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Oral Drug Delivery System
References
• Oral Controlled Release Formulation design
Oral delivery
• Both conventional and new drug delivery
system:
• More flexibility in dosage forms
• No sterility
• Minimized damage at administration site
METHODS USED TO ACHIEVE
CONTROLLED RELEASE OF
ORALLY ADMINISTERED
DRUGS:
Ref:Oral controlled release formulation design
Ref:Oral controlled release formulation design
Bioerodable and Combination of
Diffusion and Dissolution Systems
• It is characterized by a homogeneous
dispersion of drug in an erodible matrix
DRUG DELIVERY FROM COMBINATION OF
DIFFUSION AND DISSOLUTION SYSTEM
Insoluble membrane
Entry of dissolution fluid
Diffusion of dissolved drug
Pore created by dissolution
of soluble fraction membrane
FIRST OSMOTIC PUMP
(THREE CHAMBER ROSE-NELSON OSMOTIC PUMP)
Salt Chamber
Water Chamber
Drug Chamber
Delivery orifice
Rigid Semi permeable membrane
Elastic Diaphragm
A. Elementary osmotic pump
• Major method of achieving controlled drug release
• The EOP was developed by
Alza under the name OROS for
controlled release oral drug delivery formulations
Delivery Orifice
Core
Semi permeable membrane
16/60
MECHANISM OF EOP
17/60
MECHANISM OF PPOP (push pull osmotic
pressure)
20/60
Modification in elementary osmotic pumps
Drug chamber
Inner microporous
membrane
Delivery orifice
Outer semi permeable
membrane
COMPOSITE MEMBRANE COATING USED TO DELIVER MODERATELY
SOLUBLE DRUGS
• Another type of L-OROS consists of a hard gelatin capsule
containing a liquid drug layer, a barrier layer and a push
layer surrounded by a semipermeable membrane. The LOROS hardcap system was designed to accommodate more
viscous suspensions with higher drug loading than would be
possible using softcap design.
Delivery orifice
Barrier layer
Inner
Compartment
Rate controlling membrane
Push layer
Inner Capsule
Marketed products
ELEMENTARY OSMOTIC PUMP
BRAND NAME
Efidac 24®
API
Chlorpheniramine
Acutrim ®
Phenylpropanolamine
Sudafed 24®, Efidac 24®
Pseudoephedrine
Volmax ®
Minipress XL®
Albuterol
Prazosin
SYSTEMS
PUSH-PULL OSMOTIC
Ditropan XL ®
Oxybutynin chloride
Procardia XL®
Nifedipine
Glucotrol ®
Glipizide
Covera HS ®
Verapamil HCl
DynaCirc CR®
Isradipine
Invega®
Paliperidone
Alpress LP®
Prazosin
Fig.no-1
Fig.no-4
1- GAS GENERATING SYSTEMS
30
Cont…
Fig.no-6
FDDS: A review
High density systems
• Barium sulphate , zinc oxide, iron powder, and
titanium dioxide are examples for excipients used.
Fig.no-8