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Preferred Drug List NEW DRUG REVIEW Proprietary Name: U-KERA® Cream Common Name: Urea Cream 40% PDL Category: Topical - Emollients Preferred Drug List/ Recommended Drug List Status Preferred Preferred Comparable Products Vanamide® Cream Urea 40% Lotion Summary Indications and Usage: For wound debridement and promotion of normal healing of hyperkeratotic surface lesions, particulary where healing is slowed by local infection, necrotic tissue, fibrinous or purulent debris, or eschar. Can also be useful for the treatment of hyperkeratotic conditions such as rough, dry skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns, calluses, as well as damaged, ingrown, and devitalized nails. Dosage Forms: Cream, 40% Recommended Dosage: Apply to affected area(s) twice daily; smooth over affected tissue until cream is absorbed. May be covered with adhesive bandage or gauze Common Adverse Drug Reactions: Transient stinging, burning, itching, local irritation. Contraindications: Known hypersensitivity to any listed ingredients in the formulation Manufacturer: Taro Pharmaceuticals Analysis: Several preferred topical medications exist on the Preferred Drug List that have identical active ingredients as U-KERA® which are more cost effective. IME Recommendation: Preferred Drug Non-Preferred Drug Preferred Drug with Conditions Prepared By: Iowa Medicaid Enterprise Recommended Drug Non-Recommended Drug Date: 5/8/2006