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Wellman Center for Photomedicine Lecture Series Andrew L. Kung, M.D., Ph.D. Assistant Professor of Pediatrics Department of Pediatric Oncology Dana-Farber Cancer Institute, Boston, MA Cellular and Molecular Bioluminescence Imaging in Mouse Cancer Models Mouse cancer models play a critical role in the development of new cancer therapies. However, over the years, serious questions have been raised as to the value of traditional subcutaneous xenograft models for predicting clinical efficacy. The fidelity of tumor models may be improved by localizing tumors to their originating anatomical sites. Socalled orthotopic models, however, are generally inaccessible to caliper measurements, necessitating alternative methods of tumor quantification. Bioluminescence imaging (BLI) is a conceptually and technically simple methodology for noninvasive imaging of tumor cells located anywhere within small animals. BLI can be used to create orthotopic models of essentially any solid tumor, such as prostate, breast, kidney, or brain tumors. BLI can also quantify disseminated tumors such as hematologic malignancies and metastases. These cellular imaging applications of BLI are useful for assessing drug effects on tumor burden. However, BLI can also be used for molecular imaging, where light emission is a biomarker of molecular pathways. These approaches can serve as near real-time pharmacodynamic read-outs of drug effects. Together, these approaches hold the promise of accelerating targeted drug discovery by allowing rapid in vivo assessment of drug efficacy. Tuesday, March 21, 2006 Thier 1 (formerly Wellman 1) Conference Room Massachusetts General Hospital 2:00 - 2:15 coffee reception 2:15 - 3:15 lecture For all events, please visit: http://www.massgeneral.org/wellman/calendar.asp Nicole De Voe Wellman Center for Photomedicine Massachusetts General Hospital 55 Fruit Street - EDR 202A Boston, MA 02114 T: 617-726-2822 F: 617-726-1206 E: [email protected] http://www.massgeneral.org/wellman
