. Medical Rounds, Lincoln General Hospital, Lincoln NE, October 12, 1993. 315. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Grand Rounds, Research Hospital, Kansas City, MO, October 13, 1993. 316. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Orthopedic Surgery Grand Rounds, Research Hospital, Kansas City, MO, October 13, 1993. 317. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Orthopedic Surgery Grand Rounds, Truman Medical Center, Kansas City, MO, October 14, 1993. 318. Turpie AGG: Prophylaxis and treatment of deep vein thrombosis (Low molecular weight heparin: Enoxaparin). Thursday Conference, St. Joseph Hospital, Kansas City, MO, October 14, 1993. Turpie AGG: Deep venous thrombosis. Medical Grand Rounds, Grant Medical Center, Columbus, Ohio, November 2, 1993. 319. 320. Turpie AGG: Prevention of deep vein thrombosis and pulmonary embolism following total joint replacement: New advances with low molecular weight heparin. The Southern Tier Orthopedic Society, Binghamton, New York, November 15, 1993. 321. Turpie AGG: New advances in the prophylaxis of deep vein thrombosis and pulmonary embolism. The Medical Symposia, Atlanta Georgia, November 16, 1993. 322. Turpie AGG: Prophylaxis and treatment of DVT and pulmonary embolism: Update on low molecular weight heparin. Grand Rounds, The Wellesley Hospital, November 17, 1993. 323. Turpie AGG: Anticoagulants in Haemodialysis. Nephrology Association of Thailand. Chiang Mai, Thailand, November 23, 1993. 323. Turpie AGG: Low molecular weight heparin. Its benefits in clinical practice. Heart Association of Thailand, Bangkok, Thailand, November 25, 1993. 324. Turpie AGG: New progress in antiplatelet therapy. International Scientific Meeting of Haematologists from South-East Asian Countries. Medan, Indonesia, December 2, 1993. 55 56 325. Turpie AGG: State-of-the-art Lecture. Low molecular weight heparin. Its benefits in clinical practice. International Scientific Meeting of Haematologists from South-East Asian Countries. Medan, Indonesia, December 2, 1993. 327. Turpie AGG: An Overview of antiplatelet in cardiology and neurology. Heart Association, Jakarta, Indonesia, December 4, 1993. 328. Turpie AGG: Recent experience with the use of Ticlopidine in cardiology and neurology. Indonesian Heart Institute, Jakarta, Indonesia, December 4, 1993. 329. Turpie AGG: Deep vein thrombosis and pulmonary embolism in surgery. Philippines College of Surgeons, Plenary Lecture. Manila, Philippines, December 8, 1993. 330. Turpie AGG: New progress in antiplatelet therapy. International Scientific Meeting of Haematologists from South-East Asian Countries. Medan, Indonesia, December 2, 1993. 331. Turpie AGG: State-of-the-art Lecture. Low molecular weight heparin. Its benefits in clinical practice. International Scientific Meeting of Haematologists from South-East Asian Countries. Medan, Indonesia, December 2, 1993. 332. Turpie AGG: Thrombolytics - Prevention of deep vein thrombosis. Medical Grand Rounds, St. Alphonsus Regional Medical Center, Boise Idaho, December 10, 1993. 333. Turpie AGG: Thrombolytics - Prevention of deep vein thrombosis. Orthopedic Association, Boise Idaho, December 10, 1993. 334. Turpie AGG: The role of low molecular weight heparin in the management of thromboembolic disease. Medical Grand Rounds. St. Vincent Hospital, Indianapolis, Indiana, December 13, 1993. 335. Turpie AGGT: The role of low molecular weight heparin in the management of thromboembolic disease. Medical Grand Rounds. Lutheran Hospital of Indiana, Fort Wayne, Indiana, December 14, 1993. 336. Turpie AGG: New insights on aortic disease, valvular heart disease and anticoagulation therapy. New Perspectives on the Marfan Syndrome: An Anniversary Celebration. Stanford University Medical Centre, January 8, 1994. 337. Turpie AGG: Advances in antithrombotic therapy: role of low molecular weight heparins. Sutter Community Hospital Noon Conference, San Francisco, CA, February 11, 1994. 338. Turpie AGG, Gent M: Comparison of warfarin and ASA in patients with bioprosthetic heart valves. 19th Int'l Joint Conference on Stroke and Cerebral Circulation. American Heart Association, February 18, 1994. 339. Turpie AGG: Venous thromboembolism. Advances in prophylaxis and treatment. Medical Grand Rounds, Baylor University Medical Centre, Dallas, Texas, February 22, 1994. 340. Turpie AGG: Venous thromboembolism. Advances in prophylaxis and treatment. Medical Grand Rounds, Presbyterian Hospital, Dallas, Texas, February 23, 1994. 56 Indonesian Idaho 57 341. Turpie AGG: Venous thromboembolism. Advances in prophylaxis and treatment. Medical Grand Rounds, South Western Medical School, Dallas, Texas, February 23, 1994. 342. Turpie AGG: Antithrombotic Therapy; A major contributor to stroke prevention in patients with NVAF. The Ukrainian Medical Association of Toronto, Toronto, March 9, 1994. 343. Turpie AGG: Advances in antithrombotic therapy: role of low molecular weight heparin. Medical-Surgical Grand Rounds, New Britain General Hospital, New Britain, CT. March 24, 1994. 344. Turpie AGG: Advances in antithrombotic therapy: role of low molecular weight heparin. Surgical Grand Rounds, Hartford General Hospital, Hartford, CT. March 25, 1994. 345. Turpie AGG: Antithrombotic therapy following heart valve replacement. Surgery Fellows Symposium, Minneapolis, Minnesota, April 9, 1994. 346. Turpie AGG: Anticoagulants: Current usage and future prospects. Conference on Thrombolysis: Montreal, April 15, 1994. 347. Turpie AGG: Atrial Fibrillation. Practical approach to antithrombotic therapy in the 1990's. Sunnybrook Health Science Centre, Toronto, June 1, 1994. 348. Turpie AGG: Advances in antithrombotic therapy: role of low molecular weight heparin. Medical Grand Rounds, Cedar Sinai Hospital, Los Angeles, California, June 9, 1994. 349. Turpie AGG: The role of low molecular weight heparin. Kaiser Foundation Hospital, Medicine Grand Rounds, Honolulu, Hawaii, July 6, 1994. 350. Turpie AGG: Current advances in therapy: The role of low molecular weight heparin. Straub Clinic & Hospital, Honolulu, Hawaii, July 7, 1994. 351. Turpie AGG: Optimizing Oral Anticoagulant Rx. Niagara-on-the-Lake, July 17, 1994. 352. Turpie AGG: Hirudin, Low MW Heparin. the-Lake, July 17, 1994. 353. Turpie AGG: Coagulation tests in the diagnosis and management of arterial and venous thrombosis. American College of Clinical Chemists, New Orleans, Louisiana, July 19, 1994. 354. Turpie AGG: Pathophysiology of thromboembolic diseases. American College of Clinical Chemists, New Orleans, Louisiana, July 19, 1994. 355. Gawad YA, Skea D, Takahashi M, Tanser PH, Stanton EB, Sayles MJ, Turpie AG et al. Development and evaluation of an assay specific for human anti-streptokinase antibodies (IgG). Clin Chem 40 (6): 991, 1994. 356. Turpie AGG: Coagulation tests in the diagnosis and management of arterial and venous thrombosis. American Association for Clinical Chemistry, New Orleans, Louisiana, July 19, 1994. 357. ISIS-3 Collaborative Group. Mortality in relation to female sex in ISIS-3. Circulation 88 (4) II: #1178, 1994. 57 Cardiac First McGill Canadian Therapeutics Update, Canadian Therapeutics Update, Niagara-on- 58 358. ISIS Collaborative Group: ISIS-4: Randomised study of oral captopril in over 50,000 patients with suspected acute myocardial infarction. Circulation 88 (4) II: #2113, 1994. 359. ISIS Collaborative Group: ISIS-4: Randomised study of oral isosorbide mononitrate in over 50,000 patients with suspected acute myocardial infarction. Circulation 88 (4) II: #2115, 1994. 360. Turpie AGG: Anticoagulation in cardiovascular diseases. XVI Congress of the European Society of Cardiology, Berlin, Germany, September 10, 1994. 361. Turpie AGG: Thrombolysis in venous thrombosis and pulmonary embolism. Int'l Congress on Fibrinolysis, Leuven, Belgium, September 19, 1994. 362. Turpie AGG: Thrombogenesis and Atherosclerosis. 39th Annual Scientific Meetings of the Royal College of Pathologists of Australia, October 4, 1994. 363. Turpie AGG: Hyper-coagulability. Pathology Professional Activities Committee, 39th Annual Scientific Meetings of the Royal College of Pathologists of Australia, October 6, 1994. 364. Turpie AGG: Haemostatic risk factors in thrombosis. Plenary Lecture, 39th Annual Scientific Meetings of the Royal College of Pathologists of Australia, October 6, 1994. 365. Turpie AGG: The effectiveness of thromboembolic prophylaxis in the general surgical patient. New insights into the Etiology and Prevention of Postsurgical DVT. Temple University School of Medicine, Chicago, October 8, 1994. 366. Turpie AGG: Prevention of deep vein thrombosis and pulmonary embolism. Continuing Medical Education, St. James Hospital, Chicago, Il, October 10, 1994. XIIth 367. Turpie AGG: Prevention of deep vein thrombosis and pulmonary embolism - The role of low molecular weight heparin. Continuing Medical Education, St. Anthony Hospital, Chicago Il, October 12, 1994. 368. Turpie AGG: Cardiomyopathy and mitral prosthesis malfunction. 5th Annual Cardiovascular Therapeutics Related to Anticoagulant Therapy, Hamilton, October 19, 1994. 369. Turpie AGG: Curso de actualizacion en tromboembolismo pulmonar: Hospital Britanico de Buenos Aires, Buenos Aires, Argentina, October 22, 1994. 370. Turpie AGG: Antiagregantes en la prevencion primaria y secundaria del Stroke. III Congreso Interdisciplinaro de Enfermedades Encefalovasculares (Stroke), Buenos Aires, Argentina, October 24, 1994 371. Turpie AGG: Queda algo por decir acerca de la fibrilacion auricular. Jornadas Rioplanteneses de Cardiologia, Buenos Aires, Argentina, October 25, 1994. 372. Turpie AGG: Advances in antithrombotic therapy: The role of low molecular weight heparin. Illinois Scientific Meeting, American College of Physicians, October 28, 1994. 373. Turpie AGG: New anticoagulant agents. Contemporary Management of Cardiovascular Diseases. Heart and Stroke Foundation of Ontario. December 9, 1994. 58 59 374. Turpie AGG: Low dose ASA therapy with coumadin. Coagulation Dilemmas in the Treatment of Cardiovascular Disease, Mercy Heart Institute, February 26, 1995. 375. Turpie AGG: Oral anticoagulants and aspirin in the prevention of thromboembolism in patients bearing prosthetic heart valves. Simposio Sulla Terapia Anticoagulante. Rome, Italy, March 11, 1995. 376. Turpie AGG: Low molecular weight heparin and prevention of thromboembolic disease. Brotman Medical Staff Foundation, 33rd Annual Scientific Seminar. Century City, CA, March 25, 1995 377. Turpie AGG: Chairman, International Symposium on Thrombosis and LMWH. College of Physicians of Thailand, Pattaya, Thailand, April 21, 1995. 378. Turpie AGG: Venous thromboembolism: Consensus statements and management strategies. The Royal College of Physicians of Thailand, Pattaya, Thailand, April 21, 1995. 379. Turpie AGG: Overview of antithrombotic therapy in Cardiology. The Royal College of Physicians of Thailand, Pattaya, Thailand, April 21, 1995. 380. Turpie AGG. Venous thromboembolism: CONA Meeting, Calgary April 1995. 381. Turpie AGG: Overview of antithrombotic therapy in Cardiology. of Cardiology. April 24, 1995. 382. Turpie AGG: Adjuvant and long-term therapies: Symposium, Hamilton, April 29, 1995. 383. The Royal Appropriate assessment and interventions. Anticoagulants. Hong Kong College McMaster Turpie AGG: Assessing venous thromboembolic risk and initiating appropriate interventions. New Insights in the Prevention of Venous Thromboembolism in Joint Replacement. Calgary, April 30, 1995. 384. Turpie AGG: Overview of antithrombotic therapy in Cardiology. of Cardiology, Hong Kong, April 24, 1995. 385. Turpie AGG: Management of perioperative anticoagulant therapy. Haemostatic problems in adult cardiac surgery. Mechanisms and Management Symposium Proceedings. May 1995. 386. Turpie AGG: Anticoagulation in cardiovascular disease. McMaster University, Hamilton, May 10, 1995. 387. Turpie AGG: Antithrombotic Therapy: Role of low molecular weight heparin. St Francis Hospital and Medical Centre, Topeka, Kansas 66606-1609, May 11, 1995. 388. Turpie AGG. Emerging concepts in the clinical use of low molecular weight heparins. US Pharmacist Educational Symposia, University of Georgia College of Pharmacy, June 4, 1995. 389. Turpie AGG. Clinical perspective on heparin, hirudin and other antithrombin drugs. XVth Congress of the International Society on Thrombosis and Hemostasis. Satellite Meeting, Eilat, Israel, June 17.95. 390. van Riel AM, Henkens CMA, Koopman MMW, Turpie AGG et al: Low molecular weight heparin (LMWH) and compression stockings in the prevention of venous 59 Hong Kong College Cardiology Update, 60 thromboembolism (VTE) in neurosurgery. XVth Congress of the International Society on Thrombosis and Hemostasis, Jerusalem, June 12, 1995 #285. 391. Cogo A, Lensing AWA, Koopman MMW Turpie AGG et al: Compression ultrasound for the diagnostic management of clinically suspected deep vein thrombosis. XVth Congress of the International Society on Thrombosis and Hemostasis, Jerusalem, June 12, 1995 #758. 392. Hirsh J, Levine M, Gent M, Turpie AGG. Out patient low molecular weight heparin versus in-hospital standard heparin for the treatment of venous thrombosis. XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, June 12, 1995, #733. 393. Turpie AGG: Advances in antithrombotic therapy: Novel agents. Wright Schultz Plenary Lecture. XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, June 15, 1995. 394. Turpie AGG. Venous Thromboembolism: Appropriate assessment and interventions. Hospital Pharmacy Practice, June 1995. 395. Turpie AGG: LMWH in unstable angina. XVII Congress of the European Society of Cardiology, Amsterdam, August 20, 1995. 396. Turpie AGG: The role of aspirin in patients with heart valve prostheses. XVII Congress of the European Society of Cardiology, Amsterdam, August 20, 1995. Turpie AGG: HOT LINE III. FRIC Investigators. XVII Congress of the European Society of Cardiology, Amsterdam, August 20, 1995. 397. 398. Baird M, Toal CB, Klinke WP, Kostuk WJ, Belanger L, Turpie AG. A randomized, double-blind multi-centre study of the effects of nifedipine (GITS) in patients with chronic stable angina. Canadian Journal of Cardiology 11 (Supple E):132E, August 1995. 399. Turpie AGG, Ruddy TD, Sussex BA et al. Low molecular weight heparin (Dalteparin) in unstable coronary artery disease (FRIC). Canadian Journal of Cardiology 11 (Suppl E):110E, August 1995. 400. Yusuf S, Michaelis W, Hua A, Turpie AGG et al. Effects of oral anticoagulants on mortality, reinfarction and stroke after myocardial infarction. Canadian Journal of Cardiology 11 (Suppl E):111E, August 1995. Davies RF, Butt R, Foris K for the Canadian Zatebradine in Angina Research Group. Effect of zatebradine and diltiazem on ischaemia during ambulatory monitoring. Canadian Journal of Cardiology 11 (Suppl E):132E, August 1995. 401. 402. Turpie AGG: Rationale and use of low molecular weight heparin. "Deep venous thrombosis and pulmonary embolism: An update on diagnosis, prophylaxis and management" Symposium. Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania, October 14, 1995. 403. Turpie AGG: New therapeutic opportunities for heparin: What does low molecular weight offer? Towards 2000: New pathways for the clinical management of acute ischemic syndromes. CCS Satellite Symposium, October 24, 1995. 404. Turpie AGG: Newer Clinical use of heparin and low molecular weight heparins. Heparin and Related Drugs Session, The Sixth IBC International Symposium, Washington, October 23, 1995. 60 61 405. Turpie AGG: Successors to heparin; new antithrombotic agents. Medical Center symposium at the AHA, November 14, 1995. Duke University 406. Turpie AGG. 407. Turpie AGG: Antithrombotic therapy following heart valve replacement. Surgery Fellows Symposium. March 28-31, 1996. 408. Turpie AGG: Nhung nghien cuu ve thuoc tan soi huyet. Sixth Vietnam National Congress of Cardiology. Ho Chi Minh City, April 27, 1996. 409. Turpie AGG: The Prevention IV Conference. Arizona, May 1, 1996. 410. Turpie AGG. Carotid disease: Medical approach. International Multidisciplinary Vascular Disease Symposium. Winnipeg, May 15, 1996. 411. Turpie AGG: Platelets and Thrombosis: Platelet Inhibitors. International Multidisciplinary Vascular Disease Symposium. Winnipeg, May 15, 1996. 412. Turpie AGG: Anticoagulation for DVT: LMWH: HIT. International Multidisciplinary Vascular Disease Symposium. Winnipeg, May 17, 1996. 413. Turpie AGG: State of the art treatment of thrombotic disorders. Chemistry 42 (6):S78, 1996. 414. Turpie AGG. Advances in antithrombotic therapy and the expanding role of low Molecular weight heparin. The University of Illinois at Chicago. July 19, 1996. 415. Turpie AGG. Clinical aspects of thrombolytic therapy in AMI. The 2nd Great Wall International Symposium and Exhibition on Interventional Cardiology (GWISIC '96), October 7, 1996. 416. Turpie AGG. Use of low molecular weight heparin and hirudin in unstable coronary disease. The 2nd Great Wall International Symposium and Exhibition on Interventional Cardiology (GWISIC '96), October 7, 1996. 417. Turpie AGG. Advances in antithrombotic therapy: The expanding role for low molecular weight heparins. Columbian Society of Internal Medicine, Bogota, Columbia, October 11, 1996. 418. Turpie AGG. Antithrombotic therapy in cardiac disease: New horizons. Society of Internal Medicine, Bogota, Columbia, October 11, 1996. 419. Wells P, Ginsberg J, Anderson D, Hirsh J, Turpie A et al. The use of a clinical model in a prospective management study of patients with suspected pulmonary embolism (PE). Haemostasis 26 (3) #8, 1996. 420. Turpie AGG. 1996. 421. Ginsberg J, Wells P, Anderson D, Hirsh J, Turpie A et al. The value of the Simplired7 D-dimer in a prospective management study of patients with suspected pulmonary embolism (PE). Haemostasis 26 (3) #316, 1996. 422. Scazziota A, Altman R, Rouvier J, Gurfinkel E, Turpie GG, Glancszpigel R. Low versus high dose aspirin plus oral anticoagulant in heart valves prostheses. Final Report. Haemostasis 26 (3) #560, 1996. Management of perioperative anticoagulant therapy. Cardiac American Heart Association, Tucson, Management of venous thromboembolism. 61 pp 18-19, 1995. Clinical Columbian Haemostasis 26 (3) #291, 62 423. 424. Turpie AGG. Low molecular weight heparins: A major breakthrough in heparin therapy. The 2nd International Antithrombotic Therapy Symposium. Proceedings 10-12, 1996. Turpie AGG. Calf vein thrombosis: (2):6-8, October 1996 To treat or not to treat. Thrombosis Forum 2 425. Turpie AGG (for the FRIC Study Group). Low molecular weight heparin (LMWH) in the initial and prolonged treatment of unstable coronary artery disease: The Fragmin in unstable Coronary heart disease study (FRIC). Canadian Cardiovascular Society Meeting, Montreal, October 31, 1996. 426. Klein W for the FRIC Study Group. Low molecular weight heparin in the initial and prolonged treatment of unstable coronary artery disease - the fragmin in unstable coronary heart disease study (FRIC). European Heart J 17:306, 1996 427. Ray JG, Turpie AGG. Current antithrombotic therapy following heart valve replacement in Canada and the United States. Canadian Cardiovascular Society Meeting, Montreal, October 31, 1996. 428. Cohen M, Demers C, Gurfinkel E, Fromell G, Langer A, Turpie AGG (ESSENCE Group). Primary endpoint analysis from the ESSENCE Trial: Enoxaparin vs unfractionated heparin in unstable angina and non-Q wave infarction. Circulation 94 (8) #3240, 1996. Turpie AGG, Cruickshank MK, Latour Y, Laupacis A, Gent M, Hirsh J. Double blind comparison of aspirin with warfarin following bioprosthetic heart valve replacement. Circulation 94 (8) #3802, 1996. 429. 430. Turpie AGG. Introduction. Presentations in Focus. ASH Meeting, Dec 7-10, 1996. 431. Turpie AGG. 1997. Arterial thrombosis - new treatment approaches. 432. Turpie AGG: Venous Thrombosis Prophylaxis in Stroke. Conference, Amsterdam 1997. 433. Turpie AGG: Unstable Coronary Disease: heparin. Uppsala, 1997. Vienna, February, European Stroke The rationale for low molecular weight 434. Turpie AGG. Arterial thrombosis - New treatment approaches. Annals of Haematology 1996; 74 (Suppl II):373. 434. Goodman S, Langer A, Demers C, Turpie A et al. One year follow-up of the ESSENCE trial (Enoxaparin vs heparin in unstqble angina/non Q wave myocardial infarction): Sustained clinical benefit. Can J Cardiol 14: (Supp F) 122F, 1998. 434. Turpie AGG, Gent M, Cruickshank M, Kovacs M. et al. Randomized comparison of moderate (INR 3.0-3.5) with low intensity (INR 2.0-2.5) anticoagulant therapy in ptients with prosthetic heart valves treated with aspirin (100 mg/dah). Can J Cardiol 14: (Supp F) 123F, 1998. 434. Turpie AGG. Cardiac Update: Low molecular weight heparin. American College of Chest Physicians. Toronto, Nov 12, 1998. 62 63 435. Cohen Marc, Demers Christine, Gurfinkel Enrique, Fromell Gregg, Langer Anatoly, Turpie A.G.G. (ESSENCE Group). Management of acute ischemic coronary syndromes in the next millenium - Review of recent clinical trials, ESSENCE and TIMI 11A-B Trials. Annals of Haematology 1996; 74 (Suppl II):372. 436. Cohen M, Demers C, Fromell GJ, Califf RM, Turpie AGG, Gurfinkel E, Langer A, Fox KA. Hemorrhage incidence with low molecular weight heparin vs unfractionaed heparin in patients with unstable angina or non-Q-wave myocardial infarction. Anaheim, March 1619, 1997. 437. Turpie AGG. Surgery Symposium. Antithrombotic therapy following heart valve replacement. Minneapolis April 4, 1997. Cardiac 438. Kearon C (for the LAFIT Investigators). Two years of warfarin versus placebo following three months of anticoagulation for a first episode of idiopathic venous thromboembolism. XVIth Congress of the International Society on Thrombosis and Haemostasis. Florence June 6-12, 1997. 439. Ageno W, Turpie AGG. Randomized comparison of anticoagulant control by a computer generated system with a manual system. Thrombosis and Haemostasis (Supplement) #PS2858, June 1997. 440. Cohen M, Turpie AGG, Demers C et al. Blind comparison of enoxaparin (a low molecular weight heparin) with standard heparin in the treatment of unstable coronary arery disease ESSENCE trial. Thrombosis and Haemostasis (Supplement) #SC1528, June 1997. 441. Lowe GDO, Haverkate F, Thompson SG, Bertina RM, Turpie AGG, Mannucci PM. Prediction of deep vein thrombosis after elective hip surgery by preoperative haemostatic tests: The ECAT DVT Study. Thrombosis and Haemostasis (Supplement) #OC742, June 1997. 442. Fox KAA, Cohen M, Demers C, Gurfinkel E. Fromell G, Bigonzi F, Premmereur J, Langer A, Goodman S, Califf R, Turpie AGG* for the ESSENCE Group. A double blind comparison of Enoxaparin (a low molecular weight heparin) with standard heparin in the treatment of unstable coronary artery disease "THE ESSENCE TRIAL". Heart 77 (Suppl 1) #58, 1977. 443. Turpie AGG. Current clinical considerations in venous thromboembolic disease: The role of low molecular weight heparin. Lafayette, IN, July 14, 1997. 444. Turpie AGG. Advances in antithrombotic therapy: The role of low molecular weight heparins. St. Vincent Hospital, Grand Rounds, Indianapolis, IN, July 15, 1997. 445. Wells PS, Ginsberg J, Anderson DR, Hirsh J, Turpie AGG et al. The value of bilateral venous compression ultrasonography in patients with suspected pulmonary embolism (PE). Clin Invest Med 20:#201, 1997. 446. Buchanan MR, Brister SJ, Turpie AGG. Ticlopidine as an alternate antiplatelet agent for aspirin nonresponders. Canadian Cardiovascular Society, Winnipeg October 5-9, 1997. 447. Cohen M, Fox K. Turpie AGG, Demes C. Gurfinkel E, Langer A, Califf R, Fromell G, Bigonzi F on behalf of the ESSENCE Group. Patient populations and clinical practices: inter-region differences observed in the international ESSENCE trial. European Heart Journal 18 (Abstract Supplement) P1046, 1997. 63 64 448. Bozovich G, Gurfinkel E, Duronto E, Colorio C, Cohen M, Mautner B on behalf of the ESSENCE Investigators. Relationship between acute thrombotic markers and silent ischaemic events in patients with unstable angina or non-Q wave myocardial infarction. European Heart Journa 18 (Abstract Supplement) #2647, 1997. 449. Ageno W, Johnson J, Nowacki B, Siguenza M, Turpie AGG. Management of the initial phase of warfarin treatment: Retrospective analysis of post-operative heart valve replacement patients compared with nonsurgical patients. Blood 1997 90 (10): #3199 450. Turpie AGG. Management of acute coronary syndromes with low molecular weight heparin: TIMI 11A & 11B. A meeting for Canadian investigators in the ESSENCE trial. June 28, 1997. 451. Hommel M (for the FISS bis investigators Group). Fraxiparine in ischaemic Stroke Study (Fiss bis). Cerebrovasc Dis 8 (suppl 4):19, 1998. 452. Ageno W, J Nowacki B, Turpie AGG. Accuracy and clinical utility of anticoagulation induction using a computer generated system compared with manual dosing in hospitalized patients. Thrombosis Research 91 (Suppl 1) #156, 1998 453. Ageno W, Johnson J, Nowacki B, Sloane D, Turpie AGG. The role of coagulation factors II, V, VII and X in the response to oral anticoagulants in patients following heart valve replacement. Thrombosis Research 91 (Suppl 1) #158, 1998 453. Zighetti ML, Cattaneo M, Turner RM, Thompson SG, Lowe GDO, Haverkate F, Bertina RM, Turpie AGG, Mannucci PM on behalf of the ECAT DVT Study Group. Fasting plasma homocysteine levels do not predict the occurrence of deep vein thrombosis after elective hip replacement. Thrombosis Research 91 (Suppl 1) #30, 1998 454. Turpie AGG, Gent M. Randomized comparisoN of moderate (INR 3.0 3.5) with low intensity (INR 2.0-3.5) anticoagulant therapy in patients with prosthetic heart valves treated with aspirin. Circulation 98 (17) #4026, 1998. 455. Holper EM, Antman EM, McCabe CH, Turpie AGG et al. A simple, readily available method for risk stratification of patients with unstable angina or non-Q myocardial infarction: A TIMI 11B Substudy. Circulation 98 (17) #2594, 1998. 455. Antman EM, McCage CH, Premmereur, Gurfinkel E, Bernink PJLM, Turpie AGG: Enoxaparin for the acute and chronic management of unstableangina/non-Q wave myocardial infarction: Results of TIMI 11B. Circulation 98 (17) #2649, 1998. 456. Turpie AGG: Antiplatelet agents: Current status and future perspectives. ISCVS, Gold Coast, Australia, October #109, 1998. 457. Turpie AGG: The role of low molecular weight heparin in arterial disease and following arterial interventions. ISCVS, Gold Coast, Australia, October #110, 1998. 458. Turpie AGG: Thrombophilia update: Guidelines for investigation and treatment. ISCVS, Gold Coast, Australia, October 112, 1998. 459. Turpie AGG: Pharmacology of the low molecular weight heparins. Heart Journal (Supp) 135 (6):S329, 1998. Am 460. Turpie AGG. Reducing stroke risk – what can family physicians do? 29th Heart and Stroke Clinical Update. Toronto, Ontario, December 10, 1998. 64 65 462. Turpie AGG. Update on Antiplatelet Drugs. Medical Grand Rounds, December 15, 1998. Joseph Brant Memorial Hospital, 463. Bath PM for the TAIST Investigators. Tinzaparin in acute ischaemic stroke trial (TAIST). XVII Congress of ISTH. August 1999. 464. Turpie AGG. 1999. Looking forward in DVT treatment. ISTH Satellite Symposium, August 465. Turpie AGG, Samama M, Cohen A, Darmon J, Desjardins L, Eldor A, Janbon C, Leizorovicz A, N’Guyen, Olsson C-G, Weisslinger N. prophylaxis of venous thromboembolism in acute medical patients with enoxaparin: An international, randomized double-blind, placebo-controlled trial. Circulation 1999; 100 (18) Abst #3264. 466. Cohen M, Antman E, Gurfinkel E, Turpie A, Furst J, Bigonzi F, Radley D. The benefit of enoxaparin in Q-wave myocardial infarction: A sub-study of the TIMI 11B and ESSENCE meta-analysis. Circulation 1999; 100 (18) Abst #4182. 467. Antman E, Gurfinkel E, Turpie A, Bernink P, Salein D, Bayes de Luna A, Fox K, Lablanche J-M, Radley D, Furst J, Braunwald E. Treatment benefit of enoxaparin in unstable angina/non-Q wave myocardial infarction is maintained at one year followup in TIMI 11B. Circulation 1999; 100 (18) Abt #2621. 468. Turpie AGG. New Role for low molecular weight heparins in unstable angina-Basis and Clinical Experience. Donnerstag, May 18, 2000. 469. Turpie AGG, Johnson J. Temporary discontinuation of oral anticoagulants: role of low molecular weight heparin (dalteparin). Can J Cardiol 16 (Suppl F) September 2000. 470. Turpie AGG, Johnson J. Temporary discontinuation of oral anticoagulants. low molecular weight heparin (Dalteparin). Circulation 2000 #3983.. Role of 471. Cohen M, Antman EM, Gurfinkel EP, Turpie AGG, Furst J, Bigonzi F, Radley D. The benefit of enoxaparin in Q-wave myocardial infarction: A Substudy of the TIMI 11B and ESSENCE meta-analysis. Circulation 2000 #2992. 472.Treatment benefit of enoxaparin in unstable angina/non-Q wave myocardial infarction is maintained at one year followup in TIMI 11B. Circulation 2000 #106863. 473. Batchelor WB, Radley D, Cohen M, Turpie Alexander G.G., Langer, A, Goodman S. A comparison of the impact of practice patterns on the outcomes of patients with acute coronary syndromes in the USA and Canada: Post Hoc analysis of ESSENCE and TIMI 11B. JACC 37 (2) Suppl A, Feb 2001: 863-5 p 359. 474. Turpie AGG, Bauer KA, Eriksson B, Lassen MR. Pentasaccharide significantly reduces venous thromboembolism after orthopedic surgery compared with low molecular weight heparin. Am Coll of Chest Physicians, 2001. 475. Bauer KA, Turpie AGG, Eriksson B, Lassen M. Superiority of pentasaccharide over low molecular weight heparin for venous thromboembolism prophylaxis is independent of age, gender and obesity. Am Coll of Chest Physicians, 2001. 476. Peters PC, Turpie AGG, Bauer KA, Eriksson B, Lassen MR. The first synthetic factor Xa inhibitor, Arixtra/Xantidar (pentasaccharide), shows superiority over low molecular weight heparin in prevention of venous thromboembolism after orthopedic surgery. Am Coll of Chest Physicians, 2001-05-15 65 66 477. Turpie AGG, Bauer KA, Eriksson B, Lassen MR, Hawkins DW on behalf of the Pentasaccharide Orthopedic Prophylaxis Studies Investigators. Petasaccharide superiority over low-molecular-weight heparin for prevention of venous thromboembolism after major orthopedic surgery is independent of age. Am Soc of Consultant Pharmacists (ASCP), 2001. 478. Inverso SM, Antman EM, Spinler SA for the ESSENCE and TIMI11B Investigators. Safety and efficacy of unfractionated heparin versus enoxaparin in obese patients and patients with severe renal impairment: analysis from the ESSENCE and TIMI 11B Studies. ACC, 2001. 479. Turpie AA, Bauer KA, Eriksson B, Lassen MR, Peters PC. Pentasaccharide (Fondaparinux): A novel factor Xa inhibitor that is superior to low-molecular-weight heparin for the prevention of venous thromboembolism after orthopaedic surgery. American Assoc of Hip and Knee Surgery. Dallas, Texas, November 9, 2001. 480. Turpie AGG. Pentasaccharide significantly reduces venous thromboembolism after orthopedic surgery compared with low-molecular-weight heparin. ACCP, Nov 2001. 481. Lassen MR, Eriksson BI, Bauer KA, Turpie AGG. Pentasaccharide (Fondaparinux), Aristra®) versus enoxaparin for the prevention of venous thromboembolism (VTE) in major orthopedic surgery: subgroup analyses on efficacy. Blood 98 (11) Abstract #1117, 2001. 482. Alikhan R, Cohen AT, Combe S, Samama MM, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Olsson G-G, Turpie AGG. Benefit of enoxaparin in medical patients: a subgroup analysis. Blood 98 (11) Abstract #119, 2001. 483. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Effect on efficacy and safety of the timing of the first pentasaccharide (Fondaparinux, Aristra®) administration in the prevention of venous thromboembolism (CTE) after major orthopedic surgery. Blood 908 (11) Abstract #119, 2001. 484. Eriksson B, Bauer KA, Lassen MR, Turpie AGG. Current management of venous thromboembolism prophylaxis after major orthopedic surgery in North America and Europe: lessons from the pentasaccharide (Fondaparinux, Arixtra®) databse. Blood 98 (11) Abstract #1133, 2001. 485. Bauer A, Eriksson BI, Lassen MR, Turpie AGG. Relevance of systemic venographic outcomes in venous thromboembolism (VTE) p[rophylaxis studies: lessons from the pentasaccharide (Fondaparinux, Arixtra®) clinical program. Blood 98 (11) abstract #1144, 2001. 486. Kearon C, Ginsberg JS, Anderson DR, Kovacs M, Wells P, Julian J, MacKinnon B, Demers C, Douketis J, Turpie AG, van Nguyen P, Green D, Kassis J, Kahn S, Solymoss S, Desjardins L, Geerts W, Weitz J, Hirsh J, Gent M. Sofast Investigators. Four weeks versus 12 weeks of anticoagulation for a first episode of venous thromboembolism (VTE) provoked by a transient risk factor: A randomized double-blind trial. Blood 98 (11): Abst#1879,2001. 487. Turpie AGG. Highlights from Presentations of Thromboprophylaxis: an emerging field. Manila, The Philippines. 488. Turpie AGG. orthopedic surgery. Overview of the clinical results of Haematologica 86 (Supp II) Nov. 2001. the Medenox May 29, 2000. pentasaccharide Study. in major 489. Eriksson BI, Turpie AGG, Lassen MR, Bauer KA, Comparison of the first synthetic Factor Xa inhibitor, Fondaparinux sodium, with low molecular weight heparin in the prophylaxis of venous thromboembolism following major orthopaedic surgery. 7th Congress of the European Association of Hospital Pharmacists, March 20-22, 2001. 66 67 490. Turpie Alexander G.T. Setting a standard for venous thromboembolism prophylaxis. Am J Heath – Syst Pharm 58 (Suppl 2):S-18-S23, 2001. 491. Turpie AGG. Low molecular weight heparins, novel anticoagulants and strategies. Am College of Cardiology, March 2002. 492.Turpie AGG. Meet the Experts Meeting. Am College of Cardiology, March 2002. 493. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux versus enoxaparin for the prevention of venous thromboembolism in major orthopaedic surgery. An overview of efficacy and safety results. International Union of Angiology, New York, April 8/02 494. Turpie AGG. Fondaparinux in the prevention of venous thromboembolism after major orthopaedic surgery. The Official Journal of the International Society of Cardiovascular Pharmacotherapy 16 (Supp 1) 2002 #016. 495. Leizorovicz for the PREVENT Study Group. Evaluation of the thbenefits of dalteparin for thromboprophylaxis in acutely ill medical patients. 9 Int’l Symposium on Thromboembolism, Seville, June7-8,2002. 496. Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Efficacy and Safety of Fondaparinux in the thromboprophylaxis of venous thromboembolism (VTE) following major orthopaedic surgery according to the recommendations for use in the United States (USA). The Hematology Journal, 3: (Suppl 1) June 2002, Abstract #1229. 497. Turpie AGG, Bauer KA, Eriksson B, Lassen MR. Consistency of fondaparinux superiority for venous thromboembolism prevention in orthopedic surgery according to different composite efficacy endpoints. Chest 122 (4) 59S. October 2002 Supplement. 498. Muntz JE, Turpie AGG, Bauer KA, Eriksson B, Lasdsen MR. Role of the duration of fondaparinux prophylaxis in preventing venous thromboembolism following major orthopedic surgery. Chest 122 (4) 59S. October Supplement, 2002. 499. Cohen AT, Alikhan R, Combe S, Samama MM, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Olsson C-G, Turpie AGG. Prevention of venous thromboembolism in medical patients with enoxaparin: A subgroup analysis of the MEDENOX Study. ICT, Bologna October 2002. 500.Turpie AGG, Bauer KA, Eriksson BI, Lassen MR. Role of the duration of fondaparinux prophylaxis in preventing venous thromboembolism following major orthopedic surgery. AAPM&R. Orlando, Florida, Nov. 22, 2002. 501.Bauer KA, Eriksson BI, Lassen MR, Turpie AGG. Influence of the duration of fondaparinux prophylaxis in preventing venous thromboembolism following hip fracture surgery. Blood 100 (11):304, 2002. 502.The MATISSE Investigators. Fondaparinux (Arixtra) in comparison to (low molecular weight) heparin for the initial treatment of symptomatic deep venous thrombosis or pulmonary embolism – The Matisse clinical outcome studies. Blood 100 (11):302, 2002. 503. Levine MN, Lee AY, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles F, Julian JA, Haley S, Kovacs M, Gent M and the CLOT Investigators. A randomised trial of long term dalteparin low molecular weight heparin (LMWH) versus oral anticoagulant (OA) therapy in cancer patients with venous thromboembolism (VTE). Blood 100 (11): #298, 2002. 67 68 504. Bauer KA, Eriksson BI, Lassen MR, Turpie AGG. Effect of age on the benefit-risk ratio of fondaparinux thromboprophylaxis in patients undergoing major orthopedic surgery. Blood 100 (11): 1066, 2002. 505. Cohen AT, Alikhan R, Arcelus J, Haas S, Spyropoulos, Tapson V, Turpie AGG. thromboembolism risk assessment in medical patients. Blood 100 (11): 1074, 2002. Venous 506. Hull R, Schellong S, Tapson V, Yusen R, Monreal M, Samama MM, Turpie AGG. Extended thromboprophylaxis in acutely ill medical patients with prolonged immobilisation: The EXCLAIM Study. Blood 100 (11): 3988, 2002. 507. Kovacs M, Kahn S, Solymoss S, Anderson D, Desjardins L, Rodger M, Turpie A, Bates S, Douketis J, Kearon C, Wells P. Prospective multicentre trial of bridging therapy with dalteparin for patients who require temporary discontinuation of OAC for prosthetic valves or high risk atrial fibrillation. Blood 100 (11):559, 2002. 508. Kearon C, Ginsberg JS, Kovacs M, Anderson DR, Wells P, Julian J, MacKinnon B, Weitz JI, Crowther MA, Dolan S, Turpie AGG, Geerts WH, Solymoss S, van Nguyen P, Demers C, Kahn S, Kassis J, Rodger M, Hambleton J, Gent M for the ELATE Iinvestigators. Low intensity (INR 1.5-1.9) versus conventional intensity (INR 2.0-3.0) anticoagulation for extended treatment of unprovoked VTE: a randomised double blind trial. Blood 100 (11): 562, 2002. 509. Piovella F, Turpie AG, Planes A, Gallus A, Wang CJ, Lee WC, lee K, Perdriset G, Roullon A for the AIDA Steering Committee. AIDA-Assessment of the incidence of deep vein thrombosis in Asia following major orthopaedic surgery: Rationale and study design. 6th Congress of the European Federation of National Associations of Orthopaedics and Traumatology. Helsinki Finland, July 4-10, 2003, #P6108. 510. Lassen MR, Bauer KA, Eriksson BI, Turpie AGG. Elastic stockings do not influence superior efficacy of fondaparinux over enoxaparin for thromboprophylaxis in orthopaedic surgery. 6th Congress of the European Federation of National Associations of Orthopaedics and Traumatology. Helsinki Finland, July 4-10, 2003, #P1062. 511. Lassen MR, Bauer KA, Eriksson BI, Turpie AGG. Effect on efficacy and safety of the timing of the firstth fondaparinux administration for the thromboprophylaxis in orthopaedic surgery. 6 Congress of the European Federation of National Associations of Orthopaedics and Traumatology. Helsinki Finland, July 4-10, 2003, #P1063. 512. Eriksson BI, Bauer KA, Lassen MR, Turpie AGG. Management of orthopedic surgery patients in North America, Europe and other countries: Lessons from the fondaparinux database. 6th Congress of the European Federation of National Associations of Orthopaedics and Traumatology. Helsinki Finland, July 4-10, 2003, #P1064. 513. Eriksson BI, Bauer KA, Lassen MR, Turpie AGG. Fondaparinux is enoxaparin for thromboprophylaxis in orthopedic surgery irrespective of surgery characteristics. 6th Congress of the European Federation Associations of Orthopaedics and Traumatology. Helsinki Finland, July #P1066. superior to patients or of National 4-10, 2003, 514. Eriksson BI, Bauer KA, Lassen MR, Turpie AGG. Influence of the duration of fondaparinux prophylaxis in preventing venous thromboembolism following hip fracture surgery. 6th Congress of the European Federation of National Associations of Orthopaedics and Traumatology. Helsinki Finland, July 4-10, 2003, #P1067. 68 69 515. Turpie AGG, Leizorovicz A, Cohen AT, Olsson C-G, Vaitkus PT, Goldhaber SZ for the PREVENT medical thromboprophylaxis study group. A randomised, multicentre, placebocontrolled trial of dalteparin for the prevention of venous thromboembolism in 3706 patients hospitalised with acute medical illnesses. 10th Int’l Symposium on Thromboembolism, London June 13-14, 2003. 516. Spyropoulos AC, Turpie AGG, Dunn A, Spandorfer J for the REGIMEN Investigators. Clinical outcomes with the use of unfractionated heparin or low molecular weight heparin as perioperative bridging therapy in patients on long-term oral anticoagulants: rationale, objectives, design and interim analysis of a large, long-term multicenter study (REGIMEN). ISTH, Birmingham, July 2003. 517. Turpie AGG, Colwell CW Jr. Bauer KA, Eriksson BI, Lassen MR. fondaparinux for thromboprophylaxis in high-risk patients. Efficacy of 518. Turpie AG, Colwell CW, Bauer K, Eriksson BI, Lassen MR. Fondaparinux reduces long-term risk of venous thromboembolism after surgery for hip fracture. Chest 124 (4 Suppl): 132S, 2003. 519. Turpie AG, Colwell CW, Bauer K, Eriksson BI, Lassen MR. Efficacy of fondaparinux for thromboprophylaxis in high-risk patients undergoing hip fracture surgery. Chest 124 (Suppl 4):240S, 2003. 520. Cohen AT, PREVENT Medical the prevention (Suppl 4):132S, Leizorovicz A, Turpie AG, Olsson C-G, Vaitkus PT, Goldhaber SZ. The Thromboprophylaxis Study Group. Thromboprophylaxis with dalteparin for in acutely ill medical patients with respiratory failure. Chest 124 2003. 521. Turpie AGG, Leizorovicz A, Cohen AT, Olsson CG, Vaitkus PT, Goldhaber SZ. Dalteparin for the prevention of venous thromeobmeolism in acutely ill medical patients: A randomised placebo-controlled trial in 3,706 hospitalized patients. Can J of Cardiol 19 (Suppl A) Abstract #861, 2003. 522.Turpie Alexander G, Colwell, Clifford W, Bauer K, Eriksson Bengt I, Lassen, Michael R. Fondaparinux reduces long-term risk of venous thromboembolism after surgery for hip fracture. Chest 124, #4, Suppl, October 2003, pp 132S. 523. Turpie Alexander G, Colwell Clifford W, Bauer Kenneth, Eriksson Bengt I, Lassen Michael R. Efficacy of fondaparinux for thromboprophylaxis in high-risk patients undergoing hip fracture surgery. Chest 124, #4 Suppl, October 2003, pp. 240S. 524. Cohen AT, Davidson B L, Gallus AS, Lassen MR, Tomkowski W, Turpie AGG, Cariou RG, Egberts JfM, Lensing AWA. Findaparinux for the prevention of VTE in acutely ill medical patients. Blood 102 (11) #42, 2003. 525.Vaitkus PT, Leizorovicz A, Goldhaber SZ, Olsson C-G, Cohen AT, Weitz JI, Turpie AG. Mortality is increased in patients with proximal, but not distal, deep vein thrombosis in medically ill patients entered in the PREVENT trial. Blood 102 (11) #575, 2003. 526.Piovella F, Wang C-J, Lu H, Lee K, Lee LH, Lee WC, Turpie AG, Gallus A, Planes A et al. Deep vein thrombosis in Asia after major orthopedic surgery. An epidemiological study with mandatory bilateral venography and central indepdent adjudication. Blood 102: (11) #733, 2003. 527.Anderson FA, Tapson VF, Decousus H, Spyropoulos AC, Turpie AGG, FitzGerald G for the IMPROVE Investigators. IMPROVE, a multinational observational cohort study of practices 69 70 in prevention of venous thromboembolism in acutely ill medical patients: A comparison with clinical study patient populations. Blood 102: (11) #1146, 2003. 528.Leizorovicz A, Cohen AT, Turpie AG, Olsson C-G, Vitkus PT, Weitz JI, Goldhaber SZ. Efficacy and safety of combining dalteparin with aspirin in preventing venous thromboembolism in medical patients. Blood 102 (11) #1153, 2003. 529.Spyropoulos AC, Turpie AGG, Dunn Investigators. Registry of patients on (Low molecular weight) heparin for an (REGIMEN): Rationale, design and interim cohort study. Blood 102 (11) #1161, 2003. A, Jacobson A, Douketis for the REGIMEN chronic oral anticoagulant therapy requiring elective surgical intervention or procedure analysis of a large, long-term, multicenter 530. Becker F, Leizorovicz A, Olsson C-G, Cohen AT, Vaitkus PT, Turpie AG, Weitz JI, Goldhaber SZ. Venous ultrasound: An alternative to venography for evaluation of dalteparin prophylaxis in 3706 medically ill hospitalised patients. Blood 102 (11) #1165, 2003. 531. Panju A, Kahn S, Geerts W, Pineo G, Desjardins L, Turpie A, Glezer S, Sebaldt R. Utilization of venous thromboprophylaxis in acutely ill medical patients in Canada: results from the Canadian Registry (CURVE). Blood 102 (11) #1813, 2003. 532. Hull R, Tapson VF, Schellong S, Yusen RD, Monreal M, Samama MM, Turpie AGGl, Wildgoose P, Cort S. The EXCLAIM study: extended thromboprophylaxis with enoxaparin in acutely ill medical patients with restricted mobility. Blood 102 (11) #4208, 2003. 533. Tapson VF, Decousus H, Piovella F, Zotz RB, Allegrone J, Anderson FA for the IMPROVE Investigators. A multinational observational cohort study in acutely ill medical patients of practices in prevention of venous thromboembolism: findings of the International medical prevention registry on venous thromboembolism (IMPROVE). Blood 102 (11) #1154, 2003. 534. Kucher N, Leizorovicz A, Cohen AT, Turpie AGG, Olsson C-G, Vaitkus PT, Goldhaber SZ for the PREVENT Medical Thromboprophylaxis Study Group. Obesity does not attenuate the effectiveness of low-dose dalteparin in preventing venous thromboembolism. ACC New Orleans, March 2004. 535.Turpie AGG. The diagnosis and treatment of DVT and PE. Lake Louise, April 2004. Turpie AGG. New Anticoagulants: Will they alter how we treat patients. Lake Louise, April 2004. 536.Turpie AGG. New anticoagulants: will they alter how we treat patients. Louise, April 2004. Lake 537. Cohen AT, Davidson BL, Gallus AS, Lassen MR, Tomkowski W, Turpie AGG, Cariou RG, Egberts JFM, Lensing AWA. ARTEMIS Investigators (London, UK, Seattle WA, USA, Bedford Park, SA Australia, Hoersholm Denmark, Warsaw Poland, Hamilton Ontario, Canada, Chilly Mazarin, France, OSS, The Netherlands). Thromboprophylaxis with fondaparinux acutely ill medical patients aged 75 years or more. 21st World Congress of the Int’l Union of angiology, May 22-26, 2004. 70 71 538. Cohen AT, Davidson BL, Gallus AS, Lassen MR, Tomkowski W, Turpie AGG, Cariou RG, Egberts JFM, Lensing AWA. ARTEMIS Investigators (London, UK, Seattle WA, USA, Bedford Park, SA Australia, Hoersholm Denmark, Warsaw Poland, Hamilton Ontario, Canada, Chilly Mazarin, France, OSS, The Netherlands). Thromboprophylaxis with fondaparinux in acutely ill medical patients with moderate renal impairement. 21st World Congress of the Int’l Union of angiology, May 22-26, 2004. 539. Turpie AGG. May 22-26, 2004. Future in ACS. 21st World Congress of the Int’l Union of Angiology, 540. Turpie AGG. VTE prophylaxis: clinical benefits of new antithrombotics. Int’l Society on Thrombosis and Haemostasis. Venice, June 17-19, 2004. 541. Turpie AGG. Preventing VTE in medical patients – clinical evidence to support a role for LMWH. Int’l Society on Thrombosis and Haemostasis. Venice, June 17-19, 2004. 542.Fiessinger JN on behalf of the TAIPAID stdy Group. S18886, a new specific oral TP receptor antagonist, is safe and as effective as aspirin in inhibiting platelet aggregation in patients with peripheral arterial disease. European Society of Cardiology, Munich 2004. 543. Davidson B, Turpie AGG, Colwell C, Kwong LM. Early vs delayed initiation of fondaparinux prophylaxis to prevent postoperative pulmonary embolism: A clinical endpoint study. Chest 126 (4) October 2004 (783S abstr) 544. Anderson FA for the Improve Investigators. A multinational comparison of prophylaxis practices for venous thromboembolism during medical intensive care: findings from IMPROVE. Chest 126 (4) October 2004 (784S abstr). 545. Fitzgerald G. Tapson V, Spyropoulos AC, Froehlich JB, Decousus H, Bergmann J-F, Bhong BH, Kakkar AK, Merli GJ, Monreal M, Nakamura M, Pavanello R, Pini M, Piovella F, Turpie AG, Zotz RB, Anderson FA for the IMPROVE investigators. Does obesity influence physician practices in provision of prophylaxis for venous thromboembolism? Lessons from IMPROVE. Chest 126 (4) October 2004 (785 abstr). 546. Dunn AS, Spyropoulos AC, Sirko SP, Turpie AG. PROspective Perioperative Enoxaparin Cohort Trial: a Multicenter Cohort Study of Perioperative Bridging with Enoxaparin in Patients Requiring Interruption of Long-term Oral Anticoagulant Therapy (PROSPECT). ASH, San Diego, December 2004. 547.Turpie AGG for the PROVE Investigators. A prospective registry on venous thromboembolic events: The PROVE registry. ASH, San Diego Abstr #923, December 2004. 548. Tapson VF, Decousus H, Bergmann J-F, Eriksson BI, Froehlich, Kakkar AK, Merli GJ, Monreal M, Spyropoulos AC, Turpe AGG, Zoltz RB, Fitzgerald F, Anderson FA for the IMPROVE investigators. The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE): Venous thromboembolism prophylaxis practices in acutely ill medical patients. ASH, San Diego, Abst #1762, Dec. 2004 549. Piovella F, Wang Ching-Jen, Lu Housan, Lee Kenneth, Lee Lai Heng, Lee Lee Won Chui, Turpie AGG, Gallus A Planes A, Passera R, Roillon A, The AIDA Investigators. High rate of deep vein thrombosis in Asia after major orthopedic surgery: The AIDA Study final results. ASH, San Diego, Abst 2580, Dec. 2004. 71 72 550. Spyropoulos AC, Turpie AGG, Dunn AS, Spandorfer J, Douketis J, Jacobson A, Frost FJ for the REGIMEN Investigators. Clinical outcomes with unfractionated heparin or lowmolecular weight heparin as bridging therapy in patients on long-term oral anticoagulants: results from the REGIMEN Registry. ASH, San Diego, Abst #709, Dec. 2004. 551. Cohen AT, Alikhan R, Arcelus JI, Bergmenn J-F, Haas S, Merli GJ, Spyropoulos AC, Tapson VF, Turpie AGG. Identification of medical patients who should receive venous thromboembolism prophylaxis. ASH, San Diego, Abstr #1786, Dec 2004. 552. Dunn AS, Spyropolous AC, Spyropoulos AC, Sirko SP, Turpie AGG. Perioperative bridging therapy with enoxaparin in patients requiring interruption of long-term oral anticoagulant therapy: a multicenter cohort study. ASH, San Diego, Abstr #1786, Dec 2004. 553. Turpie AGG, Douketis JD. Enoxaparin is effective and safe as bridging anticoagulation in patients with a mechanical prosthetic heart valve who require temporary interruption of warfarin because of surgery or an invasive procedure. ASH, San Diego, Abstr #703, Dec 2004. 554. Cohen AT, Gallus AS, Davidson BL, Lassen MR, Prins MH, Tomkowski W, Turpie AGG, Egberts JFM, Lensing AWA. Benefit of fondaparinux in medical patients: a subgroup analysis. ASH, San Diego, Abstr #4079, Dec 2004. 555. Kearon C, Ginsberg jS, Julian J, Douketis J, Solymoss S, Ockelford P, Jackson S, Turpie G, McCarty D, MacKinnon B, Hirsh J, Gent M, FIDO Investigators. Fixed dose, weight-adjusted, unfractionated heparin (UFH) given subcutaneously (sc) without laboratory monitoring for acute treatment of venous thromboembolism (VTE): Randomized comparison with low molecular weight heparin (LMWH). ASH, San Diego, Abstr #707, Dec 2004. 556. Spyropoulos AC, Dunn AS, Gurpie AGG, Kaatz S, Spandorfer J, Douketis J, Jacobson A, Frost FJ for the REGIMEN Investigators, Lovelace Medical Centre, Albuquerque, NM. Perioperative bridging therapy with unfractionated heparin or low molecular weight heparin in patients with mechanical heart valves on long-term oral anticoagulants: Results from the REGIMEN Registry. JACC 45 #3 (Suppl A): 1016-47, 2005. 557.Eriksson BI, Borris LC, Dahl OE, Haas SK, Huisman MV, kakkar AK, Kalebo P, Misselwitz F, Muhlhofer EM for the ODIXa-HIP Study Investigators. Prevention of venous thromboembolilsm with an oral, direct factor Xa inhibitor – Bay 59-7939 –in Elective Hip Replacement: a dose-ranging study. Oral presentation at the XXth ISTH, Sydney, Australia, 6-12 August, 2005. 558. Turpie AGG, Fisher WD, Bauer K, Kwiong L, Gent M, Misselwitz F for the ODIXa-Knee Investigators. An oral, Direct Factor Xa Inhibitor – Bay 59-7939 – for prophylaxis against venous Thromboembolism after total knee replacement: a dose-ranging study. Oral presentation at the XXth ISTH, Sydney, Australia, 6-12 August, 2005. 559.Zotz RB, Decousus H, Monreal M, Chong BH, Pavanello R, Pini M, Turpie AGG, Huang W, Anderson Jr. FA for the IMPROVE Investigators. J Thromb Haemost 3 (Suppl 1), 2005. 560. Turpie AGG for the PROVE Investigators. The PROVE Registry: A Prospective Registry on venous Thromboembolic Events. J Thromb Haemost 3 (Suppl 1), 2005. 72 73 561. Turpie AGG for the PROVE Investigators. A comparison of patients with DVT in Asia and Europe/Australia: Findings from the PROVE Registry. J Thromb Haemost 3 (Suppl 1), 2005. 562. Julian J, Kearon C, Solymoss S, Douketis J, Ockelford P, Jackson S, Turpie AGG, McCarty D, MacKinnon B, Hirsh J, Gent M, Ginsberg JS for the FIDO Investigators. Heparin levels with subcutaneously (sc) low molecular weight heparin (LMWH) and Unfractionated heparin (UFH): results from a randomised trial. J Thromb Haemost 3 (Suppl 1), 2005. 563. Kearon C, Ginsberg JS, Julian J, Douketis J, Solymoss S, Ockelford P, Jackson S, Turpie AGG, McCarty D, MacKinnon B, Hirsh J, Gent M (for the FIDO Investigators). J Thromb Haemost 3 (Suppl 1), 2005. 564. Spyropoulos AC, Turpie AGG, Dunn AS, Spandorfer J, Douketis J, Jacobson A, Frost FJ for the REGIMEN Investigators. low molecular weight heparin or unfractionated heparin as bridging therapy in patients on long-term oral anticoagulants: results from the REGIMEN Registry. J Thromb Haemost 3 (Suppl 1), 2005. 565. Kwong LM, Colwell CW, Turpie AGG, Davidson BL. Self-injection of fondaparinux (Arixtra) in the prophylaxis against venous Thromboembolism after major orthopedic surgery is well accepted, effective and save: data from the FLEXTRA Trial. J Thromb Haemost 3 (Suppl 1), 2005. 566. Turpie AG, investigators. versus IPC along APOLLO study. J Bauer K, Caprini J, Comp P, Gent M, Muntz J on behalf of the APOLLO Fondaparinux combined with intermittent pneumatic compression (IPC) in the prevention of VTE after major abdominal surgery: Results of the Thromb Haemost 3 (Suppl 1), 2005. 567. O’Donnell MJ, Kearon C, Johnson J, Turpie ID, Zondag M, Robinson M, Turpie AGG. Predictors of mid-interval low molecular weight heparin anti-Xa levels. J Thromb Haemost 3 (Suppl 1), 2005. 568. O’Donnell MJ, Kearon C, Johnson J, Turpie ID, Zondag M, Robinson M, Turpie AGG. Residual anticoagulant activity following bridging low molecular weight heparin: prevalence and risk factors. J Thromb Haemost 3 (Suppl 1), 2005. 569. Turpie AGG, Douketis J. Bridging anticoagulation with enoxaparin is effective and safe in patients with a mechanical heart valve (MHV) who require temporary interruption of vitamin K antagonist (VKA) therapy. J Thromb Haemost 3 (Suppl 1), 2005. 570. Tapson VF, Spyropoulos AC, Froehlich JB, Kakkar AK, Merli GJ, Monreal M, Pavanello R, Turpie AGG, Fitzgerald G, Anderson Jr. FA for the IMPROVE investigators. Does body weight influence physician practices for providing venous Thromboembolism prophylaxis to acutely ill medical patients: Findings from IMPROVE. J Thromb Haemost 3 (Suppl 1), 2005. 571.Piovella F, Wang CJ, Lee LH, Lee WC, Turpie AG, Gallus A, Planes A, Passera R for the AIDA Investigators. Long-term outcomes after deep vein thrombosis in Asia. The AIDA-extension study. J Thromb Haemost 3 (Suppl 1), 2005. 572. Piovella F, Wang CJ, Lu H, Lee K, Lee LH, Lee WC, Turpie AG, Gallus A, Planes A, Passera R, Rouillon A for the AIDA Investigators. High rate of deep vein thrombosis in Asia after major orthopedic surgery: an epidemiological study with mandatory bilateral venography and central independent adjudication. J Thromb Haemost 3 (Suppl 1), 2005. 73 74 573. Kwong LM, Bauer KA, Eriksson BI, Lassen MR, Turpie AGG. The benefit-to-risk ratio of fondaparinux thromboprophylaxis in patients undergoing major orthopedic surgery is independent of age. J Thromb Haemost 3 (Suppl 1), 2005. 574. Turpie AGG for the PROVE Investigators. Clinical history, risk factors and use of VTE prophylaxis in patients with symptomatic DVT in China. J Thromb Haemost 3 (Suppl 1), 2005. 575. Turpie AGG for the PROVE Investigators. A characterization of patients with symptomatic DVT in India. J Thromb Haemost 3 (Suppl 1), 2005. 576. Turpie AGG, Fisher WD, Bauer K, Kwong L, Gent M, Misselwitz F for the ODIXa-KNEE Investigators. An oral, direct factor Xa inhibitor – BAY 59-7939 – for prophylaxis against venous Thromboembolism after total knee replacement: a dose ranging study. J Thromb Haemost 3 (Suppl 1), 2005. 577. Cohen AT, Davidson BL, Gallus Egberts JFM, Lensing AWA for the fondaparinux in acutely III medical renal impairment. J Thromb Haemost 3 AS, Lassen MR, Prins MH, Tomkowski W, Turie AGG, ARTEMIS Investigators. Thromboprophylaxis with patients aged 75 years or more, or with moderate (Suppl 1), 2005. 578. Cohen AT, Gallus AG, Davidson BL, Lassen MR, Prins MH, Tomkowski W, Turpie AGG, Egberts JFM, Lensing AWA for the ARTEMIS Investigators. Benefit of fondaparinux in medical patients: A subgroup analysis. J Thromb Haemost 3 (Suppl 1), 2005. 579. Anderson FA Jr., Decousus H, Fitzgerald G, Bergmann JR, Froehlich JB, Nakamura M, Spyropoulos AC, Zotz RB, Spender F, Turpie AGG for the IMPROVE Investigators. Observed rates of clinically apparent venous Thromboembolism and death due to pulmonary embolism among unselected hospitalised acutely ill medical patients compared to rates predicted from clinical trials. J Thromb Haemost 3 (Suppl 1), 2005. 580. Davidson BL, Turpie AGG, kwong LM, Colwell CW Jr. for the FLEXTRA Investigators. Thromb Haemost 3 (Suppl 1), 2005. 581. Douketis Jd, Johnson JA, Turpie AG. anticoagulation during interruption of periprocedural anticoagulation regimen. 17(2):176, 2005. J Low molecular weight heparin qs bridtging warfarin: assessment of a standardized Perspect Vasc Surg Endovasc Ther June 582. Eriksson BI, Turpie AGG. An oral, direct factor Xa inhibitor thromboprophylaxis after orthopaedic surgery; pooled results. AAOS, March 2005. for 581.Bauer K, Caprini J, Comp P, Gent M, Muntz J, Turpie AGG. Combined pharmacologic and mechanical prophylaxis for the prevention of VTE after major abdominal surgery: Results of the APOLLO Study. ASCRS, Dec 1, 2005. 582. Turpie AGG, Bauer KA, Borris L, Dahl OE, Fraser WD, Gent M, Haas S, Menno, Huisman MV, Kakker AK, Kalebo P, Kwong LM, Homering M, Misselwitz F, Eriksson B. Thromboprophylaxis after orthopaedic surgery with an oral, direct factor Xa inhibitor: Pooled results of two phase IIb lclinical trials. Blood 106 (11), 2005, #277. 583. Schellong SM, Beyer J, Halbritter K, Schmidt B, Turpie AGG, Eriksson BI, Misselwitz F, Kalebo P. VENUS – a study to validate centrally adjudicated venous ultrasound against venography after major orthopaedic surgery. Blood 106 (11), 2005, #281. 74 75 584. Monreal M, Zotz RB, Decousus H, Chong BH, Merli G, Pavanello R, Pini M, Turpie AGG, Huand W, Anderson FA. Influence of perceived risk factors for bleeding on venos thromboembolism prophylaxis practices in acutely ill medical patients: findings from IMPROVE. Blood 106 (11), 2005. #917 585. Eriksson BI, Turpie AGG, Lassen MR, Prins MH, Agnelli G, Gaillard ML, Meems B (Intr by Jawed Fareed). YM150, an oral direct factor Xa inhibitor, as prophylaxis for venous thromboembolism in patients with elective primary hip replacement surgery. A dose escalation study. Blood 106 (11), 2005. #1865 586. Piovella F, Anderson FA, Decousus H, Fitzgerald G, Bergmann J-F, kakkar AK, Spyropoulos AC, Zotz RB, Spencer FA, Turpie AGG for the IMPROVE investigators. Rates of clinically apparent venous thromboembolism and death resulting from pulmonary embolism among unselected hospitalised acutely ill medical patients versus rats predicted from clinical studies. Blood 106 (11), 2005 #1620. 587. Turpie AGG, Bauer KA, Caprini JA, Comp PP, Gent M, Muntz JE. Fondaparinux combined with intermittent pneumatic compression (IPC) versus IPC alone in the prevention of venous thromboembolism after major abdominal surgery: The randomised APOLLO study. Blood 106 (11), 2005 #279. 588. Caprini j, Bauer K, Comp P, Gent M, Muntz J, Turpie AGG for the APOLLO investigators. Combined pharmacologic and mechanical prophylaxis for the prevention of VTE after major abdominal surgery: results of the APOLLO study. ASCRS, 2005. 589. Turpie AGG. Is it time to rethink the management of venous thromboembolic disease – evidence-based approached. ASH, Atlanta, 2005. 590. Piovella F, Wang C-J, Lee LH, Lee WC, Turpie AG, Gallus A, Planes A, Passera R. Long-term outcomes of post-surgical deep vein thrombosis in Asia: The AIDA-Extension Study. ASH, December, 2005. 591. Colwell CW, Kwong LM, Turpie AGG. Timing of the first dose of fondaparinux for thromboprophylaxis after major orthopaedic surgery: The FLEXTRA Trial. AAOS, 2006. 592. Turpie AGG. Haematologica reports. New anticoagulant drugs in venous and La Thuile Italy, March 26-April 1, 2006. arterial thrombosis. 593. Caprini J, Bauer K, Comp P, Gent M, Muntz J, Turpie AGG on behalf of the Apollo Investigators. Fondaparinux combined with intermittent pneumatic compression (IPC) versus IPC along in the prevention of VTE after major abdominal surgery: An analysis of higher risk patients. ASCRS June 2006. 594. Colwell CW, Kwong LM, Turpie AGG. Timing of the first dose of fondaparinux for thromboprophylaxis after major orthopaedic surgery: The FLEXTRA Trial. 75 76 BOOK CHAPTERS 1. Clinical Pharmacology (Dilling) Formulary, 21st Edition. 2. 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