Download Currently funded projects 2015

Currently funded projects 2015
Type
ARUK and CSO
Project Grant into
Translational
Dementia Research
Title
Institution
Lead Applicant
Targeting tau to prevent Abeta mediated synapse
degeneration in Alzheimer’s
University of
Edinburgh
Tara Spires-Jones
Clinical Research
Fellowship
Investigating the role of the microglial receptor
TREM2 in Alzheimer's disease
Clinical Research
Fellowship
Emergency support
grant
Systemic and central inflammation in Dementia with
Lewy Bodies
Calcium abnormalities associated with
neurodegeneration in Alzheimer’s disease
High-throughput and high-resolution digital slide
scanner Nanozoomer-XR for studies in dementia
Ensuring High Quality DNA and RNA isolation from
the Brains for Dementia Research (BDR) Resource
using the Agilent 2200 TapeStation Nucleic Acid
System.
Confocal laser scanning microscope for dementia
researchers in Southampton
The use of a histology slide scanner to aid in the
understanding of disease progression and
mechanisms in dementia
Phenotyping the immune response in Alzheimer’s
disease by flow cytometry
THE ROLE OF ASTROCYTES IN TAU-RELATED
NEURONAL CELL DEATH
Equipment grant
Equipment grant
Equipment grant
Equipment grant
Equipment grant
Extension grant
University College
London, Institute of
Neurology
University of
Southampton
Pablo Garcia Reitboeck
Jay Amin
King's College London
Wendy Noble
University of
Southampton
Delphine Boche
University of
Nottingham
Keeley Brookes
University of
Southampton
University College
London, Institute of
Neurology
University of
Southampton
University of
Cambridge
Roxana Carare
Janice Holton
Diego Gomez-Nicola
Maria Grazia Spillantini
Currently funded projects 2015
Extension grant
Interdisciplinary
Research Grant
Interdisciplinary
Research Grant
Interdisciplinary
Research Grant
Interdisciplinary
Research Grant
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Using network analysis to understand why patients
with small vessel disease suffer cognitive impairment
– extension
The molecular basis of the innate response to
oligomers of beta amyloid and alpha synuclein
PSK kinases and tau pathology in Alzheimer's
disease
Neurovascular dysfunction in Alzheimer’s disease:
the search for early biomarkers
Determining the role of lysosomal Ca2+ signalling in
the pathogenesis of Alzheimer's disease
The ARUK supplement for the JPND funded
PERADES consortium
Endoplasmic reticulum-mitochondria interactions and
Alzheimer's disease
Evaluating the relationship between ischaemia and
neurodegeneration in post-mortem brain tissue
Live cell tracking of amyloidogenic species related to
Alzheimer’s disease
The role of Dkk1 in Amyloid-beta mediated effects on
dendritic spines and long-term depression
Evaluation of tau aggregation detected by novel tau
tracer, [18F]T807 PET in mild cognitive impairment
subjects: a preliminary collaborative PET study.
Combinatorial biomarkers for dementia prodromes,
prediction, pathology and progression
University of
Cambridge
Hugh Markus
University of
Cambridge
Clare Bryant
King's College London
Jonathan Morris
University of Sheffield
Jason Berwick
Cardiff University
Emyr Lloyd-Evans
Cardiff University
Julie Williams
King's College London,
Chris Miller
Institute of Psychiatry
University of Bristol
University of
Cambridge
University College
London
Seth Love
Clemens Kaminski
Patricia Salinas
Imperial College
London
Paul Edison
University of Oxford
Simon Lovestone
Currently funded projects 2015
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Major project
Major project
University College
London, Institute of
Neurology
Using network analysis to understand why patients
University of
with small vessel disease suffer cognitive impairment. Cambridge
An Investigation of the role of the ageing process in
University College
Alzheimer’s Disease
London
A cell surface, lipid raft-based signalling complex links University of
amyloid-beta to tau via Fyn
Manchester
Imaging amyloid and neuroinflammation in subjects
Imperial College
"at risk" for Alzheimer's disease
London
Automated subcortical brain segmentation using
University College
multispectral MRI for improved AD diagnosis and
London, Institute of
disease tracking
Neurology
Title: Alpha-Synuclein and Cellular Iron Reduction
University of Bath
Investigation into the impact of systemic inflammation
University of
due to infection on microglial phenotype and its
Southampton
contribution to Alzheimer’s disease neuropathology
Phosphorylation of kinesin light chain and
King's College London,
calsyntenin-1/alcadein mediated axonal transport and
Institute of Psychiatry
processing of APP in Alzheimer’s disease
Enabling high-throughput genomic approaches in
University of
Alzheimer’s disease.
Nottingham
Mechanisms of neurodegeneration in an animal
Newcastle University
model of cerebral hypofusion
Targeting perivascular innervation and vascular tone
The Open University
for improved clearance of ß-amyloid from the brain
Determining the causes and consequences of brain
amyloidosis, atrophy and cerebrovascular disease
Nick Fox
Hugh Markus
Linda Partridge
Nigel Hooper
David J Brooks
Josephine Barnes
David Brown
Delphine Boche
Chris Miller
Kevin Morgan
Raj Kalaria
Cheryl Hawkes
Currently funded projects 2015
Major project
The impact of the accumulation of brain beta-amyloid
and tau with ageing on the development of
Alzheimer's disease in Down's syndrome adults: a
cross-sectional and longitudinal study.
University of
Cambridge
Anthony Holland
Major project
Causes and consequences of dystrophic axons
University of
Cambridge
Michael Coleman
University of Bristol
Seth Love
Newcastle University
Alan Thomas
University of
Manchester
Nigel Hooper
University of Leeds
John Boyle
University College
London
Sebastian Crutch
King's College London
Wendy Noble
University of Dundee
Mike Ashford
Cardiff University
Lesley Jones
University of Oxford
Richard Wade-Martins
Aston University
Eric Hill
Queen's University
Belfast
Brian Green
Major project
Major project
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Hypertension, hypoperfusion and neurodegeneration
in Alzheimer's disease
123I-MIBG Scintigraphy Utility as a biomarker for
Prodromal DEmentia with Lewy Bodies (SUPErB)
Alzheimer's Research UK Manchester and North
West Network Centre Grant
Alzheimer's Research UK Yorkshire Network Centre
Grant
Alzheimer's Research UK University College London
Network Centre Grant
Alzheimer's Research UK King's College London
Network Centre Grant
Alzheimer's Research UK Scotland Network Centre
Grant
Alzheimer's Research UK Cardiff Network Centre
Grant
Alzheimer's Research UK Oxford Network Centre
Grant
Alzheimer's Research UK Midlands Network Centre
Grant - Year 1
Alzheimer's Research UK Northern Ireland Network
Centre Grant
Currently funded projects 2015
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network Centre
Network
cooperation grant
Network
cooperation grant
Network
cooperation grant
Network Support
Grant
Alzheimer's Research UK Cambridge Network Centre
Grant
Alzheimer's Research UK Imperial College London
Network Centre Grant
Research into early-onset dementia
Alzheimer's Research UK South West Network
Centre Grant - Year 1
Alzheimer's Research UK Bristol and Bath Network
Centre Grant
Alzheimer's Research UK South Coast Network
Centre Grant
Alzheimer's Research UK Newcastle Network Centre
Grant
Alzheimer's Research UK South West Network
Centre - Year 2
Alzheimer's Research UK Midlands Network Centre
Grant - Year 2
Functional deficits in a novel murine model of
frontotemporal lobar degeneration
A biological resource for metagenomic studies of
dementia
Next Generation Sequencing of Alzheimer's Disease
(AD) Genes in non-familial early-onset AD (EOAD).
Characterisation of the unfolded protein response,
apoptosis and autophagy in human AD cases
The Babraham
Institute
Imperial College
London
University College
London, Institute of
Neurology
Michael Coleman
Paul Edison
Nick Fox
University of Plymouth
Oleg Anichtchik
University of Bristol
Patrick Kehoe
University of
Southampton
Amrit Mudher
Newcastle University
Raj Kalaria
University of Exeter
Katie Lunnon
Loughborough
University
Eef Hogervorst
University of Bristol
Andrew Randall
King's College London
John Powell
University of
Nottingham
Kevin Morgan
University of Aberdeen
Bettina Platt
Currently funded projects 2015
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
PhD Scholarship
PhD Scholarship
PhD Scholarship
Canadian Consortium on Neurodegeneration in Aging
Alzheimer's Research UK Drug Discovery Institute
2015: University College London
Identifications of druggable pathways that influence
tau toxicity
Alzheimer's Research UK Drug Discovery Institute
2015: University of Oxford
Canadian Institutes of
Health Research
(CIHR)
University College
London
University of
Cambridge
University of Oxford
University College
London
Alzheimer's Research UK Drug Discovery Institute
University of
2015: University of Cambridge
Cambridge
Pharmacological modulation of CSF1R activation to
University of
control microglial proliferation in Alzheimer’s disease
Southampton
University of
Alzheimer's Research UK Stem Cell Research Centre
Cambridge
Moving autophagy inducers into the clinic for
University of
tauopathies
Cambridge
International Centre for
ALS disease models and therapeutic drug screen
Genetic Engineering
and Biotechnology
Molecular mechanisms of C9ORF72 repeat
King's College London
expansion toxicity in frontotemporal dementia
Differential production of amyloid-beta from the APP
University of
isoforms
Manchester
O-GlcNAc as a strategy for the treatment of
University of York
tauopathies
CRACK IT - UnTangle Challenge
CIHR Canadian Institutes of Health Rese
Giampietro Schiavo
David Rubinsztein
Simon Lovestone
Selina Wray
David Rubinsztein
Diego Gomez-Nicola
Frederick Livesey
David Rubinsztein
Marco Baralle
Jean-Marc Gallo
Nigel Hooper
Gideon Davies
Currently funded projects 2015
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
The role of TREM2 in neurodegeneration
Investigating the effect of ApoE genotype on synaptic
dysfunction using sporadic Alzheimer’s disease
patient iPSC-derived cells
Impaired Tight Junction Protein Signalling in
Astrocytes In Alzheimer's Disease
Title: Identification of the Alzheimer pre-protein as a
potential regulator of endosomal phosphoinositide
metabolism; a novel mechanistic pathway to
neurodegeneration?
Emergence of cognitive impairment in an Alzheimer's
Disease mouse model: the role of NMDA receptor
currents.
Convergence of Abeta and tau pathogenic
mechanisms on axonal transport
Understanding Alzheimer's disease using mouse
models of Down syndrome
Imaging cerebral vascular alterations and their
modulation in experimental models: a translational
approach
Fe65/APP signalling and brain-derived neurotrophic
factor in Alzheimer's disease
Modelling hexanucleotide expansion repeats of
C9ORF72 in Frontotemporal Dementia
University College
London
Tammaryn Lashley
University of Oxford
Colin Akerman
University of Sheffield
Stephen Wharton
Aston University
Thomas Wassmer
University of
Southampton
Mariana Vargas-Caballero
The Babraham
Institute
University College
London, Institute of
Neurology
University of
Edinburgh
Michael Coleman
Frances Wiseman
Karen Horsburgh
King's College London,
Chris Miller
Institute of Psychiatry
King's College London,
Frank Hirth
Institute of Psychiatry
Currently funded projects 2015
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
PhD Scholarship
Pilot project grant
Altered Heparan Sulfate in Ageing and Dementia: a
Potential Axis for Dysregulation of BACE-1 in
Alzheimers Disease
Using genetic variability in whole transcriptome
expression in the hippocampus and temporal cortex
to understand the pathogenesis of Alzheimer's
disease
Characterisation of a novel in vivo model of human
tauopathy
Investigation of the mechanism by which the
C9ORF72 intronic repeat expansion causes
frontotemporal dementia
NeuroTraffic: Orientated neuronal networks for
investigating mechanisms of tau propagation
Hippocampal sclerosis – a poorly understood cause
of dementia among the older old
Using iPSC-derived neurons to study homeostatic
control of aSyn by the E3-ubiquitin ligase and cochaperone CHIP
Contribution of TREM2 and neuroinflammation to
neurodegeneration and cognitive dysfunction in
response to chronic cerebral hypoperfusion
Alterations in autophagy in frontotemporal lobar
degeneration: identifying new targets for therapeutic
intervention
A PK11195 PET Study of neuroinflammation in
dementia with Lewy bodies
University of Liverpool
Jeremy Turnbull
University College
London, Institute of
Neurology
John Hardy
King's College London,
Institute of Psychiatry
University College
London, Institute of
Neurology
University of
Southampton
University of
Cambridge
Diane Hanger
Adrian Isaacs
Katrin Deinhardt
Carol Brayne
University of
Edinburgh
Kathryn Ball
University of
Edinburgh
Barry McColl
University of Salford
Gemma Lace-Costigan
University of
Cambridge
John O'Brien
Currently funded projects 2015
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Developing a new biomarker for the early diagnosis of
dementia; a novel nonlinear signal processing
approach using resting state EEG.
Understanding oligodendrocyte progenitor dynamics
and myelin loss in Alzheimer's Disease
Epigenetic modification of mitochondrial genes in
Alzheimer's disease (AD)
Imaging copper trafficking in Alzheimer’s disease with
PET: potential clinical applications
Harnessing the Ubiquitin-Proteasome System in the
Brain: Implications for Dementia
Super resolution microscopy in human brain white
matter
Identification of unfolded protein response, apoptosis
and autophagy markers in human AD
Pilot project grant
The role of TMEM106B and CHMP2B in neuronal
lysosomal trafficking in frontotemporal dementia
Pilot project grant
CARASIL - a window into Alzheimer's disease?
Pilot project grant
Exploring endogenous mediators regulating blood
brain barrier functionality in Alzheimer’s disease
Pilot project grant
Cellular modelling of C9orf72 di-peptide repeat
proteins
University of Sheffield
Daniel Blackburn
University of
Southampton
Diego Gomez-Nicola
University of Exeter
Katie Lunnon
King's College London
Philip Blower
University of Bath
Julien Licchesi
St. George's University
of London
Atticus Hainsworth
University of Aberdeen
Bettina Platt
University College
London, Institute of
Neurology
Institute of Neurology,
University College
London
Barts and The London
School of Medicine
and Dentistry, Queen
Mary University of
London
University of
Manchester
Adrian Isaacs
Rita Guerreiro
Egle Solito
Stuart Pickering-Brown
Currently funded projects 2015
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Pilot project grant
Rare variants in inflammatory pathways in
Alzheimer's disease
Complement and microglial activation in mouse
models of dementia
Validation of an O-GlcNAcase inhibitor as a novel
therapeutic agent against Alzheimer pathology
Interhemispheric processing in Alzheimer Disease
Ultra-high field MRI in early Alzheimer’s disease:
characterising iron deposition
Double-blind randomised crossover placebocontrolled pilot trial with intra-nasal Oxytocin to
increase social cognitive function and reduce carer
burden in frontotemporal dementia.
Characterisation of enteric nervous system function of
the intestine in Alzheimer’s disease
Cortico-striatal contributions to symptomology in
dementia: new targets for therapy
Repressor Element 1-Silencing Transcription Factor
(REST): A blood-based biomarker for Alzheimer’s
disease linking molecular neuropathology with
psychological stress
Testing a new diagnostic tool for Alzheimer's disease
and Dementia with Lewy Bodies
Development of small molecule Usp8 inhibitors as
therapeutics in Lewy body dementia
Investigating the role of kinesin motor proteins in a
human neuronal cell model of Alzheimer’s Disease: a
new drug discovery target?
King's College London
Angela Hodges
Cardiff University
Paul Morgan
University of Bradford
Ritchie Williamson
University of Leeds
Jean-Francois Delvenne
University of Oxford
Klaus Ebmeier
University of
Cambridge
Michael Hornberger
University of
Portsmouth
University of
Cambridge
Jerome Swinny
Michael Hornberger
King's College London
Richard Killick
University of
Cambridge
David Klenerman
University of Oxford
George Tofaris
University of
Cambridge
Isabel M Palacios
Currently funded projects 2015
Preparatory Clinical
Research
Fellowship
Preparatory Clinical
Research
Fellowship
Research
Fellowship
Research
Fellowship
Research
Fellowship
Research
Fellowship
Research
Fellowship
Sabbaticals/Second
ments
Senior Research
Fellowship
Senior Research
Fellowship
Senior Research
Fellowship
Fronto-thalamic effective connectivity in familial
Alzheimer’s disease
Evaluation of microglial activation in Alzheimer’s
disease and mild cognitive impairment subjects using
a novel TSPO marker, GE180
The role of the nuclear transport system in
frontotemporal dementia.
Astrocytes influence interactions between Abeta and
tau to cause synaptotoxicity in AD
Selective vulnerability to Alzheimer’s disease –
understanding changes in white matter connectivity of
the visual system in Posterior Cortical Atrophy
Investigating the role of BIN1 in tau missorting and
secretion
Dysfunctional synaptic and neuronal network
encoding in tauopathy-associated dementia
Mapping the cellular relationship between RNA
metabolism and endosome dysfunction in
Frontotemporal Dementia
Regulation of iron homeostasis by beta-amyloid
precursor protein in health and disease.
Interaction of systemic and central apolipoproteins in
the pathogenesis and treatment of cerebral amyloid
angiopathy
Identifying functional molecular pathways that
underlie the earliest changes associated with
Alzheimer’s Disease
Dementia Research
Centre, UCL Institute
of Neurology
Kirsi Kinnunen
Imperial College
London
Valeria Calsolaro
University of London
Tammaryn Lashley
King's College London,
Beatriz Gomez Perez-Nievas
Institute of Psychiatry
University College
London, Institute of
Tim Shakespeare
Neurology
King's College London,
Elizabeth Glennon
Institute of Psychiatry
University of Bristol
Jonathan Witton
University of York
Sean Sweeney
University of Leeds
James Duce
The Open University
Cheryl Hawkes
University College
London
Dervis Salih
Currently funded projects 2015
Senior Research
Fellowship
Senior Research
Fellowship
Therapeutic potential of boosting astrocytic Nrf2mediated antioxidant signalling in combating white
matter damage, amyloid pathology and cognitive
deficits caused by chronic cerebral hypoperfusion
Measuring, Tracking and Disentangling the Impact of
White Matter Disease in AD and Mixed Disease: A
Longitudinal MRI and CSF Study
University of
Edinburgh
Jill Fowler
University College
London, Institute of
Neurology
Josephine Barnes
Jon Brown
Senior Research
Fellowship
Neuronal network disruptions in a model of tauopathy
University of Exeter
Senior Research
Fellowship
Alzheimer’s disease and posterior cortical atrophy:
cognitive and neuroimaging studies of visual
dysfunction
Senior Research
Fellowship
Are multiple mechanisms involved in FTLD-TDP
pathogenesis; will one drug fit all?
University College
London, Institute of
Neurology
Institute of Neurology,
University College
London
Travelling Research
Fellowship US
High-throughput genotyping of rare variants identified
through next-generation sequencing of Alzheimer's
disease candidate genes
University of
Nottingham
Sebastian Crutch
Tammaryn Lashley
Christopher Medway