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Regulation of anterior pituitary hormone release (rectangles) by hypothalamic releasing hormones (circles). Major target tissues for the anterior pituitary hormones are indicated. GnRH, gonadotropin releasing hormone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; GHRH, growth hormone releasing hormone; GHIH, growth hormone inhibiting hormone (somatostatin); GH, growth hormone; TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone; PIH, prolactin inhibiting hormone (dopamine); CRH, corticotropin releasing hormone; ACTH, adrenocorticotropic hormone. +, stimulatory; −, inhibitory (Modified from Hedge et al., 1987). Source: Toxic Responses of the Endocrine System, Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e Citation: Klaassen CD. Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e; 2012 Available at: http://mhmedical.com/ Accessed: May 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved