Download Antimycobacterial drugs

ANTIMYCOBACTERIAL DRUGS11
Dr Galya Stavreva (2012)
Faculty of Medicine, Medical University – Pleven
1. The main reason for the use of drug combinations in the treatment of tuberculosis is to:
A) Decrease the incidence of adverse drug reactions; B) Prevent the emergence of
resistance; C) Prevent other bacterial infections; D) Shorten the duration of therapy to
less than 6 months.
2. Which one of the following antitubercular agents is not first line drug? A) Isoniazid; B)
Rifampin; C) Ethambutol; D) Ethionamide.
3. Which of the followings are accurate? A) Rifampin inhibits mycolic acids synthesis; B)
Isoniazid inhibits mycolic acids synthesis; C) The reduced expression of katG gene is a
mechanism of high-level isoniazid resistance; D) Metabolism of streptomycin is
genetically regulated.
4. Which of the followings statements about rifampin are accurate: A) For tubercular
infection it is used along with isoniazid, pyrazinamide, and ethambutol; B) When used
alone, there is a risk of the emergence of resistant mycobacteria; C) Orange
discoloration of body fluids is serious adverse drug reaction; D) It is very effective
antileprotic drug.
5. All of the followings statements are correct, EXCEPT: A) Isoniazid is the most potent
tuberculocidal drug; B) The most important side effect of ethambutol is optic neuritis; C)
Pyrazinamide is second line antitubercular drug; D) Ethionamide is a structural analog
of INH.
6. All are features of ethambutol toxicity, EXCEPT: A) Retrobulbar neuritis; B) Colour
vision disturbances; C) Arrhythmogenic effect; D) Hyperuricemia
7. A pregnant woman develops tuberculosis. Which one of the following drugs should not
be used? A) Isoniazid; B) Streptomycin; C) Ethambutol; D) Rifampin.
8. Which of the followings statements concerning antileprotic drugs is LEAST accurate?
A) Resistance develops to dapsone when it is used in combination with rifampin and
clofazimine; B) Dapsone inhibits folate synthesis; C) Clofazimine may cause skin
discoloration; D) Ethionamide, ofloxacin, and clarithromycin are alternative drugs for
leprosy.
9. A patient with AIDS has pulmonary disease that is due to M. avium complex. The
optimal decision is to: A) Give azithromycin for prophylaxis of dissemination of infection;
B) Treat with isoniazid, clarithromycin, and pyrazinamide at least 6 months; C) Treat
the patient with clarithromycin, ethambutol, and rifabutin at least 12 months; D) Treat
the patient with clarithromycin, ethambutol, and rifabutin at least 6 months.
10. Bactericidal and the fastest acting drug in leprosy is: A) Dapsone; B) Clofazimine; C)
Isoniazid; D) Rifampin.
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Answers: 1 B; 2 D; 3 B, C; 4 A, B, D; 5 C; 6 C; 7 B; 8 A; 9 C. 10 D.