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Key Point
“Wholesome nutrition is the key to a
healthy immune system and
resistance to disease. “
 diet = potent mechanism to alter cellular
 especially in GI tract (intestinal biosis and
 diet supports metabolism and vital functions
of skin
 diet long recognized cause of
hypersensitivity-like skin reactions in dogs,
cats, people
 delayed sensitivities 2-72 hrs after eating;
difficult to connect symptoms with foods
 high correlation of delayed sensitivity with
amount and frequency of food eaten
 primary food allergens : corn, wheat, soy,
beef, eggs, milk
 secondary food allergens: lamb, rabbit,
venison, buffalo, chicken, turkey, barley,
millet, oatmeal, salmon, white fish, rice,
quinoa, potatoes, peanut butter
 3 rd most common after flea bite sensitivity
and atopy (inhalant allergy)
 at least 15% of all allergic skin disease
 no age, breed, sex predilection
 most affected animals eating offending
foods for > 2 years
 mimics other skin syndromes
 major complaint
is pruritis (itching)
 pruritic bilateral otitis externa
 secondary seborrhea, pyoderma
 15% have concurrent GI tract issues
 some peripheral lymphadenopathy,
especially cats
 tension-fatigue, malaise, dullness
 non-seasonal and poor response to
 create healthy acid-base balance through
optimal nutrition
 diet elimination trials for 4-8 weeks; often
poor compliance
 must be individualized; use nutrigenomic
 avoid additives & supplements; avoid
switching from diet-diet
Restricted Antigen Source
Commercial source or homemade diets of restricted or
novel antigens are given for 6-12 weeks. Many pets are now
reactive to diets with lamb and rice.
Liver Cleansing Diet
White potato + sweet potato (50/50) and white colored fish –
2/3 potato mix and 1/3 fish. Season with garlic, mixed Italian
herbs or parsley, salt and pepper. Later, can add chopped
carrots, and scrambled eggs, if tolerated. Liquid or other
gluten-free multivitamin
Dietary Effects of Soy Protein
Effects on thyroid function (inhibits thyroid peroxidase)
Soy isoflavones present in most premium cat foods
Effects protected by dietary iodine; pet foods rich in iodine
Potential trigger of feline hyperthyroidism
Soy is a phytoestrogen; concern for dog and cat diets [skin,
hair coat, immune response, delayed puberty, infertility]
 Immune function requires zinc, selenium and vitamin E,
vitamin B6 , and linoleic acid; and carotenoids, especially
lutein and beta-carotene.
 Sterols + sterolins in combination = immune balancing and
stress modulating fats from fruits, vegetables and medicinal
 Natural antioxidants and preservatives (e.g. vitamins E
and C, citric acid, rosemary, turmeric, oregano, blueberries).
Dietary Supplements
Novel or restricted protein source diet, probiotics,
Carotenoids, kelp, garlic, high fiber foods, nutritional herbs
Medicinal herbs, vitamins E and C, whole apple cider vinegar
Essential oils, flower essences, unpasteurized yogurt
Taurine and DMG for epileptics, milk thistle or denosyl
methionine as liver cleanse, herbal pain remedies
Bee Pollen – for infections, colds, rich in vitamin B complex
Colostrum – stimulates and regulates immune system
DGP - Dog Gone Pain; herbal remedy for pain
DLPA- D,L phenylalanine; endorphin stimulant for chronic bone
and muscle pain
Ginger – mostly for digestion
Medicinal Mushrooms - dried reishi and maitake; many
antimicrobial , anticancer, and immune support properties
MSM - methylsulfonylmethane; anti-inflammatory for joints
Oils – wild salmon, coconut, hemp, olive, canola ; for fatty acids,
skin and coat conditioner
Transfer Factor - for immune enhancement and stress control
Yuca (Cassava) – not Yucca ; used for IBD , gluten –free starch
 Individuals deficient in selenium show clinical signs of
hypothyroidism because tissue levels of thyroid
hormones are depleted, while blood thyroid levels rise
 Diagnosis could be overlooked on the basis that blood
levels of thyroid hormones appear normal
Iodine excess causes alterations in thyroid activity, blocking
both its characteristic functions and cell proliferation
Feeding excessive amounts of iodine in foods and
supplements (kelp, seaweed) reduces thyroid function
Contributes to the rising prevalence of hypothyroidism in
young dogs, and hyperthyroidism in older cats
Iodine increases auto-antigenic potency of thyroglobulin
leading to induction of autoimmune thyroiditis
High quality lower protein diets
Increasing dietary tryptophan (turkey)
Limit "hot foods" (venison, chicken, mutton)
Limit high copper foods (lamb, unless grass fed)
Rosemary and Oregano– added today as pet food
preservative and antioxidant. NOT to be given to
epileptics. (Peppermint Oil can help protect epileptics)
Grapes and Raisins – toxic to dogs; acute renal failure
Corn, Corn Starch, Fructose from Corn – associated with
food sensitivity, intolerance.
Chicken, Venison, Mutton – “hot foods” in Chinese
Beef, Cow’s Milk – food sensitivity , intolerance.
Wheat, Soy – food sensitivity , intolerance.
Lamb – too much copper unless grass fed.
Onions – produces “ Heinz body” hemolytic anemia.
Vasoactive Amines – tuna, mackerel, skipjack, bonito
 emerging science that studies the
molecular relationships between nutrition
and the response of genes in the genome in
promoting health
 different diets alter gene expression, and
protein/metabolite production
 specific nutrients affect body responses in
a form defined as a “signature”
 individual response = “molecular dietary
 diet can be serious risk factor for a number
of diseases
 common dietary ingredients act on animal
genome directly /indirectly, to alter gene
 degree of dietary influence on balance of
healthy and disease states depends on
individual’s genetic makeup
 certain diet-regulated genes play a role in
onset, incidence, progression, and/or
severity of chronic diseases
 dietary intervention based on animal’s
nutritional requirement/ status plus
genotype used to prevent, mitigate or cure
chronic disease
What is the Alternative ?
Molecular Dietary Signature
”Heat Map “ Dog
Liver Cleansing
Molecular Dietary
28 days on
marianum (milk
“Heat Map”
28 days on
paniculata +
Curcuma longa
Food Sensitivity -- Prior Testing
typically based on IgE, IgG 4, and immune
complexes with complement
high sensitivity but lower individual specificity
measures more immediate-type reactions
Food Sensitivity -- Newer Testing ● ● ● 1, 2, 3
 newer tests can use serum, saliva or feces
 ELISA or other immunoassay platforms
 identify IgG, IgA , or immune complexes to foods in serum
 IgA or IgM antibodies to foods in saliva
 antibodies to foods appear in saliva before GI tract
clinical/biopsy diagnosis of IBD or “leaky gut syndrome”
 saliva testing can thus reveal the latent or pre-clinical form
of food sensitivity
Three Levels of Testing
● ● ● 1, 2, 3
 Saliva Screening Kit --- POS owner/ vet clinic testing;
65 % of market, several times annually for life
 Tests for salivary IgA and IgM reactants in healthy pets
and those with known or suspected food intolerances
 Client obtains test kit [from vet or pet supply store],
follows directions, adds saliva, seals kit, sends to
diagnostic laboratory
Your dog has itchy skin, a leaky gut?
What is the test?
Medium tested
Antibody measured
How performed
Addressing the real
food issues
Which foods
Price per panel
Intolerance+ Sensitivity
IgA and IgM
Home use or Vet visit
Delayed and long term food issuesExcellent clinical correlation
20 antigens (2 panels of 10 each:-a
primary and a secondary panel)
$130 or $250 for both panels
Hypersensitivity (Allergy)
IgE or IgG
Veterinary visit required
Immediate food issues only; poor clinical
correlation to more delayed food reactions
About 20 antigens
Varies –about $100
Vets and pet owners need to concentrate on more long term control of
food-related health issues, rather than the more immediate acute
hypersensitivities. Otherwise animals will not get better.
The patented NutriScan is the only available test to provide this clinical
information on food intolerance.