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Overview of the flow of nitrogen in the biosphere. Nitrogen, nitrites, and nitrates are acted upon by bacteria (nitrogen fixation) and plants and we assimilate these compounds as protein in our diets. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. Reproduced with permission of the medical biochemistry page, LLC. Source: Nitrogen: Nitrogen Homeostasis and Disposal via Urea, Integrative Medical Biochemistry Examination and Board Review Citation: King MW. Integrative Medical Biochemistry Examination and Board Review; 2014 Available at: http://mhmedical.com/ Accessed: May 13, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved