Download Comparative Fish Pathology

Gross Presentation of
the Diseases of Fish
Judy St. Leger, DVM, DACVP
SeaWorld, San Diego
Acknowledgements:
Ruth Frances Floyd, Ron Hedrick, Greg Lewbart,
Lewbart, Gary Marty,
Paul Bowser, Jan Spitzbergen,
Spitzbergen, Mike Kent and Center for Fish
Disease Research (University of Oregon), Tatsuya Kobayashi,
USF&WS – NCTC, American Fisheries Society, Hawai'i Institute
of Marine Biology
Bacterial diseases
1
2
IHC for Renibacterium
3
Fungal Diseases
4
Viral Diseases
The Pathology of Systemic Iridoviral Disease in
Fish Comp Path vol 129, 22-3, 2003, 111111-119
S. GibsonGibson-Kueh,
Kueh, et al.
5
Andy Goodwin
6
Neoplastic Diseases
7
8
Parasitic Diseases
9
J. G. Sánchez;
nchez; D. J. Speare;
Speare; R. J. F. Markham; G. M. Wright; F. S. B. Kibenge
Localization of the Initial Developmental Stages of Loma salmonae in Rainbow
Trout (Oncorhynchus mykiss) Vet Pathol 2001 38: 540540-546.
10
11
Methemoglobilemia
12
13
Gross Pathology of Fishes - 2009
organ
slide
1
***
2
***
3
***
condition
4
liver
Furunculosis
5
skin
Furunculosis
6
skin
7
skin
8
skin
9
skin
10
head (skin)
morphologic diagnosis
acute necrotizing
hepatitis/splenitis
subacute cutaneous ulceration
focally extensive cutaneous
goldfish ulcer disease ulceration
focally extensive cutaneous
goldfish ulcer disease ulceration
flounder ulcer
focally extensive cutaneous
disease
ulceration
focally extensive cutaneous
ulceration
Yersinosis (Y.
multifocal to diffuse cranial
ruckeri )
congestion & hemorrhage
notes
Title slide
Acknowledgements
Bacterial diseases
Aeromonas
salmonicida
Aeromonas
salmonicida
Aeromonas
salmonicida
Aeromonas
salmonicida
Aeromonas
salmonicida
Aeromonas
hydrophila
red mouth
11
liver
edwardsiellosis
acute form
Acute hepatic necrosis & ascites Edwardsiella ictaluri
12
skin
Milk spots
Multifocal cutaneous necrosis
and ulceration
bone necrosis and cutaneous
ulceration - meningoencephalitis chronic form
chronic multifocal granulomatous Renibacterium
nephritis
salmoninarum
Renibacterium
massive renomegaly
salmoninarum
granulomatous stomatitis
moray eel
Necrotizing brachitis & cutaneous Gliding bacteria
erosions and ulceration
"haystacks"
Flavobacterium,
focally extensive cutaneous
Flexibacter or
necrosis
Cytophaga spp.
13
skin
14
kidney
15
16
kidney
oral cavity
Hole in the head
disease
Bacterial kidney
disease
Bacterial kidney
disease
mycobacteriosis
17
skin/gills
Flavobacterium
columnare
18
19
20
skin
skin
tail fin/skin
coelom, liver,
gills
21
tail rot
tail rot
tail rot
of Ayu
cutaneous and bone necrosis
acute necrotizing hepatitis and
ascites
acute form
Edwardsiella ictaluri
Pseudomonas
plecoglossicida
22
skin
Vibriosis
23
24
25
26
27
28
29
blood vessels
***
gills
gills
skin
***
Skin
Vibriosis
saprolegniasis
saprolegniasis
Fusarium solani
***
lymphocystis
Major bacterial
disease agent in
chronic granulomatous dermatitis marine fishes
acute congestion and
Opportunistic
hemorrhage
infections
Fungal diseases
Acute necrotizing branchitis
Acute necrotizing branchitis
Granulomatous dermatitis
bonnethead shark
***
Viral diseases
severe fibroblast hypertrophy
Iridovirus
Skin
lymphocystis
31
Skin
Multifocal cutaneous petechia
Channel catfish virus and ulcerations
32
abdomen
channel catfish virus ascites
Iridovirus - can be
focal or multifocal or
a systemic infection
Focal to diffuse
necrosis of
hematopoeitic and
renal tissues
fry R/O Bacterial
kidney disease
(based on species
affected)
33
skin
Carp pox
Epidermal hyperplasia
Cyprinid herpes virus
1- low mortality
Cyprinid herpes virus
3 - high mortality
30
34
severe fibroblast hypertrophy
gills
Koi herpes virus
acute necrotizing branchitis
35
abdomen
36
skin
Infectious
hematopoeitic
necrosis virus (IHNV)
Spring viremia of
carp
acute hepatic and splenic
necrosis
exophthalmia, ascites, acute
heptatic and splenic necrosis
37
skin
Spring viremia of
carp
cutaneous and swim bladder
hemorrhages, ascites
rhabdovirus of carp
grass carp transmitted by fish
lice
38
skin
Sardine viral
hemorrhagic
septicemia
cutaneous petechia
endothelial necrosis
and hemorrhage rhabdovirus
39
***
rhabdovirus of
salmonids
Neoplastic diseases
40
41
skin
skin
playfish hybrid
melanomas
Melanoma
Melanoma
42
Liver
hepatic adenoma
43
liver
hepatocellular carcinoma
44
skin
45
swim bladder
46
swim bladder
seasonal occurance autumn
Walleye sarcoma
specialized
pigmentary cells
47
48
49
skin
Skin/muscle
Skin/muscle
50
51
oral cavity
***
52
Skin
53
Skin
Progression to
carcinomas
***
Ichthyophthirius
multifiliis (Ich)
Cryptocarian irritans
(marine Ich)
54
gills
Henneguya sp
55
whirling disease
57
spine
skin/whole
body
skin/whole
body
58
whole body
Skinny disease
59
skin
Glugea sp.
56
whirling disease
whirling disease
loss of modifier
genes
Zon Zebrafish
aflotoxin B1 classical lesion with
species sensitivity
adenomas in
salmon; carcinomas
in trout
retroviral association
Swimbladder sarcoma
atlantic salmon
retroviral association
Swimbladder sarcoma
retroviral association
Chromatophoroma
Fibroma
Fibroma
goldfish
salmon
Orocutaneous papilloma
***
Mild ulcerative and hyperplastic
dermatitis
Mild ulcerative and hyperplastic
dermatitis
Gill xenomas - proliferative
branchitis
chondritis, chondronecrosis,
vertebral malformation
Brown bullhead
Parasitic diseases
mucous!
mucous!
Myxosporidian characteristic "tail"
Myxobolis cerebralis
focally extensive tail discoloration Neurologic control
Myxozoan with a 2focally extensive tail discoloration host cycle
zebra fishNeurotropic
Microsporidiosis Pseudoloma
neurophilia
Severe myelitis and myositis
sea horse Cutenous xenomas
microsporidia
60
skeletal
muscle
61
skin
62
skin
63
eye
64
kidney
65
kidney
66
heart
67
68
Loma salmonae
Lernea sp. - anchor
worms
Argulus
Diplostomum
spathaceum
Multifocal granulomatous
myositis
focal dermatitis
cutenous pediculosis
cataracts
Nephrocalcinosis
Renal degeneration and
mineralization
Cardiac degeneration and
mineralization
69
whole bodies Nitrite toxicity
blood
Nitrite toxicity
Hole in the head and
lateral line disease
skin
(HHLL)
70
skin
HHLL
71
72
eye
gills….
gas bubble disease
gastric eversion
Mass mortality - sudden death
Methemaglobinemia
Epidermal necrosis and
ulceration
Epidermal necrosis and
ulceration
retrobulbar hemorrhage
Parasitic copepod
Carrier of Spring
viremia of Carp
blindness impacts
feeding
salmonids - high
ratio of calcium or
phosphorus to
magnesium
rays and sharks
Cooler waterDecreased
denitrifying bacteriaDecreased dissolved
O2
Progresses along
lateral lines and
capital canals
Role of
Spironucleus?
Nutrition?
super satuarated
water
R/O goiter