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PET FOODS AND DIAGNOSITICS OF THE “NEAR” FUTURE Key Point “Wholesome nutrition is the key to a healthy immune system and resistance to disease. “ diet = potent mechanism to alter cellular environment especially in GI tract (intestinal biosis and dysbiosis) diet supports metabolism and vital functions of skin diet long recognized cause of hypersensitivity-like skin reactions in dogs, cats, people delayed sensitivities 2-72 hrs after eating; difficult to connect symptoms with foods high correlation of delayed sensitivity with amount and frequency of food eaten primary food allergens : corn, wheat, soy, beef, eggs, milk secondary food allergens: lamb, rabbit, venison, buffalo, chicken, turkey, barley, millet, oatmeal, salmon, white fish, rice, quinoa, potatoes, peanut butter 3 rd most common after flea bite sensitivity and atopy (inhalant allergy) at least 15% of all allergic skin disease no age, breed, sex predilection most affected animals eating offending foods for > 2 years mimics other skin syndromes major complaint is pruritis (itching) pruritic bilateral otitis externa secondary seborrhea, pyoderma 15% have concurrent GI tract issues some peripheral lymphadenopathy, especially cats tension-fatigue, malaise, dullness non-seasonal and poor response to steroids create healthy acid-base balance through optimal nutrition diet elimination trials for 4-8 weeks; often poor compliance must be individualized; use nutrigenomic principles avoid additives & supplements; avoid switching from diet-diet Restricted Antigen Source Commercial source or homemade diets of restricted or novel antigens are given for 6-12 weeks. Many pets are now reactive to diets with lamb and rice. Liver Cleansing Diet White potato + sweet potato (50/50) and white colored fish – 2/3 potato mix and 1/3 fish. Season with garlic, mixed Italian herbs or parsley, salt and pepper. Later, can add chopped carrots, and scrambled eggs, if tolerated. Liquid or other gluten-free multivitamin Dietary Effects of Soy Protein Effects on thyroid function (inhibits thyroid peroxidase) Soy isoflavones present in most premium cat foods Effects protected by dietary iodine; pet foods rich in iodine Potential trigger of feline hyperthyroidism Soy is a phytoestrogen; concern for dog and cat diets [skin, hair coat, immune response, delayed puberty, infertility] Immune function requires zinc, selenium and vitamin E, vitamin B6 , and linoleic acid; and carotenoids, especially lutein and beta-carotene. Sterols + sterolins in combination = immune balancing and stress modulating fats from fruits, vegetables and medicinal plants. Natural antioxidants and preservatives (e.g. vitamins E and C, citric acid, rosemary, turmeric, oregano, blueberries). Dietary Supplements Novel or restricted protein source diet, probiotics, antioxidants Carotenoids, kelp, garlic, high fiber foods, nutritional herbs Medicinal herbs, vitamins E and C, whole apple cider vinegar Essential oils, flower essences, unpasteurized yogurt Taurine and DMG for epileptics, milk thistle or denosyl methionine as liver cleanse, herbal pain remedies Bee Pollen – for infections, colds, rich in vitamin B complex Colostrum – stimulates and regulates immune system DGP - Dog Gone Pain; herbal remedy for pain DLPA- D,L phenylalanine; endorphin stimulant for chronic bone and muscle pain Ginger – mostly for digestion Medicinal Mushrooms - dried reishi and maitake; many antimicrobial , anticancer, and immune support properties MSM - methylsulfonylmethane; anti-inflammatory for joints Oils – wild salmon, coconut, hemp, olive, canola ; for fatty acids, skin and coat conditioner Transfer Factor - for immune enhancement and stress control Yuca (Cassava) – not Yucca ; used for IBD , gluten –free starch Individuals deficient in selenium show clinical signs of hypothyroidism because tissue levels of thyroid hormones are depleted, while blood thyroid levels rise Diagnosis could be overlooked on the basis that blood levels of thyroid hormones appear normal Iodine excess causes alterations in thyroid activity, blocking both its characteristic functions and cell proliferation Feeding excessive amounts of iodine in foods and supplements (kelp, seaweed) reduces thyroid function Contributes to the rising prevalence of hypothyroidism in young dogs, and hyperthyroidism in older cats Iodine increases auto-antigenic potency of thyroglobulin leading to induction of autoimmune thyroiditis High quality lower protein diets Increasing dietary tryptophan (turkey) Limit "hot foods" (venison, chicken, mutton) Limit high copper foods (lamb, unless grass fed) Rosemary and Oregano– added today as pet food preservative and antioxidant. NOT to be given to epileptics. (Peppermint Oil can help protect epileptics) Grapes and Raisins – toxic to dogs; acute renal failure Corn, Corn Starch, Fructose from Corn – associated with food sensitivity, intolerance. Chicken, Venison, Mutton – “hot foods” in Chinese medicine. Beef, Cow’s Milk – food sensitivity , intolerance. Wheat, Soy – food sensitivity , intolerance. Lamb – too much copper unless grass fed. Onions – produces “ Heinz body” hemolytic anemia. Vasoactive Amines – tuna, mackerel, skipjack, bonito emerging science that studies the molecular relationships between nutrition and the response of genes in the genome in promoting health different diets alter gene expression, and protein/metabolite production specific nutrients affect body responses in a form defined as a “signature” individual response = “molecular dietary signature” diet can be serious risk factor for a number of diseases common dietary ingredients act on animal genome directly /indirectly, to alter gene expression/structure degree of dietary influence on balance of healthy and disease states depends on individual’s genetic makeup certain diet-regulated genes play a role in onset, incidence, progression, and/or severity of chronic diseases dietary intervention based on animal’s nutritional requirement/ status plus genotype used to prevent, mitigate or cure chronic disease What is the Alternative ? MDS Molecular Dietary Signature Dog ”Heat Map “ Dog Liver Cleansing MDS Molecular Dietary Signature 28 days on Silybum marianum (milk thistle) “Heat Map” Molecular Dietary Signature DOG Arthritis 28 days on Andrographis paniculata + Curcuma longa Food Sensitivity -- Prior Testing typically based on IgE, IgG 4, and immune complexes with complement high sensitivity but lower individual specificity measures more immediate-type reactions Food Sensitivity -- Newer Testing ● ● ● 1, 2, 3 newer tests can use serum, saliva or feces ELISA or other immunoassay platforms identify IgG, IgA , or immune complexes to foods in serum IgA or IgM antibodies to foods in saliva antibodies to foods appear in saliva before GI tract clinical/biopsy diagnosis of IBD or “leaky gut syndrome” saliva testing can thus reveal the latent or pre-clinical form of food sensitivity Three Levels of Testing ● ● ● 1, 2, 3 Saliva Screening Kit --- POS owner/ vet clinic testing; 65 % of market, several times annually for life Tests for salivary IgA and IgM reactants in healthy pets and those with known or suspected food intolerances Client obtains test kit [from vet or pet supply store], follows directions, adds saliva, seals kit, sends to diagnostic laboratory ADVANTAGE OF THE NUTRISCAN DIFFERENCE Your dog has itchy skin, a leaky gut? What is the test? Medium tested Antibody measured How performed Addressing the real food issues Which foods Price per panel NUTRISCAN OTHER FOOD SENSITIVITY TESTS Intolerance+ Sensitivity Saliva IgA and IgM Home use or Vet visit Delayed and long term food issuesExcellent clinical correlation 20 antigens (2 panels of 10 each:-a primary and a secondary panel) $130 or $250 for both panels Hypersensitivity (Allergy) Serum IgE or IgG Veterinary visit required Immediate food issues only; poor clinical correlation to more delayed food reactions About 20 antigens Varies –about $100 Vets and pet owners need to concentrate on more long term control of food-related health issues, rather than the more immediate acute hypersensitivities. Otherwise animals will not get better. The patented NutriScan is the only available test to provide this clinical information on food intolerance.