Download Table S1: DIANA-miRPath v2.0 identified significantly enriched

Table S1: DIANA-miRPath v2.0 identified significantly enriched pathways for upregulated miRNAs.
KEGG pathway
p-value
Prion diseases
Colorectal cancer
Pancreatic cancer
Glioma
Chronic myeloid leukemia
Melanoma
Bladder cancer
Pathways in cancer
Prostate cancer
Hepatitis B
HTLV-I infection
Small cell lung cancer
Non-small cell lung cancer
PI3K-Akt signaling pathway
Viral carcinogenesis
Cell cycle
Endometrial cancer
Acute myeloid leukemia
TGF-beta signaling pathway
Transcriptional misregulation in cancer
p53 signaling pathway
HIF-1 signaling pathway
Hepatitis C
Renal cell carcinoma
Focal adhesion
Epstein-Barr virus infection
Glycosaminoglycan biosynthesis - chondroitin sulfate
Thyroid cancer
ErbB signaling pathway
mTOR signaling pathway
VEGF signaling pathway
Measles
Fatty acid elongation
Toxoplasmosis
B cell receptor signaling pathway
Progesterone-mediated oocyte maturation
Herpes simplex infection
Wnt signaling pathway
0
0
0
0
0
0
0
0
0
0
2.22E-15
2.88E-13
2.95E-11
3.20E-11
2.83E-09
4.02E-09
9.49E-08
2.26E-07
4.01E-06
5.42E-06
9.63E-06
6.23E-05
7.72E-05
0.001471
0.002323
0.003873
0.007903
0.010042
0.010397
0.011079
0.024568
0.068133
0.096564
0.172572
0.174819
0.222301
0.317898
0.340238
#genes #miRNAs
1
11
13
10
24
20
17
70
28
41
53
26
18
23
18
29
14
18
19
14
8
6
29
5
32
13
4
6
16
3
15
11
6
23
6
17
11
8
1
8
12
11
11
12
12
13
13
16
11
9
14
6
8
10
8
8
6
8
7
6
6
4
6
6
1
6
4
4
4
3
1
5
3
1
4
3
Insulin signaling pathway
Endocytosis
Osteoclast differentiation
Neurotrophin signaling pathway
Adipocytokine signaling pathway
MAPK signaling pathway
Fatty acid metabolism
T cell receptor signaling pathway
Influenza A
Phosphatidylinositol signaling system
Jak-STAT signaling pathway
Tight junction
Rheumatoid arthritis
Apoptosis
Adherens junction
Endocrine and other factor-regulated calcium reabsorption
Tuberculosis
GnRH signaling pathway
Fc epsilon RI signaling pathway
Chagas disease (American trypanosomiasis)
Vasopressin-regulated water reabsorption
Chemokine signaling pathway
NOD-like receptor signaling pathway
Huntington's disease
Toll-like receptor signaling pathway
Shigellosis
Circadian rhythm
Inositol phosphate metabolism
Natural killer cell mediated cytotoxicity
Cell adhesion molecules (CAMs)
Long-term potentiation
Regulation of actin cytoskeleton
Cholinergic synapse
NF-kappa B signaling pathway
Axon guidance
Melanogenesis
Pathogenic Escherichia coli infection
Leishmaniasis
Dopaminergic synapse
Amphetamine addiction
Spliceosome
0.350084
0.351602
0.373191
0.431142
0.704691
0.737876
0.75925
0.7797
0.813065
0.84776
0.856815
0.90979
0.911044
0.914372
0.941269
0.941933
0.950009
0.964068
0.968218
0.975783
0.97646
0.982372
0.984084
0.987469
0.988231
0.990715
0.991189
0.99213
0.992563
0.993364
0.99431
0.994743
0.995534
0.995655
0.995911
0.996039
0.997809
0.998154
0.998583
0.99869
0.999018
8
13
8
20
1
1
9
5
5
1
4
2
2
3
15
1
1
14
10
3
6
1
13
1
5
12
3
1
1
1
1
1
1
4
18
3
12
3
1
2
6
4
4
4
2
1
1
1
3
3
2
2
2
2
1
2
1
1
1
1
1
2
1
2
1
2
2
2
1
1
1
1
1
1
2
2
1
2
2
1
2
2
Salmonella infection
Gap junction
Cytokine-cytokine receptor interaction
ECM-receptor interaction
mRNA surveillance pathway
Notch signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Fc gamma R-mediated phagocytosis
Dorso-ventral axis formation
Malaria
Amyotrophic lateral sclerosis (ALS)
RNA degradation
Viral myocarditis
Hedgehog signaling pathway
Oocyte meiosis
Aldosterone-regulated sodium reabsorption
Bacterial invasion of epithelial cells
African trypanosomiasis
Steroid biosynthesis
RIG-I-like receptor signaling pathway
Leukocyte transendothelial migration
Basal cell carcinoma
Amoebiasis
Terpenoid backbone biosynthesis
Alcoholism
Lysine degradation
Vascular smooth muscle contraction
Staphylococcus aureus infection
Pentose and glucuronate interconversions
Primary bile acid biosynthesis
Pentose phosphate pathway
Synthesis and degradation of ketone bodies
Valine, leucine and isoleucine degradation
Amino sugar and nucleotide sugar metabolism
Glycosaminoglycan biosynthesis - keratan sulfate
Ether lipid metabolism
Sphingolipid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
PPAR signaling pathway
Mismatch repair
0.999284
0.999371
0.99966
0.999689
0.999691
0.999791
0.999809
0.999817
0.999851
0.999885
0.99991
0.99991
0.999917
0.999926
0.999948
0.999951
0.999961
0.999969
0.99997
0.999982
0.999993
0.999995
0.999995
0.999997
0.999997
0.999998
0.999998
1
1
1
1
1
1
1
1
1
1
1
1
1
1
15
14
5
11
5
3
12
2
1
1
1
4
3
2
4
2
14
2
4
2
1
2
14
5
1
2
1
1
2
1
6
1
8
2
3
1
8
2
2
1
1
1
1
1
2
2
2
2
2
2
1
1
1
2
1
2
3
1
2
1
1
1
2
1
1
1
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Homologous recombination
SNARE interactions in vesicular transport
Phagosome
Peroxisome
Antigen processing and presentation
Cytosolic DNA-sensing pathway
Intestinal immune network for IgA production
Type II diabetes mellitus
Legionellosis
Allograft rejection
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
1
1
1
1
1
1
1
1
1
1
1
1
7
2
1
1
2
1
1
2
1
8
1
1
1
1
1
1
1
1
1
1
1