Download Data Sheet Danoprevir (ITMN-191)

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Data Sheet
Danoprevir (ITMN-191)
Catalog #: 27052
Size: 5 mg
Lot #: 130909
Structure:
CAS Registry #: 850876-88-9
Purity: ≥ 95%
Chemical Formula: C35H46FN5O9S
Molecular Weight: 731.83
Description: Danoprevir is a peptidomimetic inhibitor. It inhibits of the NS3/4A protease of hepatitis
C virus (HCV).
Appearance: Off-white powder.
Solubility: Soluble in DMSO at 144 mg/mL, in ethanol at 144 mg/mL, and poorly soluble in H2O.
Biological Activity: Danoprevir inhibits NS3/4A protease of HCV with an IC50 of 0.2-3.5 nM. It also
shows antiviral inhibition effects against HCV genotypes 1, 4 and 6 with IC50 of 2-3 nM.
Storage/Stability: Room temperature for 24 months as powder, +4°C for 2 weeks in DMSO, or
−80°C for 6 months in anhydrous DMSO. Keep DMSO stock solutions out of contact with air.
Protect from moisture.
Quality Control: The purity was determined by HPLC.
References:
1. Robinson M, et al., Curr Protoc Microbiol; 17,17.7 (2011).
2. Saeed M., et al., J Antimicrob Agents Chemother; 56(10): 5365-5373 (2012).
For R&D use only. Not for human, drug, diagnostic, household or other uses. MSDS available. Product of USA.
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