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IMMUNOLOGY
I.
Name of the unit offering the course: Department of Immunology
II.
Head of the Unit/course coordinator: prof. dr hab. Jacek Michałkiewicz
III.
2nd year, number of hours: 45
IV.
Form of the classes: lecture: 15, tutorials: 15, seminars:15
V.
Form of crediting: credit with grade
VI.
Number of ECTS points: 6
VII.
The main topics
o
o
Lectures:
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General mechanisms of innate immune system action
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Phagocytosis-types of cells involved, effector mechanisms, regulations
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Pathogen recognition receptors (Toll and NOD systems)
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Complement system main characteristics
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Leucocyte rolling, adhesion, leucocyte extravasation
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Lymphocyte receptors generation
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Mechanisms of antigen recognition by lymphocytes
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Antigen presenting cells (professional and non-professional)
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Co-stimulation as a second and third signal of T cells induction
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Phenotype and function of main effector T cell subsets
Seminars:
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Characteristics of antibodies – forms, classes, structure and functions,
Monoclonal antibodies in medicine
o
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Primary and secondary immunodeficiencies
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Regulatory T cells – characteristic and functions
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Human antibacterial, antiviral, antifungal and anti-parasite response
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Tumor stromal cells - basic tumor immunology
Tutorials:
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Cells of the immune system and antigen recognition
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The analysis of cell phenotype in immunodeficiencies, the flow cytometry method
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Mechanisms of cytotoxicity
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Cell death as a significant process in immunology
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Components of innate immune system – the evaluation of the function of phagocytic
cells
VIII.
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Flow cytometric measurement of intracellular proteins
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Cell isolation and culture procedures in immunology
Booklist:
Basic:
1.
Abul K. Abbas, Andrew H. Lichtman: Basic Immunology, Sauders Elsevier
2.
Roderick Nairn, Matthew Helbert: Immunology for medical students, Mosby Elsevier
3.
Mark Peakman, Diego Vergani: Basic and clinical immunology, Churchill Livingstone Elsevier
Additional:
4. Tak W. Mak, Mary E. Saunders: Primer to the immune response, Academic Press Elsevier
5. Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai: Cellular and molecular immunology,
Sauders Elsevier
6. Kenneth M. Murphy, Paul Travers, Mark Walpor
Janeway’s Immunobiology, Garland
http://www.ncbi.nlm.nih.gov/books/NBK10757/ (free)
http://www.ncbi.nlm.nih.gov/sites/entrez?db=books
(free)
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