Download VET 1415 URINAID A4 Brochure

17/5/10
07:57
Page 1
VetPlus Ltd
‘Docklands’, Dock Road,
Lytham, Lancashire FY8 5AQ, UK
When should URINAID® be used?
Customer Services
01253 66 74 22
To help improve urinary tract health in dogs.
Technical Helpline
0800 867 283
Composition
Fax
01253 66 74 35
Yeast, Flavouring, D-Mannose, Cranberry, Pomegranate,
E-mail
[email protected]
Ashwagandha, Magnesium stearate.
Website
www.vetplus.co.uk
Administration
For optimum results, feed before meals as directed below or as
advised by your veterinary surgeon.
<10 kg
: 1 tablet per day
10 – 19 kg : 1½ tablets per day
20 – 29 kg : 2 tablets per day
>30 kg
: 3 tablets per day
Daily intake may be increased if required.
Summary
References
1.
Martinez JJ et al (2000). Type 1 pilus-mediated bacterial invasion
of bladder epithelial cells. EMBO Journal 19(12): 2803-12.
2.
Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ
(2000). Bacterial pili: molecular mechanisms of pathogenesis.
Current Opinion in Microbiology 3(1): 65-72.
3.
Michaels EK, Chmiel JS, Plotkin BJ, Schaeffer AJ (1983). Effect
of D-mannose and D-glucose on Escherichia coli bacteriuria in
rats. Urology Research 11(2): 97-102.
4.
Stothers L (2002). A randomized trial to evaluate effectiveness
and cost effectiveness of naturopathic cranberry products as
prophylaxis against urinary tract infection in women. Canadian
Journal of Urology 9(3): 1558-1562.
5.
Jepson RG, Mihaljevic L, Craig J (2004). Cranberries for
preventing urinary tract infections. Cochrane Database Syst Rev
2: CD001321.
6.
Foo YP, Lu Y, Howell AB, Vorsa N (2000). The structure of
cranberry proanthocyanidins which inhibit adherence of
uropathogenic P-fimbriated Escherichia coli in vitro.
Phytochemistry 54: 173-181.
7.
Schmidt DR, Sobota AE (1988). An examination of the antiadherence activity of cranberry juice on urinary and non-urinary
bacterial isolates. Microbios 55: 173-182.
8.
Gil MI, Hess-Pierce B (2000). Antioxidant activity of pomegranate
juice and its relationship with phenolic composition and
processing. Journal of Agricultural Food Chemistry 48: 45814589.
9.
Seeram NP, Adams LS, Henning SM, Nui Y, Shang Y, Nair MG,
Herber D (2005). In vitro antiproliferative, apoptotic and
antioxidant activities of punicalagin, ellagic acid and a total
pomegranate tannin extract are enhance in combination with
other polyphenols as found in pomegranate juice. Journal of
Nutritional Biochemistry 16: 360-367.
®
• URINAID is a unique product for the adjunctive therapy of
canine urinary tract infections.
®
• URINAID has a unique combination of four ingredients:
D-Mannose, Cranberry, Pomegranate and Ashwagandha.
• URINAID® can help the urinary tract in four different ways: antibacterial adhesion, anti-bacterial proliferation, anti-inflammatory
and stress-relieving.
• URINAID® is highly palatable, and most
dogs will take it as a treat.
• URINAID® is presented
in blister pack formation,
so it is easy to dispense
and prevents moisture
from entering.
URINAID
®
VET 1415 URINAID A4 Brochure URIVET-001:VET 1415 URINAID A4 Brochure
URINAID®
Help them to help themselves
A highly palatable nutritional
supplement to help improve
urinary tract health in dogs
10. Naz S, Siddiqi R, Ahmad S, Rasool SA, Sayeed SA (2007).
Antibacterial Activity Directed Isolation of Compounds from
Punica granatum. Journal of Food Science 72(9): 341-345.
11. Grandhi A, Mujumdar AM, Patwardhan B (1994). A comparative
pharmacological investigation of ashwagandha and ginseng.
Journal of Ethnopharmacoly 44(3): 131-5.
VetPlus
VET 1415 URINAID A4 Brochure URIVET-001:VET 1415 URINAID A4 Brochure
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VetPlus
URINAID®
A nutritional aid for urinary tract in dogs
®
URINAID
How does URINAID® promote urinary tract health?
Background : Lower Urinary
Tract Infection (UTIs)
Why use URINAID®?
Most lower urinary tract infections in
ingredients.
URINAID® is formulated using four natural
dogs are bacterial in nature.
No other product on the market uses this
Bacteria adhere to the epithelial surface of
unique formulation of ingredients: D-
the urinary tract using rigid, filamentous,
Mannose, Cranberry, Pomegranate and
proteinaceous appendages known as
Ashwagandha, all known to be beneficial
fimbriae. These attach to specific
in promoting improved urinary tract health
receptors on the epithelium and prevent
in canines, while at the same time helping
the bacteria from being washed away
to reduce the inflammation and stress
during urination, facilitating proliferation
(1-2)
.
associated with such problems.
The situation is usually associated with
pre-disposing health problems such as
hyperadrenocorticism, diabetes mellitus,
renal insufficiency or the long-term use of
medications such as glucocorticosteroids.
URINAID® can reduce
the need for antibiotics
and lowers the risk of
antibiotic resistance.
D-Mannose
Tests have shown
that URINAID® is
highly palatable and
most dogs will take it
as a treat.
Cranberry
(Vaccinium macrocarpon)
D-Mannose mimics the receptors of the
urinary tract wall, thereby competitively
Clinical studies using cranberries in
blocking attachment of bacteria to the
humans have shown it to be effective in
urinary tract(1-2).
the prevention of UTIs, especially in those
patients who experience recurrent
D-Mannose is not stored in the liver as
problems(4-5).
glycogen and does not undergo normal
sugar metabolism. It is safe to use in
It’s unique chemical structure helps
diabetic animals as it is filtered through the
prevent attachment of bacteria to the
kidney and routed directly to the
epithelial lining of the urinary tract(4-7) and
bladder .
the resultant bacteria-Mannose-cranberry
(3)
complexes are eliminated in the urine.
Pomegranate
(Punica granatum)
Ashwagandha
(Withania somnifera)
The pomegranate extract used in
Ashwagandha is a root extract containing
URINAID® is standardised with
saponins, withanolides and alkaloids,
punicalagins. These polyphenols attach to
which are believed to have anti-
bacteria and can help prevent their
inflammatory and stress-relieving effects.
proliferation. They are also reported to
have anti-inflammatory properties(8-10).
X-ray image kindly supplied by Dr Alistair Freeman of University of Liverpool.
Cytology image kindly supplied by Laura Blackwood and Ronne Barron.
levels of α-2 glycoproteins and reduces
Studies have shown that it decreases the
anxiety(11).