Download Hydrocortisone


Home

> Martindale: The Complete Drug Reference

> Drugs and Ancillary Substances

> By therapeutic use

> Corticosteroids

> Drug Monographs
Hydrocortisone
Sub-sections

Hydrocortisone

Hydrocortisone Acetate

Hydrocortisone Buteprate

Hydrocortisone Butyrate

Hydrocortisone Cipionate

Hydrocortisone Hydrogen Succinate

Hydrocortisone Sodium Phosphate

Hydrocortisone Sodium Succinate

Hydrocortisone Valerate

Adverse Effects, Treatment, Withdrawal, and Precautions

Interactions

Pharmacokinetics

Uses and Administration

Preparations
Hydrocortisone
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 30-Jan-2013)
Synonyms: 17-Hydroxycorticosterone; Anti-inflammatory Hormone;
Compound F; Cortisol; Hidrocortisona; Hidrokortizon; Hidrokortizonas;
Hydrocortison; Hydrocortisonum; Hydrokortison; Hydrokortisoni;
Hydrokortyzon; NSC-10483; ヒドロコルチゾン
BAN: Hydrocortisone
INN: Hydrocortisone [rINN (en)]
INN: Hidrocortisona [rINN (es)]
INN: Hydrocortisone [rINN (fr)]
INN: Hydrocortisonum [rINN (la)]
INN: Гидрокортизон [rINN (ru)]
INN: 氢化可的松 [rINN (cn)]
Chemical name: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O5 =362.5
CAS: 50-23-7
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QD07XA01; QH02AB09; QS01BA02; QS01CB03; QS02BA01
UNII code: WI4X0X7BPJ
Chemical Structure of Hydrocortisone
NOTE:
Use in Sport.
Hydrocortisone may be restricted in certain sports (see
) as it is
considered to be a member of the prohibited group, Glucocorticoids
(topical preparations are not prohibited when used for specified
disorders); competitors should check with the appropriate sports
authorities.
Pharmacopoeias:
In Chin., Eur. (see
), Int., Jpn, and US.
Ph. Eur. 7 (Hydrocortisone). A white or almost white, crystalline
powder. It shows polymorphism. Practically insoluble in water; sparingly
soluble in alcohol and in acetone; slightly soluble in dichloromethane.
Protect from light.
USP 36 (Hydrocortisone). A white to practically white, odourless,
crystalline powder. Very slightly soluble in water and in ether; soluble 1
in 40 of alcohol and 1 in 80 of acetone; slightly soluble in chloroform.
Store at a temperature of 25 degrees, excursions permitted between 15
degrees and 30 degrees.
Hydrocortisone Acetate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 12-Feb-2013)
Synonyms: Cortisol Acetate; Hidrocortisona, acetato de; Hidrokortizon
Asetat; Hidrokortizon-acetát; Hidrokortizono acetatas;
Hydrocortisonacetat; Hydrocortisone, acétate d'; Hydrocortisoni Acetas;
Hydrokortison-acetát; Hydrokortisonacetat; Hydrokortisoniasetaatti;
Hydrokortyzonu octan; ヒドロコルチゾン酢酸エステル
BAN: Hydrocortisone Acetate [BANM]
INN: Hydrocortisone Acetate [rINNM (en)]
INN: Acetato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Acétate d' [rINNM (fr)]
INN: Hydrocortisoni Acetas [rINNM (la)]
INN: Гидрокортизона Ацетат [rINNM (ru)]
Chemical name: Hydrocortisone 21-acetate
Molecular formula: C23H32O6 =404.5
CAS: 50-03-3
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: 3X7931PO74
NOTE:
HCOR is a code approved by the BP 2013 for use on single unit doses of
eye drops containing hydrocortisone acetate where the individual
container may be too small to bear all the appropriate labelling
information.
Use in Sport.
Hydrocortisone Acetate may be restricted in certain sports (see
) as
it is considered to be a member of the prohibited group, Glucocorticoids
(topical preparations are not prohibited when used for specified
disorders); competitors should check with the appropriate sports
authorities.
Pharmacopoeias:
In Chin., Eur. (see
), Int., Jpn, US, and Viet.
Ph. Eur. 7 (Hydrocortisone Acetate). A white or almost white, crystalline
powder. Practically insoluble in water; slightly soluble in dehydrated
alcohol and in dichloromethane. Protect from light.
USP 36 (Hydrocortisone Acetate). A white to practically white,
odourless, crystalline powder. Insoluble in water; soluble 1 in 230 of
alcohol and 1 in 200 of chloroform.
Hydrocortisone Buteprate
Date of monograph review: 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28Jul-2010; (latest modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 10-Oct-2011)
Synonyms: Hidrocortisona, buteprato de; Hydrocortisone Butyrate
Propionate; TS-408; 酪酸プロピオン酸ヒドロコルチゾン
BAN: Hydrocortisone Buteprate [BANM]
USAN: Hydrocortisone Probutate
INN: Hydrocortisone Buteprate [rINNM (en)]
INN: Buteprato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Butéprate d' [rINNM (fr)]
INN: Hydrocortisoni Butepras [rINNM (la)]
INN: Гидрокортизона Бутепрат [rINNM (ru)]
Chemical name: Hydrocortisone 17-butyrate 21-propionate
Molecular formula: C28H40O7 =488.6
CAS: 72590-77-3
ATC code: D07AB11
ATC code (veterinary): QD07AB11
UNII code: O6550D6K3A
NOTE:
Use in Sport.
Hydrocortisone Buteprate may be restricted in certain sports (see
as it is considered to be a member of the prohibited group,
)
Glucocorticoids (topical preparations are not prohibited when used for
specified disorders); competitors should check with the appropriate
sports authorities.
Hydrocortisone Butyrate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 30-Jan-2013)
Synonyms: Cortisol Butyrate; Hidrocortisona, butirato de; Hidrokortizon
Bütirat; ヒドロコルチゾン酪酸エステル
BAN: Hydrocortisone Butyrate [BANM]
USAN: Hydrocortisone Butyrate
INN: Hydrocortisone Butyrate [rINNM (en)]
INN: Butirato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Butyrate d' [rINNM (fr)]
INN: Hydrocortisoni Butiras [rINNM (la)]
INN: Гидрокортизона Бутират [rINNM (ru)]
Chemical name: Hydrocortisone 17α-butyrate
Molecular formula: C25H36O6 =432.6
CAS: 13609-67-1
ATC code: D07AB02
ATC code (veterinary): QD07AB02
UNII code: 05RMF7YPWN
NOTE:
Use in Sport.
Hydrocortisone Butyrate may be restricted in certain sports (see
) as
it is considered to be a member of the prohibited group, Glucocorticoids
(topical preparations are not prohibited when used for specified
disorders); competitors should check with the appropriate sports
authorities.
Pharmacopoeias:
In Chin., Jpn, and US.
USP 36 (Hydrocortisone Butyrate). A white to practically white,
practically odourless crystalline powder. Practically insoluble in water;
soluble in alcohol, in acetone, and in methyl alcohol; freely soluble in
chloroform; slightly soluble in ether.
Hydrocortisone Cipionate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 10-Oct-2011)
Synonyms: Cortisol Cypionate; Hidrocortisona, cipionato de;
Hydrocortisone Cyclopentylpropionate; Hydrocortisone Cypionate;
ヒドロコルチソンシピオナート
BAN: Hydrocortisone Cipionate [BANM]
INN: Hydrocortisone Cipionate [rINNM (en)]
INN: Cipionato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Cipionate d' [rINNM (fr)]
INN: Hydrocortisoni Cipionas [rINNM (la)]
INN: Гидрокортизона Ципионат [rINNM (ru)]
Chemical name: Hydrocortisone 21-(3-cyclopentylpropionate)
Molecular formula: C29H42O6 =486.6
CAS: 508-99-6
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: 4XDY25L70B
NOTE:
Use in Sport.
Hydrocortisone Cipionate may be restricted in certain sports (see
)
as it is considered to be a member of the prohibited group,
Glucocorticoids (topical preparations are not prohibited when used for
specified disorders); competitors should check with the appropriate
sports authorities.
Hydrocortisone Hydrogen Succinate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 30-Jan-2013)
Synonyms: Cortisol Hemisuccinate; Hidrocortisona, hidrogenosuccinato
de; Hidrokortizon-hidrogén-szukcinát; Hidrokortizono hemisukcinatas;
Hydrocortisone Hemisuccinate; Hydrocortisone Succinate;
Hydrocortisone, hydrogénosuccinate d'; Hydrocortisonhydrogensuccinat;
Hydrocortisoni Hydrogenosuccinas; Hydrokortison-hydrogen-sukcinát;
Hydrokortisonivetysuksinaatti; Hydrokortisonvätesuccinat;
ヒドロコルチゾンコハク酸エステル; ヘミコハク酸ヒドロコルチゾン
BAN: Hydrocortisone Hydrogen Succinate [BANM]
INN: Hydrocortisone Hydrogen Succinate [rINNM (en)]
INN: Hidrogenosuccinato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Hémisuccinate d' [rINNM (fr)]
INN: Hydrocortisoni Hemisuccinas [rINNM (la)]
INN: Гидрокортизона Гемисукцинат [rINNM (ru)]
Chemical name: Hydrocortisone 21-(hydrogen succinate)
Molecular formula: C25H34O8 =462.5
CAS: 2203-97-6 (anhydrous hydrocortisone hydrogen succinate);
83784-20-7 (hydrocortisone hydrogen succinate monohydrate)
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: LIU00Z1Z84
NOTE:
Use in Sport.
Hydrocortisone Hydrogen Succinate may be restricted in certain sports
(see
) as it is considered to be a member of the prohibited group,
Glucocorticoids (topical preparations are not prohibited when used for
specified disorders); competitors should check with the appropriate
sports authorities.
Pharmacopoeias:
In Eur. (see
) and Jpn. US allows the anhydrous form or the
monohydrate.
Ph. Eur. 7 (Hydrocortisone Hydrogen Succinate). A white or almost
white, hygroscopic powder. Practically insoluble in water; freely soluble
in dehydrated alcohol and in acetone; dissolves in dilute solutions of
alkali carbonates and alkali hydroxides. Store in airtight containers.
Protect from light.
USP 36 (Hydrocortisone Hemisuccinate). It contains one molecule of
water of hydration or is anhydrous. Store in airtight containers.
Hydrocortisone Sodium Phosphate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 12-Feb-2013)
Synonyms: Cortisol Sodium Phosphate; Hidrocortisona, fosfato sódico
de; ヒドロコルチゾンリン酸エステルナトリウム
BAN: Hydrocortisone Sodium Phosphate [BANM]
INN: Hydrocortisone Sodium Phosphate [rINNM (en)]
INN: Fosfato sódico de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Phosphate Sodique d' [rINNM (fr)]
INN: Natrii Hydrocortisoni Phosphas [rINNM (la)]
INN: Натрия Гидрокортизона Фосфат [rINNM (ru)]
Chemical name: Hydrocortisone 21-(disodium orthophosphate)
Molecular formula: C21H29Na2O8P =486.4
CAS: 6000-74-4
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: 0388G963HY
NOTE:
Use in Sport.
Hydrocortisone Sodium Phosphate may be restricted in certain sports
(see
) as it is considered to be a member of the prohibited group,
Glucocorticoids (topical preparations are not prohibited when used for
specified disorders); competitors should check with the appropriate
sports authorities.
Pharmacopoeias:
In Br., Jpn, and US.
BP 2013 (Hydrocortisone Sodium Phosphate). A white or almost white,
hygroscopic powder. Freely soluble in water; practically insoluble in
dehydrated alcohol and in chloroform. A 0.5% solution in water has a pH
of 7.5 to 9.0. Protect from light.
USP 36 (Hydrocortisone Sodium Phosphate). A white to light yellow,
odourless or practically odourless, exceedingly hygroscopic, powder.
Soluble 1 in 1.5 of water; slightly soluble in alcohol; practically insoluble
in chloroform, in dioxan, and in ether. Store in airtight containers.
Hydrocortisone Sodium Succinate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 30-Jan-2013)
Synonyms: Cortisol Sodium Succinate; Hidrocortisona, succinato sódico
de; Hydrokortyzonu bursztynianu sól sodowa;
ヒドロコルチゾンコハク酸エステルナトリウム
BAN: Hydrocortisone Sodium Succinate [BANM]
INN: Hydrocortisone Sodium Succinate [rINNM (en)]
INN: Succinato sódico de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Succinate Sodique d' [rINNM (fr)]
INN: Hydrocortisoni Natrii Succinas [rINNM (la)]
INN: Гидрокортизона Натрия Сукцинат [rINNM (ru)]
Chemical name: Hydrocortisone 21-(sodium succinate)
Molecular formula: C25H33NaO8 =484.5
CAS: 125-04-2
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: 50LQB69S1Z
NOTE:
Use in Sport.
Hydrocortisone Sodium Succinate may be restricted in certain sports
(see
) as it is considered to be a member of the prohibited group,
Glucocorticoids (topical preparations are not prohibited when used for
specified disorders); competitors should check with the appropriate
sports authorities.
Pharmacopoeias:
In Chin., Int., It., Jpn., Pol., and US.
USP 36 (Hydrocortisone Sodium Succinate). A white or nearly white,
odourless, hygroscopic, amorphous solid. Very soluble in water and in
alcohol; very slightly soluble in acetone; insoluble in chloroform. Store in
airtight containers. Protect from light.
Hydrocortisone Valerate
Date of monograph review: 17-Jun-1997; 09-Jul-1998; 28-Feb-2000; 17Aug-2001; 04-Mar-2004; 19-Jul-2006; 10-Sep-2008; 28-Jul-2010; (latest
modification: 14-Nov-2011)
Drug Nomenclature (Latest modification: 10-Oct-2011)
Synonyms: Cortisol Valerate; Hidrocortisona, valerato de;
吉草酸ヒドロコルチゾン
BAN: Hydrocortisone Valerate [BANM]
USAN: Hydrocortisone Valerate
INN: Hydrocortisone Valerate [rINNM (en)]
INN: Valerato de hidrocortisona [rINNM (es)]
INN: Hydrocortisone, Valérate d' [rINNM (fr)]
INN: Hydrocortisoni Valeras [rINNM (la)]
INN: Гидрокортизона Валерат [rINNM (ru)]
Chemical name: Hydrocortisone 17-valerate
Molecular formula: C26H38O6 =446.6
CAS: 57524-89-7
ATC code: A01AC03; A07EA02; C05AA01; D07AA02; H02AB09;
S01BA02; S02BA01
ATC code (veterinary): QA01AC03; QA07EA02; QC05AA01;
QD07AA02; QH02AB09; QS01BA02; QS02BA01
UNII code: 68717P8FUZ
NOTE:
Use in Sport.
Hydrocortisone Valerate may be restricted in certain sports (see
) as
it is considered to be a member of the prohibited group, Glucocorticoids
(topical preparations are not prohibited when used for specified
disorders); competitors should check with the appropriate sports
authorities.
Pharmacopoeias:
In US.
Adverse Effects, Treatment, Withdrawal, and Precautions
(Latest modification: 24-Jun-2010)
As for corticosteroids in general (see
,
, and
, respectively).
When applied topically, particularly to large areas, when the skin is broken,
or under occlusive dressings, corticosteroids may be absorbed in sufficient
amounts to cause systemic effects. Prolonged use of ophthalmic
preparations containing corticosteroids has caused raised intra-ocular
pressure and reduced visual function.
(last reviewed 2010-07-28; last modified 2010-06-24)
Effects on fluid and electrolyte balance (Latest modification: 21-Mar-2004)
A report of marked hypokalaemia and hypomagnesaemia associated with
high-dose intravenous hydrocortisone therapy in an alcoholic patient with
suspected immune thrombocytopenia.1 Cardiac arrhythmias developed,
and prolonged infusion of magnesium and potassium was required to
restore normal plasma concentrations.
(last reviewed 2010-07-28; last modified 2004-03-21)
1. 1. Ramsahoye BH, et al. The mineralocorticoid effects of high dose
hydrocortisone. BMJ 1995; 310: 656–7. PubMed
Effects on the nervous system (Latest modification: 21-Mar-2004)
For reports and comments on paraesthesia or perineal irritation associated
with hydrocortisone sodium phosphate given intravenously, see
(last reviewed 2010-07-28; last modified 2004-03-21)
.
Hypersensitivity and anaphylaxis (Latest modification: 19-Jul-2006)
References to hypersensitivity reactions and anaphylaxis associated with
the intravenous use of hydrocortisone;1-7 topical application can also result
in hypersensitivity.8
(last reviewed 2010-07-28; last modified 2006-07-19)
1. 1. Chan CS, et al. Hydrocortisone-induced anaphylaxis. Med J Aust 1984;
141: 444–6. PubMed
2. 2. Seale JP. Anaphylactoid reaction to hydrocortisone. Med J Aust 1984;
141: 446.
3. 3. Corallo CE, Sosnin M. Bronchospasm, tachycardia following intravenous
hydrocortisone. Aust J Hosp Pharm 1985; 15: 103–4.
4. 4. Al Mahdy H, Hall M. Anaphylaxis and hydrocortisone. Ann Intern Med
1988; 108: 487–8. PubMed
5. 5. Fulcher DA, Katelaris CH. Anaphylactoid reaction to intravenous
hydrocortisone sodium succinate: a case report and literature review. Med
J Aust 1991; 154: 210–14. PubMed
6. 6. Kawane H. Anaphylactoid reaction to intravenous hydrocortisone sodium
succinate. Med J Aust 1991; 154: 782. PubMed
7. 7. Currie GP, et al. An unexpected response to intravenous hydrocortisone
succinate in an asthmatic patient. Br J Clin Pharmacol 2005; 60: 342.
PubMed
8. 8. Wilkinson SM, et al. Hydrocortisone: an important cutaneous allergen.
Lancet 1991; 337: 761–2. PubMed
Porphyria (Latest modification: 14-Nov-2011)
The Drug Database for Acute Porphyria, compiled by the Norwegian
Porphyria Centre (NAPOS) and the Porphyria Centre Sweden, classifies
hydrocortisone as possibly porphyrinogenic; it should be used only when
no safer alternative is available and precautions should be considered in
vulnerable patients.1
(last reviewed 2010-07-28; last modified 2011-11-14)
1. 1. The Drug Database for Acute Porphyria. Available at: online (accessed
17/10/11)
Interactions (Latest modification: 16-Jun-1998)
The interactions of corticosteroids in general are described on
.
(last reviewed 2010-07-28; last modified 1998-06-16)
Pharmacokinetics (Latest modification: 24-Jun-2010)
For a brief account of the pharmacokinetics of corticosteroids, see
.
Hydrocortisone is readily absorbed from the gastrointestinal tract and peak
blood concentrations occur in about an hour. The plasma half-life is about
100 minutes. It is more than 90% bound to plasma proteins. Following
intramuscular injection, the absorption of the water-soluble sodium
phosphate and sodium succinate esters is rapid, while absorption of
hydrocortisone free alcohol and its lipid-soluble esters is slower. Absorption
of hydrocortisone acetate after intra-articular or soft-tissue injection is also
slow. Hydrocortisone is absorbed through the skin, particularly in denuded
areas.
Hydrocortisone is metabolised in the liver and most body tissues to
hydrogenated and degraded forms such as tetrahydrocortisone and
tetrahydrocortisol. These are excreted in the urine, mainly conjugated as
glucuronides, with a very small proportion of unchanged hydrocortisone.
Hydrocortisone readily crosses the placenta.
(last reviewed 2010-07-28; last modified 2010-06-24)
Uses and Administration (Latest modification: 04-Aug-2010)
Hydrocortisone is a corticosteroid with both glucocorticoid and to a lesser
extent mineralocorticoid activity (
); 20 mg of hydrocortisone is
equivalent in anti-inflammatory activity to about 5 mg of prednisolone. As
cortisol it is the most important of the mainly glucocorticoid corticosteroids
secreted by the adrenal cortex. Hydrocortisone is used, usually with a more
potent mineralocorticoid, for replacement therapy in adrenocortical
insufficiency (
). It may also be used for its glucocorticoid properties in
other conditions for which corticosteroid therapy is indicated (
) but drugs
with fewer mineralocorticoid effects tend to be preferred for the long-term
systemic therapy of auto-immune and inflammatory disease.
The dose may be expressed in terms of the base, and the following are each
equivalent to about 100 mg of hydrocortisone:
hydrocortisone acetate 112 mg
hydrocortisone buteprate 135 mg
hydrocortisone butyrate 119 mg
hydrocortisone cipionate 134 mg
hydrocortisone hydrogen succinate 128 mg
hydrocortisone sodium phosphate 134 mg
hydrocortisone sodium succinate 134 mg
hydrocortisone valerate 123 mg
However, esterification generally alters potency and compounds with
equivalent hydrocortisone content may not have equivalent clinical effect.
When given orally hydrocortisone free alcohol is usually used; the cipionate
ester is used in some formulations. For replacement therapy in acute or
chronic adrenocortical insufficiency the normal requirement is 20 to 30 mg
daily (usually taken in 2 doses, the larger in the morning and the smaller in
the early evening, to mimic the circadian rhythm of the body). Additional
sodium chloride may be required if there is defective aldosterone secretion,
but mineralocorticoid activity is usually supplemented by fludrocortisone
acetate orally. Similar regimens have also been used to correct
glucocorticoid deficiency in the salt-losing form of congenital adrenal
hyperplasia (
).
Hydrocortisone may be given intravenously, by slow injection or infusion,
in the form of a water-soluble derivative such as hydrocortisone sodium
succinate or hydrocortisone sodium phosphate when a rapid effect is
required in emergencies: such conditions are acute adrenocortical
insufficiency caused by Addisonian or post-adrenalectomy crises, by the
abrupt accidental withdrawal of therapy in corticosteroid-treated patients, or
by the inability of the adrenal glands to cope with increased stress in such
patients; certain allergic emergencies such as anaphylaxis; acute severe
asthma (status asthmaticus—see also
); and shock. The usual dose is
the equivalent of 100 to 500 mg of hydrocortisone, repeated 3 or 4 times in
24 hours, according to the severity of the condition and the patient's
response. Fluids and electrolytes should be given as necessary to correct any
associated metabolic disorder. Similar doses to those specified above may
also be given intramuscularly but the response is likely to be less rapid
than that seen after intravenous doses. Corticosteroids are considered to be
of secondary value in anaphylactic shock because of their relatively slow
onset of action, but intravenous hydrocortisone may be a useful adjunct to
adrenaline to prevent further deterioration in severely affected patients.
For doses used in children, see
.
In patients with adrenal deficiency states supplementary corticosteroid
therapy may be necessary during some surgical operations and
hydrocortisone sodium succinate or sodium phosphate may be given
intramuscularly or intravenously before surgery. Various regimens have
been proposed (see also Surgery,
). In patients taking more than 10 mg
of oral prednisolone or its equivalent daily, the BNF 59 recommends the
following regimen:
minor surgery under general anaesthesia, either the usual oral
corticosteroid dose on the morning of surgery or hydrocortisone 25 to
50 mg (usually as the sodium succinate) intravenously at induction; the
usual oral corticosteroid dose is resumed after surgery
moderate or major surgery, the usual oral corticosteroid dose on the
morning of surgery, plus hydrocortisone 25 to 50 mg intravenously at
induction, and followed by similar doses of hydrocortisone 3 times daily,
for 24 hours after moderate surgery and 48 to 72 hours after major
surgery; the usual corticosteroid dose is resumed once hydrocortisone
injections are stopped
For local injection into soft tissues hydrocortisone is usually used in the
form of the sodium phosphate or sodium succinate esters; doses in terms of
hydrocortisone are usually 100 to 200 mg. For intra-articular injection
hydrocortisone acetate is usually used in doses of 5 to 50 mg depending
upon the size of the joint.
For topical application in the treatment of various skin disorders
hydrocortisone and the acetate, buteprate, butyrate, and valerate esters are
normally employed in creams, ointments, or lotions. Concentrations usually
used have ranged from 0.1 to 2.5%. Although it is considered that
hydrocortisone has fewer adverse effects on the skin and is less liable to
cause adrenal suppression than the more potent topical corticosteroids (see
for a rough guide to the clinical potencies of topical corticosteroids), it
should be borne in mind that this property may be considerably modified
both by the type of formulation or vehicle used and by the type of
esterification present; other factors that may also influence the degree of
absorption include the site of application, use of an occlusive dressing, the
degree of skin damage, and the size of the area to which the preparation is
applied.
Hydrocortisone or its esters are also available in a variety of other dosage
forms including those for ophthalmic, aural, dental, and rectal application,
for use in allergic and inflammatory disorders.
Other esters of hydrocortisone that have occasionally been used include the
aceponate, caproate, glycyrrhetinate, and propionate. Esters such as the
aceponate may show modified topical activity.
(last reviewed 2010-07-28; last modified 2010-08-04)
Administration in children (Latest modification: 24-Jun-2010)
When given orally as replacement therapy in adrenocortical insufficiency,
the BNFC 2009 suggests that neonates and children aged from 1 month to
18 years of age may be given hydrocortisone in usual doses of 4 to
5 mg/m2 every 8 hours, although higher doses may be needed. Larger
portions of the daily dose are given in the morning and smaller portions in
the evening. In congenital adrenal hyperplasia, initial oral doses of 6 to
7 mg/m2 every 8 hours may be used in neonates, and 5 to 6.5 mg/m2
every 8 hours in children aged from 1 month to 18 years old; again, higher
doses may be needed and the dose should be adjusted according to
response.
When used intravenously for emergencies such as acute adrenocortical
insufficiency, the following doses may be given:
neonates: initially 10 mg as a slow injection, then 100 mg/m2 daily as a
continuous infusion or in divided doses every 6 to 8 hours; the dose
should be adjusted according to response and, when stable, reduced
over 4 to 5 days to an oral maintenance dose
1 month to 12 years old: initially 2 to 4 mg/kg as a slow injection or
infusion, then 2 to 4 mg/kg every 6 hours; the dose should be adjusted
according to response and, when stable, reduced over 4 to 5 days to an
oral maintenance dose
12 to 18 years old: 100 mg every 6 to 8 hours by slow injection or
infusion
(last reviewed 2010-07-28; last modified 2010-06-24)
Preparations (Latest modification: 01-Jul-2013)
Single-ingredient Preparations (Latest modification: 01-Jul-2013)
The symbol ¤ denotes a preparation which is discontinued or no longer
actively marketed.
Argentina: Alfacort; Anusol-HC; Azuthidrona; Cortenem¤; Demacort;
Efficort¤; Fridalit; Hidrotisona; Idenona¤; Lactid HC; Locoid; Medrocil;
Microsona; Oralsone; Proavenal H; Schericur¤; Sirotamicin HC; Stiefcortil;
Transderma H; Australia: Adacor¤; Colifoam; Corlan¤; Cortaid¤; Cortef;
Cortic; Derm-Aid; Dermacort¤; DermAid; Efcortelan¤; Egocort; Hycor;
Hydrosone¤; Hysone-A¤; Hysone; Nordicort¤; Procort¤; Sigmacort; Siguent
Hycor; Solu-Cortef; Squibb-HC¤; Austria: Colifoam; Ekzemsalbe F; Hydoftal
sine neomycino¤; Hydrocortone; Hydroderm; Locoidon¤; Retef¤;
Schericur¤; Belgium: Azacortine; Buccalsone¤; Colifoam¤; Cortril¤;
Cremicort-H; Locoid; Nozema¤; Pannocort; Sential Hydrocortisone¤; SoluCortef; Brazil: Androcortil; Ariscorten; Benzenil; Berlison; Cortisonal;
Cortiston; Cortizol; Cortizon¤; Flebocortid¤; Hicortin¤; Hidrocol¤;
Hidrocortex; Hidyn H; Locoid; Nutracort; Solu-Cortef; Stiefcortil; Therasona;
Westcort¤; Canada: A-Hydrocort¤; Alocort¤; Aquacort¤; Barriere-HC;
Claritin Skin Itch Relief; Cortacet¤; Cortamed; Cortate; Cortef; Cortenema;
Corticreme¤; Cortifoam; Cortiment¤; Cortoderm; Dermaflex HC; Dermarest
Dricort Anti-Itch¤; Emo-Cort; Hycort; Hyderm; Hydrosone; HydroVal;
Lanacort¤; Neo-HC¤; Novo-Hydrocort; Prevex HC; Rectocort¤; Sarna HC;
Solu-Cortef; Soothing Cream; Texacort¤; Unicort¤; Westcort¤; Chile:
Aquanil HC¤; Calmurid; Cortisol; Efficort; Hipoge; Lacticare-HC¤; Locoid;
Nutracort; Nutralona¤; Pandel; Solu-Cortef; Vitulpas¤; China: Efficort;
Locoid; Youzhouer; Czech Republic: Laticort¤; Locoid; Solu-Cortef¤;
Denmark: Colifoam; Dermil¤; Hyderm; Locoid; Mildison; Plenadren; SoluCortef; Uniderm¤; Finland: Ampikyy; Apocort; Bucort; Colifoam; Cortril¤;
Dermacort¤; Hyderm; Kyypakkaus; Locoid; Mildison¤; Nutracort¤; SoluCortef; Uniderm¤; France: Aphilan; Calmicort; Colofoam; Cortapaisyl;
Cortisedermyl; Dermaspraid Demangeaison¤; Dermaspray demangeaison¤;
Dermofenac; Efficort; Hydracort¤; Locoid; Mitocortyl¤; Proctocort¤;
Germany: Alfason; Colifoam; Cordes H¤; Dermallerg¤; Dermo Posterisan¤;
Ebenol; Ekzesin¤; Fenistil Hydrocort¤; Ficortril; Glycocortison¤; HydroWolff¤; Hydrocort Mild¤; Hydrocort¤; Hydrocutan mild¤; Hydrocutan;
Hydroderm HC¤; Hydrogalen; Laticort; Latimit¤; Linola Akut; Linolacort
Hydro; Muni; Munitren¤; Neuroderm Akut; Pandel¤; Posterine Corte¤;
Posterisan cort; ratioAllerg¤; Remederm HC¤; Retef; Sagittacortin¤;
Sanatison Mono¤; Schericur¤; Scheroson F¤; Soventol HC¤; Soventol
HydroCort; Soventol HydroSpray; Systral Hydrocort; velopural¤; Greece:
Colifoam; Filocot; Lyo-Cortin; Nutracort; Rolak; Solu-Cortef; Hong Kong:
BF-Hycort¤; Cortef; Corticreme¤; Cortosone¤; Derm-Aid; Dhacort; Efficort¤;
Egocort; Hycortin¤; Hydrosone; Hytisone; Lacticare-HC¤; Rectocort¤;
Sigmacort; Solu-Cortef; Uni-Cort¤; Hungary: Cortef; Laticort; Locoid; SoluCortef; India: Arvisone; Cardol; Cipcorlin; Cort-H; Cort-S; Cortygard;
Cutisoft; Efcorlin; Eldercoid; Entofoam; Geocort; H-Cort; Hisone; Hobutide;
HS; Hy-Sone; Hycort; Hycoson; Hyss; Hyver; Intacorlin; Irays; Labocort;
Lacticare-HC; Locoid; Lycor; Lycortin-S; M-Cort; Multicort; Niscort;
Novacort; Wycort; Indonesia: Berlicort; Calacort¤; Enkacort; Lexacorton;
Locoid¤; Steroderm¤; Ireland: Colifoam; Corlan; Cortopin; Dioderm;
Efcortelan Soluble¤; Emucream HC¤; Hc45; Hydrocortisyl; Hydrocortone;
Locoid; Mildison¤; Plenadren; Solu-Cortef; Israel: Colifoam¤; Cortifoam;
Cortizone; Efficort; Hydrocort¤; Lanacort; Solu-Cortef; Italy: Algicortis¤;
Colifoam; Cortaid¤; Cortidro; Cortop; Dermirit; Dermocortal; Efficort¤;
Flebocortid; Foille Insetti; Idracemi; Idrocortigamma¤; Lanacort; Lenirit;
Locoidon; Novocortal¤; Paro¤; Rapicort¤; Sintotrat; Solu-Cortef;
Urecortyn¤; Japan: Pandel; Saxizon; Malaysia: Derm-Aid; Dhacort¤;
Efficort; Egocort; H-Cort; Hycort; Hydrocort; Solu-Cortef; Mexico: Aquanil
HC; Collicort¤; Efficort; Fadol¤; Flebocortid; Flemex; Icorsan; Lacticare-HC;
Locoid; Microsona; Nositrol; Nutracort; Solhidrol; Vicortin¤; Westcort;
Netherlands: Buccalsone¤; Cremicort; Hydro-Adreson¤; Locoid; Mildison¤;
Plenadren; Solu-Cortef; Zure oordruppels met hydrocortison; Norway:
Apocortal¤; Colifoam¤; Locoid; Mildison; Plenadren; Solu-Cortef; New
Zealand: BK HC; Colifoam; Cortaid¤; Derm-Aid; DP Hydrocortisone¤;
Egocort; Lemnis Fatty Cream HC; Lipocort; Locoid; Mildison; Skincalm;
Solu-Cortef; Philippines: Biocort; Clovisone; Cortin; Cortizan; Costeron-H;
Droxiderm; Efficort; Hovicor; Hycort; Hycortil; Hydrotopic; Lacticare-HC;
Ocecor; Pharmacort; Primacort; Solu-Cortef; Sorvilor; Stericort; Syntesor;
Poland: Corhydron; Hydrocort; Laticort; Locoid; Procortin; Portugal:
Colifoam; Dermimade Hidrocortisona¤; Hidalone; Hydrocortone; Lactisona;
Locoid; Pandel; Pandermil; Rapicort; Solu-Cortef; Russia: Cortef (Кортеф);
Laticort (Латикорт); Locoid (Локоид); Solu-Cortef (Солу-кортеф)¤;
Sopolcort N (Сополькорт Н)¤; South Africa: Biocort; Colifoam¤; Covocort;
Cutaderm¤; Dilucort; Locoid; Mezzoderm; Mylocort; Procutan; Skincalm;
Solu-Cortef; Stopitch; Singapore: Cortisone; Derm-Aid; Dhacort; Efficort;
Egocort; H-Cort; Hydro-Adreson¤; Hydrocort; Hydroderm; Nu-Derm
Tolereen¤; Solu-Cortef; Spain: Actocortina; Aftasone; Calmiox; Ceneo;
Crema Transcutan Astier¤; Derminovag¤; Dermosa Hidrocortisona;
Hemodren; Hemorrane; Hidroaltesona; Hidrocisdin; Isdinium; Lactisona;
Nutrasona; Oralsone; Picosyl¤; Scalpicin Capilar¤; Schericur; Suniderma;
Supralef¤; Sweden: Amberin¤; Colifoam; Ficortril; Hyderm; Locoid;
Mildison; Solu-Cortef; Solu-Glyc¤; Uniderm¤; Switzerland: Alfacortone;
Colifoam¤; Dermacalm¤; Glycocortisone H¤; Hydrocortone; Locoid;
Sanadermil; Solu-Cortef; Thailand: H-Cort; HC; Hydro-Adreson¤; Hytisone;
Lacticare-HC; Prevex HC¤; Solu-Cortef; Turkey: Cortimycine; Hipokort;
Locoid; United Arab Emirates: Alfacort; United Kingdom: Anflam¤;
Colifoam; Corlan¤; Cortacream Bandage¤; Cortenema¤; Cortopin;
Cortropin; Dermacort; Dioderm; Efcortelan Soluble¤; Efcortelan¤;
Efcortesol; Exe-Cort; Hc45; Hydrocortistab; Hydrocortisyl¤; Hydrocortone¤;
Jungle Formula Sting Relief Cream¤; Lanacort; Locoid; Mildison; Plenadren;
Solu-Cortef; Timocort¤; Waspeze Hydrocortisone¤; Zenoxone; Ukraine:
Laticort (Латикорт); Locoid (Локоид); Solu-Cortef (Солу-Кортеф); United
States: A-Hydrocort; Acticort; Aeroseb-HC¤; Ala-Cort; Anucort-HC;
Anuprep HC¤; Aquanil HC; Bactine; CaldeCort; Carmol HC; Cetacort;
Colocort; Cort-Dome; CortaGel¤; Cortaid; Cortef Feminine Itch; Cortef;
Cortenema¤; Corticaine¤; Cortifair¤; Cortifoam; Cortizone; Cortril¤;
Delcort¤; Dermacort¤; Dermarest Dri-Cort; Dermol HC; Dermolate; EarSolHC; Gynecort; Hemril-HC; Hi-Cor; Hycort¤; Hydrocortone; HydroSkin;
HydroTex¤; Hytone; Itch-X; Lacticare-HC¤; Lanacort; Locoid; Massengill
Medicated; Maximum Strength Dermarest Dricort¤; Maximum Strength
KeriCort-10¤; Neutrogena T/Scalp; no more itchies¤; NuCort; Nutracort;
Orabase HCA; Pandel; Penecort; Preparation H Hydrocortisone¤; Procort¤;
Proctocort; Proctocream HC 2.5%¤; Recort Plus; Rectacort-HC; S-T Cort¤;
Scalacort DK; Solu-Cortef; Synacort; Tegrin-HC; Texacort; U-Cort;
Westcort; Xerese; Venezuela: Corticina; Efficort; Hidrocort; Hidrozona;
Histasona¤; Lacticare-HC¤; Liocort; Nutracort; Pantocort¤; Solu-Cortef;
Stricort;
Multi-ingredient Preparations (Latest modification: 27-Jun-2013)
The symbol ¤ denotes a preparation which is discontinued or no longer
actively marketed.
Argentina: Aeromicrosona C¤; Alercortil¤; Altus; Antibiocort; Anusol Duo S;
Anusol Duo; Anusol-HC; Atomoderma Plus; Bactisona¤; Bexon; Biocortin¤;
Butimerin Complex; Cipro HC; Ciprocort; Ciprocort; Ciproflox-Otic¤; Cirflox
Otic; Ciriax Otic L; Ciriax Otic; Colirio Antibiotico CNH; Cristalomicina NF;
Cristalomicina; Delos Otic; Dercotex; Derivoco¤; Dermoperative; Disel
Hidrocortisona; Epiprocto¤; Epiprocto; Fucidin H; Gargadrin-R; Gentacler;
Gramicortil¤; Gripace; Griseoplus; Hidrocortin¤; Hipoglos con
Hidrocortisona; Irigal; Labsa Otic L; Labsa Otic; Lactiderm HC¤; Lidocort
Proct; Linfol Dermico; Magicrem; Magnal; Masivol Urea; Micozol
Compuesto¤; Microsona C; Microsona Otica; Monizol Cort; Otex HC; Oto
Biotaer¤; Otobiotic; Otocipro; Otolef HC; Otoseptil; Otosporin C; Otosporin
L; Otosporin; Procto-Ikatral; Proctocrem; Proctyl HC; Prootocipro;
Prurisedan Biotic¤; Quemicetina con Hidrocortisona; Reacur¤; Start NP¤;
Terra-Cortril Nistatina¤; Terra-Cortril; Tocorectal; Tricur; Tridermal;
Triefect¤; Vagicural; Xilocler; Xyloprocto; Australia: Acne-Sol¤;
Aerocortin¤; Anusol-HC¤; Chlorocort¤; Ciproxin HC; Hydroform; Hydrozole;
Neo Hycor¤; Neo-Cortef¤; Plegettes¤; Proctocort¤; Proctosedyl; Rectinol
HC¤; Resolve Plus; Soov It; Vioform-Hydrocortisone¤; Xyloproct; Austria:
C-Bildz¤; Calmurid HC¤; Ciproxin HC¤; Cortison Kemicetin¤; Daktacort¤;
Ecomytrin-Hydrocortison¤; Endomethazone¤; Hydoftal; Hydrocortimycin¤;
Hydrodexan¤; Ichtho-Cortin¤; Otosporin; Systrason¤; Terra-Cortril mit
Gentamicin¤; Terra-Cortril mit Polymyxin B-Sulfat¤; Terra-Cortril¤;
Tropoderm¤; Belgium: Alphaderm¤; Daktacort; Dolanal¤; Eoline¤; Fucidin
Hydrocortisone; Onctose a l'Hydrocortisone¤; Otosporin¤; Pimafucort¤;
Sulfo-Selenium¤; Terra-Cortril + Polymyxine B; Terra-Cortril; Xyloproct¤;
Brazil: Anusol-HC; Cipro HC; Cliotisona; Dermilan¤; Elocort¤; Furazolon¤;
Gingilone; Hemodase; Hemodotti¤; Hermodotti¤; Hidrocorte; Hidroneo¤;
Hipoglos Oftalmico¤; Infladerm¤; Nitrolerg¤; Otociriax; Otosporin; TerraCortril com Polimixina B¤; Terra-Cortril; Vioformio-Hidrocortisona;
Xyloproct; Canada: Actinac¤; Anodan-HC; Anugesic-HC; Anusol-HC;
Anuzinc HC Plus; Anuzinc HC; Calmurid HC¤; Cipro HC¤; Coly-Mycin Otic¤;
Cortimyxin; Cortimyxin; Cortiphenol H¤; Cortisporin; Cortisporin; Diospor
HC¤; Egozinc-HC; Endomethasone; Fucidin H; HC-Atropine¤; Neo-Cortef¤;
Ophthocort¤; Otizol-HC¤; Pentamycetin-HC; Pramox HC; Proctodan-HC;
Proctofoam-HC; Proctol; Proctomyxin HC; Proctosedyl; ratio-Hemcort-HC;
ratio-Proctosone; Rectogel HC; Rivasol HC; Sential¤; Sopamycetin/HC¤;
Spor-HC; Sterex Plus¤; Ti-U-Lac HC¤; Uremol-HC; Vanoxide-HC¤; VioformHydrocortisone; VoSoL HC¤; Chile: Cortifenol H¤; Fucidin H; Otex HC;
China: Posterisan; Czech Republic: Ciprobay HC Otic¤; Dobexil Plus¤;
Fucidin H; Ophthalmo-Framykoin Compositum; Otosporin¤; Pimafucort;
Proctosedyl¤; Septomixine; Xerclear; Denmark: Brentacort; Ciflox; FucidinHydrocortison; Hydrocortison med Terramycin og Polymyxin-B;
Hydrocortison med Terramycin; Locoidol¤; Proctosedyl; Xerclear; Finland:
Ciproxin-Hydrocortison; Daktacort; Duocort; Fucidin-Hydrocortison;
Locoidol¤; Oftan C-C; Pantyson; Pimafucort; Proctosedyl; Sibicort; TerraCortril P; Terra-Cortril; Trosycort; Xyloproct¤; France: Actidilon
Hydrocortisone¤; Anti-Hemorroidaires¤; Anusol a l'Hydrocortisone¤;
Arthrisone¤; Auriswell¤; Bacicoline; Biocidan-Hydrocortisone¤; Carbo-Cort¤;
Cortexan Framycetine; Cortibiotique¤; Cortneo¤; Cutisan a
l'Hydrocortisone¤; Daktacort¤; Dermiclone¤; Dermocalm¤; Dermokalixan¤;
Dulcicortine¤; Jadit-Hydrocortisone¤; Locoide N¤; Madecassol Neomycine
Hydrocortisone¤; Onctose Hydrocortisone; Phleboidine¤; Rhinosterine a
l'Hydrocortisone et a la Framycetine¤; Rhinosterine a l'Hydrocortisone¤;
Septomixine; Soframycine Hydrocortisone Gramicidine¤; Soframycine
Hydrocortisone¤; Stovalone¤; Terramycine Hydrocortisone¤; VitaseptineHydrocortisone¤; Germany: Achromycin¤; Alfason-Fucidine¤; Antiprurit¤;
Anusol + H¤; Baycuten HC; Bykomycin F¤; Calmurid HC¤; Canesten HC¤;
Condilan¤; Corti Jaikal¤; Corti-Flexiole¤; Corti-Refobacin¤; Cortiphenol H¤;
Daktar-Hydrocortison¤; Dermaethyl-H¤; Ecomytrin H¤; Efisol-H¤; Eksalb¤;
Ekzemex¤; Farco-Tril¤; Ficortril Lotio m. Neomycin¤; Fucidine H; Fucidine
plus¤; Fungisalb¤; Hydrodexan; Ichthocortin; Kolpicortin¤; Novifort¤; Nubral
4 HC¤; Nystaderm comp; Otosporin¤; Pantocrinale¤; Pigmanorm;
Pimafucort¤; Pimarektal¤; Poloris HC¤; Polycid N¤; Polyspectran HC;
Polyspectran OS¤; Posterisan Forte¤; Potanal¤; Proctofoam-HC¤; Psoil¤;
Soorphenesin-H¤; Tampovagan C-N N¤; Terracortril¤; Topoderm N¤; TrichoKolpicortin¤; Tropoderm¤; Xylocain¤; Greece: Ciprobay; Ciprofloxacin HY¤;
Cortiphenol H; Daktodor; Endomethasone¤; Eyecort; Fucidin H; Fusindac-H;
Hemorroidal-H; Hydrofusin; Ichthocortex; Neo-Otil; Proctosedyl-N; TerraCortril; Xyloproct; Hong Kong: Anusol-HC¤; Axcel Fungicort¤; Candacort;
Canesten HC; Cipro HC; Cliocort¤; Corticin¤; Cortiphenol H¤; Cortison
Kemicetine¤; Daktacort; Fucidin H; Hemcort HC¤; Hydro-Funga¤; HydrocinN¤; Hydrocort & Neomycin Biorex¤; Micosone; Neosone¤; Otosporin;
Posterisan Forte; Proctosedyl¤; Proctosone¤; Protozone¤; Uni-Cort-N¤; UniMizole-HC¤; Uni-Rax-HC¤; Xyloproct; Zaricort¤; Hungary: Chlorocid-H¤;
Ciprobay¤; Fucidin H; Otosporin; Oxycort; Pimafucort; Posterisan Forte;
Tetran-Hydrocortison; India: A-Ret HC; Acsolve-H; Anaproct; Anomex; Bell
Diono Resolvent¤; Bell Resolvent¤; Belmycetin-C¤; Cortecyclin; Cortison
Kemicetine¤; Cortola-M; Cortoquinol; Crotorax-HC; Daktacort; Derobin-HC;
Drocort; Efcorlin; Fucidin H; Furacin-S¤; Fuson-H; Gentasporin-HC; Genticyn
HC; Hydrozole; Keralin; Medithane; Melalite Plus; Melanorm-HC; Multifungin
H; Neosporin-H; Neosporin-H; Pino-Cort¤; Proctosedyl; Shield; Wycort with
Neomycin; Indonesia: Anusol-HC¤; Brentan; Chloramphecort; Dermacort;
Enpicortyn; Haemocaine; Indoson; Kemiderm; Nufacort; Particol¤;
Ramicort; Sancortmycin; Terra-Cortril; Thecort; Viohydrocort; Visancort;
Zolacort; Ireland: Actinac¤; Alphaderm; Alphosyl HC¤; Anugesic-HC;
Anugesic-HC; Anusol-HC; Calmurid HC; Canesten HC; Cortucid¤; Daktacort;
Eurax-Hydrocortisone; Fucidin H; Genticin HC¤; Gentisone HC; Hydrocal¤;
Locoid C¤; Multifungin H¤; Neo-Cortef¤; Nystaform-HC¤; Otosporin; Perinal;
Proctofoam-HC; Proctosedyl; Quinocort¤; Terra-Cortril Nystatin¤; TerraCortril¤; Timodine; Vioform-Hydrocortisone¤; Xyloproct¤; Israel: Alphosyl
HC¤; Benzantine H; Calmurid HC¤; Ciproxin HC¤; Daktacort; Epifoam;
Fucidin H; Hycocin; Hycomycin; Hydroagisten; Otosporin¤; Panthisone;
Perinal; Procto-Glyvenol¤; Proctofoam-HC; Proctosedyl¤; Proctozorin-N;
Xyloproct¤; Italy: Antiemorroidale Milanfarma¤; Argisone; Cort-Inal;
Cortilen TC¤; Cortison Chemicetina; Daktacort¤; Emorril; Epartisone¤;
Flogosone¤; Fucidin H; Idracemi Eparina; Idracemi; Idrocet¤; Idroneomicil¤;
Kinogen; Mediflox; Mictasone¤; Mixotone; Mobilat¤; Molidex¤; Nasomixin¤;
Neocortigamma¤; Neocortovol¤; Nevacort; Oftalmosporin¤; Otobiotic¤;
Pimafucort¤; Pomata Midy HC¤; Prepacort H; Preparazione
Antiemorroidaria¤; Proctidol¤; Proctofoam-HC; Proctosedyl; Proctosedyl;
Proctosoll; Reumacort; Scalpicin; Sedalen Cort¤; Sinrinal¤; Sinsurrene¤;
Vasosterone Antibiotico¤; Vasosterone Collirio¤; Vasosterone¤; Xyloproct¤;
Malaysia: Becacort¤; Candacort; Cipro HC¤; Crotamiton H; Daktacort;
Decocort; Foban-Hydro; Fucidin H; Liproct; Miconazole H¤; Neo-Hydro¤;
Pocin H; Proctosedyl; Proctosone¤; Setarin H¤; Ucort; Xyloproct; Zaricort;
Mexico: Angenovag; Biotarson N¤; Ciproxina HC; Clioderm-H¤; Cortisporin;
Daktacort; Dermanol; Dermucor-H; Hidrofenil¤; Hidropolicin¤; Litiset;
Ofodex; Orecil NF; Otifar; Otiser; Oto Eni; Otolone¤; Poral; Sodrimax;
Soldrin; Sulfa Hidro¤; Ultracortin¤; Vioformo-Cort; Xyloderm; Xyloproct
Plus; Netherlands: Alphacortison¤; Bacicoline-B; Calmurid HC; Daktacort;
Fucidin + Hydrocortisone¤; Otosporin; Pimafucort; Proctofoam-HC¤;
Proctosedyl; Terra-Cortril Gel Steraject met polymyxine-B¤; Terra-Cortril
met polymyxine-B; Terra-Cortril¤; Xyloproct¤; Norway: Corticyklin¤;
Cortikinol¤; Cortimyk¤; Daktacort; Ecomytrin-Hydrocortison¤; FucidinHydrocortison; Locoidol¤; Proctosedyl; Salvizol med Hydrocortison¤; TerraCortril Polymyxin B; Terra-Cortril; Xyloproct¤; New Zealand: Ciproxin HC;
Coly-Mycin S Otic¤; Daktacort; DP Lotion - HC; Fungocort¤; Locoid C;
Micreme H; Pimafucort; Proctosedyl; Resolve Plus; Xyloproct; Philippines:
Candacort; Cortisporin; Daktacort; Fucidin H; Hydrospor; Ircos; Isonep H;
Proctosedyl; Trimycin-H; Poland: Atecortin; Chlorchinaldin H; Daktacort¤;
Hemcort HC¤; Hemkortin-HC; Laticort-CH¤; Oxycort; Pimafucort; Posterisan
H; Proctosone¤; Proktosedon; Portugal: Alphosyl HC¤; Anucet¤; Anucet;
Clorcorticil¤; Corticil T¤; Daktacort; Davimicina¤; Fucidine H; Leuco
Hubber¤; Locoid C¤; Otolys¤; Otosporin; Pimafucort; Proctonostrum¤;
Russia: Cortomycetin (Кортомицетин); Fucidin H (Фуцидин Г); Gioxyson
(Гиоксизон); Oxycort (Оксикорт); Pimafucort (Пимафукорт); Posterisan
Forte (Постеризан Форте); Proctosedyl (Проктоседил); Proctosedyl M
(Проктоседил М); Relief Ultra (Релиф Ультра); Sulfodecortem
(Сульфодекортэм); South Africa: Anusol-HC¤; Calmurid HC¤; Chloramex
H¤; Ciprobay HC; Corti-Flexiole¤; Daktacort; Elozart; Fucidin H; Locoid C¤;
Manoderm¤; Nasomixin¤; Neoderm; Otoseptil¤; Otosporin; Proctofoam¤;
Proctosedyl; Quinoderm-H¤; Terra-Cortril¤; Viocort; Singapore: Axcel
Fungicort; Candacort; Canesten HC; Ciprobay HC; Cortaid with Aloe¤;
Crotorax-HC; Daktacort; Decocort; Fucidin H; Hydroderm-C; Micon-H; NeoCortisone; Neo-Hydro; Otosporin; Proctosedyl; Ucort; Xyloproct¤; Zaricort;
Spain: Aftajuventus; Aftasone B C; Alantomicina Complex¤; Anginovag;
Antialergico¤; Antiblef Eczem¤; Antihemorroidal¤; Antihemorroidal;
Antiinflamat¤; Bacisporin; Brentan; Cilinafosal Hidrocortisona¤; Cinfaotin¤;
Ciproxina; Cohortan Antibiotico¤; Cohortan¤; Cohortan; Cortenema¤;
Cortison Chemicet Topica; Cortos¤; Dermacortine¤; Dermisone Hidroc
Neomic¤; Dermo Hubber; Detraine; Ecomitrin¤; Eczemacort¤; Edifaringen;
Euraxil Hidrocort¤; Fucidine H; Ginesona¤; Gingilone Comp¤; Grietalgen
Hidrocort¤; Grinal Hidrocortisona¤; Halibut Hidrocortisona¤; Hemodren
Compuesto¤; Hepro; Heridasone¤; Hidroc Clora¤; Hidroc Cloranf¤; Hidroc
Neomic¤; Hidrocort Neom¤; Indertal¤; Leuco Hubber; Milrosina Hidrocort¤;
Milrosina Nistatina¤; Nasal Rovi¤; Nasokey¤; Neo Bacitrin Hidrocortis¤; Neo
Hubber; Neo Visage¤; Oftalmo¤; Ophtacortine¤; Oto Difusor¤; Oto Neomicin
Calm¤; Oto Vitna¤; Otocaina Hidrocort¤; Otogen Hydrocortisona¤;
Otorrilan¤; Otosporin¤; Polirino¤; Puodermina Hidrocor¤; Rino Vitna¤;
Rinocusi Descong¤; Roberfarin; Sulfo Selenio¤; Syner Atom¤; Terra-Cortril;
Terra-Cortril; Tetra Hubber Otico¤; Tisuderma; Tododermil¤;
Tyroneomicin¤; Xilorroidal¤; Sweden: Calmuril-Hydrokortison¤;
Chloromycetin Hydrocortison¤; Cortimyk; Daktacort; EcomytrinHydrocortison¤; Fenuril-Hydrokortison; Fucidin-Hydrocortison; Proctosedyl¤;
Sterosan-Hydrocortisone¤; Terracortril med polymyxin B; Terracortril;
Xerclear; Xyloproct; Switzerland: Antiprurit¤; Bacicoline¤; Calmurid HC¤;
Ciproxin HC; Cortifluid N; Cortimycine¤; Cortiphenol H¤; Daktacort;
Dermacalm-d; Ecomytrin-Hydrocortison¤; Endomethasone¤; EuraxHydrocortisone¤; Fucidin H; Haemocortin¤; Hydrocortisone compositum¤;
Neo-Hydro; Otosporin¤; Proctosedyl¤; Quinoderm Hydrocortisone¤; Rocanal
Permanent Gangrene¤; Septomixine; Terracortril¤; Thailand: Antergan;
Candacort; Daktacort; Decocort¤; Dermasol; Doproct; Fucidin H; Ladocort;
Neo-Hytisone¤; Otosporin¤; Proctosedyl; Xyloproct¤; Turkey: Cormisin¤;
Fucidin H; Hipokort Arti; Kortos; Kortos; Ma-Ka-Ta; Ureacort; United
Kingdom: Actinac¤; Alphaderm; Alphosyl HC¤; Anugesic-HC¤; AnugesicHC; Anusol-HC, Plus HC; Barquinol HC¤; Calmurid HC; Canesten HC; CarboCort¤; Chloromycetin Hydrocortisone¤; Cobadex¤; Cortucid¤; Daktacort HC;
Daktacort; Econacort¤; Eczederm with Hydrocortisone¤; Epifoam¤; Eurax
Hc; Framycort¤; Fucidin H; Genticin HC¤; Gentisone HC; Germoloids HC;
Gregoderm¤; Hydrocal¤; Hydroderm¤; Hydromol HC Intensive; Locoid C¤;
Neo-Cortef¤; Nystaform-HC; Otosporin; Perinal; Proctocream HC¤;
Proctofoam-HC; Proctosedyl; Quinocort¤; Quinoderm with Hydrocortisone¤;
Sential HC¤; Tarcortin¤; Terra-Cortril Nystatin¤; Terra-Cortril¤; TerraCortril; Timodine; Tri-Cicatrin¤; Uniroid-HC; Uniroid¤; VioformHydrocortisone¤; Xyloproct; Ukraine: Anginovag (Ангиноваг); Oxycort
(Оксикорт); Pimafucort (Пимафукорт); Proctosedyl (Проктоседил); Relief
Ultra (Релиф Ультра); United States: 1 + 1-F; AA-HC Otic¤; Acetasol HC;
Ak-Spore HC¤; Ala-Quin¤; Albaform HC¤; Alcortin A; Alphaderm¤; Analpram
E; Analpram-HC; AnaMantle HC¤; AntibiOtic¤; Anumed HC; Bacticort¤;
Bencort; Chloromycetin Hydrocortisone¤; Cipro HC; Coly-Mycin S Otic;
Coracin¤; Corque; Cortamox¤; Cortane-B; Cortatrigen; Cortic ND;
Corticaine¤; Cortimycin; Cortimycin; Cortisporin-TC; Cortisporin¤;
Cortisporin; Cyotic; Dermtex HC with Aloe; Drotic¤; Ear-Eze¤; Emergent-Ez;
EndaRoid; Enzone; Epifoam; First Duke's Mouthwash; First Mary's
Mouthwash; Fungoid HC; HC Derma-Pax; HC Pram; HC Pramoxine; HydroIodoquinol; Hysone; Iodo-Cortifair¤; Keratol HC; LazerSporin-C; LidaMantle
HC¤; LidoCort; Mantadil¤; Mayotic¤; Medicone Derma-HC¤; Mediotic-HC;
Neo-Cortef¤; Neotricin HC¤; Novacort; Octicair¤; Ophthocort¤; Oti-Med¤;
Otic-Care; Oticin HC; OtiTricin; Oto-End; Otobiotic; Otocort; Otomar-HC;
Otomycin-HPN; Otosporin; Pedi-Cort V¤; Pediotic¤; Pram-HCA; PramCort;
Pramosone; ProCort; Proctofoam-HC; Pyocidin-Otic¤; Terra-Cortril; TriOtic¤; TriOxin; UAD Cream or Lotion¤; UAD-Otic; Vanoxide-HC; Vioform-
Hydrocortisone¤; VoSoL HC; Vytone; Xolegel CorePak; Xyralid; Zone-A;
Zoto-HC; ZyPram; Venezuela: Hipoglos con Hidrocortisona¤; Otalex;
Quinotic HC; Terra-Cortril¤;
Pharmacopoeial Preparations (Latest modification: 06-Feb-2013)
BP 2013: Gentamicin and Hydrocortisone Acetate Ear Drops;
Hydrocortisone Acetate and Neomycin Ear Drops; Hydrocortisone Acetate
and Neomycin Eye Drops; Hydrocortisone Acetate and Neomycin Eye
Ointment; Hydrocortisone Acetate Cream; Hydrocortisone Acetate Injection;
Hydrocortisone Acetate Ointment; Hydrocortisone Acetate Oral Suspension;
Hydrocortisone and Clioquinol Cream; Hydrocortisone and Clioquinol
Ointment; Hydrocortisone and Neomycin Cream; Hydrocortisone Cream;
Hydrocortisone Ointment; Hydrocortisone Oromucosal Tablets;
Hydrocortisone Sodium Phosphate Injection; Hydrocortisone Sodium
Phosphate Oral Solution; Hydrocortisone Sodium Succinate Injection;
Miconazole and Hydrocortisone Acetate Cream; Miconazole and
Hydrocortisone Cream; Miconazole and Hydrocortisone Ointment; USP 36:
Chloramphenicol and Hydrocortisone Acetate for Ophthalmic Suspension;
Chloramphenicol, Polymyxin B Sulfate, and Hydrocortisone Acetate
Ophthalmic Ointment; Clioquinol and Hydrocortisone Cream; Clioquinol and
Hydrocortisone Ointment; Colistin and Neomycin Sulfates and
Hydrocortisone Acetate Otic Suspension; Hydrocortisone Acetate Cream;
Hydrocortisone Acetate Injectable Suspension; Hydrocortisone Acetate
Lotion; Hydrocortisone Acetate Ointment; Hydrocortisone Acetate
Ophthalmic Ointment; Hydrocortisone Acetate Ophthalmic Suspension;
Hydrocortisone and Acetic Acid Otic Solution; Hydrocortisone Butyrate
Cream; Hydrocortisone Cream; Hydrocortisone Gel; Hydrocortisone
Injectable Suspension; Hydrocortisone Lotion; Hydrocortisone Ointment;
Hydrocortisone Rectal Suspension; Hydrocortisone Sodium Phosphate
Injection; Hydrocortisone Sodium Succinate for Injection; Hydrocortisone
Tablets; Hydrocortisone Valerate Cream; Hydrocortisone Valerate Ointment;
Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Cream;
Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Ophthalmic
Suspension; Neomycin and Polymyxin B Sulfates and Hydrocortisone
Ophthalmic Suspension; Neomycin and Polymyxin B Sulfates and
Hydrocortisone Otic Solution; Neomycin and Polymyxin B Sulfates and
Hydrocortisone Otic Suspension; Neomycin and Polymyxin B Sulfates,
Bacitracin Zinc, and Hydrocortisone Acetate Ophthalmic Ointment; Neomycin
and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ointment;
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone
Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin, and
Hydrocortisone Acetate Ointment; Neomycin and Polymyxin B Sulfates,
Bacitracin, and Hydrocortisone Acetate Ophthalmic Ointment; Neomycin and
Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Acetate Cream;
Neomycin Sulfate and Hydrocortisone Acetate Cream; Neomycin Sulfate and
Hydrocortisone Acetate Lotion; Neomycin Sulfate and Hydrocortisone
Acetate Ointment; Neomycin Sulfate and Hydrocortisone Acetate Ophthalmic
Ointment; Neomycin Sulfate and Hydrocortisone Acetate Ophthalmic
Suspension; Neomycin Sulfate and Hydrocortisone Cream; Neomycin Sulfate
and Hydrocortisone Ointment; Neomycin Sulfate and Hydrocortisone Otic
Suspension; Oxytetracycline Hydrochloride and Hydrocortisone Acetate
Ophthalmic Suspension; Oxytetracycline Hydrochloride and Hydrocortisone
Ointment; Polymyxin B Sulfate and Hydrocortisone Otic Solution;
Martindale: The Complete Drug Reference © 2013 The Pharmaceutical Press.
MedicinesComplete © The Pharmaceutical Press 2013