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Target:
ADDL
Synuclein?
LTP or LTD
ADDL
reduce LTP
Disease
relevance
Mouse
models
K-channels
A-current
Proteins
Genes
Gene
expression
patterns
ModelDB
BrainPharm
GenSat
AllenBrain
PubMed
How does ADDL
impair synaptic
plasticity?
Does LTP occur
in the right place?
What is the
mechanism?
What cell types
are affected?
Right cell type?
Go to slide 3
What genes
and proteins
are
involved?
Go to next slide
Channel  cell
type
Which
genes are
expressed
in the
relevant
part of the
brain?
Synuclein
reduces
LTP?
Dataset/
Source:
SWAN
Questions:
What form
of Abeta
cause AD?
Alzgene
2: driving question
How does ADDL impair
synaptic plasticity?
What cell types are
affected?
Brings to mechanism
question
Brain Pharm
ADCA1
NeuronDB
CA1extracellular
Abeta
CA1has
currentA-current
A-currenthas
channelK+
Missing datasets
Currents that have
K+ ions are
conducting K+
channels?
CA1LTP
3: mechanisms
K-channels 
proteins
K-channels
genes
CA1LTP
LTPpapers
MeSH “LTP” and
“K-channel” colocalization
network
PubMed :
Kv4.2 pmid:
17122039
PaperGene
Orthomap
AlzGene:
Potassium
channel gene 
HilleWashUch
annel database
EntrezgenePub
Med
GeneRIFSPubM
ed
Jax synaptic
plasticity
Jax
hippocampal
biology