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Concepts of Genetics
Ninth Edition
Klug, Cummings, Spencer, Palladino
Chapter 5
Chromosome Mapping in Eukaryotes
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5.1 Genes Linked on the Same
Chromosome Segregate Together
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Figure 5.1
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Figure 5.1a
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Figure 5.1b
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Figure 5.1c
5.1 Genes Linked on the Same
Chromosome Segregate Together
5.1.1 The Linkage Ratio
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Figure 5.2
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Figure 5.2-01
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Figure 5.2ab
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Figure 5.2a
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Figure 5.2b
5.2 Crossing Over Serves as the Basis of
Determining the Distance between
Genes in Chromosome Mapping
5.2.1 Morgan and Crossing Over
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Figure 5.3
5.2 Crossing Over Serves as the Basis of
Determining the Distance between
Genes in Chromosome Mapping
5.2.2 Sturtevant and Mapping
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Figure 5.4
5.2 Crossing Over Serves as the Basis of
Determining the Distance between
Genes during Chromosome Mapping
5.2.3 Single Crossovers
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Figure 5.5
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Figure 5.6
5.3 Determining the Gene Sequence in
Mapping Requires the Analysis of
Multiple Crossovers
5.3.1 Multiple Exchanges
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Figure 5.7ab
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Figure 5.7a
5.3 Determining the Gene Sequence in
Mapping Requires the Analysis of
Multiple Crossovers
5.3.2 Three-Point Mapping in Drosophila
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Figure 5.8
5.3 Determining the Gene Sequence in
Mapping Requires the Analysis of
Multiple Crossovers
5.3.3 Determining the Gene Sequence
5.3.3.1 Method I
5.3.3.2 Method II
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Figure 5.9
5.3 Determining the Gene Sequence in
Mapping Requires the Analysis of
Multiple Crossovers
5.3.4 A Mapping Problem in Maize
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Figure 5.10
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Figure 5.10a
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Figure 5.10b
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Figure 5.11
5.4 Interference Affects the Recovery of
Multiple Exchanges
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5.5 As the Distance Between Two Genes
Increases, the Results of Mapping
Experiments Become Less Accurate
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Figure 5.12
RF= 0.5(1-e-m) x 100
m is the mean number of crossovers
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Figure 5-13
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5.6 Drosophila Genes Have Been
Extensively Mapped
Actually, the Drosophila genome has been sequenced
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Figure 5.14
5.7 Lod Score Analysis and Somatic Cell
Hybridization Were Historically
Important in Creating Human
Chromosome Maps
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Figure 5.15
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Figure 5.16
5.8 Chromosome Mapping is Now Possible
Using DNA Markers and Annotated
Computer Databases
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5.9 Crossing Over Involves a Physical
Exchange between Chromatids
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Figure 5.17
5.10 Recombination Occurs between
Mitotic Chromosomes
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Figure 5.18
5.11 Exchanges Also Occur between Sister
Chromatids
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Figure 5.19
5.13 Did Mendel Encounter Linkage?
(maybe) 
I won’t
tell
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