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1150 ROLE OF 3D CISS SEQUENCES AND CSF FLOW STUDY IN INTRAVENTRICULAR NEUROCYSTICERCOSIS. Neurocysticercosis is the most common parasitic infection of CNS world wide. Intraventricular cysticercosis contributes to 7 to 25% of neurocysticercosis infection. The lesions are silent until obstruction occurs secondary to the location of cystic lesion or associated ependymitis caused by adjacent granulomatous response. IV ventricle is the most common site of involvement. Two patients came to radiology department Coimbatore MCH with clinical features of increased ICT Patients undergone MRI Brain with routine T1,T2 FLAIR SEQUENCES After observing tetraventricular system dilatation and suspicious intraventricular lesion ,3D CISS sequence,CSF Flow study and contrast MRI was done 3D CISS(Constructive Interference in Steady State Imaging) Since small intraventricular lesion was suspected patients undergone 3D CISS 3D CISS is a gradient echo sequence in which Image contrast is determined byT2/T1 of the tissue. So tissues having long T2 and short T1 relaxation time have increased signal intensity.eg-water With CISS there will be excellent contrast between CSF and other strucures CASE 1 59 yr old male presented with severe headache, ataxia and visual disturbance 15 days back patient undergone MRI elsewhere and reported as a case of Normal pressure hydrocephalus. T2 W images show dilated ventricles with periventricular seepage. Lesion in the IV ventricle with cerebellar oedema FLAIR SHOWS CYSTIC LESION IN IV Ventricle T1 SAG image shows IV ventricular obstruction CISS showing cyst 3d CISS Adherent cyst in the right lateral wall of IV ventricle Adhesion and obstruction in Foramen of Luschka CSF flow study shows obstruction at IV ventricle CISS Shows cystic lesion in IV ventricle with mural nodule Post contrast T1 images show ring enhancing lesion in IV ventricle and ependymal enhancement (ependymitis) CASE 2 29 YR Old female patient presnted with c/o severe headache and visual disturbance. Fundal examination showed papilloedema. Patient undergoneMRI Brain with routine T1,T2 FLAIR SEQUENCES After observing tetraventricular system dilatation and suspicious intraventricular lesion ,3D CISS sequence,CSF Flow study and contrast MRI was done 1 T2 image showing dilated lateral ventricles with no seepage. 2 FLAIR image shows dilated IV ventricle with intraventricular cystic lesion. Pre and post contrast sag T1 Images show dilated IV ventricle with cystic lesion and enhancing mural nodule. 3D CISS showing cysticercosis CISS IV NC RESULTS BOTH CASES SHOWED 4TH VENTRICULAR NEUROCYSTICERCOSIS WITH OBSTRUCIVE HYDROCEPHALUS INTRAVENTRICULAR CYST WITH MURAL NODULE IS VERY WELL SEEN IN 3D CISS SEQ DUE TO HIGH SNR CSF FLOW STUDIES SHOWED THE OBTRUCTION AT IV VENTRICLE POST CONTRAST STUDIES WERE USEFUL IN IDENTIFYING COMPLICATIONS LIKE EPENDYMITIS CONCLUSION 3D CISS SEQUENCE IS HIGHLY DIAGNOSTIC IN IDENTIFICATION OF INTRAVENTRICULAR NEUROCYSTICECOSIS Reference Anne Osborne brain imaging pathology and anatomy. 1st edition AJNR 2000, 21, 679-684 IJRI 2002 VOL12 329-332 IJRI 2001 VOL21