Download Cancer attacks immune cells

Cancer attacks immune cells
A balance between cancer and anti-metastasis defense in the metastasis-target organs is
a key factor in the process of metastasis formation. HMGB1 is a bifunctional protein; a
chromatin component regulating transcriptional gene expression and DNA repair, and
an inflammatory cytokine worsening endotoxic shock. HMGB1 is released from nuclei
under chromatin histone acetylation or cell necrosis. In cancer cells, HMGB1 activates
its receptor, RAGE (receptor for advanced glycation end products), which is a
multifunctional membrane protein, to accelerate proliferation, motility, invasion,
angiogenesis, and metastasis. In macrophages and dendritic cells, HMGB1 induces
apoptosis at high concentration via JNK phosphorylation. HMGB1-induced apoptosis
inhibits macrophage infiltration into the tumors. HMGB1 also affects resident
macrophages in the lymph nodes and
liver. HMGB1 secreted from colon
cancer cells in the primary tumors
reaches the metastasis-target organs
via portal or lymphatic flow, and
suppresses the resident macrophages
to reduce resistance on cancer cell
embedding.
The
effect
of
cancer-derived cytokines on the
metastasis-target organs might be a
pivotal scenario in cancer metastasis.
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Sasahira T, Kirita T, Bhawal UK, Ikeda M, Nagasawa A, Yamamoto K, Kuniyasu H: The expression of
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Fujii K, Luo Y, Sasahira T, Denda A, Ohmori H, Kuniyasu H: Co-treatment with deoxycholic acid and
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Cell Prolif, in press.
Kusume A, Sasahira T, Luo Y, Isobe M, Nakagawa N, Tatsumoto N, Fujii K, Ohmori H, Kuniyasu H:
Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human
colon cancer. Pathobiol, in press.