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Hypertension
Volume 59 Number 1 January 2012
Editorial Board ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Editorial Commentaries
Ambulatory and Home Blood Pressure Measurement: Complementary Rather Than Competitive Methods
Paolo Palatini ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Arterial Baroreflex Modulation of Sympathetic Activity and Arterial Wall Properties: New Evidence
Gianfranco Parati, Grzegorz Bilo ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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The J-Shaped Curve in Secondary Prevention: Shall Clinical Practice Change?
Peter M. Nilsson ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Unraveling the Mechanism of Renin-Angiotensin-Aldosterone System Activation and Target Organ Damage
in Hypertensive Blacks
Stephen K. Williams, Gbenga Ogedegbe ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Dual Role of Microsomal Prostaglandin E Synthase 1 in Chronic Kidney Disease
Kevin R. Regner ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Original Articles
Epidemiology/Population Science
Relation Between Blood Pressure and Vascular Events and Mortality in Patients With Manifest
Vascular Disease: J-Curve Revisited
Johannes A.N. Dorresteijn, Yolanda van der Graaf, Wilko Spiering, Diederick E. Grobbee, Michiel L. Bots,
Frank L.J. Visseren, on behalf of the Secondary Manifestations of Arterial Disease Study Group ььььььььььььь
• Online Data Supplement CME
Editorial Commentary, p 8
Ambulatory Versus Home Versus Clinic Blood Pressure: The Association With Subclinical Cerebrovascular
Diseases: The Ohasama Study
Azusa Hara, Kazushi Tanaka, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Hirohito Metoki,
Takanao Hashimoto, Michihiro Satoh, Ryusuke Inoue, Kei Asayama, Taku Obara, Takuo Hirose, Shin-Ichi Izumi,
Hiroshi Satoh, Yutaka Imai ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Editorial Commentary, p 2
Vascular Biomarkers in the Prediction of Clinical Cardiovascular Disease: The Strong Heart Study
Mary J. Roman, Jorge R. Kizer, Lyle G. Best, Elisa T. Lee, Barbara V. Howard, Nawar M. Shara,
Richard B. Devereux ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Hypertension (ISSN 0194-911X) is published monthly by Lippincott Williams & Wilkins at 16522 Hunters Green Parkway, Hagerstown, MD 21740. Business offices are located at
Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. In the US, individuals
may subscribe for their personal use at the following annual rates: $249 for members of the American Heart Association and $443 for non-members. International: $329 for members
of the American Heart Association and $577 for non-members. Additional rates can be found online at www.lww.com. Information related to membership can be found online at
my.americanheart.org. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to HYPERTENSION, American Heart
Association, Lippincott Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740.
Fish, n-3 Fatty Acids, and Cardiovascular Diseases in Women of Reproductive Age: A Prospective Study in
a Large National Cohort
Marin Strøm, Thorhallur I. Halldorsson, Erik L. Mortensen, Christian Torp-Pedersen, Sjurdur F. Olsen ььььььь
Subclinical Coronary Atherosclerosis Predicts Cardiovascular Risk in Different Stages of Hypertension:
Result of the Heinz Nixdorf Recall Study
Raimund Erbel, Nils Lehmann, Stefan Möhlenkamp, Sofia Churzidse, Marcus Bauer, Hagen Kälsch,
Axel Schmermund, Susanne Moebus, Andreas Stang, Ulla Roggenbuck, Martina Bröcker-Preuß, Nico Dragano,
Christian Weimar, Johannes Siegrist, Karl-Heinz Jöckel, on behalf of the Heinz Nixdorf Recall
Study Investigators ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Carotid Stiffness in Young Adults: A Life-Course Analysis of its Early Determinants: The Amsterdam
Growth and Health Longitudinal Study
Isabel Ferreira, Roel J. van de Laar, Martin H. Prins, Jos W. Twisk, Coen D. Stehouwer ььььььььььььььььььь
• Online Data Supplement
Contribution of Circulating Angiotensinogen Concentrations to Variations in Aldosterone and Blood
Pressure in a Group of African Ancestry Depends on Salt Intake
Frederic S. Michel, Gavin R. Norton, Olebogeng H.I. Majane, Margaret Badenhorst, Leanda Vengethasamy,
Janice Paiker, Muzi J. Maseko, Pinhas Sareli, Angela J. Woodiwiss ььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Editorial Commentary, p 10
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Weight Loss/Caloric Restriction
Left Ventricular Mass and Function With Reduced-Fat or Reduced-Carbohydrate Hypocaloric Diets in
Overweight and Obese Subjects
Sven Haufe, Wolfgang Utz, Stefan Engeli, Petra Kast, Jana Böhnke, Martin Pofahl, Julius Traber, Verena Haas,
Mario Hermsdorf, Anja Mähler, Andreas Busjahn, Susanne Wiesner, Christoph Otto, Heidrun Mehling,
Friedrich C. Luft, Michael Boschmann, Jeanette Schulz-Menger, Jens Jordan ььььььььььььььььььььььььььььь
• Online Data Supplement
Caloric Restriction Ameliorates Angiotensin II–Induced Mitochondrial Remodeling and Cardiac Hypertrophy
Piet Finckenberg, Ove Eriksson, Marc Baumann, Saara Merasto, Maciej M. Lalowski, Jouko Levijoki,
Kristiina Haasio, Ville Kytö, Dominik N. Muller, Friedrich C. Luft, Matej Oresic, Eero Mervaala ьььььььььььь
• Online Data Supplement
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Familial Hyperaldosteronism
A New Presentation of the Chimeric CYP11B1/CYP11B2 Gene With Low Prevalence of Primary
Aldosteronism and Atypical Gene Segregation Pattern
Cristian A. Carvajal, Carmen Campino, Alejandro Martinez-Aguayo, Juan E. Tichauer, Rodrigo Bancalari,
Carolina Valdivia, Pamela Trejo, Marlene Aglony, René Baudrand, Carlos F. Lagos, Cecilia Mellado,
Hernán Garcia, Carlos E. Fardella ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Progeria Syndrome
Mechanisms of Premature Vascular Aging in Children With Hutchinson-Gilford Progeria Syndrome
Marie Gerhard-Herman, Leslie B. Smoot, Nicole Wake, Mark W. Kieran, Monica E. Kleinman, David T. Miller,
Armin Schwartzman, Anita Giobbie-Hurder, Donna Neuberg, Leslie B. Gordon ььььььььььььььььььььььььььь
• Online Data Supplement
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Nervous System
Relationship Between Sympathetic Baroreflex Sensitivity and Arterial Stiffness in Elderly Men and Women
Yoshiyuki Okada, M. Melyn Galbreath, Shigeki Shibata, Sara S. Jarvis, Tiffany B. VanGundy, Rhonda L. Meier,
Wanpen Vongpatanasin, Benjamin D. Levine, Qi Fu ьььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Editorial Commentary, p 5
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Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced
Chronic Kidney Disease
Megumi Fujita, Katsuyuki Ando, Hiroo Kawarazaki, Chiaki Kawarasaki, Kazuhiko Muraoka, Hiroshi Ohtsu,
Hideki Shimizu, Toshiro Fujita ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-␬B in the Paraventricular Nucleus
Jeffrey P. Cardinale, Srinivas Sriramula, Nithya Mariappan, Deepmala Agarwal, Joseph Francis ььььььььььььь
• Online Data Supplement
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Kidney
Microsomal Prostaglandin E Synthase 1 Deletion Retards Renal Disease Progression But Exacerbates
Anemia in Mice With Renal Mass Reduction
Zhanjun Jia, Haiping Wang, Tianxin Yang ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
Editorial Commentary, p 12
Sex Differences in the Pressor and Tubuloglomerular Feedback Response to Angiotensin II
Russell D. Brown, Lucinda M. Hilliard, Geoffrey A. Head, Emma S. Jones, Robert E. Widdop,
Kate M. Denton ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
• Online Data Supplement
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Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage
Weiru Zhang, Wei Wang, Hong Yu, Yujin Zhang, Yingbo Dai, Chen Ning, Lijian Tao, Hong Sun,
Rodney E. Kellems, Michael R. Blackburn, Yang Xia ььььььььььььььььььььььььььььььььььььььььььььььььь 136
• Online Data Supplement
Blood Vessels
Acute ␤-Adrenergic Blockade Increases Aortic Wave Reflection in Young Men and Women:
Differing Mechanisms Between Sexes
Darren P. Casey, Timothy B. Curry, Michael J. Joyner, Nisha Charkoudian, Emma C. Hart ььььььььььььььььь
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Sunitinib-Induced Systemic Vasoconstriction in Swine Is Endothelin Mediated and Does Not Involve Nitric
Oxide or Oxidative Stress
Mariëtte H.W. Kappers, Vincent J. de Beer, Zhichao Zhou, A.H. Jan Danser, Stefan Sleijfer, Dirk J. Duncker,
Anton H. van den Meiracker, Daphne Merkus ььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Role of Uncoupled Endothelial Nitric Oxide Synthase in Abdominal Aortic Aneurysm Formation:
Treatment With Folic Acid
Ling Gao, Kin L. Siu, Karel Chalupsky, Andrew Nguyen, Peng Chen, Neal L. Weintraub, Zorina Galis,
Hua Cai ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь
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Tissue Sodium
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Na Magnetic Resonance Imaging of Tissue Sodium
Christoph Kopp, Peter Linz, Lydia Wachsmuth, Anke Dahlmann, Thomas Horbach, Christof Schöfl,
Wolfgang Renz, Davide Santoro, Thoralf Niendorf, Dominik N. Müller, Myriam Neininger, Alexander Cavallaro,
Kai-Uwe Eckardt, Roland E. Schmieder, Friedrich C. Luft, Michael Uder, Jens Titze ььььььььььььььььььььььь
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Letter to the Editor
Effect of a Reduction in Uric Acid on Renal Outcomes During Losartan Treatment: A Post Hoc Analysis of
the Reduction of End Points in Noninsulin-Dependent Diabetes Mellitus With the Angiotensin II Antagonist
Losartan Trial
Neeraj Dhaun, David J. Webb ьььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь 夝e1
Corrections ььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььььь 夝e2– e5
On the cover: Interleukin 6 (IL-6) expression level is elevated in the kidneys of chronic kidney disease (CKD) patients and
is further increased in CKD patients with hypertension. Immunohistochemistry study of IL-6 expression in control
individuals with acute kidney rupture and CKD patients without and with hypertension. Microscopic examination revealed
that IL-6 expression was significantly elevated in glomeruli and tubules of kidneys of CKD patients without hypertension
and additionally elevated in CKD patients with hypertension. Scale bar⫽400 ␮m. (See page 136.)
夝 ⴝ Published online only.