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Abstract
Bone morphogenetic proteins (BMPs) do diverse and important roles in
proliferation and differentiation of adult stem cells in our tissues. Especially,
BMPs are well known to be main inducers of bone formation by facilitating
both proliferation and differentiation of bone stem cells. Interestingly, in
skin stem cells, BMPs repress their proliferation but are indispensable for
the proper differentiation into several lineages of skin cells. Here, we tested
whether BMP antagonists have an effect on prevention of wrinkle formation.
For this study we used in vivo wrinkle-induced mouse model. In this
experiment, we have found that bone morphogenetic protein receptor 1a
extracellular domain (BMPR1a-ECD) made a great anti-wrinkle effect, 6fold better than retinoic acid, which is generally used as a positive control
for anti-wrinkle activity. Our results indicate that BMP antagonists will be
good targets for skin or hair diseases.