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Chapter 2 Nerve Cells and Behavior & Chapter 4 The Cytology of Neurons 7 nm 25 nm 25 nm Neuronal cytoskeleton Four functions of neurons 1. Receive and integrate inputs dendrites, soma 2. Generate a nerve impulse (action potential) axon hillock 3. Conduct the action potential axon 4. Transmit information to target cell (neuron, muscle, gland) nerve terminals Dendrites and cell body Receive and integrate inputs Axon hillock and initial segment Generate action potentials Axon Conducts action potential Terminals Synaptic transmission Eccles, J.C. (1964) The Physiology of Synapses. N.Y.: Springer Classifications of Neurons 1. Function a. sensory neurons b. motoneurons c. interneurons Classifications of Neurons 1. Function 2. Structure a. unipolar b. bipolar c. multipolar Classifications of Neurons 1. Function 2. Structure 3. Shape e.g., pyramidal, stellate, basket, granule, etc. A B 100μm Classifications of Neurons 1. 2. 3. 4. Function Structure Shape Effect a. excitatory neurons b. inhibitory neurons Classifications of Neurons 1. 2. 3. 4. 5. Function Structure Shape Effect Axon length a. projection neurons (Golgi Type I) b. local neurons (Golgi Type II) Classifications of Neurons 1. 2. 3. 4. 5. 6. Function Structure Shape Effect Axon length Neurochemical identity e.g., cholinergic, dopaminergic, GABAergic, etc. Classifications of Neurons 1. 2. 3. 4. 5. 6. Function Structure Shape Effect Axon length Neurochemical identity Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia 4. Schwann cells Types of glial cells 1. Astrocytes a. mechanical support b. metabolic support transport nutrients and wastes c. encapsulate synapses d. regulate chemical and ionic environment e. form scar tissue f. act as phagocytes Types of glial cells 1. Astrocytes 2. Microglia a. act as phagocytes b. part of brain’s immune system Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia myelinate axons of central nervous system Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia 4. Schwann cells myelinate axons of peripheral nervous system