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The Immune System Part 3 What Could Go Wrong? A. Immune Deficiency Disorder B. Hypersensitivity Disorder C. Autoimmune Disorder D. Immunoproliferative Disorder Hypersensitivity Reactions While it is clear that immune responses serve as a protective and adaptive function, they may also prove to be damaging to the host tissue. Hypersensitivity •Body finds pollen or other substances antigenic triggering antibody production •Antigen/antibody complexing occurs on mast cells •Mast cells release histamines that cause allergies •Histamines trigger inflammation due to antigen and/or antibody complexing Hypersensitivity Treatment for Allergies 1. Environmental Control 2. Food elimination diet 3. Steroids 4. Antihistamines 5. Immunotherapy I. Type I- Anaphalactic Reactions (Atopic*) Allergens 1. Inhaled 2. Ingested- food & drugs 3. Skin Contact Outcomes (may be localized or generalized) 1. Allergic Rhinitis 2. Asthma 3. Atopic Dermatitis Treatment (avoidance of allergen) 1. Immunotherapy 2. Antihistamines 3. Corticosteroids Anaphylaxis (generalized) 1. Signs 2. Examples a. Drugs (penicillin) reactions b. Insect bites c. Treatment More Atopic Conditions Condition Urticaria-angioedema Commonly Associated Allergens Insect bites Food allergies Gastrointestinal Allergy Food Allergy (cereals, milk, eggs, shellfish, fruit) Drug hypersensitivities Serum sickness syndrome Drugs, especially penicillin Atopic Conditions Condition Anaphylaxis Commonly Associated Allergens Heterologous antisera Vaccines Iodinated radiographic material Allergic rhinitis Inhalants (spores, pollens, animal dander) Extrinsic asthma Mold spores Atopic or Allergic Reactions Autoimmunity - Auto allergy Diseases that result from antibodies or immune cells produces by the host that react with some of the host’s own antigens. May be in serum or a particular cell type Autoimmune Disorders The body cannot distinguish between self and nonself external factors The body begins to destroy itself The body begins to produce antibodies against it’s own normal cells The disorders are destructive with little treatment Women are more susceptible Examples: 1. Multiple Sclerosis--Attacks lining of CNS 2. Type I Diabetes--Attacks Beta cells 3. Systemic Lupus--Attacks DNA, body kills itself Organ Specific Multiple Sclerosis •150,000 in the U. S. •Appears as a genetic & environmental determiner •Demyelinization of the sheath of CNS nerves Organ Specific Myasthenia Gravis Breakdown of conduction @ neuromuscular junction 85% of victims show anti-acetylcholine-receptor antibodies (Incidence) = 5 / 100,000 (F) = 30 yr olds (M) = 70 yr olds 1. Clinical Features 2. Pathogenesis 3. Treatment 4. Prognosis Generalized • Rheumatoid Arthritis • Scleroderma • Systemic Lupus