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Pegylated Interferon with Ribavirin (Pegasys RBV) BC’s PharmaCare Eligibility for Pegylated Interferon with Ribavirin (Pegasys RBV) Pegylated Interferon with Ribavirin (Pegasys RBV) – General Information Commonly Abbreviations: PR, PegIFN/RBV Approvals: Federal/Canada: Yes PharmaCare: Yes Targeted Genotype: 2 – 6, also prescribed for 1 when used with DAA combinations How They Works: Interferons are proteins produced by the body in response to a viral infection. The interferons used in hep C treatments are manufactured by pharmaceutical companies. They are taken in higher doses than those which occur naturally. They can boost a person’s immune response and stop viruses. ‘Pegylated’ interferon extends the duration of the treatment’s effect. Ribavirin (RBV) is a drug that alters the body’s immune response towards viruses. It helps treatments cure. Dose: Once weekly pegylated injection and twice daily ribavirin pill interferon Length of Treatment: 12 - 44 weeks Common Side Effects: Diarrhea, flulike symptoms, nausea, tiredness, mild anxiety, depression, skin rash, anemia Direct-Acting Antivirals that may be Prescribed with PR in BC: • • • • Victrelis (boceprevir) Galexos (simeprevir) Sovaldi (sofosbuvir) Harvoni (ledipasvir and sofosbuvir) PharmaCare coverage of PR is received through a Special Authority request, a request submitted by a specialist. Ask your doctor for more information. It is for the treatment of chronic hepatitis C genotype 2, 3, 4, 5 or 6 in: • • Patients who haven’t tried hep C treatment Patients with or without cirrhosis AND who have ALL of the following: • • • • • Lab-confirmed hepatitis C genotype 2 - 6 A prescription for the treatment from a qualified healthcare provider Detectable levels of hep C in the last 6 months A liver fibrosis stage F2 or greater Special Authority request completed by a specialist or experienced physician Re-treatment requests are NOT considered. PEGAssist Patient Support Program Hoffmann-La Roche Inc. offers this patient assistance program for people who have been prescribed peginterferon (Pegasys) as part of hep C treatment. http://www.pegasys.com/hcp/ patient-support/pegassist. For more information, contact your doctor, nurse, or call the program at: 1-877-734-2797. This information is meant as a resource only and is not intended to replace qualified medical attention © PHCN’s Hepatatis C Treatment Information Project (www.pacifichepc.org/hepctip), May 2015