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Horizontal gene transfer
Maddalen Arizti Lopez de Aberasturi
Genomics
Index
 Horizontal
gene transfer
 Mechanisms
 Detection
methods
 Importance
 Conclusion
of HGT
Horizontal gene transfer (HGT)

Transfer of genes between organisms in a manner other
than traditional reproduction

Acquisition of foreign genes  evolution of many
organisms

Organism

Prokaryotes

Eukaryotes
Mechanisms of HGT
Mechanisms of HGT
Detection methods

Phylogenetic methods

Phylogeny independent methods
 Codon-based
approaches
 BLAST
 PCR-based
approaches
Importance of HGT



Adaptative advantages
 Bdelloid Rotifer
 Functional bacteria, plants and fungal genes
 Biochemistry improvements
Evolution of eukaryotes
 Plantae  plastids

Red algae  5% of coding genes

Glaucophytes  400 genes

Green plant
Implications for medicine and biotechnology
 Important role in pathogenesis
 Therapeutic targets
 Antibiotic resistance  vaccines
Conclusion

Study of mechanism in eukaryotes

Evolutionary potential in all the organism

More frequent in eukaryotes than we though

Importance for medicine and new therapies
Thank you for listening!
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