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RONALD P. KARLSBERG, MD, FACP, FSCCT, FAHA, FACC CURRICULUM VITAE Cardiovascular Medical Group of Southern California California Research Foundation of Southern California Beverly Hills 414 North Camden Drive, Suite 1100 Beverly Hills, California 90210 310-278-3400 phone 310-278-1240 fax Culver City 3831 Hughes Avenue, Suite 501 Culver City, California 90232 310-204-1146 phone 310-204-5921 fax Cedars-Sinai 8635 W3d St. Suite 1190W Los Angeles, CA 90048 310-652-46000 phone 310-659-8387 fax [email protected] www.cvmg.com BIRTHDATE: July 24, 1947 BIRTHPLACE: Syracuse, New York EDUCATION: College University of California, Los Angeles, 1965 - 1966 University of California, Berkeley, B.A. Psychology, 1966 - 1969 Medical School University of California, San Francisco School of Medicine Medical Degree, 1969 - 1973 Post Graduate Training University of Colorado School of Medicine Intern in Medicine, 1973 - 1974 Resident in Medicine, 1974 - 1975 Washington University School of Medicine Barnes Hospital, St. Louis, Missouri Cardiology Fellowship, 1975 - 1977 ACADEMIC APPOINTMENTS AND POSITIONS Washington University School of Medicine Barnes Hospital, St. Louis, Missouri Instructor in Medicine, Cardiology, 1977 - 1978 University of California, Irvine School of Medicine Assistant Professor of Medicine in Residence, 1978 - 1982 Long Beach Veterans Administration Hospital Chief, Cardiovascular Physiology, 1978 - 1981 Director, Cardiology Ward, 1978 - 1981 Director, Cardiac Rehabilitation, 1980 - 1981 University of California, Los Angeles School of Medicine Assistant Clinical Professor of Medicine, 1982 - 1992 Associate Clinical Professor of Medicine, 1992 - 1998 Clinical Professor of Medicine of Medicine, 1998 - present Cardiovascular Medical Group of Southern California Beverly Hills, California, 1981 - present Cardiology Practice – Executive Committee Consultative and Interventional Cardiology Clinical Research and Advanced Cardiac Imaging Brotman Medical Center Culver City, CA 90231 Director, Cardiac Diagnostic and Interventional Center 1990 - 2010 Cedars Sinai Medical Center Staff Member 1981 - present Cedars Sinai Heart Institute Member 2012 - present Access Clinical Trials (1995 - 2006) Beverly Hills, California, Founder and Director Neurological Research Institute of Southern California Pulmonary Research Institute of Southern California Karlsberg CV September 1,2014 P a g e |1 Metabolic Endocrine Research Institute of Southern California University of California San Francisco, School of Medicine Alumni-Faculty Association Administrative Council of the Alumni-Faculty Association Vice President and Board Member (Southern Area), 1996 - present) Cardiovascular Research Institute of Southern California, (1981 - 2008) Founder, Director Cardiovascular Research Foundation of Southern California, (2006-present) President, Co-Founder CERTIFICATION AND SPECIALTY EXAMINATIONS Diplomat Certified in Internal Medicine, 1976 Diplomat Certified in Cardiovascular Disease, 1977 Qualified Medical Evaluator, Department of Industrial Relations California, 1998 Diplomat, Certified in Cardiovascular Computed Tomography, 2008 LICENSES Colorado State, License to Practice Medicine, 1974 - 1975 Missouri State, License to Practice Medicine, 1976 - 1978 California State, License to Practice Medicine (G-037753), 1977 - Present HONORS University of California, Berkeley, Department of Psychology Honors Program, 1972 B. A. Honors, 1973 Who's Who in California, First time in 1983 Outstanding Young Men of America, First time in 1983 Who's Who in Health and Medical Services, First time in 1990 Who’s Who in America City of Culver City Commendation presented Sept 22, 1997, City Council “Whereas Dr. Ronald P. Karlsberg attended UCLA and UC Berkeley attaining a Bachelors Degree in Psychology and Whereas he has been an instructor and on the clinical faculty of Washington University School of Medicine, IC Irvine School of Medicine and UCLA School of Medicine and Whereas he has served as Chief of Cardiovascular Physiology and Director of the Cardiac and Cardiac Rehabilitation Services at the Long Beach Veteran's Administration Hospital, and whereas, he has been a member of the Cardiovascular Medical Group of Southern California practicing consultative, interventional and clinical cardiology since 1981 and whereas he has served as Director of the Cardiac Diagnostic and Interventional Center at Brotman Medical Center in Culver City since 1990 and whereas Dr. Karlsberg has dedicated his life and his career to the health and care of his patients, many of whom are members of this community, and whereas Dr. Karlsberg's commitment and talent have save lives and improved the quality of the lives of those he has cared for. Now therefore be it resolved, that the City Council of the City of Culver City hereby commends Dr. Ronald P. Karlsberg for this dedication to the health and well being of the members of this community through his work at Brotman Medical Center" Albert Vera - Mayor and members of City Council. American Heart Association Los Angeles, Life Time Excellence for CV Research, 2002 City of Los Angeles Resolution presented July 23, 2002. “Whereas, Dr. Ronald P. Karlsberg received his medical degree in 1973 from the University of California, San Francisco; and Whereas, Dr. Ronald P. Karlsberg has distinguished himself in the field of Cardiology, holding such appointments as assistant professor of Medicine, chief cardiovascular physiology and cardiology wards, cardiac rehabilitation, University of California, Irvine, Long Beach Veteran Administration Hospital from 1977 to 1981 and as assistant clinical professor of Medicine (1982)), Associate Clinical Professor of Medicine, University of California School of Medicine (1992), as well as currently serving as a clinical professor of Medicine; and Whereas, Dr. Ronald P. Karlsberg has advanced the field of Cardiovascular research as founder and director of the Cardiovascular Research Institute of southern California (1981) and Access Clinical Trials (1995); and Whereas, Dr. Ronald P. Karlsberg’ s achievements are being recognized in his receiving the American Heart Association award for excellence in Cardiovascular Clinical Research; and Whereas, Dr. Ronald P. Karlsberg is receiving this award for his contributions to the improved quality of life he has brought through his achievements to cardiovascular research; and Whereas, Dr. Ronald P. Karlsberg’s contributions have led to considerable improvements in the lives of many of the resident of our city: Now therefore, be it resolved that by the adoption of this resolution, Councilwoman Cindy Miscikowski and the council of the city of Los Angeles do hereby wish to commend and congratulate Dr. Ronald P. Karlsberg and thank him for his service to the medical community and the citizens of the city of Los Angeles.” Consumers Research Council of America: America’s Top Cardiologist, 2006 – 2011 County of Los Angeles Resolution presented Jan 2008 “In recognition of professional, compassionate and general care to citizens of the County of Los Angeles” British Cardiovascular Society -2011 Acknowledgement for Participation in the British Cardiac Society/American College of Cardiology Imaging Karlsberg CV September 1,2014 P a g e |2 Preceptorship; California ACC -Twining Project. Visionary Award from the Cardiovascular Research Foundation of Southern California, together with Mayor Richard Riordan- former Mayor of Los Angeles. Four Seasons Hotel at Beverly Hills – Oct 9, 2014 STAFF APPOINTMENTS- ATTENDING PHYSICIAN University of California, Irvine Medical Center, 1978 – 1981 Long Beach Veterans Administration Hospital, 1978 - 1981 Cedars Sinai Medical Center, Los Angeles, 1981 - present Brotman Medical Center, Culver City, 1981 - present University of California, Los Angeles, Center for the Health Sciences, 1984 - 2006 Midway Medical Center, Los Angeles, 1981 - 2004 Beverly Hills Medical Center, Los Angeles, 1981 - 2000 Westside Hospital, Los Angeles, 1981 - 1998 Century City Hospital, Los Angeles, 1981 - 2008 Kaiser Permanente Hospital, West Los Angeles, 1991 - 2000 MEDICAL ORGANIZATIONS Member, American College of Emergency Physicians, 1976 Member, American College of Physicians, 1977 Member, American Federation of Clinical Research, 1977 Fellow, American College of Cardiology, 1978 Fellow, Council on Clinical Cardiology, American Heart Association, 1978 Fellow, American College of Chest Physicians, 1979 Fellow, American College of Angiology, 1980 Member, American Physiological Society, 1980 Member, American Medical Association, 1981 Member, California Medical Association, 1981 Member, Los Angeles Medical Association, 1981 Fellow, American College of Physicians, 1981 Member, American Society of Internal Medicine, 1983 Member, National Faculty of Core Content Review of Family Medicine, 1983 Member American Association for the Advancement of Science, 1990 Member American Society of Internal Medicine 1995 Member Healthcare Information and Management Systems Society, 1997 Full Member, American Society of Nuclear Cardiology, 1999 Member (Founding), Society of Cardiovascular Computed Tomography, 2005 Fellow, Society of Cardiovascular Computed Tomography, 2008 Western State Vice - Governor, 2006- Present Councilor California Chapter of the American College of Cardiology, District X Los Angeles, 2010 Board Member Intersocietal Commission for the Accreditation of Computed Tomography Laboratories – Appointed by the American College of Cardiology- 2010 EDITORIAL CONSULTANT AND PEER REVIEWER- (not inclusive) American Journal of Cardiology, American Journal of Physiology, American Heart, Journal, Annals of Internal Medicine, Archives of Internal Medicine, Archives of Internal Medicine. British Medical Journal, Cardiovascular Research, Catheterization and Cardiovascular Diagnosis, Chest Circulation, Circulation Research, Coronary Artery Disease, European Heart Journal, Journal of the American Medical Women's Association, Journal of Cardiovascular Computed Tomography, Journal of Clinical Investigation, Journal of the American Medical Association, Journal of the American College of Cardiology, Journal of Cardiovascular Computed Tomography, Journal of Nephrology, Heart, New England Journal of Medicine, The International Journal of Cardiovascular Imaging MEDICAL, SCIENTIFIC and BUSINESS MANAGEMENT (not inclusive) President and Founder, Avalanche Nuclear Inc. Developer and manufacturer of avalanche radiation detectors. Founded 1980. Sold to Xsirus, Inc., (NASDEX) and Advanced Photonix, Inc., (American Stock Exchange, Emerging Companies), 1989. Partner, Cardiovascular Medical Group of Southern California, 1986 - present Managing Partner and Executive Committee, 1996 - present Walaka Development Company Co-owner. Developer and Manager of Medical Office Buildings, Mountain View Medical Center. LancasterPalmdale, California. 1990. Karlsberg CV September 1,2014 P a g e |3 Director Cardiac Interventional Center, Brotman Medical Center. Medical Supervisor for the selection of equipment, design and construction of 3 Cardiac Catheterization Laboratory. 1990 - 2006. Consultant to Industry (not inclusive): Alivecor, CalManage, CareTools, CompCore, CritcialCareAmerica, General Electric, Gigapixal, Hewlett Packard, Homevue Health Systems, Lexmark, Marquettee Electronics, Medivison, Medtrack Electronics, MediaOne (US West) Optivision, Magnetecs Corp, Proctor and Gamble, Prolink, Salus, Sterling Research, Laboratories, TomTec, Toshiba of America Medical, Vasco Data Security, Voquette, Zoran, Alivecor Internet Developed one of the first medical WEB sites: www.cvmg.com, Web Medical Opinions second opinions and case reviews, 1995. NotesMD Founder and Chairman (First WEB based EMR 1996 – 2012) Venture Capital Fund –TKG (Founder and President) and consultant to Axiom Venture Partners, Hartford Connecticut 1998 - 2013. Medical Advisory Board- Alivecor 2013 Advisor: Crowdfunder.com 2014 COMMITTEES University of California, Irvine, VA Medical Center, Long Beach, California Animal Care Committee 1978 - 1980 Medical Service Education Committee, 1979 - 1981 Education Evaluation Committee, 1979 - 1981 Resident Review Committee, 1979 - 1981 Committee to Evaluate Third Year Clerkship in Internal Medicine, 1980 Committee for University Promotions, 1980 American Heart Association, Orange County Chapter Chairman, Professional Education Committee, 1980 - 1981 Board of Directors, 1980 - 1981 Cedars Sinai Medical Center, Los Angeles Cardiac Catheterization Quality Control Committee, 1983 - 1984 Sub-committee on Coronary Care Utilization, 1990 Cardiac Catheterization Committee, 1989 - 1995 Telemedicine Committee, 1996 - present Interventional Cardiology Performance Improvement Committee 1995 - 2000 Cedars-Sinai Medical Center's Enterprise Systems and Networks Committee (ESNC) 1996- 1998 Cedars- Sinai Medical Center Health Informatics Committee, 2006 - 2013 Brotman Medical Center, Culver City, California. Cardiology Committee, 1983 - 2010 Utilization Committee, 1986 - 1992 Brotman Institutional Review Board, 1988 to present Pharmacy and Therapeutics, 1990 - 1996 Department of Medicine Committee, 1991 - 2010 Chairman, Pharmacy and Therapeutics, 1990 - 1992 Chairman Brotman Medical Center Institutional Review Board, 1992 -1994 Chairman Cardiology Committee 1992 - 1994 Emergency Medicine Committee, 1986 – 2000 Chairman Emergency Room Committee, 1986 - 1988 Medical Executive Committee, Elected Member at Large, 1988 - 1991 Medical Executive Committee, Senior Advisor, 1992 - 2008 Medical Service Committee, 1988 - 2000 Member Ethics and Credentials Committee 1996 - 2001 Board of Governors, 2003 - 2010 Emergency Medical Service Thrombolytic Administration Team, 1997 –2001 American College of Cardiology Informatics Committee 2005 – present Informatics Committee’s NCDR Data Elements Workgroup, 2010 California Chapter Council, Elected 2010, 2012 ACC Expert Advisor for Educational Needs Assessment – Noninvasive Imaging 2014 Karlsberg CV September 1,2014 P a g e |4 Society of Cardiovascular Computed Tomography Abstract Grading Committee, 2011-2015 Payer Advocacy Committee, 2011-2014 Philanthropy Committee, 2010-2013 Young Investigator Award Committee 2011 Government Relations Committee/Coding Task Force 2010-2014 Intersocietal Accreditation Commission (IAC) Cardiac CT Board – American College of Cardiology Representative 2011-current Chairman Committee for Cardiac CTA Structural Reporting Certification Board Cardiovascular Computed Tomography – 2014 Exam Development Committee TEACHING AND LECTURING: Positions University of California, Irvine, Long Beach VA Hospital, 1978 - 1981 Attending: Cardiology Fellows, Catheterization Laboratory, Primary Care Clinic Cardiology Clinic, Fellows, Residents, Interns, Medical Students Conferences: Grand Rounds, Medical and Surgical Rounds, Cardiology Conferences, Catheterization Conferences, Cardiovascular Physiology, Pathophysiology, School of Medicine, Mechanisms of Disease, School of Medicine Brotman Medical Center 1981 - present Chairman, Dilemmas of Dx and Rx, 1983 - 1986 Grand Rounds 1983 - 2010 Chairman, Cardiac Catheterization Conference 1990 - 2010 Cedars Sinai Medical Center, 1981 - present Attending: Medical Students, House Staff, Cardiology Fellows, Cardiac Catheterization Laboratory, Cardiology Consultative Service (Initiated rotation of private attending into the service with Dr. Jeremy Swann 1983) Teaching of the Year Award 2011 Excellence in Teaching Cardiology Fellows UCLA School of Medicine Well Being Dinners Home Hosted 1991-1994 Preceptor Program for Medical and Pre-Med Students, 1983 – 2000 Preceptor: The Basic Science Years, Clinical Years, Intern and Residency, 1998 Cardiology Grand Rounds 2011 Cutting Edge CT Level 1-3; SCCT Endorsed Cardiac CT Training program 2005-2014 One of the first Cardiac CT training programs integrated into the care of the Cardiac patient. Over 400 Radiologist, Cardiologist and Nuclear Physicians attended this course, including leading Academic and clinical centers worldwide. (on-line reviews available on request) The ACC International Twinning Program 2010- 2013 ACC Cardiology California - British Cardiovascular Society for Cardiology “In 2011, I was awarded an imaging Preceptorship by the British Cardiac Society and the California Chapter of the American College of Cardiology. This proved to be a fantastic opportunity, which significantly furthered my education and has led to an exciting research collaboration between the imaging group at the University of Edinburgh and Cedars-Sinai Medical Centre in Los Angeles. The first part of the Preceptorship was spent learning cardiovascular CT with Dr Ronald Karlsberg. It was based around the CT Masters Series Course, which is a well-established and highly rated course attended by imaging cardiologists from around the world. Each of us were provided with personal workstations and access to hundreds of pre-selected cases covering an extensive range of pathology. The quality of the teaching faculty was excellent with personal lectures from world-renowned experts in Cardiovascular CT including Dr Karlsberg himself, Dr Matthew Budoff, Dr Louise Thomson and Dr John Friedman. Each has a wealth of reporting experience and crucially each a slightly different approach to scan interpretation. The structure of the course allowed the tutors to go over cases with us on individual basis and it included a steady stream of live cases, permitting us to observe scan acquisition and real-time clinical interpretation. Teaching often continued in to the evening and if you had the energy it was possible to remain on your workstation interpreting scans all night. Consequently by the end of the week, I had reported over 150 scans and completed the necessary criteria for level 3 accreditation. More importantly my knowledge levels and CT reporting skills had improved to the extent that I have felt able to join the reporting rotation on my return to Edinburgh.” Dr Marc Dweck Cardiology SpR & BHF Clinical Research Fellow, Edinburgh POST GRADUATE TRAINING (NOT INCLUSIVE) Cardiac Angiography. Harvard Medical School. Department of Continuing Education. Boston Massachusetts. May 20-23, 1980 Calcium Antagonists - The New Wave in Cardiology. Cornell University Medical College. Department of Continuing Education. San Francisco, California. March 14, 1981 Karlsberg CV September 1,2014 P a g e |5 Coronary Angioplasty for Technologists. Emory University School of Continuing Medical Education. Course Director, Andreas Gruentzig. Atlanta, Georgia. September 22-24, 1983 Demonstrations in Percutaneous Transluminal Coronary Angioplasty. Emory University School of Continuing Medical Education. Director, Andreas Gruentzig. Atlanta, Georgia. September 25-29, 1983 Calcium Channel Blockers: Update 85. Baylor College of Medicine. Director, Robert Roberts. La Costa, California. July 22 - 23, 1985 Second Annual Tropical Retreat on Complex Coronary Angioplasty. Mid American Heart Institute. St Luke's Hospital. Course Director, Jeffrey Hartzler. February 1-9, 1986 Propafenone: A New Advance in Antiarrhythmic Therapy. The Medical College of Pennsylvania, Philadelphia, Pennsylvania. November 12-15, 1987 Fifth Annual Tropical Retreat on Complex Coronary Angioplasty. Mid American Heart Institute. St. Luke's Hospital. Course Director, Jeffrey Hartzler, M.D. January 30 - February 3, 1989 Peripheral Vascular and Coronary Interventions: A Live Demonstration Course. St. Luke's Medical Center. Course Director, Gerald Dorros, M.D. Milwaukee, Wisconsin. May 2-4, 1989 Directional Coronary Atherectomy - Symposium II. A Live Demonstration Course. Sequoia Hospital. Course Director John Simpson, M.D. Redwood City, California. October, 1989 Directional Atherectomy - Symposium III. A Live Demonstration Course. Sequoia Hospital. Course Director, Simpson. Redwood City. October 1990 Twenty-Ninth Annual Scientific Seminar. Brotman Medical Staff Foundation. February 23-24, 1991 Directional Coronary Atherectomy. DVI Directional Coronary Atherectomy Course. Las Vegas, Nevada. July 25, 1991 2nd International Symposium of Heart Failure-Mechanisms and Management. International Society of Heart Failure Inc. Geneva Switzerland May 16-20, 1993 Attendance: American Heart Association Greater Los Angeles Affiliate Annual meetings 1990- 2000 Frequent Attendance: Healthcare Information and Management Systems Society (HIMSS), Annual meeting 1996 - present. Cardiac Imaging Certification: Training in Partnership-GE Lightspeed Customer Class. October 31-November 3, 2005. Milwaukee, Minnesota. Frequent Attendance: Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography. Washington DC. Abstract reviewer, Chair of Sessions and Invited lecturer and facility 2006 - present Frequent Attendance: American College of Cardiology, Abstract reviewer and Chair of Sessions and invited lecturer and facility. Charitable Donor. 1977- Present Frequent Attendance: American Heart Association (AHA) and American College of Cardiology (ACC) National Meetings. . Abstract reviewer and Chair of Sessions. 1977 - Present Joint Symposium of the British Cardiovascular Society and the California Chapter of the ACC, Chair, Chicago 2012 Difficult Situations in CT: What to do When the Patient Has… SCCT Chair, Baltimore 2012 Controversies and Advances in the Treatment of Cardiovascular Disease American College of Cardiology California Chapter and Cedars Sinai Heart Institute. Faculty 2010 – present. HIPPA Training Certificate of Completion 2014 TEACHING, LECTURING, INTERVIEWS (NOT INCLUSIVE) 12/20/1976 1976-1978 1976-1978 10/31/1977 9/22/1978 10/25/1978 5/26/1979 7/18/1979 9/08/1979 Karlsberg CV Cardiac Rupture. Cardiology Conference. Washington University School of Medicine. St. Louis, Missouri Bedside Instructor for Introduction to Clinical Medicine. Washington University School of Medicine. St. Louis, Missouri Cardiovascular Research Meetings. Washington University School of Medicine. St. Louis, Missouri Workshop for Cardiovascular Pathophysiology Course. Washington University School of Medicine. St. Louis, Missouri Acute Ventricular Septal Defect. Clinical Case Conference. University of California, Irvine. Long Beach Veterans Administration Hospital. CPK Isoenzyme; Sensitivity, False Positive, and Infarct Size. Fall Symposium. Luncheon Panel. American Heart Association Greater Los Angeles Affiliate. Preservation of Ischemic Myocardium. Cardiology Section Meeting. University of California, Irvine. Long Beach Veterans Administration Hospital. Ventricular Tachyarrhythmias; Heart Block. Emergency Medical Series. University Of California, Irvine. Long Beach Veterans Administration Hospital. Cardiac Arrhythmias and Drugs. Pathophysiology Seminar; Department of Surgery. University of California, Irvine. Long Beach Veterans Administration Hospital. September 1,2014 P a g e |6 12/03/1979 10/15/1979 1/09/1980 1/14/1980 2/15/1980 4/26/1980 4/28/1980 9/15/1980 10/09/1980 12/02/1980 2/11/1981 4/06/1981 5/1/1981 9/19/1981 10/28/1981 11/01/1981 1/28/1982 4/29/1982 7/23/1982 9/23/1982 10/14/82 1982 1982 10/22/1985 2/27/1986 6/13/1986 7/17/1986 9/02/1986 9/12/1986 9/26/1986 12/02/1986 Karlsberg CV Preservation of Ischemic Myocardium: A concept for the 1980's? Cardiology Sub-specialty Conferences. Department of Medicine. University of California, Irvine. Eisenmenger's Syndrome. Cardiology Conference. University of California, Irvine. Long Beach Veterans Administration Hospital. Electrical Disturbances of the Heart. Major Medical Conferences. Department of Medicine. University of California, Irvine. Long Beach Veterans Administration Hospital. Coronary Artery Disease. Major Medical Conferences. Department of Medicine. University of California, Irvine. Long Beach Veterans Administration Hospital. The Heart as a Pump. Mechanisms of Disease; Cardiology. Pathophysiology Course. University of California, Irvine. Preservation of Ischemic Myocardium; A concept for the 80's. Torrance Memorial Hospital, Torrance, California Coronary Artery Disease. Medical Service Conference. University of California, Irvine. Long Beach Veterans Administration Hospital. Overview of Cardiac Pathophysiology: Anatomy, Mechanics, Hemodynamics, and Electrophysiology. Cardiology Section Meeting. University of California, Irvine. Long Beach Veterans Administration Hospital. Miniature Radiation Detector for Measuring Myocardial Blood Flow. Cardiology Section Meeting. University of California, Irvine. Long Beach Veterans Administration Hospital. Mini Rad Detector has Maxi Future, says Inventors. (Article by Peter de Vries.) The Medical Post. Coronary Artery Disease: Pathophysiology, Evaluation and Treatment of Angina Pectoris. University of California, Irvine. Long Beach Veterans Administration Hospital. Current Concepts in the Management of Patients with Coronary Artery Disease. Grand Rounds. University of California, Irvine. Myocardial Muscle Mechanics and The Heart as a Pump. Pathophysiology Course for Second Year Medical Students. University of California, Irvine. Calcium Channel Blockers for Cardiovascular Disorders. Seminar: The Uses and Abuses of Calcium Antagonists. Brotman Medical Center. Modification of Myocardial Infarction Size. Panel Chairman, (Participants: William Ganz, M.D., Robert Roberts, M.D., Elliot Rapaport, M.D.). American College of Chest Physicians, 47th Annual Scientific Assembly. San Francisco, California. Sympathoadrenal Activity Rise Occurs Early in MI International. (Article) Medical New Service; Internal Medicine News. Collapse of a Young Jogger. Clinical Pathology Conference. Brotman Medical Center. Muscle Mechanics. Pathophysiology Lecture Series for the Second Year Medical Students. University of California, Irvine. Kalzium-Antagonisten: Kennen Sie die schon richtig. (Article) Medical Tribune, Germany Nr 30. ized In Vivo Measurement of Myocardial Perfusion with Avalanche Radiation Detectors. Cardiology Fellows Conference (Dr Swan's Rounds). Cedars Sinai Medical Center. Calcium Channel Blockers. Chairman, Original Investigation Session. XIV World Congress on Diseases of the Chest. 48th Annual Scientific Assembly. Toronto, Canada. Stress Hormones and the Heart. (Interview) Cable Health National. Changing the Size of Heart Attacks. (Interview) Physicians Radio Network. New Uses of Calcium Channel Blockers. High Desert Professional Pharmacy Association. Lancaster, California. Non Ischemic uses of Calcium Channel Blockers. Educational Conference. St. Vincents Medical Center. Los Angeles. Treatment of Angina Complicated by Hypertension. Regional Visiting Professor Program. St. Frances Hospital, Santa Barbara. Calcium Channel Blockers Update. Regional Visiting Professor Program. Downey Community Hospital. Tissue-Type Plasminogen Activator (t-PA). Department of Medicine Grand Grounds. Brotman Medical Center. New Modalities in the Treatment of Angina. Regional Visiting Professor Program. Panorama Community Hospital. Panorama City. Non-Ischemic Uses of Calcium Channel-Blockers. Regional Visiting Professor Program West Hills Humana Hospital. Canoga Park. Objective Assessment of Thrombolysis (Streptokinase and Tissue Type Plasminogen Activator. Chairman, September 1,2014 P a g e |7 12/08/1986 1986 1/14/1987 1/27/1987 5/12/1987 5/23/1987 1988 5/1989 8/2-5/1990 3/02/1991 4/22/1991 4/23/1991 12/22/1991 11/01/1991 12/22/1991 1/14/1992 11/6/1992 12/10/1992 12/04/1992 1/07/1993 2/15/1993 7/14/1993 9/3/1993 11/11/1993 10/12/1993 Winter 1993 Fall 1995 Karlsberg CV Quarterly Medical Staff Meeting. Speaker, Greg Brown, M.D., PhD. Brotman Medical Center. Newer Approaches to the Treatment of Acute Myocardial Infarction; Symposium. Brotman Medical Center. New Medication for Stopping Heart Attacks. (Interview) NBC Television News. Dissolving The Clots That Cause Heart Attacks. Community Advisory Board. Brotman Medical Center. Culver City. New Developments in Heart Disease. The Exchange Club of Culver City. Calcium Channel Blocker Update. Medical Surgical Grand Round. Brotman Medical Center Interventions in Acute M.I.; Update TIMI PHASE II. Medical Grand Rounds. Brotman Medical Center. New Treatment for Patients with Heart Failure.(Interview)National TV News. "New procedure at BMC: Percutaneous Atherectomy" Brotman Medical Center News Line: Medical Staff Newsletter Milrinone IV Post-Myocardial Infarction; Symposium Principle Speaker and Chairman. Participants (Partial List): Uri Elkayam M.D., Ralph Shabetai M.D., Sponsored by Sterling Drug Inc. Biltmore Hotel, Santa Barbara, California. Keynote speaker "Milrinone: Correlation of Hemodynamics with Clinical Improvement Symposium: Therapeutic Intervention in the Treatment of Acute Heart Failure." Chairman, William W. Parmley M.D. Other Participants: David P. Lauler M.D., Robert J. Cody, M.D., Wilson S. Colucci, M.D., Richard A. Goldstein, M.D., Marvin A. Konstam, M.D., Kathleen M. Sherry, MB. Sponsored Medical Education Programs, Ltd. Ritz-Carlton, Buckhead. American College of Cardiology, Atlanta, Georgia. Congestive Heart Failure: The New and the Old. Critical Care Class. Brotman Medical Center. Acute Myocardial Infarction. Critical Care Class. Brotman Medical Center. Percutaneous Transluminal Coronary Angioplasty and Cardiac Catheterization. Critical Care Class. Brotman Medical Center. New Procedure for Removing Arteriosclerosis from Arteries: Percutaneous Atherectomy. Medical Staff Newsletter. Brotman Medical Center. "PTCA/Heart Cath." Lecture to Critical Care Students, Brotman Medical Center. Coronary Directional Atherectomy: Cedars Sinai Interventional Laboratory. Cedars Sinai Medical Center. "PTCA, Cardiac Catheterization, and Thrombolytic Therapy" Education Department Brotman Medical Center. Interview: Co-Host Hillel Laks, MD, Professor and Chief Cardiothoracic Surgery UCLA. "Ask the Doctor", BHTV. Two one hour public service presentations to Cable viewers Los Angeles, California. "Cardiology and Cardiothoracic Surgery" Aired repetitively in 1993. Keynote speaker and Planning Committee: Cardiology Update: An Intensive 1-1/2 Day Clinically Oriented Symposium. Sponsored by The Institutes for Medical Studies. Panel Discussions: "Myocardial Infarction", "Congestive Heart Failure." Meet the expert workshop: "Interventional Cardiology: Updates and Latest Techniques."` Hyatt Regency Hotel, Irvine, California Guest Speaker UCLA Symposium: Heart Failure and Heart and Lung Transplantation. Topic: "Constant Intravenous Infusion in the Treatment of Heart Failure". Lunch Panel: Diagnosis and Management of Heart Failure Case Presentations. Coordinated by Hillel Laks, MD, Professor and Chief of Cardiothoracic Surgery, Director Heart-Lung Transplant Program, UCLA. Sponsored by Divisions of Cardiothoracic Surgery, Cardiology, Pediatric Cardiology. Ritz-Carlton, Marina Del Rey Jan 7-9, 1993. "Congestive Heart Failure: New Medicines" Guest Lecture. St Joseph's Medical Center Grand Rounds. Sponsored by Boots Pharmaceuticals. National Faculty Member Health Education Technologies (HET), sponsored by Sanofi Winthrop Pharmaceuticals. National faculty member physicians forum "Inocor/Primacor." "New Treatments for CHF: Milrinone Past Present and Future Directions". Guest Lecture. Grand Rounds. University of California Medical Center, Irvine California. Sponsored by Physicians Forum: Sanofi Winthrop Pharmaceuticals. "Inodilator Therapy for CHF" Guest Lecture. Grand Rounds. Granda Hills Hospital, Granda Hills, California. Sponsored by Sanofi Winthrop. "Modern Treatment of CHF". Guest Lecture. Grand Rounds. Mercy Hospital and Medical Center. Sponsored by Physicians Forum: Sanofi Winthrope Pharmaceuticals Interview: "Cardiology and State of the Art Technology at Brotman's Cardiac Diagnostic and Interventional Center, Vim & Vigor, Vol 9, No 1 pg 5-8 "Getting to the Heart of the Matter" Vigor and Vim Magazine and lectures to the Los Angeles and Culver City Community September 1,2014 P a g e |8 Jan 1995 8/4/1995 4/26/1996 9/19/1996 10/21/1996 11/6/1996 1/07/1997 1/15/1997 5/01/1997 5/03/1997 9/1997 11/24/1997 3/5/1998 5/21/1998 9/17/1998 9/20/1998 10/2/2002 9/9/2006 07/20/2003 10/23/2003 5/27/2005 7/1/2005 03/6/2006 9/9/2006 11/21/2006 1/4/2007 2/9/2007 2/10/2007 2/9-10/2007 3/9/2007 4/1/2007 Karlsberg CV CVMG Physician and Medical Research Clinician in Profile. Straight From the Heart- The In-House Newsletter for CVMG Vol 95 Issue 1 MPEG imaging for Medical Use. American National Standards Institute, X3 Information Technology, X3L3, Auto/Picture Coding. Chairman Pete Schirling IBM Corporation. Hosted and Introduced Dean Halle T. Debas MD, University of California San Francisco School of Medicine to the Southern California UCSF, Alumni Association. Lunaria Restaurant, Los Angeles, California. Key note Speaker: The Internet. Implications for Health Care Providers. Southern California Physicans Insurance Exchange/Los Angeles County Medical Association Town Hall Meeting, Biltimore Hotel, Los Angeles, California Interviewed for article "Experts Advise and Demonstration Help Physicians Plug into Telemedicine" LACMA Physician, October 21, 1996. Pg 36-37. Keynote speaker: The Future of the Electronic Medicine and the Internet Southern California Physicians Insurance Exchange Medical Group Administrator's Seminar, Regent Beverly Wilshire Hotel, Beverly Hills, California. Keynote speaker: Medical Practice on the Internet National Conference 1977 PIAA (Physicians Insurers Association of America) Risk Management Section Workshop, Ponte Vedra Inn and Club, Ponte Verde Beach, Florida. Interviewed for Article: "The Possibilities and Risks of Online Medicine" Medical Managers Update, SCIPE, Feb 1997. Interviewed for the Toronto Star page J2 Thursday, May 1, 1997 "Medical Resources on the Net". Toronto, Canada. Keynote Speaker: "Healthcare Cybervision - The New Frontier" Brotman Medical Staff's Annual Retreat – CME (California Medical Associations Continuing Medical Education Program), The Ojai Inn, Ojai Valley, California. Interviewed Evening News: Fox News Network "How private are your electronic medical records?" Interviewed for Medical Economics: "Will telemedicine get you Sued? by Berekely Rice. Medical Economics Nov 24, 1997. Pg 56-69 Interview for Culver City News: "Heart Association Gala Honors Albert Vera: Event Raises over $43,000. Culver City News, No. 599 Thursday, March 5, 1998. Page 1-8. Interview for American Journal: Coast to Coast, CBS National Syndicated Show. Comments regarding John Derrick's hospitalization and sudden cardiovascular collapse. Interviewed for Culver City News: Culver City Council Meeting. No. 627. Sept 17, 1998 Interviewed on national television: The Leeza Gibson Show. Discussed the death of Flojo Joiner. Medical Note Creation and Distribution: Intranet and Internet. UCLA Health Care Presentation. UCLA, Los Angeles California. 11th Annual Scientific Session of the American Society of Nuclear Cardiology. “Building a Successful Cardiac CT Program; How to set up your CTA lab and expand your Practice” Medical Note Creation and Distribution; Internet and Intranet. Tenet Hospital Corporation Presentation. Culver City California. Electronic Medical Records in Cardiology. Cedars Sinai Cardiology Grand Rounds Electronic Medical Records in Cardiology. Invited Cardiology Grand Rounds. University of Ottawa Heart Institute, Ottawa, Canada. Sneak Peek: Cardiology Department 2010. HealthImaging Clinical Information Systems – Brotman Medical Center, Perot Systems and NotesMD, Brotman Hospital, Culver City California How to Set Up your CTA Lab and Expand Your Practice. American Society of Nuclear Medicine Annual Meeting, Montreal Canada University of California, San Francisco. “Cardiology Clinical Information Systems” Blue Cross of California, “2007; The Year to Reimburse for Coronary CTA” Harbor-UCLA, ”Medical Informatics” University of Nebraska. “Building a Successful Cardiac CT Program; How to set up your CTA lab and expand your Practice” Setting Up a Cardiac CT Program. Harbor – UCLA Medical Center: Cardiac Computed Tomographic Angiography Beverly Hills Courier. Group Pioneers High-Tech Heart Disease Diagnosis with CT Imaging Technology. Health Imaging & IT. Jumping on Board. Multidetector CT Grows & Flows. September 1,2014 P a g e |9 5/5-7/2007 Cardiac MRI for the Cardiologist: A Unique Problem-Based Approach to an Emerging technology. The Role of CT Coronary Angiography. Hilton La Jolla Torrey Pines. Scripps Clinic. San Diego California. 7/14/2007 Wyoming Cardiopulmonary Services, P.C., Casper, Wyoming. Keynote Speaker: “Showcasing Our New LightSpeed VCT Cardiac CT, Revolutionary CT Scanning” 10/6/2007 Annual Fellows in Training Symposium. American College of Cardiology. California Chapter. “Establishing a Research Program in a Clinical Practice: Practical and Ethical Considerations” 10/6/2007 Annual Fellows in Training Symposium. American College of Cardiology. California Chapter. “Incorporating an Electronic Medical Record System in a Clinical Practice: Reducing the Friction in Medical Care and Improving Outcomes” 1/1/2008 Tapping into IT to Improve the Office- Based Practice. 3/1/2008 The Changing Face of the Cath Lab 5/1/2008 Coronary CTA: Drafting the Strategic Plan. Cardiovascular Business 1/27/2008 Advances in Nuclear Cardiology and Cardiac CT 22TH Annual Meeting: Nuclear Cardiology and Cardiac CT: Case Review with the Experts. Workshop: “CT Coronary Angiography: the Private Practice Experience” 3/8/2008 Growing the Health of Your Patients and Practice with Cardiac CT 2nd Annual Cardiac Computed Tomography Conference. St. Johns Cardiovascular Research Center- Cardiology Torrance, California. Harbor-UCLA Medical Center. 4/24/2008 CME Distinguished Lecture Series. “Is Diagnostic Invasive Angiography Obsolete?” Brotman Medical Center. 6/03/2008 CCTA Integrated in the Cardiology Office Practice. Confessions of an Interventional Cardiologist. Shaare Sedek Medical Center, invited Cardiology Grand Rounds, Jerusalem Israel. 3/23/2009 CCTA Integrated in the Cardiology Office Practice Confessions of an Interventional Cardiologist Sharp Memorial Hospital, Grand Rounds, San Diego California. 2/1/2009 Advances in Nuclear Cardiology and Cardiac CT: 23rd Annual Case Review with the Experts. Workshop XVII – Coronary CTA in a Private Cardiology Practice. Cedars-Sinai Medical Center. 2/17-19, 2009 Introduction to Cardiac CT Interpretation. Wilford Hall Medical Center (59th Medical Wing) Air Force’s largest Medical Facility. Austin Texas. Invited Lecturer and CT training course. 2/26/2009 Cardiovascular Research Foundation Annual Event. The Four Season Hotel, Beverly Hills California 11/23/2009 Is Exercise Testing as The First Test for the Intermediate Risk Patient and Elective Diagnostic Invasive Coronary Angiography Obsolete? McKenzie-Willamette . Invited Rounds, Eugene Oregon. 1/29-31/2010 Advances in Nuclear Cardiology and Cardiac CT: 24th Annual Case Review with the Experts. Workshop XIX Coronary CTA in a Private Cardiology Practice. Cedars-Sinai Medical Center. 2/20/2010 Cardiac CT- 2010. 18th Annual Frontiers in Wyoming Medicine, Jackson Hole Colorado 5/20/2010 Cardiac CT Update-2010. How Does CCTA Fit in the Workup of the Cardiac Patient? Royal Alexandra Hospital. Cardiology Grand Rounds. Invited lecture. Edmonton, Canada 3/21/2010 Introduced and hosted Sam Hawgood, MD Dean of the School of Medicine, UCSF Alumni Meeting, Los Angeles, California.05/27/2010 Corporate Medicine v. Obama Care: Which One Is the Tougher Pill to Swallow. Medically Incorrect. Interview: http:// www.pjtv.com/v/3478 05/29/2010 What’s Up Doc ? Physicians on The Future of Patient Care. Medically Incorrect. Interview: http://www.pjtv.com/v/3479 07/15/2010 Annual Meeting SCCT. Business and Logistics: Site Requirements for Cardiac CT: Rooms, Equipment, Personnel. Invited Lecture, Las Vegas Nevada. 07/17/2010 Annual Meeting SCCT. Advice for Difficult Situation: Cardiac CT Imaging of the Obese Patient. Invited Lecture. Las Vegas, Nevada 2006 12/3/2010 UCLA Cardiology Grand Rounds. Confessions of an Interventional Cardiologist. 01/24/2011 Advances in Nuclear Cardiology and Cardiac CT 25TH Annual Meeting: Coronary CTA in the Practice Environment: Cedars Sinai, Los Angeles California. 02/15/2011 Cedar Sinai Fellows Rounds. Cardiac CT – The Perfect First Test? 6/23/2011 Going digital: Electronic medical records in cardiology practice. The Heart.Org. http://www.theheart.org/editorial-program/1239025.do 07/14/2011 Cardiac CT Anatomy the Basics (In 15 minutes) Fundamentals of Cardiac CT. Annual Meeting SCCT, Denver Colorado. 10/13-14/2011 Controversies & Advances In Treatment of Cardiovascular Disease, Cedars Sinai Heart Institute 11th Annual Meeting of the California ACC, Beverly Hills Hotel, Faculty and Moderator Beverly Hills California Karlsberg CV September 1,2014 P a g e | 10 Advances in Nuclear Cardiology and Cardiac CT 27TH Annual Meeting, Faculty Los Angeles California Controversies & Advances In Treatment of Cardiovascular Disease, Cedars Sinai Heart Institute 12th. Annual Meeting of the California ACC, Faculty, Beverly Hills Hotel, Beverly Hills, California. 07/19-22/2012 7th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography , Baltimore Washington, Session Chair and faculty 1/26/2012 Joint Symposium of the British Cardiovascular Society and the California Chapter of the American College of Cardiology, Chicago, Illinois. 3/26/2012 American College of Cardiology Annual Meeting. Plenary Presentation: Ischemic Chest Pain in the ERCardiac CT in 2012- State of the Art. Chicago, Illinois. 3/09/2014 Boom in personal health tech could be your lifesaver. USA today http://www.usatoday.com/story/tech/personal/2014/03/09/personal-tech-health-care-data-gadgetsapps/6164419/ 7/12/2013-14 Chairman: Young Investigators Award Abstract Session, Ronald P. Karlsberg, MD, FSCCT 9/1/2014 The Health of Golf – Radio Interview to 6,000,000 TeeItUp Radio Network (www.TEEITUPSHOW.com) Aug 31, 2014 PRESS RELEASES and Features News Articles (Not Inclusive) LACMA Physician. Telemedicine: Learning the licensing and liability traps before you practice online. April 7, 1997 Brotman Medical Center Seeks Patients with Coronary Artery Disease for Angiogenic Gene Therapy Study, 2003 Medcon has been selected by CVMG to provide multimodality Archival Solutions, 2005 CVMG has acquired a new state-of-the-art, CT imaging system from GE Healthcare bringing a new era in imaging to patients in Southern California, 2005 Toshiba announces launch of the five-axis infintx Cardiac Imaging System at TCT, Oct. 17, 2005 Leading Hospitals Adopt Toshiba’s Advanced Image Processing For Infinix Line; New X-Ray Feature Increases Image Quality And Diagnostic Capabilities”; Brotman Medical Center, April 2008 Health Imaging & IT - Cover Story Office of 2010: The WEB-based EMR Meets Cardiology July 2005, page 17 Cardiology ACC Publication –California Practice a Pioneer in Health IT Sep. 2006 Vol 34 Number 9 The Evidence Gap: Weighing the Costs of a CT Scan’s Look Inside the Heart. The New York Times. Published: June 29, 2008. Business Section. Page 1. By Alex Berenson and Reed Abelson Mirro MD, Michael J., and Tcheng MD, James E. Ronald P. Karlsberg, MD acknowledged as a contributing member of the ACC Health IT Committee. Demystifying the Purchase of the EHR. Cardiology. September 2009. Vol. 38. No. 9. Hernandez, Daniela. Boom in personal health tech could be your lifesaver. (Alivecor ECG recorder) USA today. March 9, 2014-http://www.usatoday.com/story/tech/personal/2014/03/09/personal-tech-health-care-data-gadgetsapps/6164419/ Ask Dr Soram-Interview with Ronald Karlsberg MD about Coronary CT Angiograms (http://www.drsoram.com) AliveCor Transforms Heart Monitor into eHealth Service, November 18,2013 01/20/2012 9/21-22/2012 Karlsberg CV September 1,2014 P a g e | 11 RESEARCH GRANTS 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. Karlsberg CV Research Assistant, Department of Psychology, University of California, Berkeley. 1967. Trainee in Medicine, Public Health Services Grant. 1969. NIH Post Doctoral Trainee in Medicine (U.S. Public Health Service Institutional National Research Service Award for Research Training, Multidisciplinary Heart and Vascular Disease). 1975. Influence of Metabolic Alterations during Evolving Myocardial Infarction. Veterans Administration Research Program, Research Advisory Group Award. (Competitive 3 year award). 1978 Metabolic Modification of Myocardial Infarction I. American Heart Association, California Affiliate. 1978. Metabolic Modification of Myocardial Infarction II. American Heart Association, California Affiliate. 1979. Myocardial Infarct Imaging with 99m Tc-DMSA. American Heart Association, California Affiliate, Research Grant-in-Aid. 1980. Regional Myocardial Flow Measured with Avalanche Detectors. (This grant received the highest priority rating in the California Affiliate compared to approximately 100 applications). 1980. Use of a New Radiation Detector of Measuring Myocardial Blood Flow. Veteran's Administration Merit Review. (Co-investigator; 3 year competitive grant). 1981. Glucose C-14 detection with the Avalanche Radiation Probe in Isolated Heart Preparations. Cardiology Special Projects. Cedars Sinai Medical Center. 1982. Cardiology Special Projects Research Fund, Cedars Sinai Medical Center (Private Donor Fund). 1983-Present. Quantitative Cardiac Perfusion/function Scintigraphy, Nuclear Cardiology Core Section of Program Project Grant. (Co-investigator). Cedars Sinai Medical Center. 1982. A Randomized, Evaluator-Blind Study for up to Three Months of the Safety and Efficacy of CL 115,347 Administered Transdermally Either as Sole Agent or in Combination with Hydrochlorothiazide in Mild to Moderate Hypertensive Patients. American Cyanamid Company. 1984. An Open Study of the Safety and Efficacy of Various Doses of BW tPA in Patients with Acute Myocardial Infarction (Protocol 01). Burroughs Wellcome Company. 1986. Lovastatin Dose-Ranging Multicenter Study of Patients with Type II Hypercholesterolemia, Total Cholesterol 320300 mg/dl With Or Without Other Risk Factors and With Or Without Evidence of Coronary Artery Disease, Protocol 022. Merck Sharp & Dohme Research Laboratories. 1987. An Open, Multicenter, Single-Dose Safety and Efficacy Study of BW t-PA in Patient with Acute Myocardial Infarction (P52 Protocol 02). Burroughs Wellcome Company 1987. A Phase III Multi-Center Study of the Comparative Efficacy and Safety of Intravenous Milrinone and Dobutamine On Left Ventricular Dysfunction In Congestive Heart Failure Following Myocardial Infarction (Mil 1036). Sterling Drug Inc. 1987. An Open, Multicenter Study of the Safety of PROLYSIS (BW t-PA) in Patients with Acute Myocardial Infarction (P52 Protocol 09). 1988. A Randomized, Phase III, Placebo Controlled Survival Study of Oral in Patients with Severe Heart FailurePROMISE (Mil 1064). Sterling-Winthrop Research Institute. 1988. A Phase II, Multicenter, Randomized, Double-Blind Study to assess in Patients with Congestive Heart Failure: 1. The Hemodynamic Effects of the Withdrawal of Intravenous Milrinone, and 2. The Pharmacodynamic Interaction of Milrinone and Digoxin (Mil 1006). Sterling-Winthrop Research Institute. 1988. Lovastatin Dose-Ranging Multicenter Study of Patients with Type II Hypercholesterolemia, Total Cholesterol 320300 mg/dl with or without other risk factors and with or without evidence of coronary artery disease. 48-week extension study. Merck Sharp & Dohme Research Laboratories. 1988. A Double-blind, Placebo-controlled, Parallel, Multicenter Study to Assess The Effects of Digoxin Withdrawal On Exercise Tolerance And Other Measures of Clinical Efficacy in Patients With Chronic Congestive Heart Failure (NYHA Class II-III In Normal Sinus Rhythm Receiving Concomitant Therapy With Diuretics And An Angiotensin Converting Enzyme Inhibitor (ACE), (GHBA-437). Burroughs Wellcome Company. 1989. A Double-blind, Placebo-controlled Parallel, Multicenter Study to Assess the Effects of Digoxin Withdrawal on Exercise Tolerance and Other Measures of Clinical Efficacy in Patients With Chronic Congestive Heart Failure (NYHA II-III) in Normal Sinus Rhythm, (GHBA-436). Burroughs Wellcome Company. 1989. A Phase II, III Clinical Evaluation Study of Patients Receiving Oral Milrinone (P-553). Sterling Drug Inc. 1988. The Safety and Efficacy of Cardizem SR in Patients with Mild to Moderate Hypertension. Marion Merill Dow. 1989. September 1,2014 P a g e | 12 RESEARCH GRANTS 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. Karlsberg CV An Open-Label Assessment of the Safety and Efficacy of Isradipine in the Treatment of Patients with Mild to Moderate Hypertension. Study No. PNH-408. Sandoz Pharmaceuticals Corporation. November 1989. A Study Comparing The Effect of Selective Withdrawal of Zestril (Lisinopril) Or Digoxin In The Treatment of Congestive Heart Failure (WIST, ZES 0-984-1) ICI Pharmaceuticals Group. 1990. A Comparison of the Effects of Eminase (APSAC) to Those of t-PA on Morbidity in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, Multicenter Study. Protocol FIB-052. SmithKline Beecham Pharmaceuticals. November 1990. Thrombolysis in Myocardial Infarction – 4 Comparison of Thrombolytic Regimens. Protocol TIMI 4. BW & Misc. December 1990. A Multicenter, Open, Randomized Parallel Comparison of the Safety and Efficacy of Chronic Flolan Infusions to Conventional Therapy in Patients with Severe Congestive Heart Failure. Protocol P18:44 Wellcome. November 1990. A Multicenter Study Comparing Pre-hospital to In-Hospital Treatment with Eminase in Patients with an Acute Myocardial Infarction. Protocol FIB –053 SmithKline Beecham Pharmaceutical. September 1990. A Double-Blind, Randomized, Placebo-controlled Study of the Effect of Flosequinan on the Survival of Patients with Chronic Congestive Heart Failure. Clinical Protocol: BPI 933. Flosequinan (BTS 49465) Boots Pharmaceuticals, Inc. May 1991. Global Utilization of Streptokinase and t-PA For Occluded Coronary Arteries. (GUSTO) 1990. Trial to Evaluate the Effect of Digital on Mortality in Heart Failure. Digitalis Investigation Group. September 1990. A Study Comparing the Effect of Selective Withdrawal of Zestril (Lisinopril) or Digoxin in the Treatment of Congestive Heart Failure (WIST) ZES 0-984-1. ICI Pharmaceuticals, December 1990. A phase II, Multicenter, Open Label Study to Evaluate the Efficacy and Safety of Intravenous Milrinone on Left ventricular Dysfunction in Patients with Congestive Heart Failure Following Acute Myocardial Infarction. Protocol # MIL-1174. Sterling Research Group. November 1990. Primacor Intra Venous Infarction Trial. MILRINONE. Sterling Research Group, 1991. Efficacy of Fosinopril Sodium in Patients with decompensated Congestive Heart Failure. Protocol 31, 138-08. David Deitchman, Ph.D., Thomas Hare, MS. Bristol-Myers Squibb, January 1991. A Randomized Comparative Trial Of N-Acetyl Procainamide (NAPA) And Procainamide (Procan SR) For The Treatment Of Paroxysmal Supraventricular Arrhythmias (SVAs), Protocol No: NA-02. 1992. A Phase IV Study to Evaluate the Occurrence of Ventricular Arrhythmias with Intravenous Milrinone or Dobutamine in Patients with Acute Congestive Heart Failure (Protocol 140.02) Sanofi Winthrop Pharmaceutical. 1992. A Phase IV Study to Evaluate the Effect of Intervention with Intravenous Milrinone or Dobutamine on the Course of Acute Hospital Admissions for Congestive Heart Failure (Protocol 140.01). Sanofi Winthrop Pharmaceutical. Division of Sterling Winthrop Inc. Nov 6 1991. A Randomized Open Label, Dose Response Study to Evaluate the Effects of BM 06.022 (r-PA) At Doses of 15 MU, 10 + 5 MU and 10 + 10MU, Relative to Altepase (100 mg), On Coronary Artery Patency and Safety In Patients With Acute Myocardial Infarction (MF 4255). Boehringer Mannheim Pharmaceutical. 1992. Long-term Efficacy of Optimized Zatebradine (UL-FS 49 CL) in Patients with Chronic Stable Angina Assessed by Randomized, Double-Blind, Parallel-Group Withdrawal. Boehringer Ingelheim. Protocol 009552A. May 4, 1992. A Double-Blind, Placebo Controlled Dose Titration Study of the Safety and Efficacy of Dilacor XR in Elderly Patients with Mild to Moderate Hypertension. Protocol 83606-601 Rhone-Poulenc Rorer, July 1992. A Pilot Study of the Anticoagulant effect of a fixed dose of 3 mg Coumadin plus 80 mg Aspirin and of dose reduction in patients with coronary artery Disease. Du Pont Merck Pharmaceutical Company IND No. 245626 Amanda No: 10092303515, August 10, 1992. A Randomized, Double-Blind Study to Compare the Efficacy and Safety of Fixed Low Doses of Coumadin Plus Aspirin to Aspirin Along in the Prevention of Reinfarction, Cardiovascular Death, and Stroke in Post-Myocardial Infarction Patients. Protocol No: 24626. 1993. Open-Label Extension To CV131-002: The Long-Term Anti-Hypertensive Activity and Safety of SR 47436/BMS 186295 (Irbesartan) in Mild to Moderate Hypertension. Protocol #CV131-002; Long-Term, Open-Label Extension Year 4. Bristol-Myers Squibb Company. 1993. September 1,2014 P a g e | 13 RESEARCH GRANTS 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. Karlsberg CV A Six-Month, Double Blind, Placebo-Controlled Multicenter Dose-Ranging Comparison of Oral Carvedilol b.i.d. in Patients with Congestive Heart Failure, NYHA Class II-IV. Protocol 220. 1993. Multicenter, Double-Blind, Randomized, Dose-Ranging Trial of BMS-200,980 in Subjects with Acute Myocardial Infarction. 1993. Efficacy and Safety of Moderate Dose Milrinone in Combination with Dobutamine, Compared with Dobutamine Alone, in the Treatment of Heart Failure Secondary to Myocardial Infarction (Protocol # MIL-SW-001). 1993. A Randomized Multicenter Study Comparing the Efficacy and Safety of Intravenous Milrinone and Nitroglycerin in Patients with Severe Congestive Heart Failure. (Protocol # MIL-SW-002). 1993. A Randomized, Open-label, Multicenter, Angiographic Study to Compare the Effects of 10+10 MU r-PA with Front-loaded Alteplase in Patients with Acute Myocardial Infarction r-PA-04. Boehringer Mannheim Pharmaceutical. 1993. A Six-Month, Double Blind, Placebo-Controlled Comparison of Oral Carvedilol b.i.d. with Placebo in Patients with Congestive Heart Failure, NYHA Class III-IV. Protocol 239. 1993. Coronary Thrombolysis in Patients with Acute Myocardial Infarction - Multicenter Study with Prourokinase (FCE 26177) and t-PA Co-Administration of Oral Carvedilol b.i.d. with Placebo in Patients with Mild Congestive Heart Failure, NYHA Class II. Protocol 240. 1993. Coronary Thrombolysis in Patients with Acute Myocardial Infarction - Multicenter Study with Prourokinase (FCE 26177) and t-PA Co-Administration. 1993. A Double-Blind, Randomized, Parallel Group Placebo Controlled, Dose Response Study To Evaluate The Safety And Efficacy Of Intravenous Lipo PGE1 Therapy In Patients With Ischemic Ulcers Due To Peripheral Vascular Disease. Protocol ATC 92-12. Alpha Therapeutic Corporation, Aug 13, 1993. PRAISE (PROSPECTIVE RANDOMIZED AMLODIPINE SURVIVAL EVALUATION). A randomized, doubleblind, dose-titration, parallel group, placebo-controlled study to evaluate the effect of amlodipine on mortality and morbidity in patients with severe heart failure. 1994. A Study to Determine the Hemodynamic Effects Of NE-10064 In Patients With Decreased Left Ventricular Function. Clinical Protocol No. 1994030. 1994. A Phase 3, Randomized, Double Blind, Long Term Continuation Study of OPC-18790 in Patients with Decompensated Heart Failure. Protocol 103-93-204. Otsuka America Pharmaceutical, Inc. 1994. A Multicenter, Double-Blind, Randomized, Parallel, Captopril-Controlled Study To Investigate The Safety And Tolerability Of Losartan In Elderly Patients With Symptomatic Heart Failure -- U.S. 1994. The Effect of Oral D-Sotalol on Mortality in Patients with Atherosclerotic Coronary Heart Disease and Left Ventricular Dysfunction. Protocol No: CV102-023A. SWORD. 1994. A Double-Blind, Placebo-Controlled, Extended Period Latin Square Design Study Assessing The Efficacy And Safety Of Five Doses Of Ranolazine Sr Monotherapy 500 Mg Bid, 750 Mg Bid 1000 Mg Bid And 2000 Mg Bid In Patients With Chronic Stable Angina. 1994. A Study of the conversion Efficacy and Safety of Repeated Intravenous Doses of Ibutilide in Patients with Atrial Flutter or Atrial Fibrillation Following Valvular or Coronary Artery Bypass Surgery. Protocol #0017. 1994. A Study of the Conversion Efficacy and Safety of Ibutilide in Patients with Atrial Flutter or Atrial Fibrillation” Protocol No. M-7550-0020. 1994. A Double-Blind, Placebo-Controlled, Parallel Design Study to assess the Efficacy and Safety of Ranolazine SR 500mg BID, 750 mg BID, 1000mg BID in patients with intermittent claudication. Protocol 2320. 1994. Evaluation of the Long-Term Safety and Tolerability of Ranolazine SR 750 Mg BID and 1000 Mg BID in Patients with Intermittent Claudication. Protocol #RAN2388. 1994. An International, Multicenter, Double-Blind, Randomized Trial to Compare the Effects of BG8967 (Hirulog) and Heparin in Subjects with Acute Coronary Syndromes: Unstable Angina or Non-Q Wave Myocardial Infarction. (Protocol C93-309). 1994. A Double-Blind, Placebo-Controlled, Extended Period Latin Square Designed Study Assessing The Efficacy And Safety Of Ranolazine SR 750mg bid and 1000mg bid In Patients On Maximal Medical Therapy With Refractory Chronic Stable Angina, Who Are Not Candidates For PTCA or CABG (Protocol No. RANS2220). 1994. A Double Blind, Multicenter Comparison of Oral Carvedilol b.i.d. with Placebo in the Treatment of Patients with Mild Congestive Heart Failure, NYHA Class II-III. Protocol 240. SmithKline Beecham. 1994. A Multicenter, Double-Blind, Randomized, Parallel, Captopril-Controlled Study to Evaluate the Effects of Losartan on Mortality in Patients with Symptomatic Heart Failure. Protocol # 164-00. Merck & Co., Inc. ELITE. 1994. September 1,2014 P a g e | 14 RESEARCH GRANTS 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. Karlsberg CV A Double-Blind, Randomized, Active-Controlled, Parallel Design Trial Comparing The Efficacy Of The Combination Of Hydrochlorothiazide 12.5 Mg Or 25 Mg Plus Valsartan 80 Mg Once Daily To Valsartan 160 Mg Daily In Hypertensive Patients Inadequately Controlled With Valsartan 80 Mg. Once Daily Protocol #19. 1994. A Randomized, Double Blind, Placebo Controlled, Multiple Dose Study of the Chronic Administration of Vesnarinone in Heart Failure. Protocol 22-94-201. Otsuka America Pharmaceutical, Inc. 1995. The Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events (Unstable Angina and NonQ-Wave MI): A Double-Blind, Randomized, Parallel Group Multicenter Study Comparing Enoxaparin and Intravenous Unfractionated Heparin. Protocol No. RP 54563-303. ESSENCE. 1995. A Double-Blind, Randomized, Parallel, Sotalol-controlled, Dose Confirmation Study to Investigate the Safety and Electrophysiologic Effects of MK-499 in Patients with Sustained Ventricular Tachyarrhythmias. 1995. D-Sotalol Phase III Clinical Trials in Patients with Life-Threatening Ventricular Arrhythmias. Protocol #CV102-017. 1995. Study of Midodrine in Patients with Neurogenic Orthostatic Hypotension- Protocol 20,762-999A. 1995. An Open-Label Evaluation of the Safety of Chronic Administration of Telmisartan as Monotherapy or in Combination with Other Antihypertensive Medications. 1995. Dose-Response Evaluation of Beraprost Sodium IR Tablets in the Treatment of Intermittent Claudication. Protocol 201129PR0008. 1995. Dose-Ranging Study of Oral Bidisomide vs. Placebo in Reducing the Recurrence Of Symptomatic Atrial Fibrillation/Flutter And Paroxysmal Supraventricular Tachycardia. Protocol #: NP8-92-02-046. 1995. A Randomized, Double-Blind, Outpatient, Dose-Titration Trial of ANA-756 versus Placebo In Patients With Essential Hypertension Protocol No.: 820-A-322-US. 1995. A Phase II, Placebo-Controlled, Multicenter Study of TLC C-53 as an Adjunct to Thrombolytic Therapy in Patients with Acute Myocardial Infarction. (Liposomal Intervention Followed by Thrombolysis, Lift) Protocol C94-D-02. The Liposome Company, Inc. 1995. A Comparison of the Effects of Mibefradil versus Placebo for Three Weeks in Patients with Chronic Stable Angina Pectoris. Protocol NC14983A. Hoffmann-La Roche, Inc. 1995. An Open Multiple Dose Study of the Chronic Administration of Vesnarinone (OPC-8212) in Heart Failure. Protocol 22-95-209. Otsuka America Pharmaceutical, Inc. 1995. A Triple-Blind, Parallel Study to Investigate the Effect of Losartan versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy. LIFE. Protocol 133-03. Merck & Co., Inc. 1995. A Randomized, Double-Blind, Placebo-Controlled Study With Two Doses of Lamifiban (Ro 44-9883) With or Without Heparin, In Patients with Acute Coronary Syndrome Without ST-Segment Elevation (Unstable Angina, Non-Q Wave Myocardial Infarction). 1995. An Open-Label Evaluation of Carvedilol in Patients with Chronic Congestive Heart Failure (NYHA Class II-IV. Protocol #257. 1995 A Randomized, Double-Blind, Placebo-Controlled Of Lamifiban (Ro 44-9883) In Patients with Acute Coronary Syndrome without Persistent ST-Segment Elevation (Unstable Angina, Non-Q Wave Myocardial Infarction). 1996. 8A Double-Blind, Placebo-Controlled, Parallel-Group, 3-Day Treatment and 3-Month Follow-up, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Fosphenytoin (Cerebyx) in Patients with Acute Ischemic Stroke. Protocol 982-025-009) Parke-Davis. August 1996. A Study to Compare the Tolerability of Toprol-XL (metoprolol succinate extended release tablets) versus placebo in patients with moderate to severe chronic heart failure (S-996). 1996. A Double-Blind, Randomized, Comparative, Multicenter Study of Zagam (Sparfloxacin) vs. Biaxin (Clarithromycin) in the Treatment of Community-Acquired Pneumonia. Protocol 601.Rhone-Poulenc Rorer Pharmaceuticals, 1996. A Multicenter, Double-Blind, Randomized, Dose-Ranging Trial of BMS-200980 in Subjects with Acute Myocardial Infarction. Protocol CV142-001. Bristol Myers Squibb. 1996. Thrombolytic Therapy in Acute Ischemic Stroke. Protocol # A027g. Genentech, Inc. February 1996. A Double-Blind, Placebo-Controlled, Parallel Design Clinical Trial to Assess the Safety and Efficacy of 100mg of Azimilide for the Prophylactic Treatment of Symptomatic Atrial Fibrillation/Flutter and/or Symptomatic Paroxysmal Supraventricular Tachycardia. Protocol 1995010. Procter and Gamble Pharmaceuticals, Inc. 1996. An Open-Label Clinical Trial to Assess the Long-Term Safety of Azimilide in Patients with Atrial Fibrillation/Flutter and /or Paroxysmal SupraventricularTachycardia. Protocol 1995011.Procter and Gamble Pharmaceuticals, Inc. 1996. September 1,2014 P a g e | 15 RESEARCH GRANTS 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. Karlsberg CV A Multi-Center , Double-Blind, Placebo-Controlled, Parallel Design Trial to Assess the Safety and Efficacy of 35mg and 75mg of Azimilide Dihydrochloride for the Prophylactic Treatment of Symptomatic Atrial Fibrillation/Flutter and/or Symptomatic Paroxysmal Supraventricular Tachycardia. Protocol # 1995115. Procter and Gamble Pharmaceuticals, Inc. 1996. A Multi-Center Open-Label Clinical Trial to Assess the Long-Term Safety of 75 mg of Azimilide Dihydrochloride in Patients with Atrial Fibrillation/Flutter and/or Paroxysmal Tachycardia. Protocol 1995116. Procter and Gamble Pharmaceuticals, Inc. 1996 A Multi-Center, Double-Blind, Placebo-Controlled, Parallel Design Clinical Trial to Assess the Efficacy and Safety of 50mg, 100mg, and 125mg of Azimilide Dihydrochloride for the Prophylactic Treatment of Symptomatic Atrial Fibrillation/Flutter and/or Symptomatic Paroxysmal Supraventricular Tachycardia. Protocol 1996033. Procter and Gamble Pharmaceuticals, Inc. 1996. An Open-Label Clinical Trial to Assess the Long-Term Safety of 100 mg of Azimilide in Patients with Atrial Fibrillation/Flutter and/or Paroxysmal Supraventricular Tachycardia. Protocol 1996034. Procter and Gamble Pharmaceuticals, Inc. 1996. A Multi-center, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of 35mg, 75mg, and 125mg/day Doses of Oral Azimilide Dihydrochloride in Patients with an Implantable Cardioverter Defibrillator for the Treatment of Ventricular Arrhythmia. Protocol 1995123. Procter and Gamble Pharmaceuticals. 1996. A Revised Clinical Protocol for Controlled Onset Verapamil Investigation of Cardiovascular Endpoints (CONVINCE), IND #39,459. Original Protocol # 126-96-12-011. G.D. Searle & Company. 1996 An Open Multiple Dose Study Of The Chronic Administration Of Vesnarinone (OPC-8212) In Heart Failure. Protocol 22-95-209. 1996. A Multi-Center, Double-Blind, Placebo-Controlled, Randomized Pilot Study of the Efficacy and Safety of Irbesartan in Combination with Conventional Therapy, Including Angiotensin Converting Enzyme Inhibitor (ACE-1), in Subjects with Heart Failure. Protocol CV 131-068. Bristol-Myers Squibb. 1996. A Double-Blind, Long-Term Extension Study of Orally Administered Dofetilide in Patients having Previously Completed the Dofetilide Study 115-120: Study Evaluating the Efficacy and Safety of Different Oral Dose Levels of Dofetilide in the Fibrillation/Flutter in Patients with Chronic Persistent Atrial Fibrillation/Flutter Converted Electrically or Pharmacologically to Sinus Rhythm. Protocol 115-120-592. Pfizer. 1996. A Double-Blind, Randomized, Comparative, Multicenter Study of Zagam (Sparfloxacin) Vs. Biaxin (Clarithromycin) In the Treatment of Acute Bacterial Exacerbations of Chronic Bronchitis. Protocol 602. RhonePoulenc Rorer Pharmaceuticals, Inc. 1996. Pacesetter, Tendril DX Model 1388T. Endocardial Steroid-Eluting Active-Fixation Pacing Lead. Phase II. 1996. Pacesetter, Model 1388T Tendril DX. Endocardial Steroid Eluting Screw-In Pacing Lead. 1996. The Effect of Ro 40-5967 on all causes of Mortality in Comparison with Placebo in Patients with Chronic Heart Failure (NYHA Class II-IV) Treated for Approximately 3 Years. Protocol BC14808E. F. Hoffmann-La Roche Ltd. MACH 1. 1996. A Phase 3, Randomized, Double Blind, Placebo Controlled Evaluation of the Acute and Chronic Efficacy and Safety of OPC-18790 in the Treatment of Patients with Decompensated Heart Failure. Protocol 103-93-203. 1996. A Multicenter Clinical Evaluation of the Safety and Efficacy of BR1 versus Albunex as A Contrast Enhancing Agent for Transthoracic Echocardiography at Rest. Protocol BR1-019B. Bracco. 1996. A Randomized, Open-label, Active-controlled, Multicenter Phase III Safety Study of Two Doses of Natrecor hBNP Administered as a Continuous Infusion in the Treatment of Decompensated CHF. Protocol 704.326. Scios Inc. 1996 A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Effects of Ro 47-0203 (Bosentan) on the Clinical Status of Patients with Advanced Chronic Heart Failure and the Pharmacokinetics of Ro 47-0203 (Bosentan). Protocol NC15462. Hoffmann-LaRoche. 1997. Open-Label, Long-Term Study in Patients with Chronic Heart Failure Who Participated in Controlled Clinical Studies with Bosentan. Protocol: NC15464. 1997. A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Oral R-568 Administered for 15 Days to Hemodialysis Patients With Second Hyperparathyroidism. Protocol # 960167. Amgen Inc. 1997. Year 4 of the Open-Label Extension to Protocol CV131-002: The Long-Term Antihypertensive Activity and Safety of Irbesartan in Mild to Moderate Hypertension. Protocol CV131-002. Bristol Myers Squibb. 1997 September 1,2014 P a g e | 16 RESEARCH GRANTS 114. 115. 116. 117. 118. 119. 120. 121. 122. 123. 124. 125. 126. 127. 128. 129. 130. 131. 132. 133. 134. 135. Karlsberg CV A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Trial To Assess The Effect Of Valsartan On Exercise Capacity, Quality Of Life And Signs And Symptoms, In Patients With Stable, Chronic Congestive Heart Failure (NYHA class II-IV). Protocol 106. Ciba Pharmaceuticals. 1997. A Double-Blind, Placebo-Controlled Survival Study with Metoprolol CR/XL in Patients with Decreased Ejection Fraction and Symptoms of Heart Failure. Protocol SH-MET-0024. ASTRA, USA, INC. 1997 A Multicenter, Double-Blind, 4-Arm, Parallel Study to Evaluate the Efficacy and Safety of Simvastatin GEM 80 and 160mg in Patients with Hypercholesterolemia. Protocol 128-00. Merck & Co., Inc. 1997. A Phase 3, Randomized, Double Blind, Dose Response, Positive Control Evaluation of the Efficacy and Safety of Toborinone in the Treatment of Patients with Heart Failure. Protocol 103-97-201. Otsuka America Pharmaceutical, Inc. 1997. A Double-Blind, Placebo-Controlled, Multinational Trial to Investigate the Effect of Na+/H+ Exchange Inhibitor HOE 642 (Cariporide) on All-Cause Mortality and Myocardial Infarction in Patients with Acute Coronary Syndrome Related to the Disease Process or to An Interventional Cardiac Procedure. Protocol #HOE642A/3001.GUARDIAN. Hoechst Marion Roussel. 1997 ASSENT Trial:. Efficacy and Safety of Tenecteplase in Combination with Enoxaparin, Abciximab or Unfractionated Heparin: the ASSENT-3 Randomised Trial in Acute Myocardial Infarction, Sanofi1997 A Randomized, Double-Blind, Placebo-Controlled, Study of Intravenous CI-1009 In Patients with Severe Head Injury. Protocol 1009-002. Parke Davis. 1997 A One Year, Open-Label, Multicenter Safety Study of Twice Daily Oral Carvedilol in NYHA Class I-IV Congestive Heart Failure. Protocol 252. SmithKline Beecham. 1997. A Single-Blind Multicenter, Randomized, Crossover Study to Evaluate the Efficacy of Sonovue Versus Albunex As a Contrast Enhancing Agent for Transthoracic Echocardiography at Rest. Protocol BR1-013. Bracco. 1997. A Phase II, Randomized, Open-Label, Parallel Group, Multicenter, International Trial of the Safety of TNK-tPA in Acute Myocardial Infarction (Assessment of the Safety of a New Thrombolytic: TNK-tPA) Protocol NO683g: Genentech, Inc. Protocol 1123.3: Boehringer Ingelheim, Ltd. 1997. A Randomized, Double-Blind, Placebo Controlled Trial of the Effect of Weekly Azithromycin on the Incidence of Coronary Artery Disease in Subjects with Evidence of Exposure to C. Pneumoniae. WIZARD. 1997. A Multicenter, Double-Blind, Randomized, Parallel, Captopril-Controlled Study to Evaluate the Effects of Losartan on in Patients with Symptomatic Heart Failure - U.S. (MK-954) Protocol No. 164-00. ELITE II. 1997. “A Multicenter, Open Label Study to Evaluate Efficacy of Cholestin at BID Dosing on Total Cholesterol in Patients with Elevated Cholesterol Levels” Pharmanex Protocol 97-002. 1997. A Multicenter, Double-Blind, Four-Arm, Parallel Study to Evaluate the Efficacy and Safety of Simvastatin GEM 80 mg and 160 mg in Patients with Hypercholesterolemia. PROTOCOL NO. 128. 1997 MERIT - HF: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure; A Double-Blind, Placebo-Controlled Survival Study with Metoprolol CR/XL in Patients with Decreased Ejection Fraction and Symptoms of Heart Failure. 1997. A Double-Blind, Placebo-Controlled, Parallel Design Study to Determine the Effect of 75 or 100mg of Orally Administered Azimilide Dihydrochloride versus Placebo on Survival in Recent Post-Myocardial Infarction Patients at Risk of Sudden Death. Protocol 1997017. ALIVE. 1997. A Multicenter Randomized Double-Blind, Placebo-Controlled Study to Determine the Effect of Carvedilol on Mortality in Patients with Severe Chronic Heart Failure (MF 4477/SB 287) COPERNICUS. 1997. A Randomized, Double-Blind Placebo-Controlled Dose-Ranging Study to Determine the Safety and Efficacy of AMP 579 in Patients with Acute Myocardial Infarction Treated with Primary Angioplasty (AMP579V-201). 1997. “A Double-Blind, Randomized, Parallel Group, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Intravenous AS-013 in Lipid Emulsion in Subjects With Severe Limb Ischemia (Fontaine Stage IV) Protocol ATC 97-03. 1997. Double-Blind, Randomized, Multicenter Trial of Single-Bolus Lanoteplase versus Accelerated Alteplase for the treatment of Subjects with Acute Myocardial Infarction (InTIME-II). 1997. MERIT - HF: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure; A Double-Blind, Placebo-Controlled Survival Study with Metoprolol CR/XL in Patients with Decreased Ejection Fraction and Symptoms of Heart Failure. 1997. PEACE: Prevention of Events with Angiotensin Converting Enzyme Inhibition. 1997. September 1,2014 P a g e | 17 RESEARCH GRANTS 136. 137. 138. 139. 140. 141. 142. 143. 144. 145. 146. 147. 148. 149. 150. 151. 152. 153. 154. 155. 156. 157. Karlsberg CV A Double-Blind, Placebo-controlled, Randomize Clinical Trial of Slow Release Propafenone (Rhythmol-SR) in the Prevention of Symptomatic Recurrences of Atrial Fibrillation - RAFT Protocol No. P-85-AF. 1998. An Open-label, Pilot Study to Determine the Effects of a Single Oral Dose of NE-11040 on Cardiac Function and Neurohumorals in Patients with Left Ventricular Dysfunction. Protocol 1997058. 1998. Safety and Efficacy of SONOVUE (Sulfur Hexafluoride Micro bubbles for Injection) For B-mode and Doppler Examination of the Extracranial Carotid Arteries; Protocol No. BR1-023 A/B. 1998. A Multi-Center Open-Label Follow-up Study to Assess the Long-Term Safety of 125mg of Oral Azimilide Dihydrochloride in Patients with an Implantable Cardioverter Defibrillator. Protocol 1997055. 1998. A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Effects of Ro 47-0203 (Bosentan) on the Morbidity and Mortality of Patients with Chronic Heart Failure. REACH 2. Protocol: NC15463. 1998. Multicenter, Randomized, Open-Label, Active-Controlled, Dose Titration, Efficacy, and Safety Study of OPC-41061 in Hospitalized Patients with Hyponatremia. Protocol 156-97-204. 1998. Clinical Protocol for a Phase III International Randomized, Double-Blind Placebo-Controlled Trial Evaluating the Efficacy and Safety of Orbofiban in Patients with Unstable Coronary Syndromes. The OPUS-TIMI 16 Trial; IND # 49380. 1998. Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy (TACTICS – TIMI 18). 1998. Multicenter, Randomized, Open-Label, Active-Controlled, Dose Titration, Efficacy, and Safety Study of OPC-41061 in Hospitalized Patients with Hyponatremia. Protocol 156-97-204. Otsuka America Pharmaceuticals. 1998. Clinical Protocol for a Phase III International Randomized, Double-Blind Placebo-Controlled Trial Evaluating the Efficacy and Safety of Orbofiban in Patients with Unstable Coronary Syndromes. The OPUS-TIMI 16 Trial; IND # 49380. Searle and the TIMI Center. 1998. A Randomized, Double-Blind, Placebo-Controlled, concentration Escalating, Crossover Study of BG9719 Alone and in Combination with Furosemide in Subjects with Moderate to Severe Congestive Heart Failure and Mild to Moderate Renal Insufficiency. Protocol C97-1205 Biogen. A Pilot Phase II Safety and Efficacy Evaluation of Integrilin (eptifibatide) in Patients Receiving Low Dose and Standard Dose Thrombolytic Therapy (Alteplase) for Acute Myocardial Infarction (AMI) Protocol: C96-395. Schering-Plough Research Institute, 1998. The Paragon B Trial: A randomized, double-blind, placebo-controlled study of Lamifiban (Ro 44-9883) in patients with unstable angina/non-Q wave myocardial infarction. Protocol: BC15686. Hoffman-LaRoche LTD and Duke Clinical Research Institute, 1998. A Double-Blind, Placebo Controlled, Safety, Efficacy, and Dose Response Trial of Two Intravenous Doses of BMS204352 in Patients with Acute Stroke. Bristol-Myers Squibb, 1998. A Phase II, Randomized, Double-Blind, Multicenter, Acetylsalicylic Acid-Controlled, Multi-Dose Study of DMP 754 Alone or in Combination with Aspirin in Patients with Coronary Artery Disease. Merck, 1998. The Effect of Sustained-Release Moxonidine on Mortality and Morbidity in Patients with Congestive Heart Failure” – Moxcon (LY326869). Eli Lilly, 1998. Protocol B7A-MC-MBBS: Protein Kinase C Inhibitor – Diabetic Peripheral Arterial Disease. Eli Lilly, 1998. Randomized, Double-Blind, Placebo-Controlled, Multi-center Trial to Evaluate the Efficacy and Safety of Adenosine (Pallacor, Adenosine Injection) as an Adjunct to Reperfusion Therapy (Thrombolysis or Mechanical Reperfusion) in the Treatment of Acute Anterolateral Myocardial Infarction (Amistad II). 1998. Atrial Dynamic Overdrive Pacing Trial – A (ADOPT-A); Prevention of Atrial Fibrillation in Patients with Sinus Node Dysfunction. St. Jude, 1998. The 2nd Symphony Trial. A Phase III, multi-center, international, randomized, double-blind, aspirin-controlled trial to evaluate the efficacy and safety of two regimens with XubixTM (sibrafiban; Ro48-3657), an oral platelet glycoprotein IIb/IIIa receptor antagonist, as therapy for the long term prevention of secondary vascular events in patients after an Acute Coronary Syndrome. Protocol No. BC15457. Hoffman LaRoche, 1998. A Phase II, Randomized, Open-Label, Crossover, Multicenter, Multidose, Study of the Safety, Pharmacokinetics, and Pharmacodynamics of DMP 754 (Roxifiban) In Combination with Aspirin In Patients With Coronary Artery Disease. Protocol No. DMP 754-017. Dupont, 1999. A Phase III Randomized, Double Blind, Parallel Group Clinical Trial Of Clopidogrel Versus Placebo In Patients With An Acute Coronary Syndrome (Unstable Angina Or Myocardial Infarction Without ST Segment Elevation. CURE: Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events (OASIS-4). Sanofi/Bristol-Myers Squibb, 1999. September 1,2014 P a g e | 18 RESEARCH GRANTS 158. 159. 160. 161. 162. 163. 164. 165. 166. 167. 168. 169. 170. 171. 172. 173. 174. 175. 176. 177. Karlsberg CV Multinational, Multi-Center, Double Blind, Randomized, Active Controlled, Parallel Group Study Comparing The Efficacy And Safety Of Long-Term Treatment With Valsartan, Captopril And Their Combination In High Risk Patients After Myocardial Infarction. VALIANT (VALsartan in Acute myocardial iNfarcTion). Novartis. 1999. Multicenter Double Blind, Randomized, Placebo Controlled, phase II/IIII Study of the Effect of Recombinant Human Tumor Necrosis Factor Receptor (p75) Fusion Protein (TNFR:Fc) (etanercept) on Clinical Improvement in Patients with Chronic Heart Failure. RENAISSANCE Protocol 16.0021. Immunex. 1999. A Twenty-Four Week, Randomized, Double-Blind Study of the Effects of Pletal® (cilostazol) versus Trental® (pentoxifylline) and Placebo Administered Orally to Patients with Intermittent Claudication Secondary to Peripheral Arterial Disease. Otsuka. 1999. A Double-Blind, Randomized, Placebo-Controlled, Multi-center Study to Assess the Safety and Efficacy of an Oral Calcimimetic Agent (AMG 073) in Secondary Hyperparathyroidism of End-Stage Renal Disease (ESRD). Amgen Protocol No. AMG 073 990101. 1999. A Phase II Randomized, Double-Blind, Placebo-Controlled Study of the Effect of h5G1.1-scFv on Total Mortality and Adverse Cardiovascular Ischemic Outcomes in Patients Undergoing Cardiopulmonary Bypass. C98-005. Alexion/Procter & Gamble. 1999. A Randomized Double-Blind, Placebo-Controlled Study of Two Intravenous Dosing Regimens of h5G1.1-scFv in Patients with Acute Myocardial Infarction Undergoing Thrombolytic Reperfusion Therapy. COMPLY. 1999052. Procter & Gamble. 1999. A Randomized Double-Blind, Placebo-Controlled Study of Two Intravenous Dosing Regimens of h5G1.1-scFv in Patients with Acute Myocardial Infarction Undergoing Percutaneous Transluminal Coronary Angioplasty Reperfusion Therapy. COMMA. 1999053. Procter & Gamble. 1999. Comparison of Medical Therapy, Pacing and Defibrillation in Chronic Heart Failure (COMPANION). Guidant. 1999. Clinical Protocol for a Double-Blind, Randomized, Placebo-Controlled Trial Evaluating the Safety and Efficacy of Eplerenone in Patients with Heart Failure Following Acute Myocardial Infarction. EPHESUS. IE3-99-02035. Searle. 2000. INTEGRILIN and Tenecteplase in Acute Myocardial Infarction (The INTEGRITI Study) Protocol #99-034. COR Pharmaceuticals. 2000. Efficacy, Dose-Ranging, and Safety For Rwj-241947 In Type 2 Diabetic Subjects Inadequately Controlled On Diet, Metformin, Or Sulfonylurea: A 24-Week Double-Blind Randomized Placebo-Controlled Study. RWJ241947-DIAB-002. Robert Wood Johnson Pharm. 2000. A Phase III Double-Blind Efficacy and Safety Study of SCH 58235 (10mg) in Addition to Simvastatin in Subjects with Primary Hypercholesterolemia Not Controlled by Starting Dose (20mg) Simvastatin. CP0700. Schering-Plough. 2000. An Open Study, with Blinded Endpoint Assessment, to assess the Safety, Tolerability and the Effect on Coronary Artery Patency of Intravenous AR-C69931MX as both Monotherapy and Adjunct to Activase in Patients with ST-elevation Myocardial Infarction. Protocol #244. AstraZeneca. 2000. Pravastatin or Atorvastatin Evaluation and Infection Therapy. PROVE IT – TIMI 22. Bristol-Myers Squibb. 2000. Randomized Evaluation in Percutaneous Coronary Intervention Linking Angiomax to reduced Clinical Events. TMC-BIV-00-01. REPLACE. 2001 A Phase II, Multi-Center, Double-Blinded, Placebo-Controlled, Dose-Finding Efficacy and Safety Study of the A1-Adenosine Receptor Agonist DTI-0009 Administered Intravenously to Patients with Atrial Fibrillation. DTI0009/003. DTI. 2000 A Phase III, Open-Label, Single-Crossover Study to Confirm the Diagnostic Potential of IntravenouslyAdministered TcN-NOET to Identify Coronary Artery Disease During Exercise and Resting Conditions by using Gated Myocardial SPECT Imaging. 300-MTcN-NOET.2001. A Multicenter, Randomized, Double-Blind, Placebo Controlled, Study to Evaluate the Efficacy and Safety of AD5.FGF-4 in Patients with Stable Angina. AGENT 3. 04386. 2001. Randomized Evaluation in Percutaneous Coronary Intervention Linking Angiomax to reduced Clinical Events; REPLACE II. TMC-BIV-02. REPLACE II. 2001. A Multi-Center, 12-Month, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of 75 mg and 125 mg Doses of Oral Azimilide Dihydrochloride in Patients with an Implantable September 1,2014 P a g e | 19 RESEARCH GRANTS 178. 179. 180. 181. 182. 183. 184. 185. 186. 187. 188. 189. 190. 191. 192. 193. 194. 195. 196. 197. 198. 199. Karlsberg CV Cardioverter Defibrillator for the Treatment of Ventricular Arrhythmia. 2000098. SHIELD. 2001 A phase III, randomized, double blind, multi-center, parallel group, placebo- controlled study of oral Enoximone vs placebo in advanced chronic heart failure subjects. ESSENTIAL – MY021. 2001. Randomized Evaluation of Intravenous Levosimendan Efficacy Versus Placebo in the Short Term Treatment of Decompensated Chronic Heart Failure. 3001069. REVIVE. 2001 A Phase III Randomized, Parallel, Double-Blind, Multi-Center, Placebo-Controlled Study of the Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery With Cardiopulmonary Bypass. 2000099. PRIMO. 2001 A Multicenter, Double-Blind, Randomized, Parallel Group, 28-week Study to Evaluate the Efficacy and Safety of Ezetimibe and Simvastatin Co-administration Versus Atorvastatin in Patients with Hypercholesterolemia”. 025-00. EZETIMIBE. 2002 A Phase IIa Prospective, Randomized, Double-blind, Placebo-controlled Dose-ranging, Multi-Centered, Tolerance and Efficacy Study of RSD1235 in Patients with Recent Onset Atrial Fibrillation. RSD1235. Cardiome. 2002 Evaluation of Radiofrequency (RF) Ablation for Atrial Fibrillation in the Right Atrium. Revelation. C97-103AF. Cardima. 2002. A Multi-Center, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study Of Efficacy and Safety Of Immune Modulation Therapy In Improving Walking Distance In Patients With Intermittent Claudication Secondary To Peripheral Arterial Disease. 0101. VASOGEN. 2002 A Multi-Center, Randomized Study to Determine The Pharmacokinetics and Pharmacodynamics of Levosimendan Metabolites in Congestive Heart Failure Patients. MO1-393. ABBOTT. 2002 A prospective, open-label, randomized, parallel-group investigation to evaluate the efficacy and safety of enoxaparin versus unfractionated heparin in subjects who present to the emergency department with acute coronary syndrome. XRP4563B/400. RESCUE. 2002 A Randomized, Double-blind, Placebo-controlled, Multi center Study of the Effects of ONO-2506 Intravenous Infusion on the Amelioration of Neurological Damage and Improvement of Stroke Assessment Scale Scores in Patients with Acute Ischemic Stroke. ONO2506/INT0104. RREACT. 2002 A Randomized, Multi-center Trial of Transcutaneous, Low-Energy Ultrasound Therapy with Thrombolysis for Patients with Acute Myocardial Infarction. T3S201. PLUS. 2002. A Phase I Multi-Center, Open-Label, Single-Dose Escalation Clinical Safety Trial of VLTS-589 for Treatment of Patients with Peripheral Arterial Disease VLTS-589-1001-01 2002 Distal Embolic Protection Device Trial SPIDER™ , 2002 A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Examine the Safety and Efficacy of Intravenous MCC-135 as an Adjunct to Standard Therapy with Primary PCI in Patients Diagnosed as Having an ST Elevation Acute Myocardial Infarction. EVOLVE. MCC-135-A02, 2003 A Phase 3, Open-Label, Multi-centre Study of Efficacy and Safety of Visipaque™ (Iodixanol) in Subjects with Suspected Peripheral Arterial Occlusive Disease Undergoing Intravenous Contrast-Enhanced Computed Tomographic Angiography. 2003 A Phase III, Randomized, Double-Blind, Double Placebo-Controlled, Multi-center, Three Parallel Group Study of Enoximone Plus Extended-Release Metoprolol Succinate in Advanced Chronic Heart Failure Subjects Previously Intolerant to Beta-Blocker Treatment EMPOWER, 2003 CVT 5131: A phase III, randomized, double blind, Study of Intravenous CVT 3146 vs. Adenoscan® in Patients Undergoing Stress Myocardial Perfusion Imaging , 2003 CVT5132: A Phase III, Randomized, Double-Blind Study of Intravenous CVT 3146 vs. Adenoscan® in Patients Undergoing Stress Myocardial Perfusion Imaging, 2003 1996. Follow-Up Serial Infusions Of Natrecor (nesiritide) for the Management of Patients with Heart Failure, 2003 (Fusion II) A Multi-center, Randomized, Double-Blind, Parallel-group, Placebo-Controlled Study of Pexelizumab in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention 2003056, (Apex-MI), 2004 Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Single Oral Tolvaptan Tablets on Hemodynamic Parameters in Subjects with Heart Failure”156-04-247 (Eclipse), 2004 Direct Inhibition of delta Protein Kinase C Enzyme to Limit Total Infarct Size in Acute Myocardial Infarction September 1,2014 P a g e | 20 RESEARCH GRANTS 200. 201. 202. 203. 204. 205. 206. 207. 208. 209. 210. 211. 212. 213. 214. 215. 216. Karlsberg CV Intracoronary KAI-9803 for Injection as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction KAI-9803-001, (DELTA MI) 2004. A 52 Week Multicenter, Randomized, Double-Blind Parallel Group Study to Evaluate the Evaluate the efficacy of Lotrel® and benazepril /hydrochlorothiazide in the Regression of Left Ventricular Hypertrophy by Magnetic Resonance Imaging in Patients with High Risk Hypertension (ALIVE CCIB002FUS16), 2004 A 12-week, Randomized, Open-Label, 3-Arm, Parallel Group, Multicenter, Phase IIIb Study Comparing the Efficacy and Safety of Rosuvastatin 20 mg and 40 mg with that of Atorvastatin 80 mg in Subjects with Acute Coronary Syndromes, (Lunar Study) 2004 A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects who are to Undergo Percutaneous Coronary Intervention/TIMI-38, 2004A Phase II Multi-Center, Double-Blind, PlaceboControlled, Trial of VLTS-589 in Subjects with Intermittent Claudication Secondary to a Peripheral Arterial Disease. VLTS 589-121. 2004. A Phase 2, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Study to Examine the Effects of AC2592 Administered by Continuous Subcutaneous Infusion in Subjects with Advanced Chronic Congestive Heart Failure. Protocol Number: PROCLAIM (Protocol 2592-101). 2005. Ultrafiltration Versus Diuretics for Patients Hospitalized for Acute Decompensated Congestive Heart Failure: A Prospective Randomized Clinical Trial. (Unload Trial), 2005 Prospective, Randomized, Controlled Assessment of Once-Daily Controlled Release COREG CR vs. Twice Daily COREG Immediate Release (IR) on Measures of Compliance and Quality of Life in Patients with Heart Failure and Left Ventricular Systolic Dysfunction. Protocol Number 2005-001. COMPLIANCE. 2005 Trial to Assess Chelation Therapy, TACT Study. 2005 A Phase 2, Randomized, Double Blind, Parallel Group, Placebo Controlled, Multicenter Study to Examine the Effects of AC2592 Administered by Continuous Subcutaneous Infusion in Subjects with Advanced Chronic Congestive Heart Failure. (Proclaim Trial), 2005. A Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety of SCH 530348 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention. (TRASCENDENCE-PCI), 2006 A Phase 3, Open-label, Multi-Center Study to Determine Efficacy and Safety of VISIPAQUE™ (iodixanol) Injection for Use in Intravenous Contrast-Enhanced CT Angiography of Coronary Arteries DXV 301, 2006. A multi-centre, randomized, double-blind, parallel group, phase IV study to compare the renal effects of the non-ionic iso-osmolar contrast medium, iodixanol 320 mg I/mL (VisipaqueTM), with the non-ionic low osmolar contrast medium, iopamidol 300 mg I/mL, in subjects with impaired renal function and diabetes mellitus undergoing multi-detector-row helical CT. Protocol DXV406, 2006. Phase 1/2a, Multicenter, Double-Blind, Vehicle-Controlled, Randomized, Escalating, Single and Repeat Dose Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of Intravenous Cardeva (BNP Analog-Recombinant Human Albumin Fusion Protein) in Subjects with New York Heart Association Class II or III Heart Failure Attributable to Ischemic Heart Disease. CARD-001 (Co-Genesys Study) 2006. Randomized, Multinational, Multicenter, Double-Blind, Placebo-Controlled, Two-Arm Parallel Group Trial Of Rimonabant 20-Mg OD For Reducing The Risk Of Major Cardiovascular Events In Abdominally Obese Patients With Clustering Risk Factors. Protocol EFC5826 (CRESCENDO) - 2006. A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Darbepoetin alfa Treatment on Mortality and Morbidity in Heart Failure (HF) Subjects with Symptomatic Left Ventricular Systolic Dysfunction and Anemia (Red-HF Trial), 2006 A Dual Arm Factorial Randomized Trial In Patients With ST Segment Elevation AMI To Compare The Results Of Using Anticoagulation With Either Unfractionated Heparin Plus Routine GP IIb/IIIa Inhibition With Bivalirudin Or Bail-Out GP IIb/IIIa Inhibition, And Primary Angioplasty With Stent Implantation With Either A Slow Rate-Release Paclitaxel-Eluting Stent (TAXUS™) Or An Otherwise Identical Uncoated Bare Metal Stent (Horizons Study), 2006. A Randomized, Double-Blind, Parallel Group, Phase 3, Efficacy And Safety Study Of AZD6140 Compared With Clopidogrel For Prevention Of Vascular Events In Patients With Non-ST Or ST Elevation Acute Coronary Syndromes (ACS) – PLATO, 2007 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Study To Evaluate The Efficacy And Safety Of Ad5FGF-4 In Female Patients With Stable Angina Pectoris Who Are Not Candidates For September 1,2014 P a g e | 21 RESEARCH GRANTS 217. 218. 219. 220. 221. 222. 223. 224. 225. 226. 227. 228. 229. 230. 231. 232. 233. 234. 235. Karlsberg CV Revascularization. AWARE Study, 2007 A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in preventing Stroke and Systemic Embolism in Subjects with Nonvalvular Atrial Fibrillation- Protocol CV185030. ARISTOTLE Study. 2007 Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure ASCEND-HF. 2007. An Open-label, Multi-center Study Evaluating the Validity, Reliability, and Responsiveness of a New Women’s Ischemia Symptom Questionnaire in Women with Chronic Angina Treated with Ranolazine Extended-release Tablets. Protocol CVT 3041. 2007. PICTURE: Perfusion Imaging and CT –Understanding Relative Efficacy; Contrast-Enhanced Cardiac Computed Tomography (CT) Using GE LightSpeed Volumetric Computed Tomography (VCT) Scanner for the Detection of Coronary Artery Disease: A Prospective Multi-Center Study Comparison with Cardiac Radionuclide Imaging. 2007. OM-8 - A Randomized, Double Blind, Placebo Controlled, Parallel-Group Trial To Assess The Efficacy And Safety Of Omacor® For The Prevention Of Recurrent, Symptomatic Atrial Fibrillation. 2007. Identifying Markers of Altered Gene Expression in Blood that Correlate with the Presence of Significant Coronary Artery Disease (CAD) by Coronary Imaging; PREDICT. 2007. A Phase II Multicenter Randomized Double-Blind Dose-Finding Study of Iopamidol Injection 370 in Multidetector Computed Tomographic Angiography (MDCTA) in Patients with Suspected Coronary Artery Stenosis. IOP-108. 2008. A Multicenter, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects With Acute Coronary Syndrome: Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA-CER #P04736). 2008. A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Tolerability of Oral BG9928 in Patients with Heart Failure and Renal Insufficiency. 161HF201. 2008. Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Effects of Intravenous BG9928 on Body Weight in Subjects with Acute Decompensated Heart Failure and Renal Insufficiency. 160HF301. 2008. A Phase III, Double-Blind, Randomized Placebo-Controlled Study, To Evaluate The Effects Of RO4607381 On Cardiovascular (CV) Risk In Stable CHD Patients, With A Documented Recent Acute Coronary Syndrome (ACS). NC20971. 2009. A Phase 3, Randomized, Double Blind, Evaluation of the Safety and Efficacy of Apixaban in Subjects with a Recent Acute Coronary Syndrome (Appraise 2); CV185068 (IND 71,881). 2009. Cheng V (Principle Investigator) , Karlsberg RK (supporting investigator):CT-Based Coronary Plaque Feature Detection for Predicting Myocardial Ischemia”. NIH funded Grant 2011. Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Sponsor: National Institutes of Health (NIH) and National Heart, Lung and Blood Institute (NHLBI) 11/10/2010. Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography (DeFacto)Sponsor: HeartFlow, Inc. 6/14/2011 The ASPECT 2 Trial; A Phase 3, Randomized, Double-Blind Trial of Apadenoson for the Detection of Myocardial Perfusion Defects using Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)Sponsor: Forest Research Institute 10/27/2011 HPS3/TIMI 55: REVEAL (Randomized Evaluation of the Effects of Anacetrapib thorough Lipid-modification): A large-scale randomized placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease. 9/14/2011 Proteomics of Atherosclerosis. Applied Proteonomics, Inc. (API) 10/1/2012 Cardiovascular and Metabolic Effects of Lorcaserin In Overweight And Obese Patients TIMI 61 - 2014 September 1,2014 P a g e | 22 PEER REVIEWED PUBLICATIONS (Excludes non-authored multicenter trials 500+) 1. Markham J, Karlsberg RP, Roberts R, Sobel, BE: Mathematical characterization of kinetics of native and purified creatine kinase in plasma. Computers in Cardiology, Long Beach, California, IEEE Computer Society, pp 3-7, 1976. 2. Karlsberg RP, Lacher JW, Bartecchi CE: Adult hemolytic-uremic syndrome: familial variant. Arch Intern Arch Intern Med. 1977 Sep; 137(9):1155-7 PMID: 901083. 3. Karlsberg RP, Henry PD, Ahmed SA, Sobel EB, Roberts R: Lack of protection of ischemic myocardium by verapamil in conscious dogs. Eur J. Pharmocol 1977 Apr 21;42(4):339-46 PMID: 856611. 4. Sobel BE, Markham J, Karlsberg RP, Roberts R: The nature of disappearance of creatine kinase from the circulation and its influence on enzymatic estimation of infarct size. Circ Res. 1977 Dec;41(6):836-44 PMID: 923034. 5. Karlsberg RP, Roberts R: Effect of altered thyroid function on plasma creatinine kinase clearance in the dog. Am. J. Physiol 1978 Dec;235(6):E614-8 PMID: 736119 6. Karlsberg RP, Sagel S, Ferguson TB: Myocardial infarction due to tumor embolization. Chest 1978 Nov;74(5):582-4 PMID: 738102 7. Ahumada GC, Karlsberg RP, Jaffe AS, Ambos HD, Sobel BE, Roberts R: Reduction of early ventricular dysrhythmia by acebutolol in patients with acute myocardial infarction. BR Heart J. Jun;41(6):654-9 PMID: 465240. 8. Karlsberg RP, Penkoske PA, Cryer PE, Corr PB, Roberts R: Rapid activation of the sympathetic nervous system following coronary artery occlusion; relationships to infarct size, site and hemodynamic impact. Cardiovasc Res 1979 Sep;13(9):523-31 PMID: 509429. 9. Aronow WS, Landa D, Plasencia G, Wong R, Karlsberg RP, Ferlinz J: Verapamil in atrial fibrillation and atrial flutter. J Clin Pharmocol Therap 1979 Nov; 26(5):578-83 PMID: 498700. 10. Karlsberg RP, Eisenstein I, Aronow WS, Edelstein J, Chandraratna PAN: Noninvasive visualization of right coronary artery aneurysms. Cardiology 1980; 66(1):18-26 PMID: 7388851. 11. Aronow WS, Plasencia G, Wong R, Landa D, Karlsberg RP, Ferlinz J: Effect of Verapamil versus placebo on PAT and MAT. Cur Therap Res 27: 823-229, 1980. 12. Karlsberg RP, Aronow WS: Reduction of myocardial infarct size; approach for the 80's. Arch Intern Med 13. 1980 May; 140(5):616-9 PMID: 6104948. 14. Karlsberg RP, Cryer PE, Roberts R: Serial plasma catecholamine determinations in patients early in the course of acute myocardial infarction. Am Heart J 1981 Jul; 102(1):24-9 PMID: 7246410. 15. Karlsberg RP, Milne N, Lyon KP, Aronow WS: Imaging of experimental myocardial infarction with technetium-99m 2, 3-dimercaptosuccinic acid. J Nucl Med 1981 Mar; 22(3):253-7 PMID: 6259303. 16. Karlsberg RP, Friscia DA, Aronow WS, Sekhon SS: Deleterious influence of hypothyroidism on evolving myocardial infarction in conscious dogs. J Clin Invest. 1981 Apr;67(4):1024-34 PMID: 7204564. 17. Karlsberg RP: Welcome, the calcium channel blockers. Chest 1981 Dec;80(6):657-9 PMID: 6118239. 18. Karlsberg RP, Gelezunas VL, Lyons KP: Highly localized in vivo measurements of myocardial perfusion with Avalanche detectors. Circulation 1982 Jan; 65(1):54-61 PMID: 7030517. 19. Karlsberg RP: Calcium channel blockers for cardiovascular disorders. Arch Intern Med; 142(3):452-5 PMID: 6279045. 20. Karlsberg RP, Aronow WS: Calcium channel blockers; indications and limitations. Clinical Pharmacology and use as an antiarrhythmic agents. Postgrad Med 72: 97-110, 1982. 21. Karlsberg RP, Aronow WS: Calcium channel blockers; use in angina and other cardiac conditions. Postgrad Med 72: 115-123, 1982. 22. Karlsberg RP, Aronow WS: Reducing myocardial infarction size. Part I. Assessment of damage. Family Practice Recertification 4 (Vol 8): 47-60, 1982. 23. Karlsberg RP, Aronow WS: Reducing myocardial infarction size. Part 2. Interventions for limiting the damage. Family Practice Recertification 4 (Vol 8): 47-60, 1982. 24. Tommassini G, Karlsberg RP, Tamagni F, Berra R, Oddone A, Orlandi M, Raimondi W, Malusardi R: Distribution volume and disappearance rate of native creatine kinase in man. Am Heart J 1983 Mar;105(3):402-7 PMID 682940. 25. Gelezunas VL, Lyons KP, Karlsberg RP: Silicon Avalanche radiation detectors; the basis for a new in vivo radiation detection probe. Eur J Nuclear Med 1983;8(10):421-4 PMID: 6653598 26. Karlsberg RP, Eugene J, Lyons KP, Shell WE, Gelezunas VL: Regional myocardial perfusion measured by the avalanche radiation probe during cardiopulmonary bypass: Pharmacologic and physiologic alterations. Amer Heart J 1984 Feb;107(2):367-74 PMID: 6695669. 27. Karlsberg RP: Cardiovascular drugs and the management of heart disease. JAMA 250: 859, 1983. 28. Karlsberg RP: Cardiology: Physiopathology of the cardiovascular system. JAMA 253: 859, 1985. Karlsberg CV September 1,2014 P a g e | 23 PEER REVIEWED PUBLICATIONS (Excludes non-authored multicenter trials 500+) 29. Lyons KP, Milne N, Olson HG, Karlsberg RP, Kuperus J: Myocardial infarction imaging in humans with technetium-99m, 2,3-dimercaptosuccinic acid; superiority of technetium-99m pyrophosphate. Clin Nucl Med. 1987 Jul;12(7):514-8 PMID: 3038447. 30. Turi ZG, Goldberg S, LittleJohn JK, Vander Ark C, Shadoff N, Karlsberg R, Williams J, Butman S, Alderman E, Wise K, Buchbinder M, Genton E, Laskey W, Demaria A, White C, Sheehan F, Comp PC, Batson-Fowler G, Edwards S, for the Wellcome Tissue Plasminogen Activator Study Group. Dose related efficacy and bleeding complications of double chain tissue plasminogen activator in acute myocardial infarction, The Wellcome Tissue Plasminogen Activator Study Group. Am J Cardiol. 1993 May 1;71(12):1009-14 PMID: 8475860. 31. Karlsberg, RP, DeWood MA. DeMaria AN, Berk MR, Lasher KP. Comparative efficacy of short-term intravenous infusion of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction. Milrinone-Dubutamine Study Group. Clin Cardiol. 19(1):21-30 1996 Jan. PMID: 8903534. 32. Goldstein S, Kennedy H, Hall C, Anderson J, Gheorghiade M, Bottlieb S, Jessup M, Karlsberg R, Friday G, Haskell L. Metoprolol CR.XL in patients with heart failure: A pilot study examining the tolerability, safety, and effect on left ventricular ejection fraction. American Heart Journal. Volume 138, Number 6, Part 1. 1999: 1158-65 PMID: 10577448. 33. Nanda NC, Wistran DC, Karlsberg RP, Hack TC, Smith WB, Foley DA, Picard MH, Cotter B. Multicenter evaluation of Sono Vue for improved endocardial border delineation. Echocardiography. 2002 Jan;19(1):27-36 PMID: 11884252. 34. Cruz D., Karlsberg RP, Takano Y, Vora D, Tobis J.Subacute Subacute stent thrombosis associated with a heparincoated stent and heparin induced thrombocytopenia. Catheter Cardiovascular Interv. 58(1):80-3; 2003. PMID: 12508203 PMID: 11884252. 35. Durand JB, Bachinski LL, Bieling LC, Czernuszewicz GZ, Abchee AB, Yu QT, Tapscott T, Hill R, Ifegwu J, Marian AJ, Brugada R, Daiger S, Gregoritch HM, Anderson JL, Quinones M, Towbin JA, Roberts, R.. Localization of a gene responsible for familial dilated cardiomyopathy to chromosome 1q32. Circulation. 1995 Dec 15;92(12):3387-9. (Acknowledgment only) 36. Grossman PM, Mendelsohn F, Henry TD, Hermiller JB, Litt M, Saucedo JF, Weiss RJ, Kandzari DE, Kleiman N, Anderson RD, Gottlieb D, Karlsberg R, Snell J, Rocha-Singh K. Results from a phase II multicenter, double-blind placebo-controlled study of Del-1 (VLTS-589) for intermittent claudication in subjects with peripheral arterial disease. Am Heart J. 2007 May; 153(5):874-80. PMID: 17452167. 37. Gopal A, Pal R, MD, Karlsberg RP, Budoff MJ. Left Ventricular Pseudoaneurysm by Cardiac CT Angiography. The Journal of Invasive Cardiology. July 2008; Vol. 20, No. 7:370–371. PMID: 18599899 38. Levisman J, Karlsberg RP. Congenital Atresia of the Left Main Coronary Artery: Catheter Cardiovasc Interv. 2009 Sep 1; 74(3):465-7 PMID: 19472349. 39. Raff GL, Abidov A, Achenbach S, Berman DS, Boxt LM, Budoff MJ, Cheng V, DeFrance T, Hellinger JC, Karlsberg RP; Society of Cardiovascular Computed Tomography. SCCT Guidelines for the Interpretation and Reporting of Coronary Computed Tomographic Angiography. J Cardiovasc Comput Tomogr 2009 Mar-Apr; 3(2):122-36. Epub 2009 Jan 29 PMID: 19272853 40. Gopal A, Mao SS, Karlsberg D, Young E, Waggoner J, Ahmadi N, Pal RS, Leal J, Karlsberg RP, Budoff MJ. Radiation reduction with prospective ECG-triggering acquisition using 64-multidetector Computed Tomographic Angiography. International Journal of Cardiovascular Imaging. 2009 April; 25(4):405-16. Epub 2008 Dec 3 PMID: 19051055. 41. Karlsberg RP, Budoff MJ, Berman DS, Thomson LE, Friedman JD. 64-slice multidetector computed tomography (MDCT) reduces other diagnostic studies for coronary artery disease. Am J Med. 2009 Nov;122(11):e13 PMID: 19854311. 42. Ro TK, Cotter BR, Simsir SA, Karlsberg RP. Complicated ruptured sinus of Valsalva: cardiac computed tomographic angiography (64 slice) predicts surgical appearance and obviates need for invasive cardiac catheterization. Interact Cardiovasc Thoracic Surg. 2009 Nov; 9(5):888-90. Epub 2009 Aug 31 PMID: 19720659.Levisman J, Shemin RJ, Robertson JM, Pelikan P, Karlsberg RP. Migrated sternal wire into the right ventricle: case report in cardiothoracic surgery. J Card Surg. 2010 Mar; 25(2):161-2. Epub 2009 Nov 30 PMID: 20002234. 43. Karlsberg RP, Budoff MJ, Thomson LE, Friedman JD, Berman DS. Integrated coronary computed tomographic angiography in an office-based cardiology practice. Rev Cardiovasc Med. 2009 Fall;10(4):194-201 PMID: 20065929. Karlsberg CV September 1,2014 P a g e | 24 PEER REVIEWED PUBLICATIONS (Excludes non-authored multicenter trials 500+) 44. Woo J, Slomka PJ, Dey D, Cheng VY, Hong BW, Ramesh A, Berman DS, Karlsberg RP, Kuo CC, Germano G. Geometric feature-based multimodal image registration of contrast-enhanced cardiac CT with gated myocardial perfusion SPECT. Med Phys. 2009 Dec; 36(12):5467-79 PMID: 20095259.Abdelkarim MJ, Ahmadi N, Gopal A, Hamirani Y, Karlsberg RP, Budoff MJ. Noninvasive quantitative evaluation of coronary artery stent patency using 64-row multidetector computed tomography. J Cardiovasc Comput Tomogr. 2010 Jan-Feb;4(1):29-37. Epub 2009 Nov 27 PMID: 20159625.Karlsberg RP, Budoff MJ, Thomson LE, Friedman JD, Berman DS. Reduction in downstream test utilization following introduction of coronary computed tomography in a cardiology practice. Int J Cardiovasc Imaging. 2010 Mar; 26(3):359-66. Epub 2009 Dec 5 PMID: 19967562. 45. Slomka PJ, Cheng VY, Dey D, Woo J, Ramesh A, Van Kriekinge S, Suzuki Y, Elad Y, Karlsberg R, Berman DS, Germano G Quantitative analysis of myocardial perfusion SPECT anatomically guided by coregistered 64-slice coronary CT angiography. J Nucl Med. 2009 Oct; 50(10):1621-30. Epub 2009 Sep 16. PMID: 19759104 46. Cheng VY, Nakazato R, Dey D, Gurudevan S, Tabak J, Budoff MJ, Karlsberg RP, Min J, Berman DS. Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study. J Cardiovasc Comput Tomogr. 2009 Sep-Oct; 3(5):312-20. Epub 2009 Jul 30 PMID: 19709947. 47. Hamirani YS, Larijani V, Isma'eel H, Pagali SR, Bach P, Karlsberg RP, Budoff MJ. Association of plaque in the carotid and coronary arteries, using MDCT angiography. Atherosclerosis. 2010 Jul;211(1):141-5. Epub 2010 Jan 25 PMID: 20153473.Karlsberg RP, Dohad SY, Sheng R; Iodixanol Peripheral CTA Study Investigator Panel. Contrast-induced acute kidney injury following intra-arterial administration of iodinated contrast media. J Nephrol. 2010 Nov-Dec; 23(6):658-66PMID: 20540038. 48. deGoma EM, Goldberg NJ, Karlsberg RP Guidewire embolization and right ventricular perforation visualized by cardiac CT.J Cardiovasc Comput Tomogr. 2011 Jan-Feb; 5(1):61-2. Epub 2010 Sep 25.PMID: 21051313. 49. Hamirani YS, Isma'eel H, Larijani V, Drury P, Lim W, Bevinal M, Saeed A, Ahmadi N, Karlsberg RP, Budoff MJ. The diagnostic accuracy of 64-detector cardiac computed tomography compared with stress nuclear imaging in patients undergoing invasive cardiac catheterization. J Comput Assist Tomogr. 2010 Sep-Oct;34(5):645-51 PMID: 20861764. 50. deGoma EM, Karlsberg RP, Judelson DR, Budoff MJ The underappreciated impact of heart disease. Womens Health Issues. 2010 Sep;20(5):299-303 PMID: 20800764. 51. Nabavi V, Ahmadi N, Bhatia HS, Flores F, Ebrahimi R, Karlsberg RP, Budoff MJ.Increased carotid wall thickness measured by computed tomography is associated with the presence and severity of coronary artery calcium. Atherosclerosis. 2011 Mar;215(1):103-9. Epub 2010 Dec 7 PMID: 21196006. 52. Min JK, Dunning A, Lin FY, Achenbach S, Al-Mallah MH, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng V, Chinnaiyan KM, Chow B, Delago A, Hadamitzky M, Hausleiter J, Karlsberg RP, Kaufmann P, Maffei E, Nasir K, Pencina MJ, Raff GL, Shaw LJ, Villines TC. Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) Registry. J Cardiovasc Comput Tomogr. 2011 Mar-Apr;5(2):84-92. Epub 2011 Feb PMID: 21477786. 53. deGoma EM, Wright CD, Pelikan PC, Leal JE, Karlsberg RP Surgically corrected right-sided aortic arch. J Am Coll Cardiol. 2011 Jun 7;57(23):2375 PMID: 21636040. 54. Weintraub WS, Karlsberg RP, Tcheng JE, Boris JR, Buxton AE, Dove JT, Fonarow GC, Goldberg LR, Heidenreich P, Hendel RC, Jacobs AK, Lewis W, Mirro MJ, Shahian DM. ACCF/AHA 2011 key data elements and definitions of a base cardiovascular vocabulary for electronic health records: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards. J Am Coll Cardiol. 2011 Jul 5;58(2):202-22. Epub 2011 Jun 7 PMID: 21652161 55. Weintraub WS, Karlsberg RP, Tcheng JE, Boris JR, Buxton AE, Dove JT, Fonarow GC, Goldberg LR, Heidenreich P, Hendel RC, Jacobs AK, Lewis W, Mirro MJ, Shahian DM, Hendel RC, Bozkurt B, Jacobs JP, Peterson PN, Roger VL, Smith EE, Tcheng JE, Wang T; American College of Cardiology Foundation; American Heart Association Task Force on Clinical Data Standards. ACCF/AHA 2011 key data elements and definitions of a base cardiovascular vocabulary for electronic health records: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards. Circulation. 2011 Jul 5;124(1):103-23. Epub 2011 Jun 6. Erratum in: Circulation. 2011 Jul 5;124(1):e174 PMID: 21646493. Karlsberg CV September 1,2014 P a g e | 25 PEER REVIEWED PUBLICATIONS (Excludes non-authored multicenter trials 500+) 56. Levisman JM, Budoff MJ, Karlsberg RP. Long-term coronary artery graft patency as evaluated by 64-slice coronary computed tomography . Coron Artery Dis. 2011 Dec;22(8):521-5 PMID: 21915050. 57. Cheng VY, Berman DS, Rozanski A, Dunning AM, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJ, Delago A, Gomez M, Hadamitzky M, Hausleiter J, Karlsberg RP, Kaufmann P, Lin FY, Maffei E, Raff G, Villines TC, Shaw LJ, Min JK. Performance of the Traditional Age, Sex, and Angina Typicality-Based Approach for Estimating Pretest Probability of Angiographically Significant Coronary Artery Disease in Patients Undergoing Coronary Computed Tomographic Angiography: Results From t h e M u l t i n a t i o n a l C o ro n a r y C T Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry (CONFIRM). Circulation. 2011 Nov 29;124(22):2423-32, 1-8. Epub 2011 Oct 24 PMID: 22025600. 58. LaBounty TM, Rana J, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng V, Chinnaiyan KM, Chow BJ, Delago A, Dunning AM, Gomez M, Hadamitzky M, Hausleiter J, Karlsberg RP, Kaufmann PA, Leipsic J, Lin FY, Maffei E, Raff G, Shaw LJ, Villines TC, Berman DS, Min JK. Improvement in Discrimination and Risk Reclassification in Asymptomatic Individuals with Diabetes by Coronary Computed Tomographic Angiography. Circulation. 2011;124:A15200 59. Chow BJ, Small GR, Achenbach S, Al-Mallah M, Berman D, Budoff MJ, Cademartiri F, Callister T, Chang HJ, Cheng VY, Chinnaiyan K, Delago A, Dunning AM, Gomez MJ, Hadamitzky M, Hausleiter J, Karlsberg RP, Kaufmann PA, LaBounty TM, Lin FY, Maffei E, Nasir K, Pencina MJ, Raff GL, Shaw LJ, Villines TC, Min JK. Potential Benefit of Statin Therapy in Patients with Non-Obstructive Coronary Artery Disease. Circulation. 2011;124:A13739 60. Karlsberg RP, Dohad SY, Sheng R; Iodixanol Peripheral Computed Tomographic Angiography Study Investigator Panel. Contrast medium induced acute kidney injury: comparison of intravenous and intraarterial administration of iodinated contrast medium. J Vasc Interv Radiol. 2011 Aug;22(8):1159-65 PMID: 21570871 61. Karlsberg DW, Elad Y, Kass RM, Karlsberg RP.Quadricuspid aortic valve defined by echocardiography and cardiac computed tomography. Clin Med Insights Cardiol. 2012;6:41-4. Epub 2012 Feb 6. PMID: 22442640 62. Madaj PM, Budoff MJ, Li D, Tayek JA, Karlsberg RP, Karpman HL. Identification of noncalcified plaque in young persons with diabetes: an opportunity for early primary prevention of coronary artery disease identified with low-dose coronary computed tomographic angiography. Acad Radiol. 2012 Jul;19(7):889-93. doi: 10.1016/j.acra.2012.03.013. Epub 2012 Apr 26 PMID:22542200. 63. Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012 Jun;11(6):503-11.. Epub 2012 May 8. Erratum in: Lancet Neurol. 2012 Dec;11(12):1021. 64. Rana JS, Dunning A, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng VY, Chinnaiyan K, Chow BJ, Cury R, Delago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann P, Karlsberg RP, Kim YJ, Leipsic J, Labounty TM, Lin FY, Maffei E, Raff G, Villines TC, Shaw LJ, Berman DS, Min JK Differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry.Diabetes Care. 2012 Aug;35(8):1787-94. Epub 2012 Jun 14 PMID: 22699296 65. Min JK, Berman DS, Dunning A, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng V, Chinnaiyan K, Chow BJ, Cury R, Delago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann P, Karlsberg RP, Kim YJ, Leipsic J, Lin FY, Maffei E, Plank F, Raff G, Villines T, Labounty TM, Shaw LJ.All-cause mortality benefit of coronary revascularization vs. medical therapy in patients without known coronary artery disease undergoing coronary computed tomographic angiography: results from CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry).Eur Heart J. 2012 Oct 9. [Epub ahead of print]PMID: 23048194 66. Jug B, Gupta M, Papazian J, Li D, Tsang J, Bhatia H, Karlsberg R, Budoff M. Diagnostic performance of 64-slice multidetector coronary computed tomographic angiography in women. J Nucl Cardiol. 2012 Oct 12. [Epub ahead of print] PMID: 23065417 Karlsberg CV September 1,2014 P a g e | 26 PEER REVIEWED PUBLICATIONS (Excludes non-authored multicenter trials 500+) 67. Shaw LJ, Hausleiter J, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Kim YJ, Cheng VY, Chow BJ, Cury RC, Delago AJ, Dunning AL, Feuchtner GM, Hadamitzky M, Karlsberg RP, Kaufmann PA, Leipsic J, Lin FY, Chinnaiyan KM, Maffei E, Raff GL, Villines TC, Labounty T, Gomez MJ, Min JKCoronary Computed Tomographic Angiography as a Gatekeeper to Invasive Diagnostic and Surgical Procedures: Results From the Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) Registry. J Am Coll Cardiol. 2012 Nov13; 60(20):2103-14.doi:10.1016/ j.jacc. 2012. 05.062. Epub 2012 Oct 17. PMID:23083780 68. Hulten E, Villines TC, Cheezum MK, Berman DS, Dunning A, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Cheng VY, Chinnaiyan K, Chow BJ, Cury RC, Delago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Karlsberg RP, Kim YJ, Leipsic J, Lin FY, Maffei E, Plank F, Raff GL, Labounty TM, Shaw LJ, Min JK; CONFIRM Investigators. Usefulness of Coronary Computed Tomography Angiography to Predict Mortality and Myocardial Infarction Among Caucasian, African and East Asian Ethnicities (from the CONFIRM [Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter] Registry). Am J Cardiol. 2012 Dec 1. doi:pii: S0002-9149(12)02313-2. 10.1016 PMID:23211358 69. Jug B, Gupta M, Papazian J, Li D, Bhatia H, Karlsberg R, Budoff M.Influence of race and ethnicity on diagnostic performance of 64-slice multidetector coronary computed tomographic angiography. Int J Cardiol. 2012 Dec 3. Epub ahead of print PMID: 23363985. 70. Jug B, Papazian J, Gupta M, Bhatia H, Derakhshani A, Koplik S, Karlsberg RP, Budoff MJ. Diagnostic performance of computed tomographic coronary angiography in patients with end‐stage renal disease. Coron Artery Dis. 2013 Mar;24(2):135-41. 71. Jug B, Kadakia J, Gupta M, Papazian J, Derakhshani A, Koplik S, Karlsberg RP, Budoff MJ. Coronary calcifications and plaque characteristics in patients with end-stage renal disease: a computed tomographic study. Coron Artery Dis. 2013 Sep;24(6):501-8. 72. Budoff MJ, Shittu A, Hacioglu Y, Gang E, Li D, Bhatia H, Alvergue J, Karlsberg RP. Comparison of transesophageal echocardiography versus computed tomography for detection of left atrial appendage filling defect (thrombus). Am J Cardiol. 2014 Jan 1;113(1):173-7. 73. Zeb I, Li D, Nasir K, Malpeso J, Batool A, Flores F, Dailing C, Karlsberg RP, Budoff M. Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. Atherosclerosis. 2013 Dec;231(2):198-204 74. Shah S, Bellam N, Leipsic J, Berman DS, Quyyumi A, Hausleiter J, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chow BJ, Cury RC, Delago AJ, Dunning AL, Feuchtner GM, Hadamitzky M, Karlsberg RP, Kaufmann PA, Lin FY, Chinnaiyan KM, Maffei E, Raff GL, Villines TC, Gomez MJ, Min JK, Shaw LJ; CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators. Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease. J Nucl Cardiol. 2014 Jun;21(3):453-66. 75. Chow B, Small G, Yeung Y, McPherson R, Achenbach S, Al-Mallah M, Berman D, Budoff M, Cademartiri F, Callister T, Hyuk-Jae C, Cheng V, Chinnaiyan K, Delago A, Dunning A, Feuchtner G, Hadamitzky M, Hausleiter J, Karlsberg R, Kaufman PA, Yong-Jin K, Leipsic J, LaBountt T, Lin F, Maffei E, Raff G, Shaw L, Villines T, Min J. Prognostic and Therapeutic Implications of Statn and Asperin Therapy in Individuals with Non-Obstructive Coronary Artery Disease –Arteriosclerosis, Thrombosis and Vascular Biology in press. Karlsberg CV September 1,2014 P a g e | 27 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. Karlsberg CV Roberts R, Karlsberg RP, Sobel BE: Does variance in CPK disappearance rate impair enzymatic estimation of infarct size? Am J Cardiol 37: 155, 1976. Karlsberg RP, Sobel BE, Roberts R: A standard model for assessment of early intervention designed to protect ischemic myocardium. The Physiologist 19: 249, 1976. Markham J, Karlsberg RP, Roberts R, Sobel BE: Mathematical characterization of kinetic of native and purified creatine kinase in plasma. Computers in Cardiology, St. Louis, October, 1976. Karlsberg R, Sobel BE, Roberts R: Appraisal of a calcium antagonist (verapamil) on infarct size and coronary flow. Clin Res 24: 519A, 1976. Roberts R, Karlsberg RP, Sobel BE: Factors retarding the decline of plasma CD activity after myocardial infarction. Am J Cardiol 39: 317, 1977. Karlsberg RP, Siegel BA, Roberts R: Effect of altered thyroid function on the disappearance of creatine kinase. Clin Res, April, 1977. Karlsberg RP, Penkoske PA, Cryer PE, Roberts R, Corr PB: Extent of myocardial infarction: relationship to early catecholamine release. The Physiologist 20: 50, 1977. Ahumada GG, Karlsberg RP, Jaffe AS, Ambos HD, Sobel BE, Roberts R: Salutary effects of a cardioselective Bblocker (acebutolol) in patients with myocardial infarction. Circulation 56(Suppl II): 111-147, 1977. Penkoske PA, Karlsberg RP, Roberts R: Salutary effects of anesthesia on myocardial infarction Clin Res 26: 10A, 1978. Karlsberg RP, Milne N, Lyons KP, Aronow WS: 99Tc-DMSA localization of acute myocardial infarction. Clin Res 27: 178A, 1979. Karlsberg RP, Cryer PE, Roberts R: Early adrenergic response to myocardial damage and late mortality. Clin Res 27: 178A, 1979. Aronow WS, Landa D, Plasencia G, Wong R, Karlsberg RP, Ferlinz J: Effect of intravenous verapamil and saline in atrial fibrillation and atrial flutter. Chest 76: 344, 1979. Karlsberg RP. Intraocular lens dislocation resulting from administration of Tedral. J Am Intraocul Implant Soc. Circulation 5(1):48; 1979. Karlsberg RP, Friscia DA, Eisenstein I, Aronow WS: Deleterious influence of hypometabolism on ischemic dysrhythmias in conscious dogs. Clin Res 28: 8A, 1980. Karlsberg RP, Friscia DA, Aronow WS: Myocardial infarct extension in hypothyroid conscious dogs. Clin Res 28: 8A, 1980. Karlsberg RP, Aronow WS: Deleterious influence of hypometabolism on evolving myocardial infarction in conscious dogs. Am J Cardiol 45: 484, 1980. Karlsberg RP, Lyons KP, Gelezunas VL, Kuperus JH, Friscia DA, Aronow WC: Precise localization of regional myocardial blood flow using a new radiation detector. Clin Res 28: 185A, 1980.Aronow WS, Plasencia G, Wong R, Landa D, Karlsberg RP, Ferlinz J: Effect of verapamil versus saline on paroxysmal atrial tachycardia and multifocal atrial tachycardia. Clin Pharmocol Therap 27: 245, 1980. Gelezunas VL, Lyons KP, Kuperus JH, Karlsberg RP: The application of a new solid state avalanche probe for the detection of low penetrating radiation. J Nucl Med 21: P101, 1980. Karlsberg RP, Gelezunas VL, Lyons KP: Miniature radiation detector for measuring regional myocardial blood flow. The Physiologist 23: 33, 1980. Karlsberg RP, Gelezunas VL, Lyons KP, Kuperus JH, Aronow WS: A new miniature radiation detector for measuring regional blood flow. Circulation 62 (Suppl III): III-292, 1980. Lyons KP, Karlsberg RP, Gelezunas VL, Kuperus JH, Friscia DA: A new solid state silicon avalanche probe for highly regionalized measurements of myocardial blood flow. Clin Nucl Med 5: 566, 1980. Karlsberg RP, Milne N, Lyons KP, Kuperus JH, Olson HG: Technetium 99m dimercaptosuccinic acid scintigraphy for detection of acute myocardial infarction in man. Clin Res 29: 213A, 1981. Karlsberg RP, Koenker RM, Gelezunas VL, Lyons KP: Validation of the avalanche radiation probe for the measurement of rapidly changing regional myocardial perfusion. Federation Proceedings 40: 751, 1981. Karlsberg RP, Eugeue J, Miller RI, Azaren KH: Regional myocardial perfusion measured with the avalanche probe during cardiopulmonary bypass. Clin Res 29: 213A, 1981. Karlsberg RP, Gelezunas VL, Konchigeri HN, Lyons KP: The avalanche radiation probe monitoring of regional myocardial blood flow auto-regulation in small volumes in-vivo. J Nucl Med. 22: P30, 1981. September 1,2014 P a g e | 28 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. Karlsberg CV Karlsberg RP. Welcome—the calcium channel blockers. Chest. 80(6):657-9; 1981. Karlsberg RP, Cryer PE, Roberts R. Serial plasma catecholamine response early in the course of clinical myocardial infarction: relationship to infarct extent and mortality. American Heart Association Journal. 102(1):24-9; 1981. Karlsberg RP, Friscia DA, Aronow WS, Sekhon SS. Deleterious influence of hypothyroidism on evolving myocardial infarction in conscious dogs. J Clin Invest. 67(4):1024-34; 1981. Karlsberg RP, Aronow WS. Calcium Channel blockers: indications and limitations 1. Clinical pharmacology and use as antiarrhythmic agents. Postgrad Med. 1982 Nov;72(5):97-9, 102-4, 107-8 passim. PMID: 7134082 Karlsberg RP, Aronow WS. Calcium Channel blockers: indications and limitations 2. Use in angina and other cardiac disorders. Postgrad Med. 1982 Nov;72(5):115-7, 120, 123.PMID: 6215636 Karlsberg RP. Calcium channel blockers for cardiovascular disorders. Arch Intern Med. 1982 Mar;142(3):452-5. PMID: 6279045 Karlsberg RP, Gelezunas VL, Lyons KP. Highly localized in vivo measurement of myocardial perfusion with avalanche radiation detectors. Circulation. 65(1):54-61; 1982. Karlsberg RP, Lyons KP, Gelezunas VL: Thallium-201 detection with the avalanche radiation probe for the localized measurement of myocardial perfusion. Clin Res 31: 10A, 1983. Lyons KP, Gelezunas VL, Karlsberg RP: Thallium-201 detection with the avalanche radiation probe for the localized measurement of myocardial perfusion. Clin Nucl Med 8(95): F2, 1983.L Tommasini G, Karlsberg RP, Tamagni F, Berra R, Oddone A, Orlandi M, Raimondi W, Malusardi R. Direct determination of distribution volume and disappearance rate of native creatine kinase in humans. Am Heart J. 1983 Mar;105(3):402-7. PMID: 6829402 Gelezunas VL, Lyons KP, Karlsberg RP. Silicon avalanche radiation detectors: the basis for a new in vivo radiation detection probe. Eur J Nucl Med. 1983;8(10):421-4. PMID: 6653598 Lyons KP, Lyons J, Gelezunas VL, Eugene J, McColgan S, Swan L, Karlsberg RP: Interstitial phase of thallium transport. J Nucl Med 25 (5): p79, 1984. Karlsberg RP, Eugene J, Lyons KP, Shell WE, Gelezunas VL. Regional myocardial perfusion measured by the avalanche radiation probe during cardiopulmonary bypass: pharmacologic and physiologic alterations. Am Heart J. 1984 Feb;107(2):367-74. PMID: 6695669. Lyons KP, Milne N, Karlsberg RP, Olson HG, Kuperus J. Myocardial infarct imaging in patients with technetium99m 2,3-dimercaptosuccinic acid. Superiority of technetium-99m pyrophosphate. Clin Nucl Med. 12 (7):514-8; 1987. Grines CL, Karlsberg R, Stadius M, for the Burroughs Wellcome Study Group: Infarct vessel patency and bleeding complications after weight-adjusted dosing of a double chain tissue plasminogen activator preparation: Final Report. J Am Coll Cardiol. 1990;15(2s1):A2-A2. doi:10.1016/0735-1097(90)91738Retaplase vs Aletplace on Coronary Artery Patency (Pending title). Circulation Nov 1993. Pending details. Stobbe DE, Lyons KP, Milner N, Krane MJ, Karlsberg RP. Diagnostic Accuracy of Dual Isotope Myocardial Perfusion Spect: Comparison to Angiography and Non-Invasive Techniques. Karlsberg RP, for the Milrinone-Dobutamine Heart Failure Study Group. Milrinone Is Superior To Dobutamine In Heart Failure Complicating Myocardial Infarction. Circulation 86-1:4 I-808 1992 Karlsberg RP, Superiority of Milrinone compared to Dobutamine in heart Failure complicating Myocardial infarction. Heart Failure Vol 1:75 May 20, 1993 Turi ZG, Goldberg S, LittleJohn JK, Vander Ark C, Shadoff N, Karlsberg RP, Williams J, Butman S, Stadius ML, Wise K, et al. Dose –related efficacy and bleeding complications of double-chain tissue plasminogen activator in acute myocardial infarction. The Wellcome Tissue Plasminogen Activator Study Group. American Journal of Cardiology. 71(12)1009-14; 1993. Gilbert EM, Colucci WS, Fowler MB, Lukas MA, Young ST, Hershberger R, Adams K, deMarchena E, Krueger S, Karlsberg R, Liang CS, for US Carvedilol Heart Failure Study Group. Carvedilol without ACE Inhibition in the Treatment of Patients with Moderate to Severe Chronic Heart Failure. Circulation 94:8 I-663, 1996 Karlsberg RP, DeWood MA, DeMaria AN, Berk MR, Lasher KP. Comparative efficacy of short-term intravenous infusions of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction. Milrinone-Dobutamine Study Group. Clin. Cardiol. Circulation: 19(1):21-30; 1996. September 1,2014 P a g e | 29 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. Karlsberg CV Kennedy HL, Goldstein S, Gottleib S, Gheorghiade M, Jessup M, Karlsberg R, Anderson J, Friday G, Haskell L,. Merti-HF Piolet Study. Additive Benefits of Beta-Blocker to ACE-Inhibitor Therapy on Heart Rate Variability in Congestive Heart Failure. European Society of Cardiology. Aug 24-28 Stockholm Sweden. 1997. Kenny HL, Goldstein S, Gottleib S, Gheorghiade M, Jessup JM, Karlsberg R, Anderson J, Friday G, Haskell L. MERIT-HF Pilot Study. Nonsustained Ventricular Tachycardia in Congestive Heart Failure and Beta-blocker Therapy. European Society of Cardiology. Aug 24-28 Stockholm Sweden, 1997 Goldstein S, Anderson J, Gheorghiade M, Gottlieb S, Jessup M, Karlsberg R, Kennedy H, Friday G, Haskell L. Extended Release Metoprolol in the Treatment of Congestive Heart Failure. European Society Cardiology Heart Failure Meeting Cologne May 24-27, 1997. Kennedy HL, Anderson J, Gheorghiade M, Goldstein S, Gottlieb S, Jessup M, Karlsberg R. Extended Release of Metoprolol in the Treatment of Heart Failure. 5th World Congress on Heart Failure. May 11-14 Washington DC, 1997. Smalling RW, Karlsberg RP, Weiner R, Ebersole DG, Thadani U, Bates, E, Habib GB, Moliterno D, Park YC, Freitag JJ. For the LIFT Investigators. Liposomal PGE-1 Adjunctive Treatment for Acute Myocardial Infarction: Final Results of the LIFT Pilot Trial. Journal of the American College of Cardiology Vol 31:2 (Supplement A), 411A, 1998. Cotter B, Karlsberg RP, Smith WB, Corretti MC, Picard M, Thomas JD, Herndon W, Foley DR, Nanda N, Batra S, DeMaria AN (for SonoVue Investigators). A Multicenter Clinical Evaluation of the Safety and Efficacy of BR1 (Sono Vue) as a Contrast Enhancing Agent for LV Endocardial Border Delineation. Journal of the American College of Cardiology Vol 33:2 (Supplement A), 413A, 1999. Goldstein S, Kennedy HL, Hall C, Anderson JL, Gheorghiade M, Gottlieb S, Jessup M, Karlsberg RP, Friday G, Haskell L. Metropol CR/XL in patients with heart failure: A pilot study examining the tolerability, safety and effect on left ventricular ejection fraction. American Heart Association Journal. 138(6Pt1):1158-65; 1999. Sanjay Rajagopalan, Jeffrey Snell, Marc Litt, Gary L Schaer, Ronald Karlsberg, Suheil Dohad, Stuart W Young. 1066-191 A phase I study of intramuscular administration of plasmid, developmentally regulated endothelial cell locus-1 gene, in humans with peripheral arterial disease J Am Coll Cardiol. 2004;43(5s2):A470-A470. doi:10.1016/S0735-1097(04)91990-0 Karlsberg RP, Thomson LEJ, Friedman JD, Berman DS, Budoff MJ. Integrated Coronary CTA in an Office Based Cardiology Practice Reduces Myocardial Perfusion Imaging in the Setting of Increased Identification of CAD and Stable Office Economics – A first Year Experience. Journal of Cardiovascular Computed Tomography. Vol.1, No. 1S, July 2007. S10, 26. Ahmadi N, Abdelkarim M, Gopal A, Sarraf G, Karlsberg RP, Budoff MJ. Non-Invasive Quantification Coronary Angiographic Evaluation of Stent Patency Using 64 Row Multi-Detector Computed Tomography. J Cardiovasc Comput Tomogr. 2010 Jan-Feb;4(1):29-37. Epub 2009 Nov 27.PMID: 20159625 Karlsberg RP, Thomson LEJ, Berman BS, Friedman JD, Budoff MJ. CCTA Integrated in the Office Setting Dramatically Reduces the Need for Invasive Angiography with Enhanced Identification of Critical Disease Not Identified by Conventional Testing and Clinical Presentation. Journal of Cardiovascular Computed Tomography. Vol.2, No. 4S. 31 S 11. July/Aug 2008 Budoff MJ, Gopal A, Mao SS, Karlsberg D, Young E, Waggoner J, Ahmadi N, Loewinger L, Pal RS, Leal J, Karlsberg RP. Radiation Reduction with Prospective Step-and-Shoot Acquistion Using 64- Multidetector Computed Tomorgaphic Angiography. Journal of Cardiovascular Computed Tomography. Vol.2, No. 4S. 54 S 20. July/Aug 2008 Ahmadi N, Abdelkarim M, Gopal A, Sarraf G, Karlsberg RP, Budoff MJ. Non-invasive quantitative coronary angiographic evaluation of stent patency using 64-row multi-detector computed tomography. JCCT 2008:2:S9. Budoff MJ, Gopal A, Mao SS, Karlsberg D, Young E, Waggoner J, Ahmadi N, Loewinger L, Pal RS, Leal J, Karlsberg RP. Radiation reduction with prospective step-and-shoot acquisition using 64multi-detector computed tomographic angiography. JCCT 2008:S20. Slomka PJ, Suski Y, Cheng V, Elad Y, Gutstein A, Karlsberg R, Germano G, Berman D, Ramish A. Combined Quantitative Analysis of 64-Slice Coronary CT Angiography and Myocardial Perfusion SPECT. Journal of the American College of Cardiology Vol51:10 Supplement A. 909-264 A173 March 11, 2008 September 1,2014 P a g e | 30 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 65. 66. 67. 68. 69. 70. 71. 72. 73. Karlsberg RP, Budoff MJ, Berman DS, Thomson LEJ, Friedman JD. Integrated Coronary CTA in an Office Based Cardiology Practice Reduces Myocardial Perfusion Imaging and Exercise Treadmill Testing in the Setting of Increased Identification of CAD, Stable Office Economics and More Aggressive Lipid Management. Journal of the American College of Cardiology Vol 51:10 Supplement A. 905-262 A130. March 11, 2008 Karlsberg RP, Dohad V. The Incidence of Contrast-Induced Nephropathy Following Osmolar Contrast Media. A Prospective Multicenter Study. Journal of the American College of Cardiology. Vol 53:10. Supplement A. 1040-122. A448. March 2009. Karlsberg RP, Dohad SY, V. Multicenter Group; Beverly Hills, CA/US. Contrast induced nephropathy (CIN); Differences between isosmolar (IOCM) and low osmolar contrast media (LOCM) in patients evaluated for peripheral arterial occlusive disease (PAOD): A prospective multicenter study. European Congress of Radiology. ECR 2009 Book of Abstracts/Volume 19/Supplement 1/March 2009/C-300. Vienna, Austria. March 6-10, 2009. Karlsberg RP, Dohad SY, V. Multicenter Group; Comparison of intravenous (IV) isosmolar contrast (IOCM) vs. intraarterial (IA) IOCM or low osmolar contrast media (LOCM): A prospective multicenter trial. Beverly Hills, CA/US. European Congress of Radiology. ECR 2009 Book of Abstracts/Volume 19/Supplement 1/March 2009/C-303. Vienna, Austria. March 6-10, 2009. Levisman, J.; Buddoff, M. Karlsberg, R., Retrospective Analysis of Long-Term Coronary Artery Graft Patency by 64-slice Coronary Computed Tomographic Angiography (CCTA)”. Journal of Cardiovascular Computed Tomography, Vol. 3, No. 4S10, July/August 2009. Cheng V, Nakazato R, Dey D, Gurudevan S, Tabak J, Budoff MJ, Karlsberg R, Min JK, Berman DS. Interscan Reproducibility of Coronary Artery Plaque Volume and Composition Quantification by 64-detecor Row Coronary Computed Tomographic Angiography. Journal of Cardiovascular Computed Tomography, Vol. 3, No. 4S44, July/August 2009. Min JK, Dunning A, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Callister TQ, Chang HJ, Cheng V, Chow B, Delago A, Hadamizky M, Hausleiter J, Karlsberg RP, Kaufmann P, Lin FY, Nasir K, Shaw LJ. Prognostic Value of Coronary CT Angiography for the Prediction of Mortality: A Prospective Multicenter Study of 10,596 Patients. J Cardiovasc Comput Tomogr 4:45 July/Aug 2010 S43.121 Min JK, Dunning A, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Callister TQ, Chang HJ, Cheng V, Chow B, Delago A, Hadamizky M, Hausleiter J, Karlsberg RP, Kaufmann P, Lin FY, Nasir K, Shaw LJ. Mortality Risk of Obstructive Coronary Artery Disease in a Propensity Score-Matched Cohort of Non-Diabetic and Diabetic Individuals: A Prospective Multicenter Study. J Cardiovasc Comput Tomogr 4:45 July/Aug 2010 S43.120 Victor Y Cheng, Daniel S Berman, Allison Dunning, Stephan Achenbach, Mouaz Al-Mallah, Matthew J Budoff, Tracy Q Callister, Hyuk-Jae Chang, Benjamin Chow, Augustin Delago, Martin Hadamitzky, Jorg Hausleiter, Ronald P Karlsberg, Philipp Kaufmann, Fay Y Lin, James K Min, Khurram Nasir, and Leslee J Shaw Abstract 12100: Marked Overestimation of Obstructive Coronary Artery Disease Probability by the Diamond-Forrester Classification in Sympomatic Patients Undergoing Coronary CT Angiography: Results from the Multinational CONFIRM Registry (Coroanry CT Angiograph Evaluation For Clinical Outcomes: An International Multicenter Registry). Circulation 2010;122:A12100 74. Hadamitzky M, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Callister TQ, Chang HJ, Cheng V, Chow B, Delago A, Hausleiter J, Karlsberg RP, Kaufmann P, Lin FY, Min JK, Nasir K, Shaw LJ. What is the optimal prognostic method for scoring coronary artery disease on a CT Angiogram? Results from the Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry). Circulation 2010:122;A12199 75. Victor Cheng, Daniel S Berman, Allison Dunning, Stephan Achenbach, Mouaz Al-Mallah, Matthew J Budoff, Tracy Q Callister, Hyuk-Jae Chang, Benjamin Chow, Augustin Delago, Martin Hadamitzky, Jorg Hausleiter, Ronald P Karlsberg, Philipp Kaufmann, Fay Y Lin, James K Min, Khurram Nasir, Leslee J Shaw Abstract 12152: Framingham Risk Score Predicts Probability of Significant Coronary Artery Stenosis in Stable Symptomatic Patients: Results from the Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) Circulation. 2010;122:A12152 Tcheng JE, Hendel RC, LizzaM Isler D, Karlsberg RP,. Roman DP, Weintraub WS. ACCF/AHA Key Data Elements And Definitions Of A Base Cardiovascular Vocabulary For Electronic Health Records. AMIA Proceeding Library Site. 2011pg 145. 76. Karlsberg CV September 1,2014 P a g e | 31 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. Karlsberg CV Madaj PM, Budoff MJ, Li D, Tayek JA, Karlsberg RP, Karpman HL. Identification Of Non Calcified Plaque In Young Diabetics: An Opportunity For Early Primary Prevention Of Coronary Artery Disease Identified With Low Dose Coronary Computed Tomographic Angiography. J Am Coll Cardiol. 2011;57(14s1):E815-E815. doi:10.1016/S0735-1097(11)60815-2 Gupta M, Jug B, Papazian J, Derakhshani A, Koplik S, Bhatia H, Karlsberg RP, Budoff M. Diagnostic Performance Of Computed Tomographic Coronary Angiography In Patients With End-Stage Renal Disease. J Am Coll Cardiol. 2011;57(14s1):E507-E507. doi:10.1016/S0735-1097(11)60507-X Gupta M, Jug B, Papazian J, Bhatia H, Karlsberg R, Budoff M. Diagnostic accuracy of 64-slice multi-detector coronary computed tomographic Angiography: a large multicenter study. J Am Coll Cardiol. 2011;57(14s1):E669-E669. doi:10.1016/S0735-1097(11)60669-4 Shittu A, Hacioglu Y, Gang E, Li D, Bhatia H, Karlsberg RP, Alvergue J, Budoff MJ. Use of cardiac computed tomography in detection (qualitative and quantitative) of left atrial appendage thrombus. J Am Coll Cardiol. 2011;57(14s1):E880-E880. doi:10.1016/S0735-1097(11)60880-2 Gupta M, Papazian J, Jug B, Li D, Bhatia H, Karlsberg R, Budoff MJ. Diagnostic Accuracy of 64 Slice MultiDetector Coronary Computed Tomographic Angiography in Patients with Left Ventricular Systolic Dysfunction. Poster Session IX:CTA Abstract 72-79, July 15. SCCT Denver, Co 2011. Jug B, Gupta M, Papazian J, Li D, Tsang J, Bhatia H, Karlsberg R, Budoff MJ. Diagnostic Performance of 64slice Multi-detector Computed Tomographic Coronary Angiography in Women. Poster Session XIV: Fat and Risk. Abstracts 128-145. July 16, 2011. SCCT. Denver Eddie Hulten; Todd C. Villines; Daniel S. Berman; Allison Dunning; Stephan Achenbach; Mouaz Al-Mallah; Matthew J. Budoff; Filippo Cademartiri; Tracy Q. Callister; Hyuk-Jae Chang; Victor Cheng; Kavitha Chinnaiyan; Benjamin J.W. Chow; Ricardo Cury; Augustin Delago; Gudrun Feuchtner ;Martin Hadamitzky, Joerg Hausleiter; Philipp Kaufmann; Ronald P. Karlsberg; Yong-Jin Kim; Jonathon Leipsic; Fay Y. Lin; Erica Maffei; Fabian Plank, Gilbert Raff; Troy M. Labounty; Leslee J. Shaw; James K. Min. Coronary Artery Disease Burden by Coronary CT Angiography Predicts Mortality and Myocardial Infarction Across Multiple Ethnicities: Results from the CONFIRM Registry, AHA Circulation 2011 James K Min; Allison Dunning; Stephan Achenbach; Mouaz Al-Mallah; Daniel S Berman; Matthew J Budoff; Tracy Q Callister; Hyuk-Jae Chang; Victor Cheng; Benjamin J Chow; Augustin Delago; Martin Hadamitzky; Joerg Hausleiter; Ronald P Karlsberg; Philipp Kaufmann; Fay Y Lin; Khurram Nasir; Leslee J Shaw Abstract 14571: Prognostic Value of 64-Detector Row Coronary CT Angiography for the Prediction of All-Cause Mortality: Results from 21,062 Patients in the Prospective Multinational CONFIRM Registry (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter Registry) Circulation. 2010; 122: A14571 Leslee J Shaw, Allison M Dunning, Kavitha Chinnaiyan, Stephan Achenbach, Mouaz Al-Mallah, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Victor Y Cheng, Benjamin J Chow, Augustin J Delago, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp A Kaufmann, Jonathon Leipsic, Erica Maffei, Gilbert L Raff, Todd C Villines, James K Min, Abstract 13042: Invasive Coronary Angiography, Revascularization, and Adverse Cardiac Events Following CCTA: A Matched Analysis of Women and Men in the Prospective Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) Fay Y Lin, and CONFIRM investigators Circulation. 2011;124:A13042 Karlsberg, D. Elad Y, Kass RM, Karlsberg RP. Super-computed Cardiac Computed Tomographic Angiography Defines Quadricuspid AorticValve Non Invasively. New York State/American Program Sackler Faculty of Medicine Research Symposium on Basic and Clinical Science. (Honorable mention amongst 30 entries for Clinical Vignettes)Tel Aviv University. Tel Aviv, Israel; March 25, 2011. Chang V, Berman DS, Callister T, Chang HJ, Delago A, Gomes, M, Hadamitzky M, Lin FY, Nasir K, Shaw, LJ, Villines TC, Achenback S, Mallah MA, Budoff, MJ, Cademartiri, F, Chinnayian K, Chow BJW, Hausleiter J, Karlsberg RP, Maffei E, Raff, G, Min JK. Cigarette smoking, proximal coronary arterial plaque composition, and risk of myocardial infarction and death: A study of nondiabetic men and women in the multinational CONFIRM registry. JACC 4/4/2011 James K. Min; Daniel S. Berman; Allison Dunning; Stephan Achenbach; Mouaz Al-Mallah; Matthew J. Budoff; Filippo Cademartiri; Tracy Q. Callister; Hyuk-Jae Chang; Victor Cheng; Kavitha Chinnaiyan; Benjamin J.W. September 1,2014 P a g e | 32 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 89. 90. 91. 92. 93. 94. 95. 96. Karlsberg CV Chow; Ricardo Cury; Augustin Delago; Gudrun Feuchtner; Martin Hadamitzky, Jörg Hausleiter; Philipp Kaufmann; Ronald P. Karlsberg; Yong-Jin Kim; Jonathon Leipsic; Fay Y. Lin; Erica Maffei; Fabian Plank, Gilbert Raff; Todd Villines; Troy M. Labounty; Leslee J. Shaw, Therapeutic Benefit of Coronary Revascularization versus Medical Therapy in Patients Without Known Coronary Artery Disease Undergoing Coronary Computed Tomographic Angiography: Results from CONFIRM registry.AHA Circulation 2011 Mouaz Al-Mallah, Stephan Achenbach, Daniel Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J Chow, Augustin Delago, Allison Dunning, Millie J Gomez, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp Kaufmann, Fay Y Lin, Erica Maffei, James K Min, Gilbert Raff, Leslee J Shaw, Todd C Villines, Victor Y Cheng Abstract 14849: Incremental Prognostic Value of Coronary CT Angiography over Coronary Calcium Score in Symptomatic Patients with Suspected Coronary Disease: Results from the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Circulation. 2011;124:A14849 Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Hyuk-Jae Chang, Cheng Victor, Benjamin J Chow, Augustin DeLago, Allison M Dunning, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp A Kaufmann, Fay Y Lin, Mouaz Al-Mallah, Khurram Nasir, Leslee J Shaw, James K Min. Abstract 14099: Prognostic Value of Coronary CT Angiography for the Prediction of Mortality and Non-Fatal Major Adverse Cardiac Events: Results from the Multinational CONFIRM Registry Circulation. 2011;124:A14099 Troy M LaBounty, Millie Gomez, Stephen Achenbach, Mouaz Al-Mallah, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Victor Cheng, Kavitha M Chinnaiyan, Benjamin J Chow, Augustin Delago, Allison M Dunning, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp A Kaufmann, Jonathon Leipsic, Fay Y Lin, Erica Maffei, Gilbert Raff, Leslee J Shaw, Todd Villines, James K Min. Abstract 15413: Increased Body Mass Index is Associated with Greater Prevalence, Extent, and Severity of Coronary Artery Disease and Increased Adverse Events. Circulation. 2011;124:A15413 Chinnalyan k, Boura J, Raff GL, Depetris A, Achenbach S, Al Mallah M, Berman BS, Budoff MJ, Cademartiri F, Callister TQ, Chang, HJ, Cheng VY, Chow B, CuryRIC, Delago A, DunningA, Feuchtner G, Gomez M, Hadamitzky M, Hausleiter J, Kaufman P, Karlsberg R, Kim YJ, Lepsic JA, Lin FY, Labounty TM, Maffei E, Shaw, LJ, Villines TC, Min JK. 108 Non-Obstructive Coronary Artery Disease Confers Worsened Prognosis in Patients with Acute versus Chronic Symptoms: Results From 9678 Patients Undergoing Coronary CT Angiography in the Prospective Multicenter, International CONFIRM Registery. Journal of Cardiovascular Computed Tomography Vol6:4S July/Augest 2012 S37 Karlsberg, D. Elad Y, Kass RM, Karlsberg RP.Super-computed Cardiac Computed Tomographic Angiography Defines Quadricuspid AorticValve Non Invasively. Rocky Mountain Hospital Medicine Symposium. Colorado ConventionCenter- (1ST place amongst 25 entries in the poster competition for Clinical Vignettes) Denver; Colorado September 27-28, 2012. Stephan Achenbach, Allison Dunning, Daniel Berman, Matthew Budoff, Tracy Callister, Hyuk-Jae Chang, Victor Cheng, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Ronald Karlsberg, Philipp Kaufmann, Fay Lin, Mouaz Al-Mallah, Khurram Nasir, Leslee Shaw, Todd Villines, James Min, CONFIRM Registry Investigators, University of Giessen, Giessen, Germany, Cedars Sinai Medical Center, Los Angeles, CA, USA. Asymptomatic Individuals With Non-Calcified Plaque Alone By Coronary Ct Angiography: Association To Coronary Artery Disease Risk Factors And Prognostic Implications For Patients In The Prospective Multicenter International Confirm Registry. J Am Coll Cardiol. 2012;59;A324 (13s1):E1325-E1325. doi:10.1016/S07351097(12)61326-61325 Naser Ahmadi, Vahid Nabavi Larijani, Fereshteh Hajsadeghi, Michael Baskett, Michael Fahmy, Lisa Han, Ferdinand Flores, Ramin Ebrahimi, Ronald Karlsberg, Matthew Budoff, Cedars Sinai Heart Institute, Los Angeles, CA, USA, University of California Los Angeles / Greater Los Angeles VA, Los Angeles, CA, USA Increased Pulse Wave Velocity Measured By Computed Tomography Angiography J Am Coll Cardiol. 2012;59 A292(13s1):E1193E1193. doi:10.1016/S0735-1097(12)61194-2 Karlsberg DW, Elad Y, Kass RM, Karlsberg RP. Super-computed Cardiac Computed Tomographic Angiography Defines Quadricuspid Aortic Valve Non Invasively. Society of General Internal Medicine- Mountain West SGIM September 1,2014 P a g e | 33 PRESENTATIONS AND ABSTRACTS (Excludes non-authored multicenter trials 500+) 2012 Regional (1ST place amongst 27 entries in the poster competition for Clinical Vignettes) Meeting. University of Colorado, Anschutz Medical Campus-Denver, CO; October 5, 2012. 97. Zeb I, Li D, Malpeso J, Nasir K, Dailing C, Flores FC , Karlsberg RP, Buddoff M. Effect of Statin Treatment on Coronary Plaque Progression: A Serial CT Angiographic Study. JACC 2013 61:10A 908-7 A200 BOOK CHAPTERS Karlsberg RP: Modification of myocardial infarct size by drugs - Book Chapter. In: Cardiac Pharmacology, (Wilkerson, R. Douglas), Academic Press, Inc., pp 415-440, 1981. Thomson LEJ, Karlsberg RP, Friedman J, Hayes S, Saouaf R, Berman DS, Cardiovascular CT Imaging: Essentials for Clinical Practice. Chapter: Adult congenital heart diseas--50e. Springer-Verlag (London) Ltd., Ashbourne House. 2008. Karlsberg CV September 1,2014 P a g e | 34
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