Download Dr. Pupak Derakhshandeh

CV : Dr. Pupak Derakhshandeh-Peykar, Ph.D.
Birth Place: Rasht – Iran
Birth Date: 09:09:1966
Marital Status: Married, two children, 16 y. & 13 y.
Academic Rank: Assistant Professor
School: Medicine
Department: Medical Genetics
Address: Tehran University of Medical Sciences, Department of Medical Genetics, Faculty of
Medicine P.O.Box 14155-6447, Tehran 14176-13151, Iran
Tel:
+98 (21) 64053-210
Fax: +98 (21) 8895-3005
Email: [email protected]
Website: http://medicine.tums.ac.ir/en/Professor_cv.aspx?lt=8&uid=5984
Ph.D. Molecular Medical Genetics
1999
University of Ludwig Maximillian (LMU), Munich–Germany
M.Sc. Biology (Molecular Cytogenetic)
1994
University of Ludwig Maximillian (LMU), Munich–Germany
B.Sc. Biology
1989
Shahid-Chamran University, Ahwaz–Iran
Positions Held
1. Assistant Professor, Dept. of Medical Genetics (MG)
2000-P
Tehran University of Medical Sciences (TUMS)
2. Head of the Molecular Genetics Lab (private)
2000-2008
3. Head of the prenatal Diagnosis Lab in NRCGEB (National Research
Center for Genetic Engineering and Biotechnology)
2002-2004
4. Research Officer, Dept. of MG, TUMS
2001-2003
5. Head of the Genetics section of Bahrami Children Hospital, TUMS
2004-P
6. Academic Advisor and Counselor for medical students
2005-P
7. Member of Comps Committee, Dept. of MG, TUMS
2008-10
Professional Experience
Experiences teaching
Teaching of various topics for M.S. and Ph.D. Students
2000-P
with different subjects, including:
Medical Genetics, Molecular Genetics
Population Genetics, Mutation's Pathology
Human Genetics & Anthropology
Early onset of Parkinson Disease
Triplex forming of oligonucleotids
DNA repairing, Transposons
Pharmacogenetics
Mutation detection & PND (prenatal Diagnosis) for:
Beta & alpha Thalassemia, Hemophilia A/B,
HbD,E,G,S (Sickle Cell disease),
SMN (I-III), DMD/BMD disease,
DGS (Di George Syndrome),
CF, Paternity, Breast cancer,
Malignant Glioma, Gastric carcinoma
Thesis Supervision
1. Detection of rare and unknown beta thalassemia mutations in
2001
Iranian population (MS.c., Mahryar Habibi Roudkenari)
2. Mutation detection and prenatal diagnosis of Iranian families
2004
Affected on SMA (I-III) gene (MS.c., Mohsen Esmaiili)
3. A study of p53 tumor suppressor gene mutations in Iranian patients
with Gastric tumors (Ph.D., Hamidreza Joshaghani)
2004
4. Mutation detection of CTFR gene, exon 4, 11, in Iranian patients by
2004
SSCP and sequencing (MS.c., Majid Mojarad)
5. Mutation detection of CTFR gene, exon 7, 10, in Iranian patients by
2004
SSCP and sequencing (MS.c., Nasrin yazdanpanahi)
6. mutation detection of alpha globine genes in Iranian
2004
(MS.c. Esfandyar Rostamzad)
7. Study of association between TGF- 1 (Cd10) gene polymorphism
2005
And GVHD in bone marrow transplant patients
(MS.c., Ali Rashidinezhad)
8. Estimation of Gene-Environment interaction in Breast cancer by
2005
Case-Control & Case-Only studies (Ph.D., Dr Ali Ardalan, MD)
9. Studies on the genetic variations among different populations
2005
of Anophels superpictus originated from Lorestan, Ardebil and
Sistan & Baluchestan provinces of Iran (Ms.c., Khadijeh Shemshad)
10. Frequent homozygous deletions of p16/CDKN2A gene in malignant
2007
Gliomas of Iranian patients (Ph.D., Dr. Mohammad Dilmaghani Zadeh,
MD)
11. A study of gene expression of TAL1, HOXIIL2, and HOXII in
2007
following cell lines : PEER, ALL, K662Hella, HPB
by multiplex RT-PCR (MS.c. Roshanak Ahani)
12. Studies of the genetic variation of different populations of
2007
Phlebotomus sergenti and Phlebotomus caucasicus in their
distribution areas in Iran (Ph.D., Vahideh Moin Vaziri)
13. A study of deletion and non-deletion of alpha globin gene and
2008
HbH disease in people receiped to khorasan and khoozestan
provinces of Iran (MS.c., Reza Ebrahimzadeh Vesal)
14. Mutation analysis of two genes: Phosphatidyl Inositol 3 Kinase (PIK3CA)
2010
and P53, as an important oncogene and molecular marker, in patients with
Anaplastic astrocytoma and Glioblastoma multiforme (MS.c., Jalil Aliwi)
15. The analysis of relationship between the hematological phenotype
2009
(CBC and Hb Electrophoresis) and the type of beta–thalassemia mutations
in beta- thalassemia minor (TMSU) between 2000-2008 (Residency
Dr Maryam Behfar)
16. A molecular study of rare and common point mutations (non relational) 2009-p
in alpha globin genes of alpha-Thalassemia carriers by DNA Sequencing and
ARMS-PCR (MS.c. Afsoun Doriani)
17. Pre implantation genetic diagnosis (PGD) of spinal muscular atrophy
2009-p
(SMA) using Whole Genome Amplification (WGA) and Nested
Multiplex PCR (Ph.D. Asghar Korzebor)
18. Molecular Genetics and Molecular Cyto Genetics Study of Gonadal
2010-p
Disorders of Sex Development (46XY) and Androgene Insensivity Syndrome
(AIS) in Iranian Patients (Ph.D. Azade Shojaei, MD)
19. Molecular Genetics analysis of Mitochondrial gene mutations in
2010-p
nonsyndromic sensorineural hearing loss that induced by Aminoglycosids
(Ph.D. Mohamad Ali Dovlati)
Own thesis
1. Molecular genetic analysis of family breast cancer in Germany
1999
(Ph.D. thesis in LMU, Germany –Munich)
2. Deletion mapping on chromosome 10p and definition of a critical
1996
region for the second DiGeorge syndrome locus (DGS2) (MS.c.
thesis in LMU, Germany –Munich)
3. Radiation (Cobalt, Gama) induced mutations of sesame Indicum L.
cultivated in Iran (BC.s. thesis Shahid-Chamran University, Ahwaz–Iran)
Language Skills
Farsi, Germany, and English
Computer Knowledge
Well in word, Power point, SPSS, and science-related software
1990
Publications
1. Simone Schuffenhauer, Peter Lichtner, Pupak Derakhshandeh-Peykar, Jan
Murken, Oskar A Haas, Elke Back, Gerhard Wolff, Bernhard Zabel, Ingeborg
Barisic5, Anita Rauch, Zvi Borochowitz, Bruno Dallapiccola, Mark Ross and Thomas
Meitinger (1998). Deletion mapping on chromosome 10p and definition of a critical
region for the second DiGeorge syndrome locus (DGS2). Eur. J. Hum. Genet. Vol. 6:
213–225.
2. Elke Holinski-Feder, Oliver Brandau, Carolin Nestle-Kr mling, Pupak
Derakhshandeh-Peykar, Jan Murken, Michael Untch, Alfons Meindl (1998).
Genetik des erblichen Mammakarzinoms. Deutsch. rzt. 95, 600-605.
3. DD Farhud, M Mahmoudi, P Derakhshandeh-Peykar, S Stengel-Rutkowski
(2001). Photoanthropometric Investigation of Facial Structures in Iranian Children
with Down syndrome and Normal Controls. Iran. J. Publ. Health, Vol. 30, No. 1-2,
61-66.
4. Farhoud D Mohammadi Asl J
Derakhshandeh-Peykar. (2002) Osteogenesis
Imperfecta: Report of a new pedigree in Iran. Iran J. Ped. 12(2) : 12-15 (In Persian)..
5. Joshaghani H, Kouchaki E, Amini R,
P Derakhshandeh-Peykar, Ehsani A,
Shabani M, Kadiwar M (2003). A study of p53 tumor suppressor gene mutations in
Iranian patients with Gastric tumors. Med. Sci. J. Gorg. Vol 12, No.5, 36-41 (In
Persian).
6. S Kheradmand kia
Pourfarzad
DD Farhud
S Zeinali
AR Mowjoodi
H Najmabadi
F
P Derakhshandeh-Peykar. (2003). Molecular Analysis of Iranian
Patients with Duchenne/Becker Muscular Dystrophies. Iran J. Publ. Health, 32(3):
47-53.
7. SA Alemohammad
Derakhshandeh-Peykar
DD Farhud
SJ Imam
M Hooshmand
M Sanati
P
M Rahmani (2003). Distribution of
Mitochondrial DNA Intergenic COII/tRNALYS 9 bp Deletion in Iranian Populations.
Iran. J. Publ. Health, 32(2): 1-5.
8. M Habibi Roudknar
H Najmabadi
P Derakhshandeh-Peykar
DD Farhud
(2003). Detection of Rare and Unknown Mutations in -thalassemia Traits in Iran
Iran J. Publ. Health, 32(1) : 11-14.
9. Ardalan A.
Holakouie Naieni K.
Mahmoudi M. Majdzadeh R.
Derakhshandeh-Peykar P. (2006). Comparison of the power and statistical
efficiency of case-control and case-only designs in estimating the gene-environment
interaction in breast cancer. J. Sch. Pub. Health Inst. Pub. Health Res., 4(2): 7-20.
10. Vahideh Moin-Vaziri , J´erˆome Depaquit , Mohammad-Reza Yaghoobi-Ershadi,
Mohammad-Ali Oshaghi , Pupak Derakhshandeh-Peykar, Hubert Fert´e , Matthieu
Kaltenbach , Maria Dolores Bargues , Nicole L´eger , Aboulhassan Nadim (2007).
Intraspecific
variation
within
Phlebotomus
sergentiParrot
(1917)
(Diptera:
Psychodidae) based on mtDNA sequences in Islamic Republic of Iran. Act. Trop. 102;
29–37.
11.
Moin-Vaziri
V,
Depaquit
J,
Yaghoobi-Ershadi
MR,
Oshaghi
MA,
Derakhshandeh-Peykar P, Ferte H, Kaltenbach M, Bargues MD, Nadim A, Javadian
E, Rassi Y, Jafari R. (2007). Geographical variation in populations of Phlebotomus
(Paraphlebotomus) caucasicus (Diptera: Psychodidae) in Iran. Bull Soc Pathol Exot.
100(4):291-5.
12. Mohammad-Reza Noori-Daloii, Ali Rashidi-Nezhad, Pantea Izadi, Arash
Hossein-Nezhad, Maryam Sobhani, Pupak Derakhshandeh-Peykar, Kamran
Alimoghaddam, Ardeshir Ghavamzadeh (2007). Transforming growth factor-b1
codon 10 polymorphism is associated with acute GVHD after allogenic BMT in
Iranian population. Ann Transpl, 12(4): 5-10.
13. Dilmaghani Zadeh M., Amini R., Firoozray M, Derakhshandeh-Peykar P.
(2007). Frequent homozygous deletions of p16/CDKN2A gene in malignant Gliomas
of Iranian patients. Pak. J. Biol. Sci.10(23): 4246-4250.
14. Pupak Derakhshandeh-Peykar*, Haleh Akhavan-Niaki, Ahmad Tamaddoni,
Shohreh Ghawidel-Parsa, Kourosh Holakouie Naieni, Manijeh Rahmani, Farbod
Babrzadeh, Mohammad Dilmaghani-Zadeh, and Dariush Daneshvar Farhud (2007).
Distribution of beta thalassemia mutations in the Northern provinces of Iran
Hemoglobin, 31 (3):351–356.
15. Pupak Derakhshandeh-Peykar*, Mohsen Esmaili, Zahra Ousati-Ashtiani,
Manijeh Rahmani, Farbod Babrzadeh, Shahla Farshidi, Elham Attaran, Mohammad
Mehdi Sajedifar, Dariush Daneshvar Farhud (2007). Molecular Analysis of the SMN1
and NAIP Genes in Iranian Patients with Spinal Muscular Atrophy. Ann. Acad. Med.
Vol. 36 No. 11, 937-941.
16. P Derakhshandeh-Peykar*
H Hourfar
Miryounesi (2008). The Spectrum of
M Heidari
M Kheirollahi
M
-thalassemia Mutations in Isfahan Province of
Iran. J. Publ. Health, 37(2) : 106-111.
17. Ahani R
Derakhshandeh Peykar P*
Raoofian R
Heidari M* (2009).
Screening of prognostic factors using multiplex RT-PCR technique on different
leukemic cell lines. The. Univ. Med. J. (TUMJ), 67(1): 42-48 (In Persian).
18. Ebrahimzadeh vesal, R Derakhshandeh-Peykar, P* Shahgholi, E (2009)
Assocaition between hematological indices and types of gene mutations in alpha
thalassemia carriers. J Sch.
Pub.
Health, Inst Pub Health Res. 7(2): 15-23 (In
Persian).
19. Behfar, M, Ehsani, MA, Salamati, P, Jamshidi, R, Holakouie Naieni, K,
Derakhshandeh-Peykar, P* (2010) Relationship between MCV/MCH and severity
of beta globin gene mutations in beta-thalassemia carriers J Sch. Pub. Health, Inst
Pub Health Res. ((In Persian, in press)
Abstracts
1. Deletion analysis and prenatal diagnosis in Iranian patients with spinal muscular
athrophy type I-III.Hum Gen Diver. Abs book. 1: 52, 2002.
2. BRCA1/2 mutation analysis in 72 families with breast cancer. Eur J Hum Genet.
9:113, Supp: 1 , 2001.
3. Beta Thalassemia mutation analysis and prenatal diagnosis in Iran. Abst. book First
Nat. Cong. Hum. Genet.S. 13, 2000.
4. Mutation detection and prenatal diagnosis of patients with cystic Fibrosis (CF) in
Iran. Mediz Genet. No.3,S. 354, 2002.
5. Deletion mapping on chromosome 10p and definition of a critical region for the
second DiGeorge syndrome locus (DGS2). Eur J Hum Genet. 6: 213-225. 1998.
6. Photoanthropometric investigation of facial structures in Iranian childern with
Down syndrom and normal controls. Iran J Pub Heal, Vol 30, No. 1-2,61-7, 2001.
7. Osteogenesis Imperfecta: Report of a new pedigree in Iran. Iran J Pediat, vol 12,
No. 2,12-15, 2002
8. Genetik des erblichen Mammakarzinoms. Deutsch Aertz, 11, 459-464, 1998
9.Detection of Rare and Unknown mutation in b-Thalassemia Traits in Iran. Iran J
Pub Heal, Vol 32, No.1, 11-14, 2003.
10.Distribution of mitochondrial DNA Intergenic COII/tRNALys 9 bp Deletion in
Iranian Population. Iran. Iran J Pub Heal, Vol 32, No. 2, 1-4, 2003.
11. Molecular Analysis of Iranian Patients with Duchenne/Becker Muscular
Dystrophies. Iran. Iran J Pub Heal, Vol 32, No. 3, 47-53, 2003.
12. 12th Iranian Congress on Infectious Diseases and Tropical Medicine . Abs book.
22, 2004.
Research Interests
My interest is in Mutation detection & PND (prenatal Diagnosis)/PGD for genetic
disease and study of gene expression and methylation.
.
Other Interests
My other interests include piano playing, swimming, and painting.