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The Correlation Between Gross Domestic Product and Reported Cases of Malaria in India (1999-2011) Abstract: Malaria is a life-threatening disease that affects millions worldwide due to parasiteinfected mosquitoes. Following the bite, the parasite can infect its new host by attacking the excretory system. Malaria morbidity and mortality commonly affect and effect many parts of Africa, the Middle East and Southeast Asia. Due to the high numbers it affects, malaria has become a major public health issue since its discovery in 1880. One of the many countries where malaria has become a major burden is India - whose malaria rate has contributed significantly to the worldwide problem. In this study, the relationship between number of reported cases of malaria and gross domestic product (GDP) of India are examined closely, resulting in a noticeable correlation factor of 0.4533. Further examination of India's malaria rate and GDP are also done by comparing it to the United States, Indonesia and Canada. Introduction: Malaria has had a rich history since its inception in 2700 BCE in China and later widely found in ancient Greek literature. Upon a discoveries by Charles Louis Alphonse Laveran and Ronald Ross, the parasite causing malaria and that these parasites could be transmitted by mosquitoes respectively, the uphill battle towards a cure began. 1 Malaria can occur after being bitten by an infected female mosquito. Infected protists from the mosquito's saliva travel into the new host's circulatory system, ultimately ending up in the human liver, where further maturation and reproduction occurs. Common symptoms include fever, headache, nausea, myalgia and diarrhea. If not treated, these symptoms can lead to death.2 Statistics have shown that 80% of malaria cases are concentrated in seventeen countries, as illustrated by Figure 1. 1 Figure 1: A global illustration of the concentration of cases amongst seventeen countries affected by malaria. Because malaria has become a common public health concern for countries within Africa, the Middle East and Southeast Asia, there has been a growing initiative to control and eradicate the disease. Organizations such as the World Health Organization (WHO) have made malaria prevention and control key global topics. In India, the highest incidence of malaria occurred in the 1950s, with approximately 75 million cases reported within a span of a decade. Since then, there has been a steady decline with the exception of a resurgence in 1965. 4 As of data collected from WHO from 2011, the number of cases reported is currently fixed around one million, with a current risk status of "moderate".2 Since 1999, India's annual GDP has positively increased from $1,800 (PPP - per capita, US$) to $3,700 in 2011.5 The decline of malaria cases in India can possibly be attributed to the increase in the country's increase in GDP. Similar studies have also been done by Gallup and Sachs in "The Economic Burden of Malaria" as well as a group of public health experts in "Malaria in India: The Center for the Study of Complex Malaria in India".3,4 This specific study aims to examine these two factors in India and their correlation with each other, as well as its overall relationship with other countries. Thus, India's annual malaria rate and GDP are compared with the United States'. However, because these two countries have such contrasting statistics - the United States has an annual GDP three times that of India and an almost non-existent malaria risk status - two other countries are brought into consideration for the purpose of running a valid t-test. For this purpose, a country with a similar malaria relative frequency as India was chosen and a country with similar annual GDP as the 2 United States was chosen. With these new parameters, Indonesia and Canada were chosen. Thus, for reported cases of malaria, the following was hypothesized: H0: The reported malaria rate for Indonesia and India is the same. H1: The reported malaria rate for Indonesia and India is different. And for annual GDP, the following was hypothesized: H0: The GDP for Canada and the United States is the same. H1: The GDP for Canada and the United States is different. Methodology: Correlation To further examine the relationship between India's GDP and malaria rate, the following data was obtained and generated: Year 1999 2000 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 India GDP (PPP - per capita, US$) 1800 2200 2540 2900 3100 3400 3800 2600 2900 3200 3500 3700 India Malaria (# of reported cases) Total Population Relative Frequency Percentage 2280000 2030000 1840000 1870000 1920000 1850000 1785109 1508927 1532497 1563574 1599986 1310367 997515000 1029991000 1045845000 1049700000 1065071000 1080264000 1095352000 1129866000 1147996000 1166079000 1173108000 1189173000 0.00228568 0.001970891 0.001759343 0.001781461 0.001802697 0.001712544 0.001629713 0.001335492 0.001334932 0.001340882 0.001363886 0.001101915 0.228567991 0.197089101 0.175934292 0.178146137 0.180269672 0.171254434 0.162971264 0.1335492 0.133493235 0.134088171 0.136388636 0.110191452 Table 1: Data collected by the World Health Organization and Index Mundi from 1999-2011. 3 Figure 2: A scatter plot depicting the relationship between annual GDP and relative frequency of Malaria in India from 1999-2011, with a correlation factor of 0.45333. Analysis of Malaria Rate To study the relationship between Indonesia and India's malaria rate, the following data was obtained: Year Indonesia Malaria (# of reported cases) 2006 2007 2008 2009 2010 2011 1150600 1149000 1142960 1085000 1067000 1052000 Total Population 245452700 234694000 237512400 240271500 242968300 245613000 Frequency 0.004687665 0.004895737 0.004812212 0.004515725 0.004391519 0.004283161 Percent 0.468766487 0.489573658 0.481221191 0.451572492 0.439151939 0.428316091 Table 2: Data collected by the World Health Organization from 2006-2011 for Indonesia. 4 India Malaria (# of reported cases) Year 2006 2007 2008 2009 2010 2011 1785109 1508927 1532497 1563574 1599986 1310367 Total Population 1095352000 1129866000 1147996000 1166079000 1173108000 1189173000 Frequency 0.001050439 0.001016935 0.000995613 0.000930469 0.00090955 0.000884648 Percent 0.105043858 0.101693475 0.099561323 0.093046869 0.090954967 0.088464841 Table 3: Data collected by the World Health Organization from 2006-2011 for India. Malaria Frequency Frequency of Reported Malaria Cases 0.006 y = -0.0001x + 0.2245 R² = 0.7205 0.005 0.004 0.003 Indonesia 0.002 y = -3E-05x + 0.0708 R² = 0.9758 India 0.001 0 2005 2006 2007 2008 2009 2010 2011 2012 Year Figure 3: A scatter plot depicting the decline in frequency of malaria in India and Indonesia from 2005-2011. 5 Using the data from Tables 2 and 3, a t-test was used to test the hypothesis at a 1% level of significance. t-Test: Two-Sample Assuming Unequal Variances Mean Variable 1 1107760 Variable 2 1550076.667 2012723200 6 23475276263 6 Variance Observations Hypothesized Mean Difference df t Stat P(T<=t) one-tail t Critical one-tail P(T<=t) two-tail t Critical two-tail 0 6 -6.786425012 0.000250381 1.943180274 0.000500761 2.446911846 Table 4: Results from a t-test assuming unequal variances, with variable 1 representing Indonesia and variable 2 representing India. Analysis of GDP To study the relationship between the United States and Canada's GDP, the following data was obtained: Year 1999 2000 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 Canada GDP - (PPP - per capita, US$) 23300 24800 29400 29800 31500 33900 35600 38600 39100 38100 39400 41100 Table 5: Data collected from Index Mundi for Canada from 1999-2011. 6 Year 1999 2000 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 US GDP (PPP - per capita, US$) 33900 36200 37600 37800 40100 41600 44000 45800 46900 46000 47200 49000 Table 6: Data collected from Index Mundi for the United States from 1999-2011. Figure 4: A scatter plot depicting the increase in annual GDP for Canada and the United States from 1999-2011. 7 Using the data from Tables 5 and 6, a t-test was used to test the hypothesis at a 1% level of significance. t-Test: Two-Sample Assuming Unequal Variances Variable 1 Variable 2 Mean Variance Observations Hypothesized Mean Difference df t Stat P(T<=t) one-tail t Critical one-tail P(T<=t) two-tail t Critical two-tail 33716.67 42175 35394242 24922045 12 12 0 21 -3.77275 0.000559 1.720743 0.001117 2.079614 Table 7: Data collected from Index Mundi for the United States from 1999-2011. Results: As demonstrated in Figure 2, there is indeed a noticeable correlation between India's annual GDP and number of reported malaria cases, with a r2 value of 0.4533. As suspected, as the annual GDP increased, the reported malaria cases decreased, therefore confirming the correlation between these two factors. Perhaps inclusion of more data over a longer period would result in an even stronger correlation factor. Due to time constraints and a limited amount of resources, a period of ten years is utilized. Following the comparison of India's annual GDP and malaria rate, a t-test was conducted separately for malaria rate (India and Indonesia) and annual GDP (United States and Canada). As mentioned in the introduction, because of the drastic differences between India and the United States, special measures were taken in order to obtain valid results. In order to run a t-test for these two countries, the country chosen must either have a similar GDP or a similar malaria rate. As a result, Indonesia was paired with India and United States was paired with Canada. For the malaria rate, each country's annual malaria frequency was graphed (Figure 3) and found to both demonstrate an annual decline. T-test results for both 1 and 2 tails at the 1% significance level resulted in very small p-values of 0.000250380692606768 and 0.000500761385213536 respectively. Such small p-values lead to rejection of H0 and acceptance of H1. The malaria rates for India and Indonesia are not the same, although both are considered to have "moderate" malaria risks by WHO. Similarly, a t-test was conducted for the annual GDP of the United States, which was paired with Canada. The annual GDP for both countries were graphed (Figure 4) and found to both have increasing annual GDPs. The t-test results in Table 7 for both 1 and 2 tails at the 1% significance level resulted in very small p-values of 0.000558575917115377 and 8 0.00111715183423075 respectively. Like the malaria rate, the small p-values for annual GDP lead to rejection of H0 and acceptance of H1. The annual GDPs for Canada and the United States are not the same, although both are considered by Index Mundi to have similar economies. Conclusion: The effects of malaria can lead to devastating levels of morbidity and mortality for those countries that are affected. Due to organizations such as WHO, a higher emphasis is put on education and immunization to prevent further outbreaks from occurring. Based on the information compiled for this study, the correlation between India's GDP and malaria rate is strong. Since 1999, India's economy (GDP) has steadily increased, leading to more money put towards public healthcare. According to the most recent GDP statistics from India, the amount spent on healthcare will rise from 1.4% to 2.5%. This bodes well for the communities that have been heavily affected by malaria. More money spent on healthcare will lead to more immunizations for young children (who are the most at risk for infection), insecticide-treated nets and insecticide sprays. Compared to the United States (where malaria has become almost non-existant), which spends approximately 7% of its GDP on healthcare, India is very far behind.6 However, with more of the country's GDP spent on public health, positive steps are being taken to ensure eradication of malaria. _____________________________________________________________________________ 1. http://www.cdc.gov/malaria/about/history 2. http://www.who.int/features/factfiles/malaria/en 3. http://www.ncbi.nlm.nih.gov/books/NBK2624/ 4. http://www.thereadgroup.net/wp-content/uploads/Das-et-al-India-ICEMR-2012.pdf 5. http://www.indexmundi.com/g/g.aspx?c=in&v=67 6. http://www.indianexpress.com/news/healthcare-spend-to-rise-to-2.5--of-gdp/918380/ 9