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(clindamycin hydrochloride capsules, USP) ® Antirobe Aquadrops (clindamycin hydrochloride liquid) Clindamycin Equivalent Activity (mcg/mL) Antirobe® C concentrations clindamycin occur 1 hour and 15 minutes after oral hydrochlorideofequivalent to 25 mg of clindamycin. dosing. The elimination half-life for clindamycin in dog serum was 75 mg Capsule, each green capsule contains clindamycin hydrochloride approximately 5 hours. There was no bioactivity accumulation after a equivalent to 75 mg of clindamycin. regimen of multiple oral doses in healthy dogs. 150 mg Capsule, each light blue and green capsule contains clindamycin Clindamycin Serum 0.5 Concentrations Cat Serum Levels: Serum levels or mg above μg/mL can be maintained hydrochloride equivalent toat150 of clindamycin. 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral by oral dosing at a rate of 5 mg/lb clindamycin liquid Doseof of Antirobe Capsules hydrochloride to Dogs mg Capsule, each light capsule contains clindamycin every300 24 hours. The average peakblue serum concentration of clindamycin 10 hydrochloride equivalent to 300 mg of clindamycin. occurs approximately 1 hour after oral dosing. The elimination half-life of clindamycin in feline serum is approximately In healthy ANTIROBE AQUADROPS Liquid (For Use7.5 in hours. Dogs and Cats) iscats, a palatable minimal accumulation occurs afteradministration. multiple oral doses formulation intended for oral Eachof mLclindamycin of ANTIROBE hydrochloride, and Liquid steady-state should be achieved by the third dose. to AQUADROPS contains clindamycin hydrochloride equivalent 25 mg clindamycin; andClindamycin ethyl alcohol, 8.64%. Serum Concentrations Microbiology: Clindamycin is a lincosaminide antimicrobial agent with activity against a wide variety of aerobic and anaerobic bacterial 0.1 pathogens. Clindamycin is a bacteriostatic compound that inhibits 0 5 10 15 20 25 bacterial protein synthesis by binding to the 5OS ribosomal sub-unit. The Time (hours) minimum inhibitory concentrations (MICs) of Gram-positive and obligate Metabolism and Excretion: Extensive studies of the metabolism and anaerobic isolated from dogs and cats in the orally UnitedinStates excretionpathogens of clindamycin hydrochloride administered animals areand presented in Table 1 and Table 2. Bacteria were isolated in 1998–1999. humans have shown that unchanged drug and bioactive and Allbioinactive MICs weremetabolites performed in accordance theand Clinical Laboratory are excreted inwith urine feces.and Almost all of the Standards Institute (CLSI). bioactivity detected in serum after ANTIROBE product administration is due to the parent molecule (clindamycin). Urine bioactivity, however, Table 1. Clindamycin Values (μg/mL) from metabolites, Diagnostic Laboratory reflects a mixture ofMIC clindamycin and active especially Survey Data Evaluating Canine Pathogens insulfoxide. the U.S. during 1998–991 N-demethyl clindamycin and clindamycin Organism of Site and Mode ofNumber Action: Clindamycin is an inhibitor of protein synthesis MIC85 toMIC Range 50 90 the 5OS sub-unit in the bacterial cell.Isolates The site ofMIC binding appears be in 2 of Tissue/Wound the ribosome. Binding occurs to the soluble RNA fraction of certain Soft ribosomes, thereby inhibiting the binding of amino acids to those Staphylococcus DESCRIPTION: ANTIROBE Capsules and ANTIROBE AQUADROPS Liquid Dog Serum Levels: Serum levels at or above 0.5 μg/mL can be maintained ribosomes. from cell wall it causes aureus Clindamycin 17 differs 0.5 0.5 inhibitors >4.0 in that 0.25–>4.0 contain clindamycin hydrochloride which is the hydrated salt of by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every irreversible modification of the protein-synthesizing subcellular elements Staphylococcus clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 12 hours. This same study revealed that average peak serum at the ribosomal level.28 intermedius 0.25 0.5 >4.0 0.125–>4.0 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced 0.1 concentrations of clindamycin occur 1 hour and 15 minutes after oral StaphylococcusClindamycin is a lincosaminide antimicrobial agent with antibiotic produced by Streptomyces lincolnensis var. lincolnensis. 0 6 12 18 24 Microbiology: 1.0 dosing. The elimination half-life for clindamycin in dog serum was spp. against a wide18variety of0.5aerobic and 0.5 anaerobic >4.0 bacterial 0.25–>4.0 Time (hours) activity approximately 5 hours. There was no bioactivity accumulation after a Beta-hemolytic ANTIROBE Capsules (For Use in Dogs Only): pathogens. Clindamycin is a bacteriostatic compound that inhibits regimen of multiple oral doses in healthy dogs. streptococci 46 by binding 0.5 0.5 5OS ribosomal >4.0 0.25–>4.0 Cat Serum Levels: Serum levels at or above 0.5 μg/mL can be maintained bacterial protein synthesis to the sub-unit. The ® Streptococcus by oral dosing at a rate of 5 mg/lb of clindamycin hydrochloride liquid 25 mg Capsule, each yellow and white capsule contains clindamycin minimum inhibitory concentrations (MICs) of Gram-positive and obligate Clindamycin Serum Concentrations spp. 11 0.5 >4.0 >4.0 0.25–>4.0 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral of clindamycin every 24 hours. The average peak serum concentration hydrochloride equivalent to 25 mg of clindamycin. anaerobic pathogens isolated from dogs and cats in the United States Dose of Antirobe Capsules to Dogs (clindamycin hydrochloride capsules, USP) occurs approximately 1 hour after oral dosing. The elimination half-life of are presented in Table 1 and Table 2. Bacteria were isolated in 1998–1999. 75 mg Capsule, each green capsule contains clindamycin hydrochloride 10 0.1 serum is approximately 7.5 hours. In healthy cats, clindamycin in feline All MICs were performed in accordance with the Clinical and Laboratory equivalent to 75 mg of clindamycin. ® 5 after 10 multiple 15 20 doses 25 of clindamycin minimal accumulation0 occurs oral Standards Institute (CLSI). Time (hours) 150 mg Capsule, each light blue and green capsule contains clindamycin hydrochloride, and steady-state should be achieved by the third dose. Metabolism and Excretion: Extensive studies of the metabolism and (clindamycin hydrochloride liquid) hydrochloride equivalent to 150 mg of clindamycin. Table 1. Clindamycin MIC Values (μg/mL) from Diagnostic Laboratory Clindamycin Serum Concentrations excretion of clindamycin hydrochloride administered orally in animals 5 mg/lb (11 mg/kg) After Single Oral Survey Data Evaluating Canine Pathogens in the U.S. during 1998–991 300 mg Capsule, each light blue capsule contains clindamycin of Antirobe drug Aquadrops Cats unchanged andtobioactive and Caution: Federal (USA) law restricts this drug to use by or on the order of and humans have shown that Dose hydrochloride equivalent to 300 mg of clindamycin. Organism Number of bioinactive metabolites10.0 are1 excreted in urine and feces. Almost all of the a licensed veterinarian. MIC85 MIC90 Range Isolates MIC50 ANTIROBE AQUADROPS Liquid (For Use in Dogs and Cats) is a palatable bioactivity detected in serum after ANTIROBE product administration is formulation intended for oral administration. Each mL ofAQUADROPS ANTIROBE Liquid due to the parent molecule (clindamycin). Urine bioactivity, however, DESCRIPTION: ANTIROBE Capsules and ANTIROBE Soft Tissue/Wound2 AQUADROPS Liquid contains clindamycin hydrochloride equivalent reflects a mixture of clindamycin and active metabolites, especially contain clindamycin hydrochloride which is the hydrated salt of to Staphylococcus 25 clindamycin. mg clindamycin; and ethylisalcohol, 8.64%. antibiotic produced by a N-demethyl clindamycin and clindamycin sulfoxide. Clindamycin a semisynthetic aureus 17 0.5 0.5 >4.0 0.25–>4.0 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced Site and Mode of Action: Clindamycin is an inhibitor of protein synthesis Staphylococcus CLINICAL PHARMACOLOGY antibiotic produced by Streptomyces lincolnensis var. lincolnensis. intermedius 28 0.25 0.5 >4.0 0.125–>4.0 in the bacterial cell. The1.0site 0.1 of binding appears to be in the 5OS sub-unit Absorption: Clindamycin hydrochloride is rapidly absorbed from the Staphylococcus of the ribosome. Binding occurs to the of certain 0 6 soluble 12 RNA fraction 18 24 canine and feline gastrointestinal tract. ANTIROBE Capsules (For Use in Dogs Only): spp. 18 0.5 0.5 >4.0 0.25–>4.0 (hours) acids to those ribosomes, thereby inhibiting the bindingTime of amino Beta-hemolytic Dog Serum Levels: Serum levels at or above 0.5 μg/mL can be maintained ribosomes. Clindamycin differs from cell wall inhibitors in that it causes mgdosing Capsule, yellow and white capsule contains clindamycin streptococci 46 0.5 0.5 >4.0 0.25–>4.0 by 25 oral at aeach rate of 2.5 mg/lb of clindamycin hydrochloride every irreversible modification of the protein-synthesizing subcellular elements equivalent to 25 mgthat of clindamycin. Streptococcus 12 hydrochloride hours. This same study revealed average peak serum at the ribosomal level. spp. 11 0.5 >4.0 >4.0 0.25–>4.0 concentrations of clindamycin occur 1 contains hour andclindamycin 15 minutes after oral 75 mg Capsule, each green capsule hydrochloride Microbiology: Clindamycin is a lincosaminide antimicrobial agent with 0.1 dosing. The elimination for clindamycin in dog serum was equivalent to 75 mg ofhalf-life clindamycin. activity against a wide variety of 5aerobic anaerobic bacterial 0 10 and15 20 25 approximately 5 hours. There was no bioactivity accumulation after a Time (hours) compound that inhibits 150 mg Capsule, each light blue and green capsule contains clindamycin pathogens. Clindamycin is a bacteriostatic regimen of multiple oral doses in healthy dogs. Metabolism and Excretion: Extensive studies the metabolism and bacterial protein synthesis by binding to the 5OSof ribosomal sub-unit. The hydrochloride equivalent to 150 mg of clindamycin. excretion of clindamycin hydrochloride orally in obligate animals minimum inhibitory concentrations (MICs) administered of Gram-positive and Clindamycin Serum Concentrations 300 mg Capsule, each light blue capsule contains clindamycin 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral and humans have shown that unchanged bioactive and anaerobic pathogens isolated from dogs anddrug catsand in the United States of Antirobe to Dogs hydrochloride equivalentDose to 300 mg ofCapsules clindamycin. areTable excreted in urinewere and isolated feces. Almost all of the arebioinactive presentedmetabolites in Table 1 and 2. Bacteria in 1998–1999. 10 ANTIROBE AQUADROPS Liquid (For Use in Dogs and Cats) is a palatable Allbioactivity in serum after ANTIROBE MICs weredetected performed in accordance with theproduct Clinical administration and Laboratoryis formulation intended for oral administration. Each mL of ANTIROBE due to the parent molecule (clindamycin). Urine bioactivity, however, Standards Institute (CLSI). AQUADROPS Liquid contains clindamycin hydrochloride equivalent to reflects a mixture of clindamycin and active metabolites, especially Clindamycin Equivalent Activity (mcg/mL) Antirobe Clindamycin Equivalent Activity (mcg/mL) Antirobe Aquadrops L) 1 5 mg/lb (11 mg/kg) After Single Oral Dose of Antirobe Aquadrops to Cats CLINICAL PHARMACOLOGY Absorption: Clindamycin hydrochloride is rapidly absorbed from the 10.0 canine and feline gastrointestinal tract. Clindamycin Equivalent Activity (mcg/mL) Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.