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Professor William Wisden Research interests and techniques: Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. Hippocampal function: parvalbuminergic GABAergic interneurons and the control of neuronal oscillations GABAergic interneurons and motor learning Hypothalamic function: the regulation of neurons which make histamine: the tuberomammillary nucleus and sleep regulation Ion channels: GABAA receptors and K2P potassium channels Neuronal type Combination of methods used directly test circuit-specific functions of parvalbuminpositive interneurons in behaving mice • • • • • Molecular technique transgenic mice and vector construct Region specific virus injection in vivo Electrophysiological recording Immunoflurescence staining Behavior test Selective expression of TeLC in parvalbuminpositive interneurons of the hippocampus Selective expression of TeLC in parvalbuminpositive interneurons of the hippocampus Selective expression of TeLC in parvalbuminpositive interneurons of the hippocampus Rostra –caudal axis Blocking parvalbumin-positive cell–mediated inhibition in the hippocampus impairs spatial working but not reference memory parvalbumin-positive basket cells cholecystokinine (CCK)-containing basket cells (Cannabinoid sensitive parvalbumin-positive axo-axonic cells Blocking parvalbumin-positive cell–mediated inhibition in the hippocampus impairs spatial working but not reference memory Hippocampal lesion and inactivation disrupt both spatial reference and working memory A population of hippocampal CA1 interneurons selectively supports encoding of spatial working, but not incremental reference memory
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