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IMMUNOLOGY I. Name of the unit offering the course: Department of Immunology II. Head of the Unit/course coordinator: prof. dr hab. Jacek Michałkiewicz III. 2nd year, number of hours: 45 IV. Form of the classes: lecture: 15, tutorials: 15, seminars:15 V. Form of crediting: credit with grade VI. Number of ECTS points: 6 VII. The main topics o o Lectures: - General mechanisms of innate immune system action - Phagocytosis-types of cells involved, effector mechanisms, regulations - Pathogen recognition receptors (Toll and NOD systems) - Complement system main characteristics - Leucocyte rolling, adhesion, leucocyte extravasation - Lymphocyte receptors generation - Mechanisms of antigen recognition by lymphocytes - Antigen presenting cells (professional and non-professional) - Co-stimulation as a second and third signal of T cells induction - Phenotype and function of main effector T cell subsets Seminars: - Characteristics of antibodies – forms, classes, structure and functions, Monoclonal antibodies in medicine o - Primary and secondary immunodeficiencies - Regulatory T cells – characteristic and functions - Human antibacterial, antiviral, antifungal and anti-parasite response - Tumor stromal cells - basic tumor immunology Tutorials: - Cells of the immune system and antigen recognition - The analysis of cell phenotype in immunodeficiencies, the flow cytometry method - Mechanisms of cytotoxicity - Cell death as a significant process in immunology - Components of innate immune system – the evaluation of the function of phagocytic cells VIII. - Flow cytometric measurement of intracellular proteins - Cell isolation and culture procedures in immunology Booklist: Basic: 1. Abul K. Abbas, Andrew H. Lichtman: Basic Immunology, Sauders Elsevier 2. Roderick Nairn, Matthew Helbert: Immunology for medical students, Mosby Elsevier 3. Mark Peakman, Diego Vergani: Basic and clinical immunology, Churchill Livingstone Elsevier Additional: 4. Tak W. Mak, Mary E. Saunders: Primer to the immune response, Academic Press Elsevier 5. Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai: Cellular and molecular immunology, Sauders Elsevier 6. Kenneth M. Murphy, Paul Travers, Mark Walpor Janeway’s Immunobiology, Garland http://www.ncbi.nlm.nih.gov/books/NBK10757/ (free) http://www.ncbi.nlm.nih.gov/sites/entrez?db=books (free)