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Undenatured Whey Protein Isolate
A patented, multi-step ultrafiltration process is used to concentrate the whey protein,
glycomacropeptides (GMPs) and bioactive immunoglobulins from pure New Zealand milk.
The whey is processed at controlled temperatures and pH, to prevent the protein from
denaturing. The immunoglobulin concentration is consistent from batch to batch due to the
standardised process by which it is derived. The final product is supplied in powder form,
as opposed to a premixed liquid, to stabilise the nutrients and the potency of the protein
without using preservatives.
NUTRITIONAL ANALYSIS:
Protein (90%)
-Lactoglobulin
-Lactalbumin
Glycomacropeptides
(GMPs)
Immunoglobulins
Directions:
48%
12%
15%
8%
Proteose peptones (Lactoferrin,
Lactoperoxidase)
7%
BCAAs
22%
l-Glutamine
8%
Total fat
0.2%
Total carbohydrate
5%
mix 1 scoop (12.4 g) into food or water as prescribed
CLINICAL APPLICATIONS
As a high quality, high strength protein supplement
Ketogenic Fat Loss System
Body builders
Athletes
Cachexia: cancer, AIDS, etc.
Pregnancy, lactation
Convalescence
Fasting
Liver function defects: as indicated by the Functional Liver Detoxification Profile pathology
test
Intestinal permeability: as indicated by the Lactulose/Mannitol pathology test)
Anaesthetics
Allergic conditions:
Poisonings
Asthma
Chronic infections
Eczema
Gut dysbiosis
Psoriasis
Sinusitis
Gut disorders:
Rhinitis
Ulcerative colitis
Mucus colitis
Autoimmune disorders:
Crohn’s disease
Rheumatoid arthritis
Inflammatory bowel disease
Ankylosing spondylosis
Irritable bowel syndrome
Multiple sclerosis
Systemic lupus erythematosis
Chronic fatigue syndrome
Scleroderma
Fibromyalgia
Graves disease
Migraine
Hashimoto’s thyroiditis
Attention deficit disorder
Raynaud’s Phenomenon
Hyperactivity
Epilepsy
Toxicity:
Immune suppression
Heavy metal exposure
Tumours
Pesticide/chemical exposure
Prolonged drug use
WHEY PROTEIN
Passive immunisation through food is unique to mammals, who all receive it through the
first mother’s milk - the colostrum - immediately after birth. As young mammals are born
without immunity, this is an essential survival adaptation.
Colostrum contains
immunoglobulins (Igs), otherwise known as antibodies. These are active, large molecular
weight proteins that are both immunostimulatory and immunosuppressive 1 . They increase
host defenses against bacteria, viruses and parasites, and also reduce inflammation and
allergic responses.
Like the newborn, certain patients are unable to make sufficient immunoglobulins, and can
benefit from a dietary means of enhancing immunity. A bioactive, pure whey protein
concentrate with naturally occurring high levels of colostrum antibodies and GMPs is the
answer.
These constituents promote immunity, and particularly a healthy, efficient
intestinal function. This in turn helps the body utilise the whey protein to help maintain
overall health, and increase lean body mass (the premier “biomarker of aging”).
A protein’s ‘Biological Value’ (BV) is an index of its capacity to be absorbed, metabolised and
retained as useful nitrogen in the body. Whey lactalbumin has the highest biological value
of any protein food source (104 out of a theoretical maximum of 100 - see Table 1). It is the
ideal protein supplement for protecting against lean muscle loss during the Ketogenic Fat
Loss System.
Table 1: Biological Values of common protein foods
Protein
Whey lactalbumin
Egg
Cow’s milk
Beef
Fish
Casein
Soy
Potato
Rice
Wheat
Beans
Biological Value
104
100
91
80
79
77
74
71
59
54
49
Undenatured Whey Protein Isolate contains 8% active colostrum antibodies that may aid in
the correction of gut dysbiosis due to overgrowth of unfriendly bacteria and yeasts. Cow’s
milk antibodies are highly resistant to peptic digestion 2 - a desirable characteristic for a
therapeutic food - but the structure of these antibodies is essentially the same as that of
other mammalian species, including man.
Whey protein contains immunoglobulins IgG1, IgG2, IgM, and IgA. IgM is an early responder
to antigenic challenge, specific to bacteria and viruses. In contrast, both IgGs attack viruses
and other antigens after IgM. IgA blocks bacterial adherence, and is pivotal in viral defense.
In conditions of gastrointestinal dysfunction, the benefit of the passive provision of these
antibodies becomes apparent. The intestinal epithelium, the interface between the internal
body and the outside world, is an excellent barrier to most chemicals, but a poor physical
barrier to penetration by foreign organisms. The body has both non-immunologic defenses,
such as gastric acid and digestive enzymes, and immune defenses, known as the gutassociated lymphoid tissue (GALT). The GALT has both cell-mediated and humoral
defenses. It produces antibodies that bind with antigens and prevent their adherence to the
gut wall and subsequent penetration.
Table 2: Amino acid profiles of high Biological Value proteins (g/100g)
Whey
Casein
Milk
Egg
white
Soy
Beef
2.45
0.4
0.94
2.24
1.3
1.12
18.99
20.9
20.9
11.74
21.64
15.0
2.34
1.8
2.13
3.45
4.46
5.45
11.82
9.1
9.8
8.12
8.41
7.9
Isoleucine
6.19
4.6
6.5
5.44
5.27
4.5
Valine
6.37
5.7
6.68
7.43
5.08
4.86
Glutathione
production
Cysteine
Glutamate
Glycine
Branched Chain
Amino Acids (BCAAs)
Leucine
The amino acid profile of whey is ideal for the promotion of tissue repair in general, and
mucosal repair in particular. Table 2 shows the amino acid profile compared to other highquality proteins. Two sets of three amino acids are of particular interest nutritionally.
Cysteine, glutamate and glycine combine to make glutathione (chemically -glutamylcysteinyl-glycine; while leucine, isoleucine and valine constitute the branched chain amino
acids (BCAAs).
Glutathione is found in all mammalian cells, and provides the principal intracellular
defense against oxidation stresses such as superoxide anions, lipid peroxidases, and irongenerated hydroxyl radicals. It is abundant in the cytoplasm, nuclei, and mitochondria, and
is the major soluble antioxidant in these fractions. It can thus detoxify both soluble and
lipid peroxidases. Undenatured whey protein has been shown to be superior to denatured
lactalbumin (e.g. exposed to heat, acid/alkali washes during processing) in the production
of glutathione for intracellular antioxidant protection and detoxification.
Levels of glutathione decrease with suboptimal nutrition, particularly of protein, and with
exercise. It is also depleted by oxidative stress, for instance from infection, trauma, or major
surgery.
Giving cysteine alone does not increase glutathione, because it is rapidly
However, dietary administration of -glutamyl-cysteine will
metabolised (and toxic) 3 .
increase glutathione. Whey contains substantial amounts of this dipeptide. The glutamylcysteine groups are located primarily in bovine serum albumin, -lactoglobulin, and
immunoglobulin G1. It is rarely found in other protein sources or plants, except raw egg
whites, which are not commonly consumed.
BCAAs are primarily an excellent source of energy for skeletal muscle. As such, they
improve athletic performance 4 , stamina and endurance 5 . When used in conjunction with
isotonic exercise (e.g. weight lifting) supplementation with BCAAs can prevent muscle
catabolism, facilitate muscle growth, and increase muscle strength 6,7 , and are thus an
excellent supplement for body builders. In combination with a low-calorie diet, they can
facilitate weight loss in obese people 8 . BCAAs have been speculated to help prevent
hypertension, through beneficial effects on cardiac muscle, and may help to prevent and
reverse cachexia 9 .
Undenatured Whey Protein Isolate contains 15% Glycomacropeptides (GMPs), which
stimulate cholecystokinin (CCK) and improve protein absorption and satiety. By promoting
satiety, these proteins confer a feeling of fullness and reduce appetite, which is very
beneficial during weight loss programs. The oligosaccharide moiety of these peptides confer
an action similar to glyconutrients in the inhibition of pathogen adherence to the gut wall.
GMPs are thought to reduce the risk of infection from viruses and bacteria, including
influenza, Salmonella, cholera and E. coli
This specially processed whey also contains other proteins that enhance immune function,
including lactoferrin, alpha-lactalbumin and bovine serum albumin. Lactoferrin binds to
iron, both enhancing its absorption, and denying it to pathogenic intestinal bacteria like
E.coli 10 . It may also modulate immune function 11 . Alpha-lactalbumin is a subunit of the
enzyme lactose synthetase, which catalyses the addition of galactose to glucose to produce
lactose. Its capacity to bind calcium may aid milk digestion and calcium absorption in
infants. Beta-lactoglobulin is involved with phosphorus metabolism in the mammary
gland, transfer of passive immunity, and binding of retinol and fatty acids, allowing the
efficient uptake of fats by cells 12 . Bovine serum albumin also binds fatty acids, while
stimulating pregastric lipases, which aids digestion in newborns.
REFERENCES
Xanthou M. Immune protection of human milk. Biol neonate 1998;74:121-133.
Watson DL. Immunologic functions of the mammary gland and its secretion - a comparative review.
Aust J Biol Sci 1980;33:402-22.
3 Bounous G. The biological activity of undenatured whey proteins: Role of glutathione. Clin Invest
Med 1991;14:269-309.
4 De Palo EF, et al.
Branched chain amino acids chronic treatment and muscular exercise
performance in athletes: a study through plasma acetyl-carnitine levels. Amino Acids. 4:255-256,
1993.
5 Calders P, et al.
Pre-exercise branched-chain amino acid administration increases endurance
performance in rats. Med Sci Sports Exer. 29:1182-1186, 1997.
6 Brainum J. Branched chain amino acids: New study shows BCAAs taken before and after training
increase strength and lean mass. All Natural Muscular Development. 35(8):149, 1998.
7 Millward DJ, et al. The need for indispensable amino acids:
The concept of the anabolic drive.
Diabetes Metab Rev. 5:191-211, 1989.
8 Mourier A, et al.
Combined effects of caloric restriction and branched-chain amino acid
supplementation on body composition and exercise performance in elite wrestlers. International
Journal of Sports Medicine. 18:47-55, 1997.
9 Cangiano C, et al. Effects of administration of oral branched chain amino acids on anorexia and
caloric intake in cancer patients. J Natl Canc Instit. 88:550-552, 1996.
10 Cataldo CB, et al. Nutrition and diet therapy. New York West publishing Co. 1995:371-402.
11 Debbabi H, Dubarry M, Rautureau M, Torne D.
Bovine lactoferrin induces both mucosal and
systemic immune response in mice. J Dairy Res 1998;65:283-293.
12 Perez MD, Calvo M. Interaction of b-lactoglobulin with retinol and fatty acids, and its role as a
possible biological function for this protein: a review. J Dairy Sci 1995;78:978-988.
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