Download Curriculum Vitae Jieun Lee, PhD

Curriculum Vitae
Jieun Lee, PhD
EDUCATION:
Postdoctoral Scholar, Stem Cell Biology in Cardiovascular Medicine
Stanford University School of Medicine, Stanford, California, USA
Mentor: Dr. John Cooke
Doctor of Philosophy, Cell Biology and Pathology in Medical Science
Yonsei University School of Medicine, Seoul, Korea
Mentor: Dr. Si-Young Song
Master of Science, Cell Biology and Pharmacology in Medical Science
Yonsei University School of Medicine, Seoul, Korea
Mentor: Dr. Si-Young Song
Bachelor of Science, Biology
Seoul Women’s University, Seoul, Korea
2008-present
2002-2008
2000-2002
1995-2000
DISSERTATION AND THESIS:
Doctoral Dissertation:
GLP-1 expressing adult pancreatic ductal precursor cells established from acinar- to-ductal transdifferentiation reverse
streptozotocin-induced diabetes in rats
Yonsei University, Seoul, Korea, 2002-2007 (research advisor: Si-Young Song, M.D., Ph.D).
- These data indicate that the adult pancreatic ductal progenitor cells established from acinar to ductal
transdifferentiation can differentiate into insulin-producing β-cells and that the homing of intravenously transplanted
cells is possible. These results have implications for potential use of adult pancreatic stem cells in regenerative therapy
for diabetes patients.
Master’s Thesis:
The role of acinar to ductal cell transdifferentiation in pancreatic carcinogenesis
Yonsei University, Seoul, Korea, 2000-2002 (research advisor: Si-Young Song, M.D., Ph.D).
- In this paper, we report the spontaneous transdifferentiation of cultured rat pancreatic acinar cells to alter their usual
phenotypic expression and attain morphological and functional characteristics of duct cells. We present in vitro system
in which the cellular differentiation of pancreatic duct-like cell and their expression of pdx-1, c-kit and SCF appeared to
induce stem cell activity potentially.
RESEARCH EXPERIENCE
Cardiovascular Institute, Stanford University, Stanford, CA
2008-present
• Planned, organized, and carried out long-term and short-term research projects
• Researched the cellular signaling mechanism of inducible pluripotent stem cell (iPSC) generation
• Investigated the angiogenic mechanisms by which endothelial α7-nAChR mediates the vascular effects of
nicotine
Comparative Gastroenterology Lab, Yonsei University, Seoul, Korea
1999-2007
• Planned, organized, and carried out long-term and short-term research projects
• Researched and studied about pancreatic carcinogenesis and developmental pathways of islet
differentiation from pancreatic precursor cells
• Developed expertise in isolation methods of stem/precursor cells
• Performed cell line establishment and characterization
• Transplanted stem cells intravenously into injured animal model (Liver and Pancreas) for cell therapy
Curriculum Vitae, Jieun Lee, PhD
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TEACHING/PROFESSIONAL EXPERIENCE:
Science Tutor and Mentor
Private Tutor and Instructor in Academy for High School students, Seoul, Korea
• Involved with teaching students the complexities of the biology and biochemistry
• Provided assistance to tutors in subjects such as biology and biochemistry
Reviewer
• Peer reviewed several manuscripts for the journal, Stem Cells and Development
Lecturer/Mentor
• Stanford EXPLOER Program
• Teaching Summer High school Interns
1999 - 2006
2009-2011
July 2012
2012
Workshop
• Teaching in Science from Stanford Faculty Development Center Program
2012
SOCIETY MEMBERSHIPS/ACTIVITIES:
2000 – 2002
Member of American Association for Cancer Research (AACR)
2000 – 2009
Member of American Gastroenterological Association (AGA)
2003 – present
Member of International Society for Stem Cell Research (ISSCR)
2012 – present
Member of American Heart Association (AHA)
RESEARCH INTERESTS:
Investigate cancer stem cells to find out the origins of cancer
• Develop cancer stem cell markers and isolation methods
• Apply findings about the mechanisms of initiation of cancer from stem cells as preventative therapy
• Find out pre-diagnostic markers of cancer
Investigate mechanism of efficient generation of iPSCs
• Understand somatic cell reprogramming mechanisms toward generating improved fidelity in iPSCs with
high efficiency
• Define the role of innate immunity signaling inducing epigenetic alteration that accelerates somatic cell
reprogramming
PROJECTS AND WORKS:
o
2008 - present
• Role of innate immunity in nuclear reprogramming: Chromatin remodeling
• Generation of inducible pluripotent stem cells (iPSCs)
• Identify role of calcium signaling in α7-nicotinic acetylcholine receptor (nAChR) induced angiogenesis
o
2000 -2007
• The role of c-kit in pancreatic acinar to ductal cell transdifferentiation
• Pancreatic development related protein expression in transdifferentiated rat pancreatic acinar cells; Shh, Wnt and
Notch
• Origin of liver-regenerating stem cells
• Effect of pancreatic development related factor in YGIC cell line; Acivin, Betacellulin and GLP-1
Curriculum Vitae, Jieun Lee, PhD
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PRESENTATIONS:
Jieun Lee, John P. Cooke (Oral Presentation)
• Activation of Innate Immunity is Required for Efficient Nuclear Reprogramming
NHLBI Progenitor Cell Biology Consortium (PCBC) 4th Annual Investigator Meeting
September 2012
Jieun Lee, Nazish Sayed, Arwen Hunter, Kin Fai Au, Wing H. Wong, Renee Reijo Pera, James Swartz, John P. Cooke
• Activation of Innate Immunity is Required for Efficient Nuclear Reprogramming
International Society for Stem Cell Research, Yokohama, Japan
June 2012
Jieun Lee, John P. Cooke (Young Investigator Oral Presentation)
• Regulation of Intracellular Calcium by Endothelial nAChRs and Pathological Angiogenesis
Tobacco-Related Disease Research Program, University of California, Sacramento, CA
April 2012
Jieun Lee, Nazish Sayed, Arwen Hunter, Renee Reijo Pera, James Swartz, John P. Cooke
• Protein-based reprogramming: Virus versus protein approach
International Society for Stem Cell Research, Toronto, Canada
June 2011
Jieun Lee, Arwen Hunter, William Yang, Renee Reijo Pera, James Swartz, John P. Cooke
• Protein-based reprogramming
NHLBI Progenitor Cell Biology Consortium, Seattle, WA
October, 2010
Jieun Lee, Arwen Hunter, William Yang, Renee Reijo Pera, James Swartz, John P. Cooke
• Transcriptional regulation of iPSC induction
International Society for Stem Cell Research, San Francisco, CA
June 2010
Jieun Lee, Arwen Hunter, William Yang, Renee Reijo Pera, James Swartz, John P. Cooke
• Transcriptional regulation of iPSC induction
National Heart, Lung and Blood Institute Symposium on Cardiovascular Regenerative Medicine
NIH, Bethesda
October 2009
Ji-Eun Lee, Jing Wen, Si-Young Song (Poster presentation as a poster of distinction)
• Successful Treatment of Diabetic Rat via Cell Therapy with GLP-1 Expressing Adult Pancreatic Ductlike Precursor Cells Established from Acinar to Ductal Transdifferentiation,
American gastroenterological Association, Washington, DC
May 2007
Jing Wen, Ji-Eun Lee, Si-Young Song (Poster presentation)
• Oct4 and Nanog as initiation molecules of the pancreatic adenocarcinoma carcinogenic process,
Keystone Symposia on Stem Cells, Senescence & Cancer, Singapore
October 2005
Ji-Eun Lee, Jing Wen, Si-Young Song (Poster presentation)
• GLP-1 induced differentiation of pancreatic ductal precursor cell line to insulin-producing cells in vivo,
International Society for Stem Cell Research, San Francisco, CA
June 2005
Ji-Eun Lee, Jing Wen, Si-Young Song (Poster presentation)
• GLP-1 induced differentiation of pancreatic ductal precursor cell line to insulin-producing cells in vitro,
American Gastroenterological Association, New Orleans, LA
May 2004
Ji-Eun Lee, Si-Young Song (Poster presentation)
• Role of overexpression of factors regulating pancreatic embryogenesis in acinar to ductal
transdifferentiation in vitro and pancreatic carcinogenesis and establishment of two normal rats
pancreatic ductal cell lines, American Gastroenterological Association, Orlando, Florida
May 2003
Seung-Woo Park, Ji-Eun Lee, Si-Young Song (Poster presentation )
• Implication of developmentally regulated genes in pancreatic carcinogenesis, American
Gastroenterological Association, Orlando, Florida
May 2003
Ji-Eun Lee, Si-Young Song (Oral presentation)
• The Role of acinar to ductal cell transdifferentiation in pancreatic carcinogenesis, Korean Association
of Gastroenterology, Seoul, Korea
December 2002
Ji-Eun Lee, Si-Young Song (Oral presentation)
• Establishment of normal rat pancreatic ductal cell lines under the concept of acinar-ductal
transdifferentiation, Kyoto-Yonsei Joint Meeting on Pancreatic Cancer, Kyoto, Japan
September 2002
Seung-Woo Park, Ji-Eun Lee, Si-Young Song (Poster presentation as a poster of distinction)
• Establishment and characterization of a new pancreatic tumor cell line from IPMT, American
Gastroenterological Association, Atlanta, Georgia
May 2001
Curriculum Vitae, Jieun Lee, PhD
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PUBLICATIONS:
Jieun Lee, Nazish Sayed, Arwen Hunter, Kin Fai Au, Wing H. Wong, Edward Mocarski, Renee Reijo Pera,
John P. Cooke
“Activation of Innate Immunity is Required for Efficient Nuclear Reprogramming”
In press to Cell, 2012; 151(3): 547-558
Jieun Lee, John P. Cooke
“Nicotine and Pathological angiogenesis”
In press to Life Sciences 2012
Jieun Lee, John P. Cooke
“The role of nicotine in the pathogenesis of atherosclerosis.”
Atherosclerosis, 2011; 215(2): 281-3, PMID: 21345436
William Yang, John Welsh, Jieun Lee, John P. Cooke, James R. Swatz
“Solubility Partner IF2 Domain I Enables High Yield Synthesis of Transducible Transcription Factors in
E. coli”
Protein Expr Purif. 2011; 80(1): 145-51, PMID: 21757009
Jieun Lee, Wen Jing, Sun-A Kim, Jeong Youp Park, Eun Jig Lee, Si Young Song
“Reversal of Diabetes in Rats Using GLP-1-Expressing Adult Pancreatic Duct-like Precursor
Cells Transformed from Acinar to Ductal Cells”
Stem Cells Dev. 2009; 18 (7): 991-1002, PMID: 19125629
William Yang, Kadar Patel, Jieun Lee, Yohannes Ghebremariam, Hea Wong, John P. Cooke, James Swartz
“Cell-free production of transducible transcription factors for nuclear reprogramming”
Biotechnol Bioeng. 2009; 104(6): 1047-58, PMID: 19718703
Jeong Youp Park, Kyung Hwa Park, Ji-Eun Lee, Sang Seok Koh, Si Young Song
“CXCL5 Overexpression is associated with Late Stage Gastric Cancer”
J Cancer Res Clin Oncol. 2007; 133(11): 835-40, PMID: 17479287
PATENTS:
1. Pancreatic precursor cell line transdifferentiated from pancreatic acinar cells
• International Patent Application
Application number: PCT/KR2004/002669
Inventor: Si-Young Song, Ji-Eun Lee, Yonsei University
• Korean Patent Registration
Patent number: 10-0660473 (Registration date: December 15, 2006)
Application number: 10-2004-0022791 (Filing date: April 02, 2004)
Patentee: Yonsei University, Seoul, Korea
Inventor: Si-Young Song, Ji-Eun Lee
2. Cell-free synthesis of active reprogramming transcription factors
• International Patent Application
Application number: PCT/US2010/041987
Inventor: William Yang and Jieun Lee et al., Stanford University
3. Activation of Innate Immunity for Enhanced Reprogramming of Cells to Pluripotency
• International Patent Application
U.S. Application Serial No. 61/587,259
Inventor: John Cooke and Jieun Lee et al., Stanford University
Curriculum Vitae, Jieun Lee, PhD
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SCHOLARSHIPS/GRANTS:
• Postdoctoral Fellowship Grant from University of California
Tobacco-Related Disease Research Program (No. 18FT-0064)
2009-2012
• Scholarship/Grant from Brain Korea 21 Project for Medical Science
Yonsei University, Korea
2000-2006
• Grant (SC 13011) from the Stem Cell Research Center of the 21st Century Frontier
Research Program of Korea
2002-2005
AWARDS:
• 2012 Junior Investigator Poster Award from International Society for Stem Cell Research (ISSCR)
• 2012 Travel Award from International Society for Stem Cell Research (ISSCR)
• 2012 Travel Award from R&D Systems (ISSCR)
• 2012 Distinct Young Investigator from Tobacco-Related Disease Research Program (TRDRP) Conference
• 2007 Poster of Distinction from American Gastroenterological Association (AGA)
• 2001 Poster of Distinction from American Gastroenterological Association (AGA)
References available upon request
Curriculum Vitae, Jieun Lee, PhD
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