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ONCOLOGY DEVELOPMENT PIPELINE PROGRAM DESCRIPTION DEVELOPMENT RIGHTS DISEASE(S) UNDER INVESTIGATION CD30 Antibody Drug Conjugate Global†‡ Hodgkin Lymphoma, Cutaneous T-Cell Lymphoma, Mature T-Cell Lymphoma VECTIBIX® Anti-EGFR Antibody Japan Only Colorectal Cancer LEUPLIN® LH-RH Agonist Japan Only Prostate Cancer, Breast Cancer, new formulation NINLARO® Proteasome Inhibitor Global Multiple Myeloma, Amyloidosis TAK-228 TORC1/TORC2 Inhibitor Global Breast Cancer, Renal Cell Carcinoma, Endometrial Cancer PEVONEDISTAT Nedd8-Activating Enzyme Inhibitor Global High-Risk Myelodysplastic Syndrome, Acute Myelogenous Leukemia TAK-659 SYK/FLT-3 Kinase Inhibitor Global Lymphoma, Acute Myelogenous Leukemia Solid Tumors TAK-117 PI3K Alpha Inhibitor Global Non-Small Cell Lung Cancer TAK-580 Pan-Raf Kinase Inhibitor Global Solid Tumors TAK-243 UAE Inhibitor Global Solid Tumors TAK-931 CDC7 Inhibitor Global Solid Tumors XMT-1522 HER2 Dolaflexin ADC Ex-US, Ex-Canada* Breast Cancer ADCETRIS® (brentuximab vedotin) †‡ (panitumumab)† (Leuprorelin acetate) (ixazomib) ‡ADCETRIS® is co-developed by Takeda and Seattle Genetics, Inc. †In-Licensed * XMT-1522 is co-developed by Takeda and Mersana Therapeutics All registered trademarks are the sole property of their respective owners. Last updated 10/20/2016 OMS/ONC/15/0015(4) PHASE 1 PHASE 2 PHASE 3