Download Professor Dr. Johnson Stanslas

CURRICULUM VITAE
Personal Particulars
Name
:
PROF. DR. JOHNSON STANSLAS
Unit/Department
:
Pharmacotherapeutics Unit, Department of Medicine
Faculty
:
Faculty of Medicine and Health Sciences
Field of Specialisation
:
Pharmacology and Therapeutics
Cancer Research (Cancer Pharmacology)
Drug Discovery and Development
Contact number
:
Office : 03-89472310
E-mail
:
[email protected]; [email protected]
Fax: 03-89472759
Membership of Professional Organisations

American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

British Association for Cancer Research (BACR)

European Association for Cancer Research (EACR)

Malaysian Oncological Society (MOS)

Malaysian Society for Neuroscience (MSN)

Malaysian Society for Music in Medicine (MSMM)
Education and Academic Qualifications
BSc (Hons), Faculty of Life Sciences, National University of Malaysia (UKM); MSc (Anticancer Research),
Faculty of Life Sciences, National University of Malaysia (UKM); PhD (Cancer Pharmacology), School of
Pharmacy, The University of Nottingham, United Kingdom
Teaching experience
Teaching activities
Code and Name of Courses
BMS 5021/6021 MOLECULAR PHARMACOLOGY
SPP3271 GENERAL AND BIOCHEMICAL PHARMACOLOGY
SPP3531 CARDIOVASCULAR SYSTEM - PHARMACOLOGY
SPP3521 URINARY SYSTEM - PHARMACOLOGY
SPP3581 CENTRAL NERVOUS SYSTEM - PHARMACOLOGY
1
SPP3561 ENDOCRINE SYSTEM - PHARMACOLOGY
NUR 3102/ BASIC BIOCHEMISTRY AND PHARMACOLOGY
YEAR 3 MD PROGRAMME - INTRODUCTORY MEDICINE - PHARMACOLOGY
MASTER OF PSYCHIARTY - NEUROPHARMACOKINETICS
MEDICAL NEUROSCIENCES - NEUROPHARMACOLOGY
BMS 3040 PHARMACOLOGY
BMS 3150 TOXICOLOGY
BMS 3020 BASIC MEDICAL BIOCHEMISTRY
BMS 3021 CLINICAL BIOCHEMISTRY
SPP3211 CELLS AND TISSUES
SPP3231 MOLECULAR BASIS OF MEDICINE I
SPP3232 MOLECULAR BASIS OF MEDICINE II
SPP3231 MOLECULAR BASIS OF MEDICINE
SPP3231 MOLECULAR BASIS OF MEDICINE
SPP3233 MOLECULAR MEDICINE
PSK5905 SPECIAL TOPICS
SPS6903 SEMINAR PROPOSAL PRESENTATION
SPP3591 PROBLEM BASED LEARNING I
SPP3591 PROBLEM BASED LEARNING II
Invited lectures

International Union of Basic and Clinical Pharmacology (IUPHAR) World Conference on the
Pharmacology of Natural and Traditional Medicine “Targeting K-Ras with Semisynthetic
Andrographolide Derivatives: A Valid Approach in the Discovery of Potential Anticancer Drug Leads”,
National University of Singapore, 22-24 July 2015.

Invited lecture at School of Biomolecular Science, School of Pharmacy, University of Nottingham,
“Exploring Malaysian Biodiversity: A Rich Source of Natural Drug Prototypes”, United Kingdom, 16th
December 2011.

Seminar on Computer Aided Drug Design Organised by School of Pharmaceutical Sciences, USM
& Malaysian Institute of Pharmaceutical and Nutraceutical (IPHARM) – 2-8 December 2010

1st Malaysian Biotechnology Seminar ‘Evaluation of New Andrographolide Derivatives for
Inhibitory Activities against Tumour Vasculature and Metastasis’ - 24 – 26 May 2010

UK-Malaysia Symposium On Drug Discovery And Development For Cancer Organised by Cancer
Research Initiatives (CARIF) ‘Andrographolide, a Versatile Template in the Synthesis of Tumour-Selective
and Potent Anticancer Agents’ - 24-25 February 2010

Indonesian Natural Products Conference 2009 – Plenary Lecture ‘A Decade of Research on
Andrographis Paniculata: The Story So Far’
2

Andalas University, West Sumatra, Indonesia, Department of Pharmacy, “Discovery and
Development of Anticancer Agents: Incorporating the Experience of the Cancer Research and Drug
Discovery Group of UPM”, August 2007.

Universiti Technology MARA (UiTM), Malaysia; Faculty of Pharmacy, “Current Advances in
Antineoplastic Research”, March 2008.

Malaysian Oncological Society Meeting, Sabah 2008: Symposium Lectures
1. New Drug Discoveries
2. Translational Research in Oncology (TRiO) in Malaysia: the way forward

Discovery and Development of Natural and Synthetic Anticancer Agents. International
Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC, Kuala Lumpur
Publications
a. Cited Journals
1.
Tan, S.F, Masoumi, H.R.F., Karjiban, R.A., Stanslas J., Kirby, B.P., Basri, M., Basri, H (2016)
Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface
methodology and evaluation of its stability. Ultrasonics Sonochemistry 29 (2016) 299–308.
2.
Daood, G.S., Basri, H., Stanslas, J., Masoumi, H.R.F and Basri, M (2015) Predicting the optimum
compositions of a parenteral nanoemulsion system loaded with azithromycin antibiotic utilizing the
artificial neural network model. RSC Advances. 5, 82654–82665.
3.
Tan SL, Stanslas J, Basri M, Abedi Karjiban RA, Kirby B, Sani D, Basri HB (2015) Nanoemulsionbased parenteral drug delivery system of carbamazepine: Preparation, characterization, stability
evaluation and blood-brain pharmacokinetics. Current Drug Delivery Sep 1.
4.
Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015). Tetraprenyltoluquinone, an
anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer
cell line. International Journal of Pharmaceutical Sciences Review and Research, 32(2):166–168.
5.
Wahyuni, F.S., Shaari, K., Stanslas, J., Hj. Lajis, N., Dachriyanus. (2015). Cytotoxic xanthones
from the stem bark of Garcinia cowa Roxb. Journal of Chemical and Pharmaceutical Research, 7(1):
227-236.
6.
Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015) Cytotoxicity studies of
tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU145. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3): 60-63.
7.
Wahyuni, F.S., Shaari, K., Stanslas, J., Lajis, N., Hamidi, D. (2015) Cytotoxic compounds from
the leaves of Garcinia cowa Roxb. Journal of Applied Pharmaceutical Science, 5 (2): 006-011.
3
8.
Lim, J.C.W., Jeyaraj, E.J., Sagineedu, S.R., Wong, W.S.F., Stanslas, J. (2015). SRS06, a New
Semisynthetic Andrographolide Derivative with Improved Anticancer Potency and Selectivity, Inhibits
Nuclear Factor-κB Nuclear Binding in the A549 Non-Small Cell Lung Cancer Cell Line. Pharmacology, 95:
70-77. [IF = 2.093]@; citations – 4 Quartile ranking: Q3
9.
Wong C.C., Sagineedu S.R., Sumon S.H., Sidik M.S., Phillips R., Lajis N.H., Stanslas J. (2014).
NCI In Vitro and In Silico Anticancer Screen, Cell Cycle Pertubation and Apoptosis-Inducing Potential of
New Acylated, Benzylidene and Isopropylidene Derivatives of Andrographolide. Environmental
Toxicology and Pharmacology, 38(2): 489–501 [IF = 2.093]@; citations – 3 Quartile ranking: Q2.
10.
Wong H.C., Wong C.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas, J. (2014). SRJ23, a new
semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest
and apoptosis in prostate cancer cells. Cell Biology and Toxicology, DOI: 10.1007/s10565-014-9282-5.
[IF = 2.067]@; citations – 0 Quartile ranking: Q3.
11.
Wong C.C., Periasamy, N., Sagineedu, S.R., Sidik, S., Sumon, S.H., Loadman, P., Phillips, R., Lajis,
L.H., Stanslas, J. (2014). In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer
andrographolide analog. Investigational New Drugs, DOI: 10.1007/s10637-014-0105-6. [IF = 2.801]@;
citations – 0 Quartile ranking: Q2.
12.
Moyeenul Huq, A. K. M., Jamal, J.A., Stanslas, J. (2014). Ethnobotanical, Phytochemical,
Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre. Evidence-Based
Complementary and Alternative Medicine, vol. 2014, Article ID 782830, 11 pages. [IF = 2.286]@;
citations – 0 Quartile ranking: Q2.
13.
Chew YL, Lim YY, Stanslas J, Ee GCL, Goh JK. (2014) Bioactivity-guided Isolation of Anticancer
Agents from Hauhinia Kockiana Korth. African Journal of Traditional Complementary Alternative
Medicine. 11(3):291-299. [IF = 0.951]@ citations – 0 Quartile ranking: Q4.
14.
Ashraf, M.F., Abd Aziz, M., Stanslas, J., Ismail, I., Abdul Kadir, M. (2013). Assessment of
antioxidant and cytotoxicity activities of saponin and crude extracts of chlorophytum borivilianum. The
Scientific World Journal 2013: 216894. citations – 1 Quartile ranking: Q2.
15.
Nasir, N.M., Rahmani, M., Shaari, K., Kassim, N.K., Go, R., Stanslas, J., Jeyaraj, E.J. (2013).
Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana 42(9): 1261-1266.
citations – 0 Quartile ranking: Q3.
16.
Abdul Latip A.F., Hussein M.Z., Stanslas J., Wong C.C., Adnan R (2013). Release behavior and
toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation
compound. Chemistry Central Journal 7(1): 119. [IF = 2.071]@; citations – 0 Quartile ranking: Q2.
17.
Ashraf M.F., Aziz M.A., Kadir M.A., Stanslas J., Farokhian E. (2013). In Vitro Tuberization of
Chlorophytum Borivilianum Sant & Fern (Safed Musli) As Influenced by Sucrose, CCC and Culture
Systems. Plant and Cell Physiology 54(8): 1356-1364. [IF = 4.972]@; citations – 0 Quartile ranking: Q1.
4
18.
Hocker H.J., Cho H.J., Chen C.Y.K., Maharaj N., Wong C.C., Wong H.C., Sagineedu S.R., Shaari K.,
Stanslas J., Hancock J.F., Gorfe A.A. (2013). Andrographolide derivatives inhibit guanine nucleotide
exchange and abrogate oncogenic Ras function. Proceedings of the National Academy of Sciences of
USA 110(25): 10201-10206. [IF = 10.727]@; citations – 34 Quartile ranking: Q1.
19.
Hasan S., Basri H.B., Hin L.P., Stanslas J. (2013). Encephalitis followed by optic neuritis: A case
report and review of literature. Pakistan Journal of Medical Sciences 29(3):859-862. [IF = 0.156]@;
citations – 0 Quartile ranking: Q4.
20.
Al-Mekhlafi N.A., Shaari K., Abas F., Jeyaraj E.J., Khallivulla S.I., Stanslas J., Lajis N.H. (2013). New
Flavan and Alkyl α,β-Lactones from the Stem Bark of Horsfieldia superba. Natural Products
Communication 8(4): 447-451. [IF = 0.956]@; citations – 1 Quartile ranking: Q4.
21.
Wong M.S., Sidik S.M., Mahmud R., Stanslas J. (2013). Molecular targets in the discovery and
development of novel antimetastatic agents: Current progress and future prospects. Clinical
Experimental Pharmacology and Physiology 40(5):307-1. [IF = 2.067]@; citations – 8 Quartile ranking:
Q2.
22.
Ashraf M.F., Aziz M.A., Stanslas J., Kadir M.A. (2013). Optimization of immersion frequency and
medium substitution on microtuberization of Chlorophytum borivilianum in RITA system on production
of saponins. Process Biochemistry, 48(1): 73-77. [IF = 2.922]@; citations – 2 Quartile ranking: Q1.
23.
Ooi C.T., Syahida A., Stanslas J., Maziah M. (2013). Efficiency of different Agrobacterium
rhizogenes strains on hairy roots induction in Solanum mammosum. World Journal of Microbiology and
Biotechnology, 29: 421-430. citations – 2
24.
Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2013). Genetic polymorphisms and drug interactions
leading to clopidogrel resistance: why the asian population requires special attention. International
Journal of Neurosciences. 123(3): 143-154. [IF = 0.967]@; citations – 5 Quartile ranking: Q4.
25.
Saha K., Lam S.K., Abas F, Hamzah A.S., Stanslas J., Lim S.H., Lajis N.H. (2012). Synthesis of
damnacanthal, a naturally occuring 9,10-anthraquinone and its analogues, and its biological evaluation
againt five cancer cell lines. Medicinal Chemistry Research 22(5): 2093-2104. [IF = 1.612]@; citations – 3
Quartile ranking: Q3.
26.
Jabir R.S., Naidu R., Azrif A.A., Ho G.F., Munisamy M., Stanslas J. (2012). Pharmacogenetics of
Taxanes: Impact of Gene Polymorphisms of Drug Transporters on Pharmacokinetics and Toxicity.
Pharmacogenomics, 13(16): 1979-1988.[IF = 3.439]@; citations – 4; Quartile ranking: Q1; #CA
27.
Jamal J.A., Ramli N., Stanslas J., Husain K. (2012). Estrogenic activity of selected Myrsinaceae
species in MCF-7 human breast cancer cells. International Journal of Pharmacy and Pharmaceutical
Sciences, 4, Suppl 4: 547-553. Scopus indexed; citations – 2; *CAU.
28.
Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2012). A young lady with thalamic stroke mimicking
acute Miller Fisher syndrome. Neurosciences, 17(4): 7-8. [IF = 0.121 ]@; citations – 0; Quartile ranking:
Q4
5
29.
Al-Mekhlafi N.A., Shaari K., Abas F., Kneer R., Jeyaraj E.J., Stanslas J., Yamamoto N., Honda
T., Lajis N.H. (2012). Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia
pumila. Phytochemistry, 80: 34-49. [IF = 3.571]; citations – 4; Quartile ranking: Q1
30.
Lim C.W., Chan T.K., Ng S.W.D., Sagineedu S.R., ^Stanslas J., ^Wong W.S.F. (2012).
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and
cancer. Clinical and Experimental Pharmacology and Physiology, 39(3): 300-310. [IF = 2.067]; citations
– 48; Quartile ranking: Q2; *CAU (^ - equal contribution).
31.
Hasan MS, Basri H.B., Lim P.H., Stanslas J. (2011). Surgical remotion of a cysticercotic granuloma
responsible for refractory seizures: A case report. Surgical Neurology International, 2:177 ; citations – 1
32.
Shaari K., Suppaiah V., Wai L.K., Stanslas J., Tejo B.A., Israf D.A., Abas F., Ismail I.S., Shuaib
N.H., Zareen S., Lajis N.H. (2011). Bioassay-guided identification of an anti-inflammatory prenylated
acylphloroglucinol from Melicope ptelifolia and molecular insights into its interaction with 5lipoxygenase. Bioorganic & Medicinal Chemistry, 19(21): 6340-6347. [IF = 3.205]; citations – 3; Quartile
ranking: Q2
33.
Chew Y.L., Chan E.W.L., Tan P.L., Lim Y.Y., Stanslas J., Goh J.K. (2011). Assessment of
phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of
Leguminosae medicinal plants in Peninsular Malaysia. BMC Complementary and Alternative Medicine,
11:12. [IF = 2.343]; citations – 17; Quartile ranking: Q1; *CAU
34.
Wong H.C., Sagineedu S.R., Lajis N.H., Loke S.C. and Stanslas J. (2011). Andrographolide induces
cell cycle arrest and apoptosis in PC-3 prostate cancer cells. African Journal of Pharmacy and
Pharmacology, 5(2): 225-233. [IF = 0.875]; citations – 3; Quartile ranking: Q4; #CA
35.
Bagalkotkar G., Tang S.C., Khalivulla S.I., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. and Stanslas
J. (2011). Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Müll.
Arg. (Euphorbiaceae). African Journal of Pharmacy and Pharmacology, 5(2): 183-188. [IF = 0.875];
citations – 4; Quartile ranking: Q4; #CA
36.
Nobakht G.M., Kadir A.M., Stanslas J. (2010). Analysis of preliminary phytochemical screening of
Typhonium flagelliforme. African Journal of Biotechnology, 9 (11): 1655-1657. [IF = 0.574]@; citations –
2; Quartile ranking: Q4.
37.
Sulaiman M.R., Zakaria Z.A., Abdul Rahman A., Mohamad A.S., Desa M.N., Stanslas J., Moin S.,
Israf D.A. (2010). Antinociceptive and Antiedematogenic Activities of Andrographolide Isolated From
Andrographis paniculata in Animal Models. Biological Research for Nursing, 11 (3): 293-301. [IF =
1.385]; citations – 14; Quartile ranking: Q1
38.
Nobakht G.M., Kadir A.M., Stanslas J. (2009). In vitro mass propagation of Typhonium
flagelliforme as affected by plant growth regulators. African Journal of Biotechnology, 8 (24): 68406843. [IF = 0.574]@; citations – 1; Quartile ranking: Q3
6
39.
Maulidiani, Shaari K., Paetz C., Stanslas J., Abas F., Lajis N.H. (2009). Naturally occurring labdane
diterpene and benzofuran from Globba pendula. Natural Product Communications, 4(8):1031-1036. [IF
= 1.019]; citations – 1; Quartile ranking: Q2.
40.
Vasudevan R., Ismail P., Stanslas J., and Shamsudin N. (2009). Analysis of three genetic
polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. African Journal of
Biotechnology, 8(10): 2069-2075. [IF = 0.574]@; citations – 2; Quartile ranking: Q3.
41.
Ramachandran V., Ismail P., Stanslas J., Shamsudin N. (2009). Analysis of renin-angiotensin
aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic
subjects. Cardiovascular Diabetology, 8:11. [IF =3.521]; citations – 11; Quartile ranking: Q2.
42.
Jabit M.L., Wahyuni F.S., Khalid R., Israf D. A., Shaari K., Lajis N.H. and Stanslas J. (2009). Cytotoxic
and Nitric Oxide Inhibitory Activities of Methanol Extracts of Garcinia Species. Pharmaceutical Biology,
47(11): 1019-1026.[IF =1.1856]; citations – 7; Quartile ranking: Q3; #CA
43.
Manikam S.D., and Stanslas J. (2009). Andrographolide inhibits growth of acute promyelocytic
leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis.
Journal of Pharmacy and Pharmacology, 51, 69-78. [IF = 2.326]; citations – 19; Quartile ranking: Q3; #CA
44.
Ahamed M.E., Ahmed M.E., Eltoum A.M., Altahir G.O., Ahmed K.M., Harbi S.O., Stanslas J., and
Mohamed A.O. (2008). Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients.
European Journal of Inflammation, 6:115-121. [IF = 0.990]@; citations – 3; Quartile ranking: Q4. *CAU
45.
Nor Aini A.S., Merrina A., Stanslas J. and Sreeramanan S. (2008). Cytotoxic Potential on Breast
Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research,
4(3): 103-109; citations – 0;
46.
Jada S.R., Matthews C., Saad M.S., Hamzah A.S., Lajis N.H., Stevens M.F.G. and Stanslas J. (2008).
Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by
inducing G1 arrest and apoptosis. British Journal of Pharmacology, 155(5):641-654. [IF = 4.994]@;
citations – 31; Quartile ranking: Q1; #CA
47.
Vasudevan R., Ismail P., Stanslas J., Shamsudin N. (2008). Association of G2350A polymorphism of
angiotensin converting enzyme gene with essential hypertension and type 2 diabetes mellitus in
Malaysian subjects. Journal of Biological Sciences. 8(6): 1045-1050. citations – 7;
48.
Vasudevan R., Ismail P., Stanslas J., Shamsudin N., and Ali A.B. (2008). Association of
insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without
type 2 diabetes mellitus in Malaysian subjects. International Journal of Biological Sciences, 4(6):362367. [IF = 4.223]@; citations – 7; Quartile ranking: Q1
49.
Vasudevan R., Ismail P., Stanslas J., Shamsudin N., Moin S. and Jas R.M. (2008). Association of
insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension
and type 2 diabetes mellitus in Malaysian subjects. Journal of the Renin-Angiotensin-Aldosterone
System, 9(4):208-214. [IF = 2.000]; citations – 16; Quartile ranking: Q3.
7
50.
Muniandy S.V., and Stanslas J. (2008). Modelling of chromatin morphologies in breast cancer
cells undergoing apoptosis using generalized Cauchy field. Computerized Medical Imaging and
Graphics, 32(7):631-637. [IF = 1.707]; citations – 12; Quartile ranking: Q3; *CAU
51.
Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). C-511T polymorphism of
interleukin-1 b gene is not associated in type 2 diabetes mellitus – a study in Malaysian population.
Journal of Medical Sciences, 8(3):216-221; citations – 1;
52.
Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). No association of BgII dimorphism
in human renin gene in hypertensive subjects in Malaysia. Research Journal of Biological Sciences,
3(10):1218-1222; citations – 0;
53.
Jabit M. L., Khalid R., Abas F., Shaari K., Hui L. S., Stanslas J., and Lajis N. H. (2007). Cytotoxic
xanthones from Garcinia penangiana Pierre. Z. Naturforsch, 62c: 786-792. [IF = 0.776] citations – 7;
Quartile ranking: Q4
54.
Khalid R. M., Jabit M. L., Abas F., Stanslas J., Shaari K., and Lajis N. H. (2007). Cytotoxic
Xanthones from the Leaves of Garcinia urophylla. Natural Product Communication. 2(3), 271-276. [IF =
1.019] citations – 7; Quartile ranking: Q2
55.
Wijayahadi N., Haron M. R., Stanslas J., Yusuf Z. (2007). Changes in Cellular Immunity during
Chemotherapy for Primary Breast Cancer with Anthracycline Regimens. Journal of Chemotherapy. 19,
716- 723. [IF = 0.969]; citations – 10; Quartile ranking: Q4; *CAU.
56. Jada S.R., Subur G.S., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J.
(2007). Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry,
68: 904-912. [IF = 3.571]; citations – 77; Quartile ranking: Q1; #CA.
57. Sagineedu S.R., Ng S-L., Razak I.A., Fun H-K., Lajis N.H. and Stanslas J. (2006). 3,19-(2,6dimethoxybenzyledine)andrographolide. Acta Crystallography. E62: o5806-o5808. [IF = 0.499]; citations
– 1; Quartile ranking: Q4; #CA
58.
Abas F., Lim S.H., Ahmad S., Shaar, K., Stanslas J., Israf D.A., Lajis N.H. (2006). Biological
Evaluation of Curcumin and Related Diarylheptanoids. Z. Naturforsch, 61c: 625-631. [IF = 0.776];
citations – 10; Quartile ranking: Q4
59. Bagalkotkar G., Sagineedu S.R., Saad M.S. and Stanslas J. (2006). Phytochemicals from Phyllanthus
niruri and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58 (12):
1559-1570. [IF = 2.326]; citations – 63; Quartile ranking: Q2; #CA
60.
Jada S.R., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J. (2006). Semisynthesis
and cytotoxic activities of andrographolide analogues. Journal of Enzyme Inhibition and Medicinal
Chemistry, 21(2): 145-155. [IF = 1.815]; citations – 27; Quartile ranking: Q3; corresponding #CA
61.
Jada S.R., McMillan K., Hamzah A.S., Saad M.S., Lajis N.H., Stevens M.F.G., Schwalbe C.H. and
Stanslas J. (2006). 14-acetylandrographolide. Journal of Chemical Crystallography, 36(2):93-97. [IF =
0.488]; citations – 2; Quartile ranking: Q4; #CA
8
62.
Ng S-L., Sagineedu S.R., Razak I.A., Fun H-K, Jada S.R. and Stanslas J., (2006). 3,19-(2bromobenzyledine)andrographolide. Acta Crystallography. E62: o592-o594. [IF = 0.499]; citations – 1;
Quartile ranking: Q4; #CA
63.
Teh B-J., Sagineedu S,R., Fun H-K., Razak I.A., Lajis N.H. and Stanslas J. (2006). 14-Deoxy-11,12didehydro-3,19-isopropyledineandrographolide. Acta Cryst. E62: o589-o591. [IF = 0.499]; citations – 1;
Quartile ranking: Q4; #CA
64.
Abas F., Lajis N.H., Shaari K., Israf D.A., Stanslas J., Yusuf U.K., and Raof S.M. (2005). A New
Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga. Journal of Natural Products, 68:
1090-1093. [IF = 3.947]; citations – 51; Quartile ranking: Q1.
65.
Ariffin H., Muthukumaran T., Stanslas J., Sabariah A.R., Veerasekaran N., Lin H.P., (2005).
Secondary B-cell acute lymphoblastic leukaemia following Wilms’ tumor: Clinical and in vitro
chemosensitivity studies. Leukaemia and Lymphoma, 46(8): 1233-1237. [IF= 2.605]@; citations – 2;
Quartile ranking: Q2; *CAU.
66.
Permana D., Abas F., Maulidiani Shaari, K., Stanslas J., Ali, A.M and Lajis N.H. (2005).
Atrovirisidone B, a New Prenylated Depsidone with Cytotoxic Property from the Roots of Garcinia
atroviridis. Z. Naturforsch. 60c: 523-526. [IF = 0.776]; citations – 14; Quartile ranking: Q4.
67.
Missailidis S., Stanslas J., Modi C., Ellis M.J., Robins R.A., Laughton C.A., Stevens M.F. (2002).
Antitumor polycyclic acridines.Part 12. Physical and biological properties of 8,13-diethyl-6methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design. Oncology Research,
13(3):175-189. [IF = 1.193]; citations – 12; Quartile ranking: Q4.
68.
Abdul Wahab K., Stanslas J., Abu Bakar A., Promwichit P., Aziz S, Marzuki S., & Oon K.W.
(2001).Cytotoxic and Antioxidant Properties of Wood Tissues of Three Malaysian Timber Species.
Journal of Tropical Medicinal Plants, 2(2): 163-168; citations – 0; *CAU
69.
Stanslas J., Hagan D.J., Ellis M.J., Turner C., Carmichael J., Ward W., Hammonds T.R., Stevens
M.F.G. (2000). Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA-affinic tetraand penta-cyclic acridines. Journal of Medicinal Chemistry 43: 1563-1572. [IF = 5.504]; citations – 57;
Quartile ranking: Q1.
70.
Hawariah A. and Stanslas J. (1998). In vitro response of human breast cancer cell lines to the
growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity.
Anticancer Research, 18(6A): 4383-4386. [IF = 1.879];citations – 14; Quartile ranking: Q3.
71.
Hawariah A. and Stanslas J. (1998). Antagonistic effects of styrylpyrone derivative (SPD) on
7,12-dimethylbenzanthracene-induced rat mammary tumors. In Vivo 12(4):403-410. [IF = 1.286];
citations – 16; Quartile ranking: Q3.
72.
Pihie A.H., Stanslas J. and Din L.B. (1998). Non-steroid receptor-mediated antiproliferative
activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Research, 18(3A):17391743. [IF = 1.879]; citations – 53; Quartile ranking: Q3.
9
73.
Noah R.M., Zauyah Y., Jais M.R., Stanslas J., Lope Pihie A.H. (1995). Modulation of macrophage
function in rats treated with a styrylpyrone derivative. Science International (Lahore), 7(2): 299-30;
citations – 0.
74. Zauyah Y., Noah R.M., Jais M.R., Stanslas J., Lope Pihie, A.H. (1995). Effect of a styrylpyrone
derivative on rat lymphoid cells. Science International (Lahore), 7(3): 373-375; citations – 0.
#
CA – corresponding author
*CAU – corresponding author from UPM
IF - 5-year impact Factor
Scopus
H-Index: 15
Total citations: 796
Google Scholar
H-Index: 17
i10-Index: 29
Citations: 1084
b. Non-cited Journal
1.
Zauyah Y., Lope Pihie, A.H., Noah R.M., Stanslas J. (1997). Cytotoxicity of goniothalamin on
hormone-dependent breast cancer cells. Malaysian Journal of Biochemistry and Molecular Biology, 2:
29-32.
2. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F and Stanslas J.
(2005). Semisynthesis of Andrographolide Analogues and Evaluation of Their Anticancer Properties.
Bioscientist, 3(2):18.
3. Jada S.R., Matthews C., Saad M.S., Hamzah A.S, Lajis N.H., Stanslas J. (2010).
Derivatives Suppress the Growth of Cancer Cells. Synthesis, 28: 7.
Andrographolide
4. Stanslas J. Translational Research and Drug Discovery for Cancer Treatment (2012). Greater Kuala
Lumpur. 165 (ISBN 978-3-932831-42-3), KVB Publishing House, Munich, Germany.
Editorial Board Member
10
 World Journal of Pharmacology
 WebMedCentral Pharmacology
 ISRN Pharmacology
Journal Reviewer
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Journal of Pharmacology and Experimental Therapeutics (JPET)
European Journal of Pharmacology
British Journal of Pharmacology
Clinical and Experimental Pharmacology and Physiology
Journal of Pharmacy and Pharmacology
Scientific Reports
Investigational New Drug
Anticancer drugs
PLOS One
Pharmaceutical Biology
Yonsei Medical Journal
Iranian Journal of Pharmacology and Therapeutics
Journal of Ethnopharmacology
Journal of Natural Products
Planta Medica
Phytochemistry
Process Biochemistry
Biochimie
Molecular and Cellular Endocrinology
Letters in Drug Design & Discovery
Medicinal Chemistry
Redox report
Journal of Cancer Research and Experimental Oncology
Malaysian Journal of Medicine and Health Sciences
Malaysian Journal of Medicine
Grant Reviewer
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University of Kuwait
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Ministry of Science, Technology and Innovation, Malaysia (Sciencefund and Technofund –
Biopharmacy and Science & Technology)

Ministry of Agriculture, Malaysia
11

Institute of Medical Research, Ministry of Health, Malaysia
Proceeding(s)
Local
1. Siti Selina AH, Fauziah O, Ghrissi M, Azmi M and Stanslas J. Gene therapy of VP in human breast
cancer cell line (MCF-7): A TEM study. (1999). Electron Microscopy Society of Malaysia: Proc 8th Scient
Conference, 133-134.
2. Azimahtol H.L.P., Stanslas J. (1994). Compound H: a natural anti-breast cancer agent. Proc.Of
COSTAM.
3. Zauyah Y., Azimahtol H.L.P., Stanslas J. (1994). Synergistic antiproliferative effect of goniothalamin
and tamoxifen on MCF-7 cells. Proc. Academy of Science Malaysia, KL, Malaysia.
4. Azimahtol H.L.P., Stanslas J., Ramli M.F., Laily D. (1994). Pharmacodynamics of a styrylpyrone
derivative. Proc. Malaysian Biochem. Soc. Conf.
5. Asmawati D., Stanslas J., Azimatol H.L.P. (1994). Effect of strylpyrone derivative as a potential
antitumor agent on physiological factors of rats. Proc. Malaysian Biochem Soc Conf..
6. Stanslas J., Azimahtol H.L.P. A preliminary study to evaluate the antitumour activity of goniothalamin
in DMBA-induced rat mammary tumor model. (1993). Proc. 2nd IRPA-UKM Workshop: 851-854.
7. Stanslas J., Azimahtol H.L.P. (1992). Goniothalamin: a naturally occurring antiprogestagenic agent
devoid of estrogenic and antiestrogenic activities in immature rat uterus. Proc. Malaysian Biochem. Soc.
Conf. 17: 113-119.
8. Stanslas J., Azimahtol H.L.P., Laily D. (1991). Effect of goniothalamin on breast cancer cell lines. Proc.
4th. Natl. Biol. Sym. (Malaysia).
10. Azimahtol H.L.P., Stanslas J., Devraj, T., Manimaran S., Laily D. The potential of Goniothalamus
extracts as antitumor agents. (1992). Proc. Malaysian Biochem. Soc. Conf. 17: 1-9.
11. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1991). Immunocytochemical evidence for the uptake
of Goniothalamus extracts by estrogen receptor positive tissues. 4thNatl. Mol. Sem.And 2nd Scientific
Meeting of Malaysian Soc.Of Molecular and Cellular Biology, 47.
International
1. Bostock-Smith C.E., Stanslas J., Gimenez-Arnau E., Missailidis S., Laughton C.A., Searle M.S., Stevens
M.F. (1999).Non-covalent encounters between DNA and a new pentacyclic heteroaromatic salt and the
biological sequelae. Proceedings of the American Association of Cancer Research 40.
12
2. Zauyah Y., Stanslas J., Azimahtol H.L.P. A comparative study of the effect of goniothalamin and
tamoxifen on three breast cancer cell lines. (1993). 10th Ann. Sem. and UNESCO Reg. Workshop on the
Bioassay Guided Isolation of Natural products, 31 (Abs).
3. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). .Antiprogesterone and antiestrogenic effects
of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and
Other Natural Products (ASOMPS VII) MP-17 (Abs).
4. Azimahtol H.L.P., Stanslas J., Laily D. (1991). Anti-implantation effect of goniothalamin from
Goniothalamus tapis. 6thSoutheast Asian Pacific Regional Meeting of Pharmacologists 4218:132.
Seminar Papers Presented (oral)
International
1. Yong, A., Lajis N., Shaari K., Saad S., Stanslas J. (2011). Anticancer potential of standardised
Andrographis paniculata extract in prostate cancer models. International Conference on Natural
Products (ICNP, 2011), 14 – 16 November 2011, Palm Garden Hotel, IOI Resort Putrajaya, Malaysia.
(Oral presentation)
2. Yong A., Shaari K., Lajis N, Saad S., and Stanslas J. (2005). Stability of Bioactive Diterpenoid Lactones in
Andrographis paniculata Nees .Inaugural International Congress on Complementary and Alternative
Medicine (ICCAM), 26-28 February, Singapore (Abs pg 58, Oral presentation).
3. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R and Stevens M.F.G. Novel polycyclic
acridines as topoisomerase II inhibitors. (1997). The 8th Conference on DNA Topoisomerases in Therapy
(Amsterdam, Netherlands), 10 (Abs.) (oral presentation).
4. Schwalbe C.H., Bache C.J., Rathbone D. L., Sagineedu S.R., Jada S.R., Stanslas J., Stevens M.F.G. (2006).
Effect of Blocking Groups on the Confirmation and Intermolecular Interactions of Andrographolide.The
2006 Meeting of the American Crystallographic Association, 22-27 July 2006, Honolulu, Hawaii (Abs
W0329, Oral Presentation).
5. Umar-Tsafe N., Stanslas J., Din L.B., Ali A.M. (2000). Apoptosis-inducing potential of goniothalamin in
human leukaemia cells. The 16th Meeting of the European Association of Cancer Research (EACR),
Halkidiki, Greece (Oral – MS38).
Local
1. Jabir R.S., Ho G.W., Azrif A.A., Stanslas J. (2012). Association of side effects and single nucleotide
polymorphism of genes involved in mwtabolism and transport of Docetaxel in Breast Cancer Patients.
Annual Scientific Congress of Malaysian Oncological Society 2012, 6th – 9th September, Melaka.
13
2. Wong M.S., Sagineedu S.R., Khalivulla S.K., Lajis N.H., Sidik S., Mahmud R., Stanslas J. (2009). New
Semisynthetic Compounds in the Treatment of Invasive and Metastatic Cancers. 23rd MSPP Scientific
Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 36, Oral Presentation).
3. Jabir R.S., Toe A.A., Annuar M.A.A., Stanslas J. (2009). Antiangiogenic Therapy in Cancer: Promises and
Realities. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 39,
Oral Presentation).
4. Zakaria S.M., Maulidiani., Khamis S., Shaaru K., Lajis N.H., Tang S.C., Lim S.H., Stanslas J. (2009).
Comparison of Cytotoxic Properties of Randomly Collected Plants From Different Localities: A Malaysian
Case Study. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg
45, Oral Presentation).
5. Hassan N.H., Lim S.M., Stanslas J, Lim S.H. (2006). Antitumour Activity of SRJ13, a New Semisynthetic
Derivative of Andrographolide in Breast Cancer Cell Lines. Proceedings of the 6th Malaysian
Pharmaceutical Society Pharmacy Scientific Conference 2006, Crown Princess Hotel Kuala Lumpur, 8th
– 10th September 2006.
6. Wijayahadi, N., Haron, M.R., Stanslas, J and Yusuf, Z. (2004). Immune Cell Changes in Primary Breast
Cancer Patients Undergoing Chemotherapy with FEC Regimens.9th National Conference on Medical
Sciences, USM, Kubang Kerian. (Abs pg 86, Oral Presentation).
7. Rozida, M.K., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004).Isolation of Bioactive Compounds from
Garcinia urophylla.20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 28, Oral
Presentation).
8. Muthukumaran T., Stanslas J., Hany Ariffin Lim S.M., Sabariah A.R., Veera Sekaran N., Lin H.P. (2002).
Paediatric secondary acute lymphoblastic leukaemia: A case study based on in vitro chemosensitivity
assay. The 4th Malaysian National Haematology Scientific Meeting, Penang, Malaysia (Oral
presentation).
Other Presentation (Poster/Product/Exhibition/Showcase)
International
1. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Vomiting in docetaxel chemotherapy: which to blame,
dose or gene? The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre.
Meeting Abstract Supplement, (FASEB J, 28,1 (655.4)).
2. Stanslas J., Wong C.C., Periasamy N., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H.
(2014). In vitro 3D evaluation of penetrability of SRJ09, a semisynthetic anticancer agent. The Faseb
Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract
Supplement (FASEB J, 28,1 (1048.4)).
14
3. Sani D., Ramli N., Kirby B., Sumon S., Basri H., Stanslas J. (2014). Andrographolide downregulates proinflammatory cytokines and free radical productions to prevent dopaminergic neuro-degeneration
induced by lipopolysaccharide. The Faseb Journal, Experimental Biology, 26th-30th April San Diego
Convention Centre. Meeting Abstract Supplement (FASEB J, 28,1 (1143.16))
4. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Docetaxel-induced mucositis in breast cancer patients:
Association with plasma alpha-1-acid glycoprotein level and SLCO1B3 genotype. American Association of
Cancer Research (AACR) annual meeting, 5th-9th April San Diego Convention Centre. (Abstract no. 5563).
5. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H. (2014). SRJ09, a
semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon
cancer cell lines. American Association of Cancer Research (AACR) annual meeting, 5th-9th April San
Diego Convention Centre. (Abstract no. 4454)
6. Chong P.L., Jaafar H.Z.., Stanslas J., Ibrahim M.H. (2013). Total phenolic content and antioxidant
activity of Labisia pumila Blume cultivated under nitrogen and potassium fertilization. 5th Global Summit
on Medicinal and Aromatic Plants, 8th-12th December, Miri, Sarawak, Malaysia.
7. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S., Summon S.H., Philips R., Lajis N.H. (2013). Mechanism
of resistance to a semisynthetic anticancer andrographolide derivative: Possible involvement of RasMAPK signaling pathway. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes
Convention Center, Boston, MA, United States. Meeting Abstract Supplement (Abs C147, pg 378)
8. Jabir S., Ho G.F., Ahmad Annuar M.A., Stanslas J. (2013). Single nucleotide polymorphisms of ABCB1,
SLCO1B3, and CYP3A5: Potential biomarkers of docetaxel adverse effects in Malaysian breast cancer
patients. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes Convention Center,
Boston, MA, United States. Meeting Abstract Supplement (Abs A210, pg 184)
9. Wong H.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas J. (2012). SRJ23, a potent inducer of cell cycle
arrest and apoptosis in prostate cancer cells. Experimental Biology 2012, 21st – 25th April, San Diego,
California, United States. Poster presentation, Meeting Abstract Supplement, 851.9 (FASEB J, 26
(851.9)).
10. Wong H.C., Sagineedu S.R., Lajis N.H. and Stanslas J. (2010).SRJ23, A new investigational antiprostate cancer agent. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.
Poster presentation, Meeting Abstract Supplement, 964.6 (FASEB J, 24 (964.6)).
11. Stanslas J., Lim S.H., Wong C.C., Sagineedu S.R. and Lajis N.H. (2010). Andrographolide as a template
in the synthesis of new anticancer agents with potentially novel molecular targets. Experimental Biology
2010, 24th-28th April, Anaheim, California, United States.Poster presentation, Meeting Abstract
Supplement, 773.2 (FASEB J, 24 (773.2)).
12. Jabir R.S., Naidu R., Azrif M and Stanslas J. (2010). Efficacy versus toxicity of docetaxel in Asian and
Caucasian cancer patients from the pharmacogenomics perspectives: a review of the literature.
Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.Poster presentation,
Meeting Abstract Supplement, 964.15 (FASEB J, 24 (964.1)).
15
13. Wong C.C., Sagineedu S.R., Lajis N.H., Stanslas J. (2010). Two Semisynthetic Anticancer Lead
Compounds: Assessment of In Vitro Activities against Breast and Colon Cancers. Recent Development in
Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological University Singapore
(Abs pg 78, Poster presentation).
14. Wong H.C., Sagineedu S.R., Lajis N.H, Stanslas J. (2010). A New Semisynthetic Compound Derived
from Andrographolide Displays Impressive In Vitro Activity Against Prostate Cancer Cells. Recent
Development in Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological
University Singapore (Abs pg 79, Poster presentation).
15. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad, M.S. (2008). New
clerodane diterpenes from Casearia capitellata as potential antitumour agents.20th EORTC - NCI - AACR
Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October
(Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008,
Pages 58)European Journal of Cancer (Suppl) 132, p 43.
16. Stanslas J., Lim S.H., Jada S.R., Sagineedu S.R., Lajis N.H., Stevens M.F. (2008). SRJ09, a lead
compound in anticancer drug design: in vitro, in vivo and mechanistic studies. 20th EORTC - NCI - AACR
Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October
(Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008,
Pages 43).
17. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. (2008). New
antitumour
agents
from
Phyllanthus
pulcher,
a
tropical
th
medicinal plant. 20 EORTC - NCI - AACR Symposium on“Molecular Targets and Cancer Therapeutics”,
Geneva, Switzerland, 21 - 24 October (Posterpresentation, European Journal of Cancer Supplements,
Volume 6, Issue 12, October 2008, Pages 58-59).
18. Stanslas J (2006). Discovery and Development of Natural and Synthetic Anticancer Agents.
International Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC,
Kuala Lumpur (Abs S6.1 pg 50, Invited Speaker).
19. Lim S.M., Stanslas J and Ariffin H. (2006). A case study of precursor B-cell ALL with BCR-ABL fusion
gene showed chemoresistance in vitro. The 10th International Symposium On Oncology Pharmacy
Practice, 3-6 April 2006, Kuala Lumpur (Abs pg 76, Poster Presentation).
20. Jada S.R., Sageneedu S.R., Hamzah A.S., Stanslas J., Stevens MFG, Chowbay B. (2005). Structure
Activity Relationship and Antitumour Activities of Andrographolide and its Novel Derivatives. Annals
Academy of Medicine NHG & SingHealth (Poster Abstracts). BAS 176, pg S70.
21. Jada S.R., Mathews C., Stevens M.F and Stanslas J. (2005). Mechanisms of Antitumour Activities of
Andrographolide Derivatives. United Kingdom National Cancer Research Institute (NCRI) Cancer
Conference, 2-5 October, Birmingham (Abs pg 15, Poster Presentation).
22. Wijayahadi N., Yusuf Z., Stanslas J., and Haron M.R. (2005). Comparison of Side Effects of
Chemotherapy Regimens with Epirubicin and Doxorubicin on Profiles of Immune Cells of Breast Cancer
16
Patients. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October,
Birmingham (Abs pg 17, Poster Presentation).
23. Wijayahadi N., Yusuf Z., Haron M.R and Stanslas J. (2005).CD28 Expression on Lymphocytes of Breast
Cancer Patients Undergoing Chemotherapy. United Kingdom National Cancer Research Institute (NCRI)
Cancer Conference, 2-5 October, Birmingham (Abs pg 18, Poster Presentation).
24. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F., and Stanslas J.
(2005). Semisynthesis of Antitumour Andrographolide Derivatives. United Kingdom National Cancer
Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 60, Poster
Presentation).
25. Ali Abdalla J., Yong A., Abdul Kadir M., Stanslas J., and Saad M. S. (2005).Molecular and
Phytochemical Variability of Andrographis paniculata Germplasms in Malaysia. Inaugural International
Congress on Complementary and Alternative Medicine (ICCAM), 26-28 February, Singapore (Abs pg
116, poster presentation).
26. Jada S. R., Stanslas J., Lajis N.H., Saad S., Hamzah A.S., McCorroll A., Mathews C and Stevens M.F.G.
(2003). APAG-1 derivatives as antitumour agents. British Cancer Meeting, 2-5 July, Bournemouth, UK
(poster presentation).
27. Stanslas J., Yahaya R.N.R and Jada S.R. (2003).Inhibition of proteasome function as a mechanism of
antitumour activities of naturally occurring lactone ring-based compounds and their synthetic
derivatives. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation).
28. Stanslas J., Manikam S.D and Holme A. (2003). Induction of differentiation and apoptosis by APAG-1
in acute promyelocytic leukaemia cells. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster
presentation).
29. Stanslas J., Liew P.S., Iftikhar N., Lee C.P., Saad S., Lajis N., Robins R.A., Loadman P., Bibby M.C.
(2001). Potential of AG in the treatment of breast cancer. 11th European Cancer Conference (ECCO),
Lisbon, Portugal (poster presentation).
30. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens MFG. Topoisomerase
II inhibiting antitumour polycyclic acridines. (2000). The 16th Meeting of the European Association of
Cancer Research (EACR), Halkidiki, Greece (poster - FP51).
31. Zauyah Y., Stanslas J., Noah R.M., Jais M.R., Lope Pihie A.H. (2000). Stimulation of the immune
system as a mechanism of tumour prevention by goniothalamin. The 16th Meeting of the European
Association of Cancer Research (EACR), Halkidiki, Greece (Poster – FP50).
32. Hagan D.J., Stanslas J., Ellis M.E., Missailidis S., Arnau E.G., Double J.A., Stevens M.F.G. (1998). New
DNA interactive aza-polycyclic compounds: Physical and biological properties. Annals of Oncology 9
No.S2, p.135.
33. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens M.F.G. (1998).
Antitumour properties of novel aza-polycyclic compounds. British Journal of Cancer, 78, No.S1, p.P32.
17
34. Arnau E.G., Missailidis S., Hagan D.J., Stanslas J., Stevens M.F.G. (1997).Studies on the interactions
between DNA and novel polycyclic acridine derivatives. British Journal of Cancer, 75, P7, 20.
35. Zauyah Y., Stanslas J., Azimahtol H.L.P. (1993) A comparative study of the effect of goniothalamin
and tamoxifen on three breast cancer cell lines. 10th Ann. Sem. and UNESCO Reg. Workshop on the
Bioassay Guided Isolation of Natural products, 31 (Abs).
36. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). Antiprogesterone and antiestrogenic effects
of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and
Other Natural Products (ASOMPS VII) MP-17 (Abs).
Local
1. Tan S.F., Basri M., Stanslas J., Basri H. (2013). Development of nanoemulsion loaded with valproic acid
with response surface methodology. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th
December, Kuching (Abs pg 4).
2. Tan S.M., Stanslas J., Karjiban R.A., Kirby B., Basri M., Basri H. (2013). The preparation and
characterization of carbamazepine-encapsulated nanoemulsion targeting the brain via parental
administration. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching
(Abs pg 24)
3. Daood G.S., Basri H., Stanslas J., Basri M. (2013). The preparation and characterization of
carbamazepine-encapsulated nanoemulsion targeting the brain via parental administration. 26th
Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 24)
4. Suppaiah V., Zareen S., Shaari K., Lajis N.H., Stanslas J. (2009). Inhibition of Leukotriene Production by
Compounds and Extracts of Melicope ptelefolia: A Potential Role in the Treatment of Asthma. 23rd MSPP
Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 75, Poster
Presentation).
5. Lim C.W., Sagineedu S.R., Khalivulla S.I., Sidik S.M., Abdul Latif A.H.D., Lajis N.H., Wong W.S.F.,
Stanslas J. (2009). In Vitro Cysteinyl Leukotriene Synthesis Inhibition by Natural and New Semi-synthetic
Diterpenoids in Murine Macrophages: Potential for Development of New Antiasthma Agent. 23rd MSPP
Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 76, Posterl
Presentation).
6. Ramli N., Stanslas J., Jamal J.A. (2009). Estrogenic Effect of Labisia Pumila Var Alata Extracts In Vitro.
23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 80, Poster
Presentation).
18
7. Wong H.C., Sagineedu S.R., Khalivulla S.I., Lajis N.H., Stanslas J. (2009). SRJ23, A Promising New Antiprostate Cancer Agent. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala
Lumpur (Abs pg 97, Poster Presentation).
8. Wong C.C., Sagineedu S.R., Khalivulla S.I., Stanslas J. (2009). SRJ09 and SRS88, Two Lead Anticancer
Agents: Growth Inhibition, Cell Cycle Arrest and Cell Death Induction of Breast and Colon Cancer Cells.
23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 99, Poster
Presentation).
9. Lim S.M., Stanslas J and Ariffin H. (2005). Development of a predictive assay for treatment of
childhood leukaemia. Malaysian Pharmaceutical Society Pharmacy Scientific Conference, Sunway
Pyramid (Abs pg 54, Poster Presentation).
10. Jabit, M.L., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004). Bioassay-directed Isolation of
Compounds from Garcinia penangiana Leaf Extract. 20th Annual Seminar of the Malaysian Natural
Products Society (Abs pg 59, Poster Presentation).
11. Faridah, A, Lajis, N.H.L., Lim S. H., Syahida, A., Stanslas, J., Israf, D.A., Khozirah, S., Umi Kalsom, Y and
Othman, A.G. (2004). Semisynthesis and Biological Evaluation of Curcumin Related Diarylheptanoids.
20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 66, Poster Presentation).
12. Ali Abdalla J., Saad S., Stanslas J., Abdul Kadir M., Mohamed R, Yong A. (2003). Genetic variations
and antitumour activity of Andrographis paniculata. 19th Annual Seminar and Workshop of the
Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 93) (poster presentation).
13. Yong A., Chong G.H., Stanslas J., Ibrahim M.N., Lajis N., Shaari K., and Saad S. (2003). Stability Study
of Bioactive Diterpenoid Lactones in Andrographis paniculata Nees. 19th Annual Seminar and Workshop
of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation).
14. Saif-Ali R., Jada S.R., Stanslas J., Saad S., Lajis N., Hamzah S.H. (2003). Antitumour Activities of
Synthetic Derivatives of APAG-1. 19th Annual Seminar and Workshop of the Malaysian Natural Product
Society, Kuala Lumpur, Abs (pg 92) (poster presentation).
15. Bagalkotkar G., Stanslas J., Lajis N., Shaari K., Saad S., Hamzah AS (2003). Cytotoxic Potential of
Compounds Isolated from A Phyllanthus Sp. 19th Annual Seminar and Workshop of the Malaysian
Natural Product Society, Kuala Lumpur, Abs (pg 89) (poster presentation).
16. Suppaiah V., Mohd Asihin M.A., Sekawi Z., Stanslas J. (2003). In Vitro Antiviral Activity of Two Local
Herbs Against Dengue Virus Type-2. 19th Annual Seminar and Workshop of the Malaysian Natural
Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation).
17. Jabit M.L., Lajis N.H., Stanslas J. (2003). Cytotoxic activities of Malaysian Garcinia species extracts.
19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg
73) (poster presentation).
19
Research activities
Research Grants
a) Project leader
Year
Project title
Source
2015-2016
Prophylaxis of asthma and COPD with
a standardised herbal extract
2014-2016
Single Nucleotide Polymorphisms,
Psycho-social and Nutritional Risk
Factors for Major Depressive Disorder
and Response to Drug Therapy
NKEA
On-going
Research
Grant Scheme
(NRGS),
Ministry
of
Agriculture
Putra Grant, On-going
Universiti
Putra
Malaysia
2013-2015
Blocking Signalling in Cancer Stem
Cells to Eradicate Relapse in Cancer
Chemotherapy
Fundamental
On-going
Research
Grant Scheme
(FRGS),
Ministry
of
Higher
Education of
Malaysia
2012-2015
SRJ23 and Its Derivatives as New
Anticancer Agents Targeting RAS-MAP
Kinase and NF-B Pathways: in vitro, in
vivo, in silico and protein
crystallography approaches
Research
On-going
University
Grant Scheme
(RUGS), UPM
2012-2014
Potential of a standardised aqueous
extract of a local herb as a cognition
enhancer via maintenance
and increased integrity of
neuroplasticity: roles of antineuroinflammation and anti-oxidative
properties
Pharmacogenetics of Docetaxel in
Malaysian Metastatic Breast Cancer
Patients
NKEA
Research
Grant Scheme
(NRGS),
Ministry
of
Agriculture
2010-2012
Status
completed
Fundamental
Completed
Research
Grant Scheme
(FRGS),
Ministry
of
20
Higher
Education
Malaysia
of
2009-2011
Molecular Mechanisms of Cell Cycle
Arrest and Apoptosis Induced by
Semisynthetic Diterpenoids in Cancer
Cell Line
Research
Completed
University
Grant Scheme
(RUGS), UPM
2007-2009
Formulation, Gastrointestinal Transit SCIENCEFUND
and Absorption from Nano-particular
Dispersion of Amphotericin B
2008-2010
Chemical
Characterization,
Standardization
and
Biological
Evaluation of Melicope ptefolia
Towards Their Development into
Antiinflammatory
Nutraceutical
Products
2007-2009
Evaluation of New Andrographolide SCIENCEFUND
Derivatives for Inhibitory Activities CYCLE 1/2006:
Against Tumour Vasculature and
Metastasis
Completed
2001-2002
Mammogram Imaging in the Diagnosis Faculty’s
of Breast Cancer (University Malaya Students’
Medical Centre - UPM)
Project Fund
Completed
2001-2003
In vitro Assessment of the Efficacy of Faculty’s
Standard Chemotherapeutic Drugs Students’
used in the Treatment of Childhood Project Fund
Leukaemia at the University Malaya
Medical Centre (UMMC-UPM)
Completed
2003-2006
Synthesis
of
andrographolide UPM-IRPA EA Completed
derivatives and evaluation of their RM8
antitumour potential
2002-2005
Stability of bioactive diterpenoid
lactones in A. paniculata’.
2000-2003
Evaluation of the antitumour potential UPM-IRPA EA- Completed
of compounds of Andrographis RM7
paniculata
(andrographolide,
neoandrographolide, andrographiside)
Completed
Biopharmacy
Completed
(National
Pharmaceutic
al
Institute)
(MOSTI):
IRPA-PR_BTK
IMR_RM8
Completed
21
1999-2000
New lecturer research scheme (two)
UPM
Completed
b) Co-researcher
Year
Project title
Project
leader
Source
Status
2015-2016
Investigating the
role of antiinflammatory
property of natural
compounds and
their derivatives in
the treatment of
psoriasis: in vitro
studies
Dr Audrey
Yong Chee
Hui
MAHSA
University
On-going
2014-2015
Medicinal
Properties,
Nutritional Values
and Safety Profiles
of Edible Bird’s
Nest
Prof Madya
Christopher
Lim
CoE Swiftlet
Grant
On-going
2011 – 2013
Standardisation of
aqueous extract of
a local medicinal
herb based on the
anti-gout and antiinflammatory
activities
Prof Madya
Dr Jamia
Azdina Jamal
NKEA
Research
Grant Scheme
(NRGS),
Ministry of
Agriculture
Completed
2011 – 2013
Biosynthesis of
acylated quercetin
analogues and
evaluation of their
anticancer
Dr Choo Wee
Sim
Sciencefund
Completed
22
activities
2011 – 2013
NMR-based
metabolomics
fingerprinting and
profiling of Labisia
Pumila varities and
biofluids (animal
metabolic study) in
the detection of
biomarker in
diabetic induced
rats
Prof Madya
Hawa Jaafar
NKEA
Research
Grant Scheme
(NRGS),
Ministry of
Agriculture
Completed
2011 - 2012
HPLC method
development and
validation of
determination of a
pharmaceutical
agent in mice
plasma
Dr. Audrey
Yong
SEGi
University
College
Research Fund
Completed
2010 - 2013
Development
of Assoc Prof Dr
Andrographolide
Fred Wong
and its Derivatives
for the Treatment
of Allergic Asthma
and
Asthma
Exacerbation
Biomedical
Research
Council
(BMRC),
Singapore
Completed
2007 – 2009
Production
of Assoc Prof Lai
Coenzyme
Q10 Oi Meng
with
Improved
Bioavailability for
Food Supplement
from
Tobacco
Leaves
Techofund
(MOSTI)
Completed
2007 – 2009
Anti-inflammatory Assoc Prof Dr Sciencefund
and
and Jamia Azlina Cycle 1: 2006
Oestrogenic Effects Jamal
of
Compounds
isolated
from
Completed
23
Labisia
spp
(MYRSINACEAE)
2005 –2007
Investigation into Dr
Mohd
Gene Expression Nazil Salleh
and Metabonomic
Profiling
of
Endometrial
Cancer
using
Transgenic Animal
Model
Scientific
Advancement
Grant
Allocation
(SAGA) Fund
Complete
2000-2005
Isolation
and Assoc Prof Dr UPM-IRPA EA Complete
characterisation of Said Saad
RM8
antitumour agents
from Phyllanthus
pulcher
Patent Filed
Patent title: Cysteinyl Leukotriene Inhibitor Comprising 2,4,6-trihydroxygeranylacetophenone (tHGA) as
an Active Ingredient (PI201000968)
Patent holder: Khozirah Shaari, Johnson Stanslas, Velan Suppaiah, Seema Zareen, Faridah Abas, Daud
Ahmad Ishraf, Nordin Haji Lajis
Consultation activities
(a) Lead project consultant
No.
1
2
Name of
Consultant(s)
Autoimmune
Sdn Bhd
Name of
Project/Program
To evaluate the
anticancer
potential of
botanical extracts
and
antihepatotoxic
effect of HepatTM
Country
Provide advice on
Heights Health the purchase and
Year
June 2004 –
May 2005
July 2005 –
June 2006
Status
(Completed/Ongoing)
Completed
Completed
24
Sanctuary
(CHHS), Palace
of
Golden
Horses,
Seri
Kembangan,
Serdang
3
running of
diagnostics and
health screening
equipment at
CHHS
Arah Mashur Assessment of in
Sdn Bhd
vitro anticancer
potential of AM
botanical extracts
January 2006
– March
2006
Completed
(b) Co-project consultant
No Company
1
Black Gold Sdn Bhd
Project title
Duration
Production
of September 2007
Coenzyme Q10 – August 2009
With
Improved
Bioavailabity for
Food Supplement
from
Tobacco
Leaves
Extension and other public services
No.
1
Name of
Activity/Project/
Program
Anugerah Tidak
Ternilai –
Anugerah Herba
Organiser
RTM TV1
Place
Malaysia
Date
November
2004
Awards
International
1. International Invention, Innovation and Technology Exhibition (ITEX) - 15-17 Mei 2009 (KLCC) ‘SRJ09,
A Lead Compound in Anticancer Drug Discovery’ - Bronze medal
2. 2nd place for Best Poster presentation for Division of Drug Discovery, Development and Regulatory
Affairs (American Society for Pharmacology and Experimental Therapeutics), Experimental Biology 2012,
21st – 25th April, San Diego, California, United States
25
National
1. Best Poster Presentation ‘In vitro cysteinyl leukotriene synthesis inhibition in murine macrophage by
natural and new semi-synthetic diterpenoids: potential for development new anti asthma agent’ - 23rd
Malaysian Society of Pharmacology and Physiology Scientific Meeting, Kuala Lumpur, 12 th – 13th May
2009.
2. Best Poster for Pharmaceutical Chemistry/Traditional and Complementary Medicine/Basis of
Therapeutics/Pharmacology - 6th Malaysian Pharmaceutical Society Pharmacy Scientific Conference
2006, Crown Princess Hotel Kuala Lumpur, 8th – 10th September 2006.
3. 2nd place for Best Presenter at the Annual Scientific Congress of Malaysian Oncological Society
(ASCOMOS) 2012, Melaka, Malaysia
University
Universiti Putra Malaysia research awards 2009 – 2 gold medals
1. Inhibition of Leukotriene Production by Compounds and Extracts of Melicope Ptelefolia: Potential Role
in the Treatment of Asthma
2. SRJ23, A Promising New Anti-Prostate Cancer Agent
Universiti Putra Malaysia research awards 2007 – 2 gold, 3 silver and 1 bronze medals
Gold
1. SRJ09, A Lead Compound In Anticancer Drug Design
2. Inhibition of Tumour Growth Through Suppression of Angiogenesis By a natural compound.
Silver
1. Therapeutic Potential of Standardised AndroPan for the Treatment of Prostate Cancer.
2. Design And Synthesis Of Andrographolides As Potential Anticancer Agents: Discovery Of Cytotoxic And
Antiangiogenic Agents.
3. Isolation of New Clerodane Diterpenes From Casearia capitellata As Potential Antitumour Agents.
Bronze
1. Structure Elucidation and Antitumoural Properties Of New Terpenoid Derivatives From Phyllanthus
pulcher
Universiti Putra Malaysia research awards 2005 - 3 bronze medals
26
1. Pharmacokinetic and Antitumour Studies of Diterpenoid Lactones of Andrographis paniculata Nees –
Institute of Bioscience.
2. HTLV-1 Tax Gene in Adult Leukaemia and Lymphoma Cells and In Vitro Chemosensitivity Profiles –
Faculty of Medicine and Health Sciences
3. Anti-Dengue Compounds from Thottea sp - Faculty of Medicine and Health Sciences
Universiti Putra Malaysia research awards 2004
Gold Medal
Title: Semisynthesis of Antitumour Andrographolide Derivatives
2. Silver Medal
Title: Mechanisms of antitumour activities of andrographolide derivatives
3. Bronze Medal
Title: Suitable Drying and Storage Conditions to Maintain the Stability of Andrographolide in Andrograhis
paniculata Nees
Excellence Service Award, Universiti Putra Malaysia: 2004 dan 2010
Administrative duties and other relevant appointment
No.
Position
Department/Faculty/Other Institution
Year
1
Head of
Pharmacotherapeutics Unit
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2008 – present
2
Course coordinator (General
and Biochemical
Pharmacology)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2010 –present
3
Course coordinator
(Molecular Pharmacology)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2004 – present
4
Course coordinator
(Molecular Medicine)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2004 – 2006
Academic duties/committee members
27
No.
1
2
3
4
5
6
7
8
9
10
11
Title
Member of the
Faculty’s
Preclinical
Curriculum
Committee
Member of the
Faculty’s
Continual
Medical
Education
(CME)
Committee
Advisor to The
Putra Medical
Club
Member of the
Faculty’s
Support Staff
Committee
Member of the
Medical
Research
Ethical
Committee
Member of the
Laboratory
Committee
Member of the
Animal Care
and Use
Committee
Research
Associate at
the Natural
Products
Laboratory
Grant reviewer
(RUGS, FRGS,
ERGS, PRGS)
Technical
reviewer
Project
reviewer
Level
(International/National/University/Faculty/Department)
Year
Faculty of Medicine and Health Sciences, UPM
2005
Faculty of Medicine and Health Sciences, UPM
2003 –
2004
Faculty of Medicine and Health Sciences, UPM
2003 –
2004
Faculty of Medicine and Health Sciences, UPM
2002 –
2003
Faculty of Medicine and Health Sciences, UPM
2008 –
present
Faculty of Medicine and Health Sciences, UPM
2008 –
present
Faculty of Medicine and Health Sciences, UPM
2009 2012
Institute of Bioscience, UPM
2001 –
present
Universiti Putra Malaysia
2011 –
2014
Universiti Malaya
2012
University of Kuwait
2011
28
12
Committee
member for
“Etika
Universiti
untuk
Penyelidikan
Melibatkan
Manusia
(JKEUPM)”
Universiti Putra Malaysia
2012
Involvement in professional association/organization/body
No.
1
2
3
4
5
6
7
Name of
Association/Organization/Body
National Seminar on ‘Translational
Research in Oncology’
National Seminar on ‘Paediatric
Neurotransmitter Diseases’
5th Malaysian Conference on Healthy
Ageing
2nd Annual Neuroscience Seminar
International Conference on Natural
Products 2011
1st World Congress on Healthy Ageing
2012
Nobel Laurate Committee of Malaysia
Role (President/Secretary/Committee
Member/Ordinary Member
Chairperson
Chairperson
Scientific Chairman
Committee Member
Committee Member
Committee Member
Committee Member
29