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CK Life Sciences Int'l., (Holdings), Inc. Oncology Neurology Drug Development DELEGATE(S) Melvin Toh 2 Dai Fu Street, Tai Po Industrial Estate NA Hong Kong China www.lsri.com.hk Incorporated: 2001 Employees: 1300 Ownership: Public Stock Exchange of Hong Kong: 0775 MISSION/BACKGROUND CK Life Sciences Int'l., (Holdings) Inc. ("CK Life Sciences") is focused on the research and development ("R&D"), commercialisation, marketing and sale of products that improve the quality of life by enhancing human health and the sustainability of the natural environment. CK Life Sciences' product range is categorised into the areas of pharmaceutical, nutraceutical and agricultural products. CK Life Sciences' pharmaceutical R&D is focused primarily on oncology and diseases with unmet needs. It is conducted at in-house laboratories, as well as in conjunction with partner companies and academic institutions around the world. The Life Sciences Research Institute carries out CK Life Sciences' pharmaceutical R&D initiatives. Headquartered in Hong Kong, the Life Sciences Research Institute is committed to the R&D of cancer-related medicines, bringing new hope to cancer patients and their families. Listed on the Hong Kong Stock Exchange, CK Life Sciences is part of the Cheung Kong Group, a leading Hong Kong-based multinational conglomerate. Significant progress has been made, with two cancer-related products in advanced stages of clinical development in North America: 1) POL-103A, a therapeutic cancer vaccine, is being developed by Polynoma LLC, a subsidiary of CK Life Sciences in the US. 2) Tetrodotoxin, for pain management, is being developed by our subsidiary Wex Pharmaceuticals Inc. TECHNOLOGY 1) POL-103A, a therapeutic cancer vaccine, is being developed by Polynoma LLC, a subsidiary of CK Life Sciences in the US. 2) Tetrodotoxin, for pain management, is being developed by our subsidiary Wex Pharmaceuticals Inc., listed on the Toronto Stock Exchange. Research is also ongoing in other focused areas, such as targeted cancer therapies, cancer immunotherapy and intranasal delivery technologies. ALLIANCES The Life Sciences Research Institute is actively seeking partnership opportunities with academic institutions and biopharmaceutical companies in order to grow its pharmaceutical pipeline. It is also exploring out-licensing possibilities and identifying potential partners for co-development. PRODUCTS Name Phase Indication Milestone Tetrodotoxin Phase III Cancer-related Pain Enrollment continuing POL-103A Cancer Immunotherapy Phase III Melanoma Special Protocol Assessment (SPA) approved by FDA; new Sponsor IND submitted December 2011 Tetrodotoxin Phase II, IIa, IIb Chemotherapy-induced Neuropathic Pain Adaptive dose-ranging/proof-of-concept study starting early 2012 POL-103A Cancer Immunotherapy Preclinical NSCLC, Breast, Others Preclinical Proof-of-Concept studies ongoing Company Profiles – 24