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Download Patterning Development in the Early Embryo Patterning
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iBioSeminars by Eric Wieshaus Patterning Development in the Early Embryo Part 1 Where does pattern come from? Eric Wieschaus HHMI Princeton University Part 1 iBioSeminars by Eric Wieshaus Rapid Uniform Cell Cycle Nuclear Mitoses No Cytokinesis Distinct Cell Behaviors Gastrulation Maternal RNAs and Proteins Zygotic RNAs and Proteins Maternal RNAs and Proteins MAJOR ONSET OF TRANSCRIPTION Zygotic RNAs and Proteins Part 1 iBioSeminars by Eric Wieshaus Rapid Uniform Cell Cycle Nuclear Mitoses No Cytokinesis Distinct Cell Behaviors Gastrulation Part 1 iBioSeminars by Eric Wieshaus Patterns of cell behavior during early Drosophila gastrulation Ventral view Part 1 iBioSeminars by Eric Wieshaus Changes in Morphology depend on local changes in cell shape Cephalic Furrow Why do certain cells change shape and others not? Patterns of cell behavior reflect underlying patterns of gene activity Where does pattern come from? How are spatial and temporal patterns of gene expression established at the blastoderm stage? Part 1 iBioSeminars by Eric Wieshaus Part 1 (Mostly) Uniform Maternal RNAs and Proteins MAJOR ONSET OF TRANSCRIPTION Patterned Zygotic Transcription (Mostly) Uniform Maternal RNAs and Proteins MAJOR ONSET OF TRANSCRIPTION Patterned Zygotic Transcription Patterning Gene Expression Patterns during Embryonic Development Maternal Bicoid Hb and Kr Gap genes prd and runt pair-rule genes Cephalic Furrow, Germband Extension iBioSeminars by Eric Wieshaus How is the embryonic gradient of maternal Bicoid protein formed? Bicoid RNA Bicoid Protein Bicoid RNA Bicoid protein Activation of gene occurs wherever Bicoid protein is above its critical threshold Hunchback Hunchback Krüppel Part 1 iBioSeminars by Eric Wieshaus Why is Bicoid so cool? Why was its discovery by Nusslen-Volhard and Driever (more than 15 years ago) so important? Information is Quantitative Response depends on concentration levels Initial localized source Final (information rich) distribution reflects simple physical parameters (diffusion, degradation) Information is Quantitative Response depends on concentration levels Part 1 iBioSeminars by Eric Wieshaus Initial localized source Final (information rich) distribution reflects simple physical parameters (diffusion, degradation) Evolution vs. conservation of developmental pathways Information is Quantitative Response depends on concentration levels Plan for this talk Part 2 Stability of Morphogen Gradients Movement of Molecules Part 3 Evolution of Bicoid scaling Part 1
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