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College of Veterinary Medicine Extramural Funding February 2011 Glenn Songer (PI) Moleular Epidemiology of Clostridium Difficile Food Contamination: Links to Human CDI Sponsor: Department of Agriculture, NIFA, $1,250,000 Glenn Songer (PI) Monoclonal Immunoprotectants for Select Agents Toxins (MAB-SAT) Sponsor: MAPP Biopharmaceuticals, $551,000 Scott Hurd (Co-PI) Subagreement for Building Functional Biosafety Systems Sponsor: International Food Policy Research Institute, $149,864 Diana Peterson (PI) Amygdalar Modulation of Processing Auditory Cortex Sponsor: National Institutes of Health, $133,200 Eldon Uhlenhopp (PI) Serbia Animal Health Technical Assistance Sponsor: Department of Agriculture, FAS, $100,748 Derald Holtkamp (PI), Butch Baker, Jim McKean, Jeff Zimmerman (Co-PIs) Development of a Model for Regional Control and Elimination of PRRS Virus in Iowa Sponsor: Iowa Pork Producers Association, $94,000 Christine Petersen (PI), Doug Jones (Co-PI) Leishmania Antigens Defined by Human Immune Responses Sponsor: Infectious Disease Research Institute, $73,828 Dusan Palic (PI), Eric Rowe, Jim Roth, Kayoko Kimura, Darin Madson, Jim Noxon, Elizabeth May (CoPIs) Effects of Epicor on Immune Response, Safety and Welfare of Dogs Sponsor: VETCARA, $59,068 Dusan Palic (PI), Kayoko Kimura, Jim Roth (Co-PIs) Immunomodulatory effects of Glucan Compounds Produced by Kitozyme Sponsor: Kitozyme, $52,383 Jim Roth (PI) FAZD Center Detailed Work Plans for Fiscal Years 2011 (Year 1) Create and Demonstrate the Secure Egg Supply “Component” to the FAZD Dashboard Sponsor: Texas A&M University, $37,000 Jesse Hostetter (PI), Doug Jones (Co-PI) Use of an Implantable Device for In Vivo Detection Mycobacterium Avium Paratuberculosis (MAP) in Asymptomatic Calves Sponsor: Iowa Veterinary Medical Association, $25,000 March 2011 Michael Wannemuehler, Kyoung-Jin Yoon, (Co-PIs) Exercise-Induced Immunomodulation in the Aged Mechanisms Sponsor: National Institutes of Health, $448,673 Jim Roth (PI), Danelle Bickett-Weddle (Co-PI) Creating Printed Manuals of Training Modules and PowerPoints with Speaker Notes for Renewal Training for the USDA-APHIS National Veterinary Accreditation Program Sponsor: Department of Agriculture, APHIS, $51,700 Greg Phillips (PI) Summer Research Training of Veterinary Students Sponsor: National Institutes of Health, $34,263 Jim West (PI) Susceptibility of Cattle with the E211K PRNP Allele to BSE Sponsor: Department of Agriculture, ARS, $25,000 Lisa Nolan (PI) Animal Health and Disease Research Sponsor: Department of Agriculture, NIFA, $23,560 April 2011 Michael Cho (PI) Characterization of Immunogenic and Structural Properties of HIV-1 Envelope Sponsor: National Institutes of Health, $863, 591 Locke Karriker, Suzanne Millman (Co-PIs) Developing Validated and Objective Industry-Ready Tools to Assess Joint Pain Manifestation and Lameness in the Sow Sponsor: Department of Agriculture, NIFA, $700,000 Suzanne Millman, Darrell Trampel (Co-PIs) Assessment of Alternative Production Systems for Laying Hens to Safeguard Animal Welfare and Sustainable Egg Supply Sponsor: Department of Agriculture, NIFA, $430,648 Derald Holtkamp (PI) A Cross-Sectional Study of PRRSV Positive Swine Breeding Herd Sites to Evaluate Associations Between Risk Factors and a Case Definition-Based Number and Severity of Clinical PRRS Episodes (Continuation) Sponsor: Boehringer Ingelheim Vetmedica, $162,036 Dusan Palic (PI), Kayoko Kimura, Jim Roth (Co-PIs) Immunomodulatory Screening of Yeast Compounds Produced by Kitozme (Phase II: Rapid In Vivo Screening of the Selected Compounds Using Effects of Dietary Application on Neutrophil Function in Research Sponsor: Kitozme, $95,448 Dusan Palic, Kayoko Kimura (Co-PIs) Influence of Trace Mineral Status on Immune Function of Beef Cattle Sponsor: Multimin, USA, $48, 945 Patrick Gorden (PI), Leo Timms (Co-PI) Randomized Non-Inferiority Clinical Trail Evaluating Three Commercial Dry Cow Mastitis Preparations Sponsor: University of Minnesota, $43,540 Derald Holtkamp (PI), Butch Baker, Jim McKean, Jeff Zimmerman (Co-PIs) Development of a Model for Regional Control and Elimination of PRRS Virus in Iowa Sponsor: Kansas State University, $31,250 Suzanne Millman (Co-PI) A Comprehensive Assessment of Aviary Laying-Hen Housing System for Egg Production in the Midwest: Aerial Emissions, Bioenergetics, Energy Use, Hen Welfare, Microbiological Quality, Indoor Environment Sponsor: Iowa Egg Council, $30,000 Lisa Nolan (PI) Research Support Agreement Sponsor: Department of Agriculture, ARS, $6,480 Darin Madson (PI), Locke Karriker (Co-PI) Maximizing the Value of Diagnostic Submissions-A Novel Web-Based Instructional Module for Veterinary Students Nationwide Sponsor: American Association of Swine Veterinarians Foundation, $6,000 Doug Jones (PI) Immune Responsive Vaccine Delivery Device Sponsor: Morris Animal Foundation, $4,000 Jessie Trujillo (PI) An Epidemiological Study of Mycoplasma Species Occurring in Cats from Shelters and Households Utilizing a Novel Pan-Myco RealTime PCR Detection and Differentiation Assay Sponsor: Morris Animal Foundation, $4,000 Claudia Baldwin (PI) Assessment of Cost-Effectiveness of Oral and Systemic Topical Anti-Flea Medication Use in Animal Shelters Sponsor: Morris Animal Foundation, $4,000 Christine Petersen (PI) Disease Surveillance, Reduction and Prevention in Animal Shelters Sponsor: Morris Animal Foundation, $4,000 Brett Sponseller (PI) Analysis of Changes in Macrophage Function and Cytokine Milieu in Foals from Birth to Maturity Sponsor: Morris Animal Foundation, $4,000 Claire Andreasen (PI) Research Support Agreement Sponsor: Department of Agriculture, ARS, $2,278 Suzanne Millman (PI) An Investigation of the Behavioral Needs of Dogs Housed at Animal Shelters Due to Cruelty/Neglect Versus Owner Relinquishment Sponsor: Morris Animal Foundation, $2,000 May 2011 Michael Kimber (PI) Cholinergic Receptors as Targets for Accelerated Anthelmintic Drug Discovery Sponsor: National Institutes of Health, $331,231 Qijing Zhang (PI) MRCE for Biodefense and Emerging Infections Diseases- Career Development Project Sponsor: Washington University, $93,706 Mark Ackermann (PI) Optimization of the Ovine Model of RSV Disease: Effects of Colostrum-Deprivation and Intratracheal Inoculation in RSV Memphis 37 Strain Disease Severity Sponsor: Gilead Sciences, Inc., $41,456 Erin Strait (PI) Pre-Licensing Laboratory Setting Study: Evaluation of Repeatability, Ruggedness, and Suitability of a Proposed New Mycoplasma Hyopneumoniae Diagnostic Test: “M. Hyopneumoniae DNA First Test” Kit Sponsor: Veterinary Resources, Inc., $10,262