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Creative Solutions to Animal Behaviour Management Dr Cam Day BVSc BSc. MACVSc. ALPRAZOLAM TABLETS (Kalma/ Xanax) Alprazolam is an anti-anxiety medication related to Valium and belongs to the class of medications call Benzodiazepines. They are used in veterinary medicine as:. Mild tranquillisers . For the taming of aggressive animals . Sedatives prior to anaesthesia . Muscle relaxants . As anti-convulsants The benzodiazepines work by slowing down the removal of a chemical, Gamma Amino Butyric Acid, from the space between the nerves. GABA is an inhibitory neurotransmitter and when more of it is available, animals are less anxious. Benzodiazepines are excreted through an animal’s kidneys. Side Effects Side effects of Benzodiazepines can, but do not always include . Sedation . Muscle relaxation seen as staggering, weak limbs or poor coordination. Your pet may have trouble climbing and going down stairs. . Occasional excitation ( in 10 - 20% of animals) . Stimulation of the appetite Benzodiazepines can interact with other medications including:. Cimetidine, erythromycin, isoniazid, disulfiram . Some contraceptive or hormone tablets used in animals . Antacids and anticholinergics may delay absorption and slow down the effect . Increased sedation can be caused when they are used with behaviour modifying drugs such as neuroleptics, narcotics, antihistamines, sedative hypnotics, heterocyclic antidepressants such as Amitryptiline and Clomipramine In aggressive animals, a worsening of the aggression can sometimes occur. Animal Behaviour Veterinarian CAM DAY Consulting P.O. Box 8406 Woolloongabba QLD 4102 Email: [email protected] Web: www.pethealth.com.au Office: (07) 33651560 Fax: (07) 3346 9769 Mobile: 0413100024 Consulting Rooms University of Queensland Small Animal Clinic, Therapies Road, St Lucia Highgate Hill Veterinary Surgery 184 Annerley Road DUTTON PARK Consultancy Services: • Telephone assessments • Telephone consultations • Clinic consultations • House call consultations • Facts Sheet Service • Aggression assessments • Breed identification Consulting to: • • • • • Services: - Stopping the Medication • If your pet is on the medication for any length of time, you should withdraw the medication gradually if you are going to stop using it. • Sometimes, a rebound effect occurs, where, on removal of the medication, more severe symptoms that were initially present may be seen for a while. Typical Reasons for Usage:1.Anxiety states 2.Where a rapid, but usually short term, reduction in anxiety is needed 3.Anxiety following death of a house-mate 4.For anticipated fears and phobias such as noise or thunder phobia and separation anxiety 5.In separation anxiety, while waiting for other medications to have effect Pet owners Local authorities Animal Welfare Groups Corporations Lawyers • • • • Behaviour consultancy Veterinary journalism Pet care articles Web support Radio/TV Pet care newsletters Behaviour seminars Open Days Public Speaking Staff training Noise Fear Solutions Noise fear audio CD’s Noise fear E-books Notes on the Usage of Alprazolam 1. 2. 3. 4. 5. It is relatively short acting ( up to 12 hours) and repeated dosage may be needed if the stimulus causing the fear is continuous. The affect of an oral tablet may take 1 - 2 hours to be seen The dose may need to be adjusted for best effect. When stopping a long course of Alprazolam, it is best to reduce the dose gradually rather that to stop it quickly If you know that your pet will be fearful or anxious because a fear-inducing stimulus is likely to occur, Alprazolam usage can be planned to prevent this fear. How to Determine the Dose of Alprazolam for your Dog Plan to medicate you dog when you are going to be home for the day. A weekend is a useful time to do this. 1. 2. 3. 4. 5. Give the advised dose in the morning. Observe the effect. If effective, your dog should be less reactive to fear-inducing stimuli. This may not be easy to pick if the fear-inducing stimulus doesn’t occur during this period though. Look for any muscle relaxation that has been caused. You will see this as ‘staggering ‘ clumsiness’ or ‘wobbliness’. Some notice the dog has difficulty climbing or going down stair or jumping into the back of their car. If no muscle relaxation occurs, increase the dose - usually by ½ a tablet, unless advised differently. Look for muscle relaxation again. If none is seen at this increased dose then please ring me. Generally the dose we want is the one that causes no, or very slight, muscle relaxation. If you find you dog is very ‘wobbly’, due to muscle relaxation, or if it is over excited or aggressive, please cease the medication and ring me for further advice. In any case, please ring me to report your progress at the end of the initial trial (usually two days) so that together, we can discuss the plan of treatment. DOSE ADVISED INITIALLY .................. INCREASE DOSE BY .................... IF NO MUSCLE RELAXATION IS SEEN. The above is provided for your guidance. Generally, side effects of Alprazolam are rare and not serious. Please let me know if you notice any unusual effects when your pet is using this medication