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isothiazolinone (MI / MCI) effects in healthcare environments and links to contact dermatitis Susan Grant Principal Architect INV405 OCC485 – isothiazolinones in paints 2 2 Background •Query to IRIC regarding use of 2 methylizotihazolinone (MI) in paints. •Dermatology out-patient department at Hospital was redecorated. •Using common brand pure brilliant white paint. •Query on suitability / risk assessment of paint containing isotihazolinone, known to cause allergic reactions following contact, or airbourne, exposure ≤40 days after application. 3 3 What are isothiazolinone •Widely used powerful synthetic biocide, antimicrobial preservatives used to prevent bacterial overgrowth in aqueous solutions of cosmetic, household, & industrial products. •Stops mould growing on products. •Low cost, highly effective mould deterrent, even in low concentrations. • Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI), are most common. Often combined, but post 2005 MI used independently 4 4 MI / MCI applications •Extensive range of personal products, e.g. soap, cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens. Between 2000 -2010 use in personal care was doubled. •from 1970s household and industrial uses e.g. detergents, paint, glue, paper, fuel, water plant. •MI /MCI side effects include: skin/ membrane irritant, hypersensitivity via direct & airbourne contact; environmental toxicity, e.g. marine life •MI legally, “causing an epidemic of skin allergy” British Journal of Dermatology (BAD) Jun 2015 5 5 MI / MCI safety regulation •Following contact dermatitis (CD) outbreaks 1980’s EC regulated combined MI/ MCI to ≤15 ppm concentrations for use in cosmetics. •2005 EC Cosmetic Regulation MI ≤ 100 ppm. •2013 EC SCCS recommend MI leave-on ban; and ≤15 ppm for rinse-off cosmetic products •2016 EC public consultation, deadline: 1 July •Regarding non-cosmetic products, currently no limits are set on MI concentrations, not even the obligation to specify its presence. 6 6 MI / MCI challenges •Often difficult to pinpoint environmental source •Identifying MI/ MCI, as not listed on household/ industrial labels e.g. paints, glues, detergents. •What are safe levels in non-cosmetic uses? •How are high risk groups /spaces identified? •If banned, will preservative simply be replaced by another, different, more harmful biocides? •Following public concern, some companies are voluntarily moving away from MI/ MCI use. 7 7 Moving forward – isothiazolinone in paint etc •EU cosmetic proposals will limit sensitisation •Has no legal requirement for MI/ MCI labelling EU lobbied to classify MI as an allergen in CLP Regulation (Classification, Labelling & Packaging) •Has no legal MI/ MCI concentration limits •HSE contacted for their position... •Assessment of risk via a short life group •Raise NHSS awareness e.g. Estate Alert •COSHH/ CDM regs (Construction Design Management) 8 8