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Resources with Free Access For NHS Medicines Information Services June 2016 This is a list of resources that are freely accessible and considered useful to NHS MI services. It includes free paper resources (e.g. BNF, drug tariff) and freely accessible websites via the Internet or via National library arrangements. This list is not intended to be exhaustive. It is organised under general subject headings and should be used in conjunction with ‘Resources for Purchase by NHS Medicines Information Services’. Other UKMi resources give guidance on what resources to use when, e.g. Enquiry Answering Guidelines. There is also guidance on the risks associated with the use of various resources, see Limitations of Common Information Sources. UKMi are in the process of assuring the quality of the listed resources, all those listed are produced by reputable/well known organisations. URLs are available via MiDatabank and are correct at the time of publication but are liable to change. Where registration is required this is indicated. This document may also be used to store details of your departmental usernames and passwords if you haven’t entered them in MiDatabank. This can then be kept in an accessible place for all staff working in MI. See also Internet and Medicines for guidance on how to assess the quality of a website. Some electronic resources may not work properly on older versions of Internet Explorer. If this affects you, try accessing the resource using an alternative browser, such as Google Chrome or Firefox. UKMi are aware that various ‘Apps’ are available for health information resources. UKMi do not intend to formally review the content or endorse the use of such Apps at this time. However, if an ‘App’ is available as another platform for an already endorsed UKMi resource, this may be highlighted as being available. Updating the List This list will be updated with new editions/ URLs etc. on a quarterly basis and published on the UKMi website. Updates to the list will be reflected in the MiDatabank masterlist. The Clinical Governance Working Group reviews the content of the list periodically. Suggestions for additions or deletions can be forwarded to [email protected]. Changes since January 2016 Title Authors/ Publisher URL and general notes DrugWise (Formally DrugScope) DrugWise Change: new name and url http://www.drugwise.org.uk/ NIHR Horizon Scanning Research and Intelligence Centre Q&A 11.7: Considerations when addressing questions about potential for adverse effects and drug interactions with homeopathic remedies Cytochrome P450 website National Institute for Health Research Change: updated name and url http://www.hsric.nihr.ac.uk/ UKMi Complementary Medicines Specialist Service Change: new recommendation http://www.medicinesresources.nhs.uk/GetDocument.aspx?page Id=781734 Indiana University Change: no longer recommended http://medicine.iupui.edu/flockhart/ This resource is no longer being updated. Palliative Care Matters Date: June 2016 Network of Palliative Care healthcare professionals. Change: new url http://m.pallcare.info Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher General British National Formulary BMA and RPS (twice yearly) One paper copy considered essential for each MI centre (only the September edition is published for free; March edition only available for purchase). Online access preferred as updated monthly www.medicinescomplete.com/mc/bnf/current/ Note: BNF Legacy website remains available through medicinescomplete.com DoH—Department of Health DoH https://www.gov.uk/government/organisations/depa rtment-of-health Drug Safety Update MHRA https://www.gov.uk/drug-safety-update Individual articles are searchable using the search box. An archive of the monthly PDF versions are also available. Drug Tariff The Stationery Office (monthly) Only available online www.ppa.org.uk/ppa/edt_intro.htm electronic Medicines Compendium (eMC) DataPharm Communications http://www.medicines.org.uk/emc/ For access to SPCs and PILs England: www.evidence.nhs.uk/nhs-evidencecontent/journals-and-databases. Athens password required. Wales: http://howis.wales.nhs.uk Scotland: www.knowledge.scot.nhs.uk/home.aspx EMBASE Google search engine Google www.google.co.uk for general seach engine but also use Google scholar for more academic focus http://scholar.google.co.uk/ Medicines Q & As UKMi http://www.ukmi.nhs.uk/activities/medicinesQAs/def ault.asp An excel spreadsheet is available (with links) to all current Q & As. Q & As can also be accessed via the NICE evidence search www.evidence.nhs.uk (filter by Type of information ‘Evidence Summaries’ and Source ‘UKMi') Medline Date: June 2016 England: www.evidence.nhs.uk/nhs-evidencecontent/journals-and-databases Athens password required. Wales: http://howis.wales.nhs.uk Scotland: www.knowledge.scot.nhs.uk/home.aspx Since changing providers last year (from OVID to PROQUEST), searches are not working as anticipated. Until further notice, it is suggested that you do not use PROQUEST (via NICE Evidence) to search Medline. Medline should be searched using OVID (if available within your Trust) or by using PubMed. PubMed Users Guides are available— See PubMed entry. Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher General MHRA—Medicines & Healthcare Regulatory Agency MHRA www.mhra.gov.uk Note. SPCs and PILs can be directly accessed via: http://www.mhra.gov.uk/spc-pil/index.htm MIMS Monthly Index of Medical Specialities Haymarket Medical Pubs. http://www.mims.co.uk/. Username and password required. NB. Access free to MICs (contact Regional Centre for details) Netdoctor Collaboration of UK and European healthcare professionals www.netdoctor.co.uk www.netdoctor.co.uk/medicines/ For information about drugs, search the “Medicines” section rather than the whole site. PubMed US National Library of Medicine and National Institutes of Health http://www.ncbi.nlm.nih.gov/pubmed Pubmed user guides are available for basic and MeSH searching. OTC Directory Proprietary Association of Great Britain Available in searchable form at www.medicinechestonline.co.uk. Use website drop down and selection criteria to access. UKMi UKMi www.ukmi.nhs.uk Some areas are password protected (contact Regional Centre for password) UKMi Discussion Group Ecompass (host) http://list.ecompass.nl/listserv/cgi-bin/wa?A0=MI-UK Adverse effects CHM—Commission on Human Medicines CHM/MHRA www.mhra.gov.uk/Committees/Medicinesadvisoryb odies/CommissiononHumanMedicines/index.htm. Drug Analysis Prints (DAPs) for Yellow Card data MHRA http://www.mhra.gov.uk/drug-analysis-prints/druganalysis-prints-a-z/index.htm INCHEM International Programme on Chemical Safety www.inchem.org/. Toxicology information on chemicals and drugs. TOXNET US National Library Medicine http://toxnet.nlm.nih.gov/. Toxicology information including pregnancy related toxicity information. Also links to LactMed (see below) for drugs in lactation information. G6PD website Associazione Italiana Favismo http://www.g6pd.org/. Associazione Italiana Favismo is affiliated with UNIAMO, Italian Federation for Rare Diseases, which is member of EURORDIS, European Organization for Rare Diseases. This site should not be used in isolation for g6pd queries; no single resource is comprehensive. This site contains lists of safe and unsafe drugs and also attempts to quantify risk (low vs. high). Date: June 2016 Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Availability IDIS World Medicines IDIS World Medicines www.idispharma.com Durbin PLC Durbin PLC www.durbin.co.uk Pro-file Database Guy’s and St Thomas’ Hospital NHS Trust Sourcing unlicensed ‘special’ medicines. www.profile.nhs.uk. Registration required. Complementary Medicine Memorial Sloan-Kettering Cancer Centre Integrative Medicine Service http://www.mskcc.org/cancer-care/integrativemedicine/about-herbs-botanicals-other-products Information for patients is also available Safety of Herbal Medicines MHRA www.mhra.gov.uk/Safetyinformation/Safetywarning salertsandrecalls/Safetywarningsandmessagesform edicines/Safetywarningsandmessagesforherbalmed icines/index.htm Q&A 11.7: Considerations when addressing questions about potential for adverse effects and drug interactions with homeopathic remedies UKMi Complementary Medicines Specialist Service http://www.medicinesresources.nhs.uk/GetDocume nt.aspx?pageId=781734 In the absence of good quality and unbiased resources within this field, this document contains the key information regarding the principles and considerations of homeopathic practice. Contraception and Hormone Replacement Therapy IPPF Directory of Hormonal Contraceptives International Planned Parenthood Federation http://contraceptive.ippf.org Registration required. Can be used to identify foreign contraceptive pills. Family Planning Association Family Planning Association www.fpa.org.uk Faculty of Family Planning and Reproductive Healthcare Royal College of Obstetricians and Gynaecologists www.ffprhc.org.uk/. Useful guidelines including choice of a contraceptive agent at different ages, in breast feeding, inflammatory bowel disease, interactions, missed pills and using pills outside their product licence, EHC and product reviews. Diagnostic tests Labtests online Collaboration of professional societies and supported by the Department of Health. www.labtestsonline.org.uk/. Patient orientated. Drug abuse Drug Misuse and Dependence— Guidelines on Clinical Management (The Orange Guide) National Treatment Agency www.nta.nhs.uk/uploads/clinical_guidelines_2007.p df DrugWise DrugWise http://www.drugwise.org.uk/ Date: June 2016 Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Drug abuse National Institute on Drug Abuse The National Institute on Drug Abuse (US) www.nida.nih.gov Talk to Frank DoH / Home Office www.talktoFrank.com Drug administration Intravenous Drug Administration Guides UKMi recommends all centres have access to good quality IV administration guidance. IMG—Injectable Medicines Guide (Medusa) Health of Wales Information Service http://medusa.wales.nhs.uk or www.injguide.nhs.uk. NB. Available free to contributing Trusts and all Trusts in Wales & N Ireland. Note also contains information on paediatric intravenous drug administration, intramuscular administration, and ocular injections. Stabilis Compiled by hospital pharmacists in France http://www.stabilis.org/ Compatibility and stability data to supplement other resources. Drug interactions HIV Drug Interactions The University of Liverpool www.hiv-druginteractions.org Hepatitis drug interactions The University of Liverpool www.hep-druginteractions.org CredibleMeds (QT prolongation) US education organisation AZCERT (renamed CredibleMeds in 2014) https://www.crediblemeds.org/ List drugs that prolong the QT Interval and/or induce Torsades de Pointes by risk category. Registration required. Medscape drug interaction checker Medscape www.medscape.com/druginfo/druginterchecker Registration required. Drugs.com interactions checker Cerner Multum http://www.drugs.com/drug_interactions.html To be used only after other approved sources have been used. Useful for information not readily available in UK sources. SuperCYP website (Cytochrome P450 database) Institute of Molecular Biology and Bioinformatics, Berlin http://bioinformatics.charite.de/supercyp/ Clinical significance of the interactions is not identified. Evidence Based Medicine Evidence Search—Health and Social care Date: June 2016 NICE www.evidence.nhs.uk. General search engine for evidence based reviews relevant to the NHS. Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Evidence Based Medicine Bandolier Pain Research Group Oxford The Cochrane Library The Cochrane Foundation John Wiley & Sons Medicines and Prescribing Centre NICE http://www.nice.org.uk/mpc/index.jsp New site following integration of the former National Prescribing Centre into NICE. NICE -National Institute for Health and Care Excellence NICE www.nice.org.uk CKS Clinical Knowledge Summaries NICE http://cks.nice.org.uk/ SIGN—Scottish Intercollegiate Guidelines Network SIGN www.sign.ac.uk WeMeRec Bulletins Welsh Medicines Resource Centre www.wemerec.org HTA assessments National Coordinating Centre for HTA www.hta.ac.uk/ Many of these evaluations inform NICE guidance. Centre for Reviews and Dissemination University of York www.york.ac.uk/inst/crd/ www.medicine.ox.ac.uk/bandolier N.B. It doesn’t look as if this site has been updated for some time. Still useful for explanations of terms e.g. NNT etc but do not use for evidence. http://www.cochranelibrary.com/ Infections The Green Book Immunisation Against Infectious Disease DoH https://www.gov.uk/government/organisations/publi c-health-england/series/immunisation-againstinfectious-disease-the-green-book NHS Immunisation Information Public Health England https://www.gov.uk/government/organisations/publi c-health-england/series/immunisation Public Health England Gov.uk https://www.gov.uk/government/organisations/publi c-health-england Replaces the Health Protection Agency site Lactation At least two resources should be used for all lactation enquiries. See also Resources for purchase list. LactMed US National Library of Medicine http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. UKMi Drugs in Lactation database Trent and West Midlands MIC UKMi www.ukmi.nhs.uk/ukdilas Legal and ethical Medicines, Ethics and Practice: A guide for pharmacists and pharmacy technicians Date: June 2016 RPS www.rpharms.com/law-and-ethics/medicinesethics-and-practice-guide.asp Only free to RPS members. Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Liver impairment LiverTox Specialist branches of NIDDK and NLM http://livertox.nlm.nih.gov/index.html This resource is a joint venture between the Liver Disease Research Branch of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Division of Specialized Information Services of the National Library of Medicine (NLM), National Institutes of Health New products NDO New Drugs Online UKMi www.ukmi.nhs.uk/applications/NDO/ Registration required (free). Also contains links to independent new medicines reviews. New medicines reviews UKMi/L(C)NDG UKMi/ L(C)NDG/ RDTC new medicines evaluations listed at http://www.ukmi.nhs.uk/activities/newProducts/defa ult.asp?pageRef=3 but available via www.evidence.nhs.uk NIHR Horizon Scanning Research and Intelligence Centre http://www.hsric.nihr.ac.uk/ Midlands Therapeutics and Review Advisory Committee (MTRAC) http://centreformedicinesoptimisation.co.uk/mtrac/c ommittee-recommendations Click on relevant alphabetical files to access ‘Commissioning support sheets’ for listed products. Tick box and download to access pdf document. Patents Database UKMi http://www.midlandsmedicines.nhs.uk/content.asp? section=5&subsection=9&pageIdx=1 UKMi username and password required Prescribing Outlook UKMi http://www.ukmi.nhs.uk/activities/newProducts/defa ult.asp?pageRef=12 Scottish medicines Consortium (SMC) reviews SMC www.scottishmedicines.org.uk/ All Wales Medicines Strategy Group (AWMSG) reviews AWMSG www.awmsg.org European Medicines Agency EMA www.ema.europa.eu Paediatrics BNF for Children Date: June 2016 BMA, RPSGB, RCPCH & NPPG (annual) One paper copy considered essential for each MI centre (published annually). Online access preferred as updated monthly. www.medicinescomplete.com/mc/bnfc/current/ Note: BNFC Legacy website remains available through medicinescomplete.com Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Paediatrics Paediatric Formulary Paediatric Formulary Committee The formulary is now hosted on: http://cms.ubqo.com/public/d2595446-ce3c-47ff9dcc-63167d9f4b80 Updates will happen monthly, rather than there being editions. The 9th edition (previously Guy’s Paediatric Formulary) may still be accessible, but this is not the official version and will no longer be updated. An App (currently only on iphone) is also available: http://www.ubqo.com/paediatricformulary Medicines for Children Partnership RCPCH, NPPG and WellChild. http://www.medicinesforchildren.org.uk/. Also contains patient information leaflets. Palliative care Palliative Adult Network Guidelines (PANG) Developed by a collaboration of UK Cancer networks http://book.pallcare.info/. Palliative Care Matters Network of Palliative Care healthcare professionals. http://m.pallcare.info Robert Twycross & Andrew Wilcock www.palliativedrugs.com Palliativedrugs.com (Palliative Care Formulary on-line) This should be used as a core resource in preference to the print version, but not the electronic version, of Palliative Care Formulary (see below). This is a mobile site (Smartphones and Tablets) but is also suitable for desktop access using the latest versions of Internet browsers. Use in preference to PANG for syringe driver compatibilities (Registration required), but the syringe driver tables are freely available using login (click on SDSD tab). Patient Information NHS Choices Gov.uk http://www.nhs.uk Patient UK Patient Information Publications/ Egton Medical Information Systems www.patient.co.uk. This site has useful healthcare professional pages (see Therapeutics section below). Pharmaceutical The Fridge Database Northwick Park MIC UKMi www.ukmi.nhs.uk/Secure/Fridge/Index.asp UKMi username and password required Medicines Compliance Aid (MCA) database Southwest Medicines Information UKMi http://www.ukmi.nhs.uk/applications/mca/ Date: June 2016 Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Pregnancy At least two resources should be used for all pregnancy enquiries. See also Resources for purchase list. TOXBASE UKTIS* UK Teratology Information Service www.toxbase.org Registration required. Monographs not suitable as patient information leaflets—see BUMPs. The summary information of the Toxbase monographs are openly available from http://www.uktis.org/ Royal College of Obstetrics and Gynaecology Royal College of Obstetrics and Gynaecology https://www.rcog.org.uk A range of guidelines on women’s health is available. BUMPS—Best use of medicines in pregnancy UKTIS www.medicinesinpregnancy.org. Produced by UKTIS. Provides information factsheets (containing essentially the same information as Toxbase) suitable for members of the public which can be used in discussion with a health care provider. Inclusion on this list does not endorse its use by patients without such support. Poisoning TOXBASE National Poisons Information Service (NPIS) www.toxbase.org Registration required. For acute poisoning or for complex cases, refer directly to the Poisons Information Service: 0344 892 0111. Before using the website, it is advisable to complete the e-learning modules available at www.toxlearning.co.uk Statistics Statistics in Divided Doses North West MIC UKMi www.ukmi.nhs.uk/activities/Research/default.asp?p ageRef=27 Therapeutics Patient UK Date: June 2016 Patient Information Publications / Egton Medical Information Systems www.patient.co.uk. After putting a term in the search box you will have a list of resources to choose from. Those with an apple and a plus sign are written for healthcare professionals and are an excellent resource with the following general headings: presentation, diagnosis, aetiology, epidemiology, assessment, management etc. Resources with Free Access For NHS MI Services Title URL and general notes Authors/ Publisher Therapeutics The Merck Manual of Diagnosis and Treatment Berkow, R et al Merck and Co. www.merckmanuals.com/professional/index.html. The latest edition can also be purchased as a hard copy. Some topics have also been written for patients. Dermnet New Zealand Dermatological Society www.dermnetnz.org/ A useful starting point for background information and advice for dermatological enquiries. Travel Malaria Reference Laboratory HPA (now part of Public Health England) www.malaria-reference.co.uk Travel Health Pro (NaTHNaC) National Travel Health Network and Centre/Public Health England http://travelhealthpro.org.uk/ The website is suitable for both healthcare professionals and travellers. Advice may differ from that in other sources (i.e. Travax, Fit for Travel). However, all advice is evidence based. It is advised that one resource only is used in these circumstances. Health Advice for Travellers NHS England http://www.nhs.uk/nhsengland/Healthcareabroad/pa ges/Healthcareabroad.aspx Fit for Travel Provided by NHS Scotland. www.fitfortravel.nhs.uk. Public access site for sister site Travax. This advice is based on that produced by NHS Scotland and may differ from advice in other sources (i.e. Travel Health Pro). However, all advice is evidence based. It is advised that one resource only is used in these circumstances. Wound management and dressings Dressings.org Date: June 2016 Surgical Materials Testing Laboratory www.dressings.org NB website last modified Nov 2011