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Vapreotide Acetate Human Growth Hormone Peptide Release Formulation Of Sanvar Brand Name QA Model Number [email protected] Certification ISO9001, Kosher, COA Place of Origin China Minimum Order Quantity 1vial Price Negotiated Payment Terms T/T, Western Union, MoneyGram,Bitcoin Supply Ability Mass stock Delivery Time within 12h after receiving your payment Packaging Details Discreet packing Molecular Formula: C57H70N12O9S2 Molecular Weight: 1131.40 Purity 98.0% Products Detailed vapreotide acetate CAS:103222-11-3 release formulation of Sanvar Delivery Sent out within 12 hours after payment confirmed Packaging Disguised package or as required Discount Larger quantity of each item Quick Detail: vapreotide acetate-Product Name:vapreotide acetate vapreotide acetate-Sequence: D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 vapreotide acetate-Alias:Sanvar,RC-160;VAPREOTIDE;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2; Octastatin; FCYWKVCW-NH2;D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Trp-NH2; vapreotide acetate-Cas No.: 103222-11-3 vapreotide acetate-Molecular Formula: C57H70N12O9S2 vapreotide acetate-Molecular Weight: 1131.40 vapreotide acetate-Purity (HPLC): 98.0% vapreotide acetate-Appearance: White powder vapreotide acetate-Single Impurity(HPLC): 1.0% vapreotide acetate-Amino Acid Composition: 10% of theoretical vapreotide acetate-Peptide Content(N%): 80%(by %N) vapreotide acetate-Water Content(Karl Fischer): 6.0% vapreotide acetate-Acetate Content(HPIC): 15.0% vapreotide acetate-Mass Balance: 95.0~105.0% vapreotide acetate-Grade : Pharmaceutical Grade vapreotide acetate-Storage: Closed, below 2 ~ 8ºC preservation vapreotide acetate-Manufacturer :SUPER STEROIDS vapreotide acetate-Delivery time : within 18 hours upon receipt of payment vapreotide acetate-Delivery: EMS, DHL, TNT, FedEx, UPS vapreotide acetate-Usage : The drug can be used for treatment of early acute esophageal variceal bleeding (EVB) and endoscopic interventional therapy before hemostasis, can also be bleeding within 5 d lens for the treatment and prevention of recurrence after endoscopic.vapreotide acetate will be the only approved treatment for esophageal variceal bleeding in the United States. 2.Description: Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects. 3.Application: The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB). Sanvar is used prior to endoscopic intervention to control haemorrhage and prevent re-bleeding during the critical five days following the onset of bleeding. EVB is a life threatening condition and the mortality rate is high (about 15% to 25%) in the first six weeks following the haemorrhage. EVB is the cause of about 70% of gastro-intestinal bleeding in patients suffering from liver cirrhosis. Sanvar (vapreotide acetate) is a synthetic octapeptide analogue of the naturally-occurring somatostatin hormone. It has similar pharmacological properties to native somatostatin, but exhibits a longer duration of action. It is the only somatostatin analogue to have demonstrated statistically significant benefits in the early treatment of EVB in association with endoscopic therapy, in a placebo-controlled clinical study (Calès et al. New England Journal of Medicine, 2001). Control of bleeding with survival at five days was achieved more often with Sanvar (p=0.021) than with placebo. Additional Phase III trials have been completed in Europe in this indication. Sanvar can be stored at room temperature, an advantage over other products requiring refrigeration, allowing immediate administration, a key benefit in a life-threatening situation. The product has been granted orphan drug status in the U.S., where there is currently no FDA approved treatment for this indication. 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