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^f il ^^^ Cancer Research TheOfficialOrganof theAMERICAN ASSOCIATION FORCANCER RESEARCH, INC.Published by THEUNIVERSITY OFCHICAGO PRE Volume 21 • No. 1 • January 1961 Contenu 1 Acknowledgment to Reviewers 2 Edwin O. Field, Joseph P. Kriss, and Lucie A. Tung. Turnover of Thymidine in the DNA of Marrow and In testinal Mucosa in Mice, and Its Response to Administra tion of 5-Fluorouracil S. Lindsay, G. E. Shcline, G. D. Potter, and I. L. Chaikoff. Induction of Neoplasms in the Thyroid Gland of the Rat by X-Irradiation of the Gland H. Francis Havas and Andrew J. Donnelly. Mixed Bacterial Toxins in the Treatment of Tumors. IV. Re sponse of Methylcholanthrene-induced, Spontaneous, and Transplanted Tumors in Mice H. L. Ratcliffe. Birds Hepatitis, Cirrhosis, and Hepatoma in Frederic P. Herter, Sanford G. Weissman, Hartwell G. Thompson, Jr., George Hyman, and Daniel S. Martin. Clinical Experience with 6-Aminonicotinamide 88 Irving Zeidman. The Fate of Circulating Tumor Cells. I. Passage of Cells through Capillaries 40 44 I. Gordon Fels and Joseph Greco. Changes in Epidermal Hydroxyproline and Tyrosine Accompanying Induced Epi dermal Carcinogenesis Kun Se Kwak, Eloise Jameson, R. Mark Ryan, and Harrison M. Kurtz. The Effect of Varying Implant Cell Numbers on the Inhibitory Activity of Guinea Pig Serum on Walker Carcinosarcoma 256 in the Rat 48 J. S. Colter, Jeanne Kühn,and K. A. O. Ellem. The Ribonucleases of Mouse Ascites Tumors 52 E. H. Mercer and G. C. Easty. The Fine Cytology of the Walker Tumor 57 G. E. Foley, O. M. Friedman, and B. P. Drolet. Studies »on the Mechanism of Action of Cytoxan. Evidence of Acti vation in Vivo and in Vitro Leo A. Miller and Anna Goldfeder. Comparison of Adenosine Triphosphatase Activity of Nuclei and Mito chondria from Mouse Mammary Adenocarcinoma 71 Sadahisa Kawamoto, A. Kirschbaum, M. L. Humez, J. J. Trentin, and H. G. Taylor. Influence of Urethan on thé Development of Spontaneous Leukemia and on the In duction of Hemangiomas in the AKR and C58 Strains of Mice 75 Bertie F. Argyris and Thomas S. Argyris. Mechanism of Mammary Duct Stimulation by Tumor Transplants 82 C. Carruthers and B. Davis. The Lipide Composition of Epidermis and Dermis of Mice Undergoing Carcinogene by Methylcholanthrene 86 Annabel G. Liebelt and Robert A. Liebelt. Effects of Single Pituitary Isograft on Mammary Tumorigenesis in Mice 92 Elling Kvamme and Gerd Svenneby. The Effect of Glucose on Glutamine Utilization by Ehrlich Ascites Tu mor Cells 99 L. F. Larionov. Peptides, Amides, and Esters of Chloroethylamino Derivatives of Amino Acids and of Phenylalkancarboxylic Acids: A New Class of Antitumor Compounds 105 Edward Bresnick and George H. Hitchings. Control in Ehrlich Ascites Cells Feedb ack 110 C. A. Pasternak, G. A. Fischer, and R. E. Handschumacher. Alterations in Pyrimidine Metabolism in L5178Y Leukemia Cells Resistant to 6-Azauridine 118 J. Frank Henderson and Irene G. Junga. The Metabo lism of 4-Aminopyrazolo(3,4-¿)pyrimidine in Normal and Neoplastic Tissues 130 Virginia I. Babcock and Chester M. Soulham. plantable Renal Tumor of the Rat Trans- 132 Enid T. Oppenheimer, Margaret Willhite, I. Danishefsky, and Arthur Purdy Stout. Observations on the Effects of Powdered Polymer in the Carcinogenic Process 135 Announcements