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Edythe D. London, Ph.D.
CURRICULUM VITAE
Personal:
Born: Rome, Italy
Citizenship: U.S.A
Address:
Semel Institute on Neuroscinece and Human Behavior, UCLA
760 Westwood Plaza, Room C8-528
Los Angeles, CA 90024-7085
Telephone:
310-825-0606 (voice), 310-825-0812 (facsimile)
Education:
The George Washington University
Major in zoology, minor in chemistry
Bachelor of Science, 1969
Towson University
Master of Science (Biological Sciences), 1973
University of Maryland
Pharmacology, supporting program in Neurobiology
Doctor of Philosophy, 1976
Present Position:
Since July 2001: Professor, Department of Psychiatry & Biobehavioral Sciences and
Department of Molecular & Medical Pharmacology
David Geffen School of Medicine, UCLA
Previous Academic Appointments:
Jan 1987 - Jun 1999:
Adjunct Professor, Dept. Pharmacology and Experimental Therapeutics,
Graduate Faculty (March 1996-June 1999), Univ. Maryland School of Medicine
Mar 1987 - Feb 2000: Associate Professor of Radiology, Part-time. Department of Radiology,
School of Medicine, Johns Hopkins University
Sep 1998 – Jun 2001:
Visiting Professor, Department of Psychiatry & Biobehavioral Sciences
Neuropsychiatric Institute, School of Medicine, UCLA
Previous Positions:
Jan 1979 - Feb 1980:
Feb 1980 - Dec 1981:
Dec 1981 - Sep 1982:
Sep 1982 - Aug 1984:
Aug 1984 - Jul 1985:
July 1985 - June 1992:
June 1992 - July 1999:
July 1999 - June 2001:
Staff Fellow, Lab. Neuroscience, Gerontology Res. Ctr., NIA
Sr. Staff Fellow, Lab. Neuroscience, Gerontology Res. Center, NIA
Pharmacologist, Lab. Neuroscience, Gerontology Res. Center, NIA
Pharmacologist, Clin. Pharmacol. Branch, Addiction Res. Center, NIDA
Acting Chief, Neuroscience Branch, Addiction Research Center, NIDA
Chief, Neuropharmacology Lab., Addiction Research Center, NIDA
Chief, Brain Imaging Section, NIDA
Research Pharmacologist, NIDA (at UCLA, Interagency Personnel Agreement)
Curriculum Vitae - Edythe D. London, Ph.D.
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Research Experience:
Oct 1976 - Dec. 1978: Characterized kainic acid subtype of glutamate receptors; tested an animal model
for Huntington's disease. Johns Hopkins Sch. Medicine, Dept. Pharmacology & Exp. Therapeutics.
Jan 1979 - Sept 1982: Established new research program on neurochemistry of aging and dementia.
Gerontology Res. Center, NIA.
Sep 1982 – Jul 1999: Established integrated research program on neurobiology of drug abuse, built new
brain imaging center. Intramural Research Program, NIDA.
Jul 1999 – present: Studies on the neurobiology of substance abuse, using and refining imaging tools to
assess cerebral abnormalities in stimulant and tobacco users, focus on the neurobiology of inhibitory
control and relevant endophenotypes. Semel Inst. for Neuroscience and Human Behavior, UCLA.
Consultation in 2005, 2006: Eli Lilly Corp. (Indiannapolis, IN); Beth Israel Hospital NY (New York,
NY); Duke University Ctr. for Nicotine & Smoking Cessation Research; Mt. Sinai College of Medicine.
Previous Consultation: Immulogic Corp. (Cambridge, MA), Pharmaceutical Peptides, Inc. (Cambridge,
MA), Dupont Merck (Wilmington, DE), Merck (Harlow, Essex, UK), Searle Pharmaceutical Corp.
(Skokie, IL), Friends Research Institute, Inc. (Los Angeles, CA); Abbott Laboratories (Abbott Park, IL);
Pharmacia –Upjohn Corp. (Kalamazoo, MI).
Honors and Awards:
Abegail Anne Brown - Henry Kirk White Scholarship, George Washington University, 1966-1967
Research Fellowship, Dept. Pediatric Res., Univ. of Maryland School of Medicine, summer 1967
Friendship Business and Professional Women's Scholarship, 1967-1968, 1968-1969
George Washington University Board of Trustees Scholarship, 1968-1970
Emerson Fellowship, Dept. Pharmacol. & Toxicol., Univ. Maryland, School of Pharmacy, 1974 - 1976
Rho Chi Pharmaceutical Honorary Society, elected 1975
National Institute on Mental Health Postdoctoral Fellowship, 1976 to 1978
Mathilde Solowey Lecture Award in the Neurosciences, 1987
ADAMHA Administrator's Award for Equal Employment Opportunity Achievement, 1988
NIDA Director's Award for Significant Achievement, presented for outstanding efforts in public
education about NIDA’s program on drug effects on the brain. July 1990.
Dean's Recognition Award to Outstanding Alumna, Towson Univ., 1996
NIDA Director’s Merit Award: Developing a Radiotracer for Nicotinic Acetylcholine Receptors, Oct
1998.
Membership and service in Professional Societies:
American College of Neuropsychopharmacology (Member since 1989, Fellow since 2001)
Credentials Committee (2004), Program Committee (2004-2006)
College on Problems of Drug Dependence (Member 1997, Fellow 2000, Board of Directors (1997-2001);
Credentials Committee (2000-2001); Progranm Committee (2003 – 2006)
American Society for Pharmacology and Experimental Therapeutics
International Soc. of Cerebral Blood Flow & Metabolism (Founder member)
Society for Research on Nicotine and Tobacco (Member since 1995)
American Society for Neurochemistry (1982 - 1997)
Society for Neuroscience (Member since 1976)
American Association for the Advancement of Science
Mid-Atlantic Acetylcholine Discussion Group, (Co-chair, 1979-1982)
International Society for Pain and Chemical Dependency, International Advisory Board (2003; 2004)
Curriculum Vitae - Edythe D. London, Ph.D.
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Patents:
Inhibitors of nitric oxide synthase (NOS) and their use to prevent glutamate neurotoxicity.
Patent #07,881,900, VL Dawson, TM Dawson, ED London, DS Bredt, and SH Snyder.
Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase.
Patent # 5,225,440, ED London and AS Kimes. Filed: May 12, 1992. Awarded: Jul 6, 1997
A method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled
pyridyl-7-azabicyclo [2.2.1] heptanes. Patent # 5,726,189, ED London, AS Kimes, A Horti, RF
Dannals, and M Kassiou. Awarded: Mar 10, 1998
Radiolabeled pyridyl-7-azabicyclo [2.2.1]heptanes.
Patent #5,969,144, ED London, AS Kimes, A Horti, RF Dannals, M Kassiou. Awarded: Oct 19,
1999 (divisional – see Patent # 5,726,189).
Funding Received:
Effects of Hydergine® on Cerebral Glucose Utilization. Sandoz, Ltd., $40,000; Mar 1983 - Jun 1985.
ED London, Principal investigator.
Effects of Opioid Agonist and Antagonist Drugs on Local Cerebral Glucose Utilization. E.I. Dupont De
Nemours & Co., $24,006; Jul 1984 - Jun 1985. ED London, Principal investigator.
Effects of CL220, 075 on Local Cerebral Glucose Utilization. American Cyanamid Co., Medical
Research Division, $4,200; Sept 1985 - Nov 1985. ED London, Principal investigator.
Effects of Hydergine® on Hippocampal Glucose Utilization Following Septal Lesions. Sandoz, Ltd.,
$29,400; May 1986 - Apr 1987. ED London, Principal investigator.
In Vivo Studies of Nicotinic Cholinergic Receptors in Human Brain. The Council for Tobacco ResearchUSA, Inc., $300,000; Jan 1988 - Dec 1990. ED London, Co-principal investigator.
Development of a Positron Emission Tomography Facility for Studies of Substance Abuse. Office of
National Drug Control Policy, Executive Office of the President, $5,982,000; 1993.
ED London, Principal investigator.
Cocaine Withdrawal: Human Laboratory Studies. National Institute on Drug Abuse, $585,243; Dec
1995 – Nov 2000. S. Walsh, Principal investigator (Dept. Psychiatry & Behav. Sci., Behav.
Pharmacol. Res. Unit, Johns Hopkins Univ., Balt., MD), ED London, Collaborator.
Neuroanatomical Substrates of Nicotine Addiction. National Institute on Drug Abuse. $2,058,535; Dec
1997 - Nov 2002. JE Rose, Principal investigator (Dept. Psychiatry, Duke Univ. Medical Ctr.,
Durham Veterans Affairs Medical Ctr., Durham, NC), ED London, Co-investigator.
Craving in Drug Abuse and Treatment. National Institute on Drug Abuse. $2,972,020; Mar 1997 - Feb
2002. DF Wong, Principal investigator (Dept. Radiol., Johns Hopkins School of Medicine and
Environmental Health Sciences, Baltimore, MD), ED London, Co-investigator.
Brain Imaging Studies of Dopamine and Serotonin Systems in Methamphetamine Abusers: Therapeutic
Implications. NIDA contract. $4,000,000; 1997 - 2000. W Ling, PI, ED London, Co-PI.
Effect of MMT on rCMRglc in Opiate Dependent Patients. NIDA: $966,445; Sept 1998 - Sept 2002. II
Galynker, PI (Dept. Psychiatry, Beth Israel Med. Ctr., New York, NY), ED London, Co-investigator.
Cocaine Abuse & Limbic Prefrontal Function. NIDA: $1,200,771; Apr 1997 - Mar 2002. KI Bolla,
Ph.D., Principal investigator (Johns Hopkins Sch. Med., Balto., MD), ED London, Co-investigator.
Mechanisms of Regulation of Cerebral Blood Flow. NINDS: Dec, 1997 – Nov, 2002. JR Kirsch,
Principal investigator (Johns Hopkins Sch. Med., Balto., MD), ED London, Co-investigator.
Tobacco Dependence and Risk Factors for Treatment Failure. NCI: $8,490,103, Oct 1999-2004. SS
O’Malley, PI (Yale Univ. & West Haven VAMC, New Haven, CT). ED London, Co- Investigator.
Enabling Technologies in fMRI and Nicotine Smoking. National Inst. Drug Abuse, NIH: $150,000, July
2000-2002. MS Cohen, Principal Investigator (UCLA, Los Angeles, CA). ED London, CoInvestigator.
Nicotine Withdrawal, Smoking & Cognition: an fMRI Study. National Inst. on Drug Abuse: $1,056,789,
Sept 2001 – Apr 2005. ED London, Principal Investigator.
Curriculum Vitae - Edythe D. London, Ph.D.
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Nicotine Withdrawal, Smoking & Attention: an fMRI Study. Tobacco Related Disease Research
Program: $475,303, July 2001 – Jun 2005. ED London, Principal Investigator.
Nicotine Withdrawal, Smoking & Cognition: an fMRI Study. Philip Morris External Research Program:
$713,367, Feb 2002 – Jan 2005. ED London, Principal Investigator.
PET Combined with Stereotactic Probes to Develop Therapeutic Interventions for Drug Abuse, Office of
National Drug Control Policy, Executive Office of the President, $3,730,503 total cost; Jun 2000 –
Jun 2006. ED London, Principal investigator.
Early Methamphetamine Abstinence: fMRI and Cognition. National Inst. on Drug Abuse: $1,182,287,
July 2003 – April 2006. ED London, Principal Investigator.
Neural Systems, Inhibitory Control, and Methamphetamine Dependence. National Inst. on Drug Abuse:
$1,262,898, Sept. 2005 – August 2009. ED London, Principal Investigator.
Methamphetamine Abuse and Inhibitory Control: Implications for Treatment. National Inst. on Drug
Abuse: $3,350,476, Sept. 2006 – August 2010. ED London, Principal Investigator.
Public, Professional and Community Service:
Grant Review:
National Science Foundation, 1981-1982.
Medical Research Council of Canada, 1985.
Extramural Research Program of NIDA, 1987.
Special Review Committee, NIDA, June, 1989.
Initial Review Group, NIDA, June, 1989.
Veterans Administration, October, 1990.
National Science Foundation, November, 1990.
Nuclear Medicine Research Program, Dept. of Energy, May, 1992.
Special Review Committee, NIDA, August, 1992.
Tobacco-Related Disease Program, University of California, May, 1994, 1997, 1999.
Program Merit Review for Department of Veterans' Affairs, 1996, 1997.
NIDA Transdisciplinary Prevention Research Centers, 2003
National Cancer Institute (NCI) Small Animal Imaging Resource Program, March, 2004
NCI Review Group: ZCA1 SRRB-C (M1), 2003
NIDA Scientific Review Group (NIDA-L-2). February, 2005
NIH Center for Scientific Review, Biomedical Imaging, Shared Instrumentation Grants. June, 2005.
Other Service to the Academic Community:
Judge, Arthur Flemming Awards, given by Downtown Jaycees, Wash. DC (1989, 1990).
Chair, Advisory Panel on Demand Reduction, Office of National Drug Control Policy, 1994.
Alumni Advisory Board, College of Natural & Math. Sciences, Towson State. Univ., 1994 - 1999.
Editorial Advisory Boards:
Neurobiology of Aging, January 1982 – December, 1993
American Journal of Drug & Alcohol Abuse, January, 1987 – present
Experimental Neurology, October 1990 – January, 1996
Neuropsychopharmacology, July 1999 – June, 2002
Synapse, January 1999 – present
Ad hoc reviewer: Am. J. Psychiatry, Arch. Gen. Psychiatry, Biol. Psychiatry, Brain Res. Bull., Clin.
Pharmacol. Ther., CNS Spectrums/CNS Drug Revs, Drug Alc. Depend., Exp. Neurol., Eur. J. J.
Neurosci., J. Cereb. Blood Flow Metab., J. Electron Microscopy Techs. (1984-1991), J. Gerontol., J.
Neurochem., J. Neurosci., J. Nuclear Med., J. Pharmacol. Exp. Ther., Life Sci., Molecular Psychiatry,
NeuroImage, Neuropsychopharmacology, Ncotine And Tobacco Research, Proc. Natl. Acad. Sci., Proc.
Soc. Exp. Biol. Med., Psychopharmacology, Trends in Cognitive Sciences; Trends Pharmacol. Sci.
Curriculum Vitae - Edythe D. London, Ph.D.
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Service on Government and University Committees:
Animal Care Advisory Comm., Gerontology Research Ctr., NIA (1980–1982), Chair (1982-1986).
Radiation Safety Comm., Francis Scott Key Med. Ctr., Johns Hopkins Sch. Medicine (1988-1991).
Women’s Advisory Committee, NIDA (1990 – 1991).
Streamlining Workshop, NIDA (1995).
Tenure Track Recruitment Committee, NIMH (1996 – 1997).
Animal Care and Use Committee, NIDA (1996 – 1997).
Tenure and Promotions Committee, Gerontology Research Center, NIA (1982 – 1999).
Chair, Promotions and Incentives Committee, NIDA (1995 – 1999).
Central Tenure Committee, NIH (1996 – 1999).
Institutional Review Board, UCLA (July 1, 2000 – June 30, 2001).
University Senate and Committees for Advancement and Promotion (2002 – 2003).
Ad Hoc Committee Member or Chair, UCLA Dept. Psychiatry & Biobehav. Sci. (1999 – present)
Proposal Evaluation Board for CTAC/ONDCP (2001 – 2003).
Invited Lectures and Participation in Scientific Meetings:
Mid-Atlantic Acetylcholine Discussion Group "Cholinergic Involvement in Alzheimer's Disease", May
23, 1980, Cornell Medical College, New York, NY. Co-chair, organizer.
European Atherosclerosis Group, May 26-27, 1981, Padova, Italy. "Cerebral Glucose Utilization During
Aging of the Rat & Dog: Implications for Brain Metabolism in Man During Aging & Dementia."
Chaired discussion, “Aging and the Brain".
Mid-Atlantic Acetylcholine Disc. Grp, Co-chair, "How Does One Assess Cholinergic Function In Vivo"?
Jun 17, 1981, Gerontol. Res. Ctr., Balto., MD. Lecture "Cerebral Metabolic Responses to the
Muscarinic Agonist Oxotremorine."
Gordon Research Conference, "Biology of Aging", Feb 1982, Ventura, CA. "Age-Related Increase in
Vmax for Choline Acetyltransferase in Brain Regions of C57BL/6J Mice", "Effect of Age on
Oxotremorine-Induced Stimulation of Local Cerebral Glucose Utilization".
Eur. Soc. Neurochem. - World Federation Neurol. Joint Meeting on Energy Transduction &
Neurotransmission, Sept 1982, Rome, Italy. "Age-related Decrease in Oxotremorine-induced
Stimulation of Local Cerebral Glucose Utilization."
Univ. MD, Balto. Co., Dept. Chemistry - Jan 10, 1983. "Neurobiology of Aging."
Sloane - Kettering Cancer Res. Center, New York, NY - Jan 14, 1983. "Metabolic Mapping with
Deoxyglucose: Studies of Aging & Cholinergic Function."
Winter Conf. Brain Res. - Jan 1983, Keystone, CO. "CNS Effects of Vasopressin."
Ohio State Univ., Columbus, Feb 17, 1983. "Metabolic Mapping with Deoxyglucose: Studies of Aging
& Cholinergic Function."
5th Int. Conf. on Acetylcholine, Nov 1983, Oglebay Park, West Virginia. "Relations Between Choline
Acetyltransferase & Muscarinic Binding in Aging & Alzheimer's Disease."
Div. Nuclear Medicine, Johns Hopkins Hosp., Dec 12, 1983. "In Vivo Mapping of Cerebral Metabolic
Effects of Opioid Agonist & Antagonist Drugs with Radiolabel led Deoxyglucose."
Univ. MD, Balto. County, Dept. Chemistry - Jan 11, 1984. "Neurobiology of Aging."
Johns Hopkins School of Medicine, Dept. Neuroscience, Mar 1, 1984. "Models of Cholinergic Deficits in
Aging and Dementia."
Symposium: Pharmacology of Hydergine® (Sandoz Corp.), Paris, Oct, 1984. "Enhanced Local Glucose
Utilization in Many Subcortical Regions of the Rat Brain Following Acute Co-dergocrine Treatment."
Univ. MD, Balto. County, Dept. Chemistry - Jan 9, 1985. "Neurobiology of Aging."
Johns Hopkins Medical Institutions, course on Neuroreceptors & Positron Emission Tomography.
Curriculum Vitae - Edythe D. London, Ph.D.
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Mar 15, 1985. "Drug Addiction & Brain Chemistry"
OHOLO Biological Conf. on Basic & Therapeutic Strategies in Alzheimer's & Related Neuropsychiatric
Disorders, Mar 24-27, 1985, Eilat, Israel. "Reversal of Cerebral Metabolic Deficits in Rodent Models
for Aging & Alzheimer's Disease."
Uniformed Services Univ. of Health Sciences, Dept. Psychiatry, May 8, 1985. "Deoxyglucose Studies of
Opioid Dependence & Abstinence."
International Congress on Gerontology, Jul 14, 1985, New York, NY. "Cholinergic Deficits in Normal
Aging & Alzheimer's Disease."
Armed Forces Radiobiol. Res. Inst., Apr 30, 1986. "Cerebral Metabolic Effects of Abused Substances."
Johns Hopkins Med. Inst., Mar 28, 1986. "Cerebral Metabolic Effects of Psychoactive Drugs" in course
on Neuroreceptors & Positron Emission Tomography.
Dept. Psychiatry, School of Medicine, Southern IL Univ., May 5, 1986. "Mapping Cerebral Effects of
Abused Drugs."
Grass Foundation Traveling Scientist Program, May 5, 1986, Sangamon County Chapter, Soc. Neurosci.
"Brain Imaging Techniques in Psychopharmacology."
Central Inst. for Experimental Animals, Nov 25, 1986, Kawasaki, Japan. "Metabolic Mapping of the
Cerebral Effects of Abused Drugs."
Nuclear Medicine Div., Dept. Radiology, Queen Mary Hosp., Nov 28, 1986, Hong Kong. "Metabolic
Mapping of Cerebral Drug Action."
AMERSA Natl. Conf., Dec 10, 1986, Wash, DC. "Imaging Cerebral Effects of Psychoactive Drugs."
Collegium Internationale Neuropsychopharmacologicum (CINP), 15th Annual Meeting, Dec. 1986, San
Juan, PR. "Mapping Cerebral Distributions of Action of Euphoriant Drugs".
Grass Foundation Traveling Scientist Program, Apr 24, 1987, Middle TN Chapter, Soc. Neurosci.
"Mapping Pathways of Drug-Induced Euphoria."
Am. Soc. Pharmacol. Exp. Ther., Aug 1987. "Distribution of Cerebral Metabolic Responses to Ligands
& Phencyclidine" in symposium "Biochemical & Pharmacological Characterizations of HaloperidolSensitive Receptors: Comparison with PCP Receptors."
FASEB, May 1988, Las Vegas, NV. Symposium Chair, "New Insights into Molecular & Behavioral
Actions of Cocaine". Lecture, "Mapping Cerebral Distributions of Cocaine's Action -- Relation to
Behavioral Effects."
European Soc. Neurochem., Jun 13, 1988, Gothenburg, Sweden. Co-chaired symposium "Imaging
Techniques to Study Brain Function". Lecture "Cerebral Metabolic Effects of Euphorigenic Drugs".
Joint meeting Am. Physiol. Soc. & Am. Soc. Pharmacol. Exp. Ther., Oct 13, 1988, Montreal.
"Neurochemical & Functional Measures of Cholinergic Neurotransmission in the Aging Brain" in
symposium "Changes in Receptor Response & Neurotransmitters with Age."
Grand Rounds, Dept. Psychiatry, & Neuroscience seminar, Dartmouth Med. School, Aug 1, 1989.
"Brain Imaging Studies of Psychotropic Drugs."
Brookhaven National Laboartory, Upton, NY, Jan 4, 1990. "Mapping Metabolic Correlates of DrugInduced Euphoria."
Dept. Pharmacol. & Toxicology, School of Pharmacy, Univ. MD, Feb 28, 1990. "Mapping the
Metabolic Correlates of Drug-Induced Euphoria."
Johns Hopkins Med. Inst., Mar 15-16, 1990. “Sigma Receptors in Mental Disorders", "Brain Chemistry
of Euphoria" in course "Drugs, Behavior & the Brain: Advances in PET & SPECT Imaging".
Am. Psychiatric Assoc., 143rd Ann. Meeting, New York, NY, May, 1990. "Decreased Brain Glucose
Utilization by Morphine", "Decreased Brain Glucose Utilization by Cocaine".
FASEB Satellite Symposium "Properties of the Neuroleptic-Sensitive Sigma-DM System", Apr 1, 1990,
Wash. DC. Lecture: Studies of  Receptors & Metabolic Responses to  Ligands in Brain.
Grand Rounds, Dept. Psychiatry, Children's National Medical Center, Wash., DC. Jun 1, 1990. "PET
Scan Studies of Euphoriant Drug Action in the Brain".
Curriculum Vitae - Edythe D. London, Ph.D.
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Committee on Problems of Drug Dependence, Ann. meeting, Jun 11, 1990, Richmond, VA. "Mapping
the Metabolic Correlates of Drug-Induced Euphoria".
Int. Symposium on Nicotine, Jun 28-30, 1990, Hamburg, FRG. "Glucose Metabolism: An Index of
Nicotine Action in the Brain".
17th Cong. CINP, Satellite Symposium on NMDA Receptor, Sept 16-17, 1990, Nagoya, Japan.
"Polyamines as Regulators of Cationic Channels in the CNS."
Medical & Chirurgical Faculty of MD "Practical Clinical Mgt.: Drug Abuse Education for the Primary
Care Physician", Oct 20, 1990. "PET Scan Mapping of the Cerebral Effects of Abused Drugs."
Brown Univ., Oct 25, 1990. Colloquium Lecture, “Taking the High Road - Cerebral Metabolic Correlates
of Drug-Induced Euphoria.”
Am. College Neuropsychopharmacol. Annual meeting, Dec 9-14, 1990, San Juan, PR. “Acute Effects of
Cocaine on Cerebral Glucose Metabolism in Substance Abusers” ; "Sigma Receptor Deficits in
Schizophrenia: Post-mortem Studies Suggest a Potential for PET Diagnosis."
Am. Psychiatric Assoc., 144th Annual meeting, New Orleans, LA, May 12-14, 1991. "Brain Metabolism
and Drug-Induced Euphoria" in symposium "PET Studies of Drug Abuse".
Int. Symposium on Nuclear Imaging in Drug Discovery, Development, & Approval, Merck Sharp &
Dohme, Balto., MD, Jun 19, 1991. "Effects of Intravenous Cocaine on Cerebral Glucose Utilization in
Human Polydrug Abusers: Relations Between Regional Metabolism & Subjective Responses."
3rd IBRO World Cong. Neurosci., Montreal, Canada, Aug 7, 1991. "Ligand-Binding Studies of
Polyamine Receptors in the Brain" in workshop "Polyamines in the Nervous Systems: New Vistas";
"Mapping the Effects of Nicotine on Metabolism in the Living Brain" in symposium "Nicotine
Actions in the CNS: From Genes to Behavior".
3rd French-U.S. Seminar "Multiple Sigma & PCP Receptor Ligands: Mechanisms for Neuromodulation
& Protection?" La Grand Motte, France, Sept 16-19, 1991. “Ligand-binding Studies of Polyamine
Receptors in Rat Brain.”
Soc. Neurosci., 21st Ann. meeting, New Orleans, LA, Nov 10-15, 1991. "The Neurochemical and
Biochemical Basis of the Opioid Abstinence Syndrome Studied through Metabolic Mapping" in
symposium "Insights into Brain and Spinal Components of the Opiate Withdrawal Syndrome".
8th Ann. Einstein Symp. Psychiatry, Albert Einstein Coll. Med. & Montefiore Med. Ctr., Dept. Psychiat.,
Nov 22, 1991. "The Anatomy of Euphoria: In Vivo Brain Imaging of Cocaine Abusers."
Am. Coll. Neuropsychopharmacology Ann. meeting, San Juan, PR, Dec 8-13, 1991. "Imaging with
Positron Emission Tomography to Investigate Drug Actions in Brain" in symposium "PET vs. SPECT
in Neuropsychopharmacological Research". Co-Chaired Panel “The Sigma Receptor: Biochemistry,
Physiology, and Clinical Potential.”
International Biomedical Research Conference on Drug Abuse, sponsored by NIDA and the US Dept. of
State, Sea Island, GA, Feb 23-26, 1992. "Seeing the Brain - The Role of PET Autoradiography, and
other Imaging Techniques".
Am. College of Nuclear Physicians 18th Ann. meeting, San Diego, CA, Mar 1-5, 1992. "Effects of Acute
Exposure of Drugs of Abuse on Regional Brain Metabolism".
Dept. Psychiatry, Univ. of PA, May 11, 1992. "PET Studies of Substance Abusers".
Medications Development Division, NIDA. "PET Studies of Substance Abusers" in Seminar on PET and
SPECT in Medications Development.
International Symposium on Contraband and Cargo Inspection Technology, sponsored by Office of
National Drug Control Policy and National Institute of Justice, Wash., DC, Oct. 27-30, 1992.
“Positron Emission Tomography and Drug Abuse”.
Grand Rounds, Dept. of Pharmacology, University of Texas Health Science Center, Houston, TX, Apr
14, 1993. “Effects of Acute Cocaine Administration on Brain Metabolism”.
University of Vermont, Burlington, VT, Apr. 19, 1993. “Taking the High Road: Studies of Substance
Abuse Using Brain Imaging” and “Polyamines and the NMDA receptor”.
Curriculum Vitae - Edythe D. London, Ph.D.
Page 8
Grand Rounds, Psychopharmacology Clinic, Albert Einstein College of Medicine of Yeshiva University,
Bronx, NY, Apr 28, 1993. "PET in the Study of Substance Abuse".
Dept. Psychiatry, School of Medicine, Yale University, West Haven, CT, May 3, 1993. “Brain Imaging
in Relation to Substance Abuse."
First Turkish Neuroscience Congress, Istanbul, Oct. 1993. “Positron Emission Tomography in Studies of
Substance Abuse”.
Dept Anatomy, School of Medicine, Howard University, Wash., DC, May 4, 1994. ”Brain Imaging
Studies of Drug Abuse.”
Dept. Psychiatry, School of Medicine, University of Buffalo, Buffalo, NY, May 6, 1994. Grand Rounds
“Structural and Functional Brain Imaging in Drug Abusers.”
Am. Psychiatric Assoc., 147th Ann. meeting, Philadelphia, PA, May 23, 1994. “Brain Metabolism in
Substance Abusers.”
NY Acad. Sci. Symposium on Functional Diversity of Interacting Receptors, Washington, DC, May 2528, 1994. Lecture “Polyamines as Endogenous Modulators of NMDA Receptor and Other LigandGated Ion Channels”.
College on Problems of Drug Dependence, Palm Beach, FL, Jun 18-23, 1994. “Brain Metabolism in
Substance Abusers”.
NIDA Technical Review on Neurotoxicity of Cocaine, Wash., DC, Jul 7-8, 1994. “Brain Imaging
Studies of Substance Abusers: Acute and Long-Term Effects of Stimulants”.
Symposium on Neuroimaging and Drug Dependence, Tokyo, Japan, Aug 9-14, 1994, Special Lecture:
“Brain Imaging Studies of Substance Abusers”.
Welcome Frontiers Meeting, London, England, Sept 16-21, 1994. Discussant ”The Biological, Social
and Clinical Bases of Drug Addiction”.
Univ. Maryland, Baltimore, MD, Sept 26, 1994. “Brain Imaging Studies of Substance Abusers”.
Johns Hopkins Medical Institutions Science Writers Seminar “Understanding Addiction”, Baltimore,
MD, Sept 27, 1994. “Where Does Craving Live in the Brain”.
NIDA Technical Review on The Role of Glutamatergic Systems in the Development of Opiate
Addiction, Gaithersburg, MD, Oct 17-18, 1994. Discussant “Clinical Implications of the Presented
Research for the Treatment of Opiate Addiction”.
Eleventh Annual Symposium in Psychiatry, New York, NY, Nov 4, 1994. “Functional Assessment of
Opiate Actions by Brain Imaging”.
Towson Univ., Balto., MD, Nov 22, 1994. “Taking the High Road: PET to Study Drug Abuse”.
Behav. Pharmacol. Res. Unit, Johns Hopkins Medical Inst., Baltimore, MD, Nov 29, 1994. “PET
Studies in Drug Abuse”.
German Society for Research on Drugs and Addiction, Frankfurt, Germany, Dec 2-4, 1994. “Positron
Emission Tomography in Studies of Substance Abuse”.
Sch. Hygiene & Pub. Hlth., Johns Hopkins Med. Inst., Jan 9, 1995. “PET Studies in Substance Abuse”.
Pfizer Central Res., Groton, CT, Jan 17, 1995. “PET Scanning Studies in Substance Abusers”.
DuPont Merck Pharmaceutical Co., Wilmington, DE, Jan 18, 1995. “Imaging Craving in the Brain”.
NIDA Advisory Council, Bethesda, MD, Feb 7, 1995. “Brain Imaging Studies of Drug Abuse”.
NHLBI, NIH, Bethesda, MD, Feb 10, 1995. “PET Studies of Drug Abuse”.
Univ. MI Med. Ctr., Jackson, May 26, 1995. Grand Rounds “Brain Img. Studies of Substance Abusers.”
FASEB Summer Conf. on Drug Abuse “Psychostimulants: Issues Related to Craving, Dependence and
Treatment”, Copper Mountain, CO, Jul 23-28, 1995. “Brain Imaging: Acute Responses to Stimulants
and Persistent Differences in Drug Abusers Compared with Controls.”
Counterdrug Technology Assessment Ctr., Off. Natl. Drug Control Policy, “Int. Workshop on Drug
Abuse Treatment Tech.”, Balto., MD, Aug 15-16. “New Approaches to Understanding Drug Abuse.”
Univ. TX Health Science Center, “Drug Abuse in the Decade of the Brain Conference”, Houston, TX,
Sept 22-23, 1995. “Effects of Cocaine on the Brain and Imaging Techniques.”
Curriculum Vitae - Edythe D. London, Ph.D.
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Med. Coll. Wisconsin, Milwaukee, WI, Mar 5, 1996. Grand Rounds “Brain Img. in Substance Abuse.”
Eur. Winter Conf. on Brain Res., Serre-Chevalier, France, Mar 16-23, 1996. "FDG and PET Studies of
Brain Metabolism and Volumetric MRI Analysis in Substance Abusers and Controls."
Pharmaceutical Peptides Incorporated, Cambridge, MA, Jun 3-4, 1996. "Positron Emission Tomography,
Cholinergic Receptors, and Alzheimer's Disease."
Texas A&M Faculty of Neuroscience, College Station, TX, Oct 22-24, 1996. “Brain Imaging Studies of
Substance Abusers.”
Am. Soc. Addiction Medicine 9th National Conference on Nicotine Dependence, Wash., DC, Nov 14-17,
1996. “Interactions of nicotine with specific receptors and circuits in brain.”
Soc. Neurosci. 26th Ann. Meeting, NIDA Satellite Symposium “Cognitive Neuroscience”, Wash., DC,
Nov 16-21, 1996. “Activation of Memory Circuits During Cocaine Craving: PET Studies.”
Am. College Neuropsychopharmacol. 35th Ann. meeting, San Juan, PR, Dec 9-13, 1996. Co-Chaired
Panel “Controversies in Nicotine and Tobacco Smoking Actions.”
Beth Israel Med. Center, New York, NY, Feb 20, 1997. Grand Rounds “Brain Imaging Studies of
Substance Abusers.”
School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, Mar 10,
1997. “Update on NIDA's Imaging Studies of Substance Abuse.”
Am. Soc. Addiction Medicine 28th Annual Medical Scientific Conference, San Diego, CA, Apr 17-20,
1997. "Neurobiology of Addiction: What's Craving Got to Do with It?"
Med. Univ. SC, Charleston, SC May 26-27, 1997. Grand Rounds: "Img. Studies in Substance Abusers."
Univ. MN Res. Training Retreat, Minneapolis, MN, May 31 - Jun 1, 1997. Lecture: “Drug Abuse”.
Int. Business Communications Conf. "Nicotinic Acetylcholine Receptors", Wash., DC, Jul 24-25, 1997.
Lecture: "Development of Tracers for Noninvasive Imaging of Nicotinic Receptors in Brain."
International Workshop on Drug Abuse Treatment Technology, Baltimore, MD, Aug 15-17, 1997.
Lecture “New Approaches to Understanding Drug Abuse.”
Am. Society of Addiction Medicine Conference entitled "Art in Addiction Medicine Conference-Models
& Measures of Early Recovery: Implications for New Treatment Strategies”, Wash., DC, Oct 24-25,
1997. “Neuroimaging: Assessing Sites of Action and Their Implications."
Am. Coll. Neuropsychopharmacology 36th Ann. Meeting, Kamuela, Hawaii, Dec 8-12, 1997. “Cerebral
metabolism during cue-elicited cocaine craving.”
School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, Jan 12, 1998.
“Update on NIDA's Imaging Studies of Substance Abuse.”
International Conference on Substance Abuse, Budapest, Hungary, October 1998. “Brain imaging studies
of opioid effects and the pathology of addiction.”
NextMed: The End of Health Care, San Diego, CA, Jan 27-29, 1998. "What Can Brain Imaging Tell Us
About the Mind and Soul?"
Soc. Res. on Nicotine & Tobacco Symposium "Brain Imaging of Nicotine and Tobacco Smoking", New
Orleans, LA, Mar 27-29, 1998. "Effects of Nicotine on Cerebral Glucose Metabolism."
Department of Pharmacology & Experimental Therapeutics, Univ. Maryland Graduate Course,
Baltimore, MD, Mar 31, 1998. "Drugs of Abuse."
Department of Psychiatry, Nicotine Research Program, Duke University Medical Center and Health
System, Durham, NC, Apr 7, 1998. “Brain Imaging Studies of Substance Abusers."
College on Problems of Drug Dependence Inc., 60th Ann. Scientific Meeting, Scottsdale, AZ, Jun 13-18,
1998. Organizer satellite meeting: "Brain Imaging in Development of Medications for Drug Abuse."
Lecture: "Imaging the Underlying Pathology of Drug Abuse."
Am. Coll. Neuropsychopharmacology 37th Ann. Meeting, Las Croabas, Puerto Rico, Dec 14-18, 1998.
Chaired panel entitled “Cerebral Responses to Nicotine: From the Perspectives of Neuroimaging and
Receptor Dynamics”, presentation in study group, "Measurement of Alcohol and Other Drug
Reactivity and Craving in the Animal and Human Lab.: Issues of Design, Ethics and Interpretation."
Curriculum Vitae - Edythe D. London, Ph.D.
Page 10
The Neurobiology of Addiction Conference, UCLA, Los Angeles, CA, Jan 12-13, 1999. “Common
Problems in Brain Imaging Studies of Drug Abuse."
32nd Annual Winter Conference on Brain Research, Snowmass, CO, Jan 22-30, 1999. In panel entitled
“Novel Approaches to Smoking Cessation: Different Smokes for Different Folks."
Interdisciplinary Substance Abuse Res. Ctr., Univ. Michigan, Oct 20, 1999. “Brain Imaging Studies of
Substance Abuse”.
Symposium on Substance Abuse, Johns Hopkins School of Hygiene and Public Health, Oct 21, 1999.
“Brain Imaging Studies of Substance Abuse”.
NIDA Symposium: LHPA Axis in Psychiatric Disorders, Sept 22, 1999, Bethesda, MD. “Cerebral
Cortex in Drug Addicts, Imaging Studies”.
6th Annual Conference on Behavior, Clinical Neuroscience, Substance Abuse & Culture. “Prefrontal
Cortex and Drug Abuse”, Nov 4, 1999, Los Angeles, CA.
Hawaii Reg. Methamphetamine Conf., Center for Substance Abuse Treatment, Dec 5-7, 1999, Honolulu.
Session Co-Chair: “What Brain Imaging Research Tells Us About Methamphetamine Effects”.
6th Int. Stockholm/Springfield Symposium on Advances in Alzheimer Therapy, Apr 5-8, 2000,
Stockholm. “Assessment of nicotinic receptors and therapy for Alzheimer’s disease”.
Am. Soc. Addiction Med., 31st Ann. Medical-Scientific Conf., lecture: Imaging nicotine activity in the
brain, Apr 14, 2000; lecture: Neurob of multiple drug abuse: implications for treatment, Apr 15, 2000.
Coll. Problems of Drug Dependence, Ann. Mtg., Jun 18, 2000. Co-chair and discussant in symposium:
Antecedents, Consequences, and Treatment of Drug Dependence: A Cognitive Science Perspective.
th
11 World Cong. on Tobacco, Aug 8, 2000, Chicago IL. “Why are Nicotinic Receptors in the Brain?”
Ctr. Substance Abuse Treatment. Sept 11, 2000, Portland, OR. “Brain Function in Addictive Disorders”.
NIDA-Sponsored Conference: New Knowledge on Medications Development Workshop. Sept 28, 2000,
Los Angeles, CA. “New Knowledge on Methamphetamine”.
7th Annual Conference on Behavioral, Clinical Neuroscience, Substance Abuse & Culture. Oct 19, 2000.
“The Utility of PET in Studies of Substance Abuse”
NIDA Conference, “Blending Clinical Practice and Research: Forging Partnerships to Enhance Drug
Addiction Treatment”, Nov 1-2, 2000. “Drugs, the Brain, and Behavior”.
Research Conference on The New Biopolitics, UCLA Center for Governance, UCLA Communication
Studies Program. “Addiction: A Disease of Brain Function”, Nov 18, 2000.
Women Professionals Panel, Women’s Leadership conference, Dept. Humanities, Sciences and Social
Sciences, UCLA, Nov 18, 2000.
Yale University School of Medicine, Transdisciplinary Tobacco Research Center, Dec 6, 2000,
“Neuroimaging of Addictive Disease”.
4th Conference on Pain Management and Chemical Dependency, Washington, DC, Dec 8, 2000.
“Neuroimaging of Addictive Disease”.
Am. Coll. Neuropsychopharmacology 40th Ann. Meeting, San Juan PR, Dec 14-18, 2000. Chaired panels:
“Addiction as a Disease of the Orbitofrontal Cortex,” “Effects of Nicotine and Smoking on Brain
Function: Imaging Studies”; lecture: “Effects of Nicotine and Smoking on Cognitive Activation: an
fMRI Study.”
Winter Conference on Brain Research, Steamboat Springs, AZ, Jan 23rd, 2001. Panel Discussion: “The
Orbitofrontal Cortex and the Addictions: Neuroimaging Studies”.
Los Angeles Psychoanalytic Institute Neuroscience Lecture Series, Los Angeles, CA Mar 16th, 2001.
“Imaging Brain Dysfunction in Substance Abuse”.
Am. Psychiatric Association, Annual Meeting. Special lecture (Frontiers in Neuroscience), “Imaging Brain
Dysfunction in Substance Abuse”, May 8, 2001, New Orleans, LA.
Am. Soc. Addiction Medicine Conference. NIDA Panel, “Alteration of motivational circuitry in brain by
drugs of abuse,” Apr 20, 2001, Los Angeles, CA.
Curriculum Vitae - Edythe D. London, Ph.D.
Page 11
ONDCP International Technology Symposium. “Development of a Molecular Imaging Laboratory at the
Sepulveda VA Vervet Research Center”, Jun 27, 2001, San Diego, California
American Psychological Assoc., 109th Convention. Lecture: “Structural Clinical Neuroimaging and the
Clinical Neurosciences.” Discussant of symposium “Integrating Neuroimaging and Neuropsychology
– An Interdisciplinary Approach to Substance Abuse,” Aug 25, 2001.
Psychiatry Grand Rounds. Cedars-Sinai Health Center, “The High Road: Brain Imaging of Drug Abuse”,
Oct 18, 2001, Los Angeles, CA.
California Soc. Addiction Medicine. Addiction Medicine: State of the Art 2001 Conference, Oct 19,
2001, Marina del Rey, CA. “New Approaches to Neuroimaging of Drug Abuse Disorders”.
th
7 Ann. Duke Nicotine Research Conference, “Nicotine’s Effect in Brain: Receptor Binding and
Functional Assays.” Nov 8, 2001, Durham NC.
An American Tragedy: The War on Drugs, sponsored by H.A. Schneiderman Memorial Bioethics
Lecture Series and the Univ. of Calif., Irvine, “Neuroimaging Studies of Drug Abuse”, Nov 19, 2001.
West Coast College of Biological Psychiatry, “Neuroimaging of Brain Function: Examples from
Addictive Disorders”, April 19, 2002, Santa Monica, CA.
XXIII CINP Congress, Symposium S19, “Regional Cerebral Metabolism in Methamphetamine Abusers”,
June 25, 2002, Montreal, Canada.
American Psychiatric Assoc. symposium, “Circuitry of Failed Cognitive Strategies in Addiction”,
Lecture: Brain Metabolism during Early Abstinence from Meth. Abuse” May 22, 2002, Phila., PA.
2002 ONDCP Demand Reduction Technology Symposium, July 8-10, 2002, Cambridge, MA. Lecture:
“Methamphetamine Abuse: Brain Imaging to Tailor Treatment.”
12th World Psychiatry Assoc. “Brain Imaging: Nicotine and Other Drugs of Abuse”, Aug 24 – 29, 2002,
Yokohama, Japan.
California Society of Addiction Medicine. Addiction Medicine Review Course 2002, “Brain Function
and Drug Abuse: Can Research Inform Treatment?”, Oct 10, 2002, Newport Beach, CA.
Annual Conference on Behavior, Clinical Neuroscience, Substance Abuse and Culture. “Brain Imaging
& Co-Occurring Mental Disorders”, Oct 24 2002, Los Angeles, CA.
National Conference on Tobacco or Health. Participated in symposium session CESS-178.
“Neurobiology of Nicotine Addiction”, Nov 20, 2002, San Francisco, CA.
UCLA Extension Course. Out of Our Minds: Brain Chemistry, Memory, Addictions, Sex, & Mood.
“Addictive Drugs – Addictive Behavior”, Nov 16, 2002, Los Angeles, CA.
nd
2 Annual Co-Occurring Disorders Conference: “Imaging the Brain: Seeing the Impact of Addiction”
sponsored by Prototypes and the Los Angeles County Department of Alcohol and Drug Programs,
June 2, 2003, Long Beach, CA.
2003 Imaging and the Brain Institute, Ctr. for Image Processing in Education, Evergreen State College,
Keynote Address: “Seeing Inside the Brain of an Addict: Why Some Take the “High” Road and
What Happens When They Do.” Olympia, WA, July 10, 2003.
10th Annual Conference: Behavior, Clinical Neuroscience, Substance Abuse and Culture: Lecture: “Brain
Imaging and Co-occurring Mental Disorders.” Los Angeles, CA, Oct 23, 2003.
8th Annual Investigator Meeting, Tobacco-Related Disease Research Program, University of California:
“Mapping the Effects of Nicotine in the Brain by Noninvasive Imaging." San Diego, CA, Dec 3, 2003.
Am. Coll Neuropsychopharmacology Annual Meeting: “Neural Substrates of Dysphoric Mood in
Addition: Targets of Medications for Substance Abuse Disorders.” San Juan, PR, Dec 6-11, 2003.
California Addiction Training and Education Series: Methamphetamine: “Methamphetamine, Behavior
and Brain Imaging.” March 30, 2004, Pasadena, CA.
University of South Florida, Excellence in Research Seminar Series: “Brain Imaging and Drugs of
Abuse.” April 28, 2004, Tampa, FL.
MIRECC Seminar: "Brain Imaging Studies of Substance Abuse." May 26, 2004, VA Hosp., L.A., CA.
Curriculum Vitae - Edythe D. London, Ph.D.
Page 12
American Psychological Assoc. 112th Convention, symposium: “Potential Predictors of Medication
Efficacy from Human Laboratory Studies”, Honolulu, HI, July 28 – Aug. 1, 2004.
Addiction Clinic, University of California Los Angeles, UCLA: “Substance Abuse: Predicting
Treatment Efficacy from Human Brain Imaging.” Sept. 28, 2004, Los Angeles, CA.
3rd Charité Conference, Psychiatric Research: Emotional Neuroscience: “Brain Imaging Studies of
Substance Dependency”, Berlin, Germany, October 3, 2004.
UCLA Neuropsychiatric Institute and Department of Psychiatry and Biobehavioral Sciences Grand
Rounds: “Imaging Cortical-Limbic Dysregulation in Substance Abuse.” Dec. 21, 2004, LA, CA.
NIH/NIDA Methamphetamine Research Meeting “Imaging Methamphetamine Dependence; Phenotype
of Corticolimbic Dysregulation.” March 9-10, 2005, Los Angeles, CA.
Mount Sinai School of Medicine Grand Rounds “Methamphetamine Dependence: Imaging Corticolimbic
Dysregulation.” March 29, 2005, New York, NY.
Veterans Administration Greater L.A. Healthcare System Grand Rounds “Imaging Methamphetamine
Dependence: Phenotype of Corticolimbic Dysregulation.” Apr. 21, 2005, Los Angeles, CA.
Canadian Soc. Addiction Medicine, 17th Ann. Sci. Conf., Keynote Address: “Brain Imaging Studies of
Methamphetamine Dependence.” Oct. 29, 2005, Vancouver, BC, Canada.
Western Conference on Addictions: Improving Treatment with Scientific Knowledge: “Understanding
Methamphetamine Dependence through Brain Imaging.” Nov. 11, 2005, Universal City, CA.
Philip Morris External Research Program Symposium. “Cognitive Deficits, Nicotine Dependence, and
the Effects of Smoking.” Dec. 6, 2005, Chantilly, VA.
ACNP – JSNP Joint Symposium “Brain Imaging Reveals Corticolimbic Dysregulation in
Methamphetamine Abusers” December 11 – 15, 2005, Waikoloa, Hawaii.
Univeristy of Texas Southwestern Medical Center, Grand Rounds. “Methamphetamine Dependence:
Corticolimbic Dysregulation and Loss of Inhibitory Control.” February 8, 2006, Dallas, TX.
National Conference on Dual Diagnosis: Integrating Neurobiological, Psychiatric and social Systems
Persopectives on Co-occurring Substance Use Disorders and Mental Illness. “Methamphetamine and the
Brain: A Problem of Inhibitory Control.” March 3, 2006. Indianapolis, IN.
Second Annual Drug Abuse Research Symposium at Drew. Keynote speech: “Methamphetamine and the
Brain: A Problem of Inhibitory Control. Charles R. Drew University of Medicine and Science, Aug. 10,
2006. Los Angeles, CA.
Addiction Neurosicne Network Australia 2006: Developing a Research Strategy to Explore the Addicted
Brain, Keynote speaker: “Why do some people becoemne addicted”? September 8, 2006. Hamilton
Island, Queensland. Australia.
BIBLIOGRAPHY
Books Edited:
1. ED London (1993): Imaging Drug Action in the Brain, CRC Press, Boca Raton, FL.
2. EB de Souza, D Clouet, ED London (1993): Sigma, PCP and NMDA Receptor Systems, NIDA
Research Monograph 133, DHHS, Washington, DC
Original Articles:
1.
GG Buterbaugh, ED London (1977): Relationship between magnitude of electroshock stimulation
and effects of digitoxigenin, pentylenetetrazol and brain monoamine reduction on electroshock
convulsive thresholds. J. Neuropharmacology 16:617-623.
2.
ED London, GG Buterbaugh (1978): Modification of electroshock convulsive responses and
thresholds in neonatal rats following brain monoamine reduction. J. Pharmacol. Exp. Ther.
206:81-90.
Curriculum Vitae - Edythe D. London, Ph.D.
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Page 13
RS London, ED London, M Siegelbaum, P Goldstein (1978): The use of doxycycline in elective
first trimester abortions. Southern Med. J. 71:672-673.
RS London, D Solomon, ED London, D Strummer, J Bankoski, PP Nair (1978): Mammary
dysplasia: Clinical response and urinary excretion of 11-deoxy, 17-ketosteroids and pregnanediol
following -tocopherol therapy. Breast J.: Diseases of the Breast 4:19-22.
ED London, LW Harris, WC Heyl, JT Coyle (1978): Effect of 2-dimethylaminoethanol in
kainate-lesioned rat striatum: Anomaly in the radioenzymatic assay of acetylcholine. Commun.
Psychopharmacol. 2:357-364.
ED London, JT Coyle (1978): Pharmacological augmentation of acetylcholine levels in kainatelesioned rat striatum. Biochem. Pharmacol. 27:2962-2965.
ED London, JT Coyle (1979): Specific Binding of [3H]-kainic acid to receptors in rat brain. Mol.
Pharmacol. 15:492-505.
ED London, JT Coyle (1979): Cooperative interactions at [3H]-kainic acid binding sites in rat and
human cerebellum. Eur. J. Pharmacol. 56:287-290.
ED London, N Klemm, JT Coyle (1980): Phylogenetic distribution of [3H]-kainic acid receptor
binding sites in neuronal tissue. Brain Res. 192:463-476.
FJ Vocci Jr., JM Rhody, ED London, GG Buterbaugh (1980): Regional brain [3H]-digitoxigenin
and monoamine content during the development of convulsions produced by systemic
digitoxigenin. Res. Commun. Mol. Pathol. Pharmacol. 29:251-263.
ED London, HI Yamamura, ED Bird, JT Coyle (1981): Decreased receptor-binding sites for
kainic acid in brains of patients with Huntington's disease. Biol. Psychiatry 16:155-162.
M Ohata, U Sundaram, WR Fredericks, ED London, SI Rapoport (1981): Regional cerebral blood
flow during development and ageing of the rat brain. Brain l04: 319-332.
ED London, SM Nespor, M Ohata, SI Rapoport (1981): Local cerebral glucose utilization during
development and aging of the Fischer-344 rat. J. Neurochem. 37:217-221.
DK Ingram, ED London, CL Goodrick (1981): Age and neurochemical correlates of radial maze
performance in rats. Neurobiol. Aging 2:41-47.
D Dow-Edwards, M Dam, JM Peterson, SI Rapoport, ED London (1981): Effect of oxotremorine
on local cerebral glucose utilization in motor system regions of the rat brain. Brain Res. 226:281289.
JM Palacios, MJ Kuhar, SI Rapoport, ED London (1981): Increases and decreases in local
cerebral glucose utilization in response to GABA agonists. Eur. J. Pharmacol. 71:333-336.
SI Rapoport, ED London, WR Fredericks, DL Dow-Edwards, PR Mahone (1981): Altered
cerebral glucose utilization following blood-brain barrier opening by hypertonicity or
hypertension. Exp. Neurol. 74:519-529.
DK Ingram, ED London, MA Reynolds, SB Waller, and CL Goodrick (1981): Differential effects
of age on motor performance in two mouse strains. Neurobiol. Aging 2:221-227.
NL Shinowara, ED London, SI Rapoport (1982): Changes in retinal morphology and glucose
utilization in aging albino rats. Exp Eye Res. 34:517-530.
SI Rapoport, ED London, H Takei (1982): Brain metabolism and blood flow during development
and aging of the Fischer-344 rat. Exp. Brain Res. Suppl. 5:86-101.
M Partanen, SI Rapoport, ED London (1982): Glucose utilization in sympathetic ganglia of male
Fischer-344 rats at different ages. J. Auton. Neurosci. 5:391-398.
Curriculum Vitae - Edythe D. London, Ph.D.
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DH Corddry, SI Rapoport, ED London (1982): No effect of hyperketonemia on local cerebral
glucose utilization in conscious rats. J. Neurochem. 38:1637-1641.
ED London, SB Waller, FJ Vocci, GG Buterbaugh (1982): Age-dependent reduction in maximum
electroshock convulsive threshold associated with decreased concentrations of brain monoamines.
Pharmacol. Biochem. Behav. 16:441-447.
JM Palacios, MJ Kuhar, SI Rapoport, ED London (1982): Effects of -aminobutyric acid agonist
and antagonist drugs on local cerebral glucose utilization. J. Neurosci. 2:853-860.
JM Thompson, ED London, JE Johnson (1982):Ultrastructural, functional and biochemical
characteristics of mouse and human neuroblastoma cell lines. Neuroscience 7:1807-1815.
M Dam, JK Wamsley, SI Rapoport, ED London (1982): Effect of oxotremorine on local glucose
utilization in the rat cerebral cortex. J. Neurosci. 2:1072-1078.
DK Ingram, ED London, MA Reynolds (1983): Circadian rhythmicity and sleep: Effects of aging
in laboratory animals. Neurobiol. Aging 3:287-297.
M Dam, ED London (1983): Effects of cholinomimetics on glucose utilization in rat brain optic
systems. Eur. J. Pharmacol. 87:137-140.
H Takei, WR Fredericks, ED London, SI Rapoport (1983): Cerebral blood flow and oxidative
metabolism in conscious Fischer-344 rats at different ages. J. Neurochem. 40:801-805.
AS Kimes, D Sweeney, ED London, SI Rapoport (1983): Palmitate incorporation into different
brain regions in the awake rat. Brain Res. 274:291-301.
ED London, M Ohata, H Takei, AW French, SI Rapoport (1983): Regional cerebral metabolic
rate for glucose in Beagle dogs of different ages. Neurobiol. Aging 4:121-126.
MJ Ball, J Macgregor, IM Fyfe, SI Rapoport, ED London (1983): Paucity of morphological
changes in the brains of aging Beagle dogs: Further evidence that Alzheimer lesions are unique
for primate central nervous system. Neurobiol. Aging 4:127-131.
R Duara, RA Margolin, EA Robertson-Tchabo, ED London, M Schwartz, JW Renfrew, BJ
Koziarz, C Grady, AM Moore, DH Ingvar, L Sokoloff, H Weingartner, RA Kessler, R Manning,
R Channing, NR Cutler, SI Rapoport (1983): Cerebral glucose utilization, as measured with
positron emission tomography, in 21 resting healthy men between the ages of 21 and 83 years.
Brain 106:761-775.
SB Waller, DK Ingram, MA Reynolds, ED London (1983): Age and strain comparisons of
neurotransmitter synthetic enzyme activities in the mouse. J. Neurochem. 41:1421-1428.
DK Ingram, ED London, SB Waller, MA Reynolds (1983): Age-dependent correlation of motor
performance with neurotransmitter synthetic enzyme activities in mice. Behav. & Neural Biol.
39:284-298.
SB Waller, ED London (1983): Age differences in choline acetyltransferase activities and
muscarinic receptor binding in brain regions of C57BL/6J mice. Exp. Gerontol. 18:419-425.
M Dam, ED London (1984): Glucose utilization in the Papez circuit: Effects of oxotremorine and
scopolamine. Brain Res. 295:137-144.
P Helén, ED London (1984): Muscimol-scopolamine interactions in the rat brain: A study with 2deoxy-D[1-14C]glucose. J. Neurosci. 4:1405-1413.
ED London, M McKinney, M Dam, A Ellis, JT Coyle (1984): Decreased cortical glucose
utilization after ibotenate lesion of the rat ventromedial globus pallidus. J. Cereb. Blood Flow
Metab. 4:381-390.
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London, SB Waller, JK Wamsley (1985): Autoradiographic localization of [3H]-nicotine
binding sites in the rat brain. Neurosci. Lett. 53:179-184.
D Bernstein, DS Olton, DK Ingram, SB Waller, MA Reynolds, ED London (1985): Radial maze
performance in young and aged mice: Neurochemical correlates. Pharmacol. Biochem. Behav.
22:301-307.
ED London, RJ Connolly, M Szikszay, JK Wamsley (1985): Distribution of cerebral metabolic
effects of nicotine in the rat. Eur. J. Pharmacol. 110:391-392.
AM Lowy, DK Ingram, DS Olton, SB Waller, MA Reynolds, ED London (1985): Discrimination
learning requiring different memory components in rats: Age and neurochemical comparisons.
Behav. Neurosci. 99:638-651.
ED London, SB Waller, AT Ellis, DK Ingram (1985): Effects of intermittent feeding on
neurochemical markers in aging rat brain. Neurobiol. Aging 6:199-204.
M Partanen, SB Waller, ED London, A Hervonen, SI Rapoport (1985): Indices of
neurotransmitter synthesis and release in aging sympathetic nervous system. Neurobiol. Aging
6:227-232.
RJ Fanelli, CM Dersch, ED London (1985): Effects of subchronic morphine on choline
acetyltransferase and muscarinic binding in the rat brain. Res. Comm. Subst. Abuse 6:189-192.
ED London, RC Walovitch (1985): Le metabolisme cerebral du glucose chez les rongeurs ages:
Action de la co-dergocrine. J. Pharmacol. 16: Suppl. III: 85-97.
ED London, RC Walovitch (1985): Cerebral glucose metabolism in aging rodents: Effects of codergocrine. J. Pharmacol. 16: Suppl. III (English Edition): 73-84.
ED London, G Wilkerson, SR Goldberg, ME Risner (1986): Effects of l-cocaine on local cerebral
glucose utilization in the rat. Neurosci. Lett. 68:73-78.
M Szikszay, FR Snyder, ED London (1986): Effects of diltiazem on morphine-induced
respiratory decline. J. Pharm. Pharmacol. 38:625-627.
M Szikszay, FR Snyder, ED London (1986): Interactions between verapamil and morphine on
physiological parameters in rats. J. Pharmacol. Exp. Ther. 238:192-197.
ED London, RA Margolin, R Duara, HW Holloway, EA Robertson-Tchabo, NR Cutler, SI
Rapoport (1986): Effects of fasting on ketone body concentrations in healthy men of different
ages. J. Gerontol. 41:599-604.
SB Waller, MJ Ball, MA Reynolds, ED London (1986): Muscarinic binding and choline
acetyltransferase in postmortem brains of demented patients. Can. J. Neurol. Sci. 13:
Suppl. IV: 528-532.
M Selmanoff, RC Walovitch, GE Walker, ED London (1987): Effects of hyperprolactinemia on
plasma prolactin and glucose on local cerebral glucose utilization. J. Neurochem. 48:94-101.
RC Walovitch, DK Ingram, EL Spangler, ED London (1987): Co-dergocrine, cerebral glucose
utilization and maze performance in middle-aged rats. Pharmacol. Biochem. Behav. 26:85-101.
JE Johnson Jr., JJ White Jr., RC Walovitch, ED London (1987): Effects of morphine on rat
kidney glomerular podocytes: A scanning electron microscopic study. Drug Alcohol Depend.
19:249-257.
RF Fanelli, M Szikszay, DR Jasinski, ED London (1987): Differential effects of mu and kappa
opioid analgesics on cerebral glucose utilization in the rat. Brain Res. 422:257-266.
Curriculum Vitae - Edythe D. London, Ph.D.
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C Ori, T-P Su, AD Weissman, ED London (1987): Extraordinary postmortem stability of kappa
opioid receptors in guinea pig brain. J. Pharm. Pharmacol. 39:951-954.
AD Weissman, M Dam, ED London (1987): Alterations in local cerebral glucose utilization
induced by phencyclidine. Brain Res. 435:29-40.
PM Wise, RC Walovitch, IR Cohen, NG Weiland, ED London (1987): Diurnal rhythmicity
and hypothalamic deficits in glucose utilization in aged ovariectomized rats. J. Neurosci.
7:3469-3473.
ED London, AS Kimes, RJ Fanelli (1987): Cerebral metabolic effects of morphine in the rat.
Substance Abuse 8:43-52.
T-P Su, ED London, JH Jaffe (1988): Steroid binding at  receptors suggests a link between
endocrine, nervous and immune systems. Science 240:219-221.
ED London, M Dam, RJ Fanelli (1988): Nicotine enhances cerebral glucose utilization in central
components of the rat visual system. Brain Res. Bull. 20:381-385.
T-P Su, SE Schell, FY Ford-Rice, ED London (1988): Correlation of inhibitory potencies of
putative antagonists for  receptors in brain and spleen. Eur. J. Pharmacol. 148:467-470.
M Szikszay, ED London (1988): Effects of subacute capsaicin treatment on local cerebral glucose
utilization in the rat. Neuroscience 25:917-923.
PM Wise, IR Cohen, NG Weiland, ED London (1988): Aging alters the circadian rhythm of
glucose utilization in the suprachiasmatic nucleus. Proc. Natl. Acad. Sci. USA. 85:5305-5309.
JA Bell, AS Kimes, ED London (1988): Increased glucose utilization in superficial layers of the
rat spinal dorsal horn during precipitated morphine withdrawal. Pharmacol. Biochem. Behav.
150:171-174.
ED London, RJ Connolly, M Szikszay, JK Wamsley, M Dam (1988): Effects of nicotine on local
cerebral glucose utilization in the rat. J. Neurosci. 8:3920-3928.
AD Weissman, T-P Su, JC Hedreen, ED London (1988): Sigma receptors in postmortem human
brains. J. Pharmacol. Exp. Ther. 247:29-33.
ED London (1989): The effects of drug abuse on glucose metabolism. J. Neuropsychiatry Clin.
Neurosci. 1: Suppl. I: S30-S36.
RJ Fanelli, RC Walovitch, DR Jasinski, ED London (1989): Naloxone fails to alter local cerebral
glucose utilization in the rat. Pharmacol. Biochem. Behav. 31:481-485.
AS Kimes, ED London (1989): Glucose utilization in the rat brain during chronic morphine
treatment & naloxone-precipitated morphine withdrawal. J. Pharmacol. Exp. Ther. 248:538-545.
EP Broussolle, DF Wong, RJ Fanelli, ED London (1989): In vivo specific binding of [3H]lnicotine in the mouse brain. Life Sci. 44:1123-1132.
JL Cadet, A della Puppa, ED London (1989): Involvement of nigrotecto-reticulospinal pathways
in the iminodipropionitrile (IDPN) model of spasmodic dyskinesias: A 2-deoxyglucose study in
the rat. Brain Res. 484: 57-64.
C Ori, F Ford-Rice, ED London (1989): Effects of nitrous oxide and halothane on mu and kappa
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SB Waller, ED London (1989): Choline acetyltransferase activity and muscarinic binding in brain
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SE Moroi-Fetters, RF Mervis, ED London, DK Ingram (1989): Dietary restriction suppresses agerelated changes in dendritic spines. Neurobiol. Aging 10:317-322.
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G Wilkerson, ED London (1989): Effects of methylenedioxymethamphetamine on local cerebral
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A della Puppa, FY Ford-Rice, FR Snyder, E Cone, ED London (1989): Time course of verapamil
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ED London, RA Margolin, DF Wong, JM Links, ND LaFrance, NG Cascella, E Broussolle, HN
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A della Puppa, ED London (1989): Cerebral metabolic effects of sigma ligands in the rat. Brain
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H Takayama, MD Majewska, ED London (1989): Interactions of noncompetitive inhibitors with
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LP Raymon, Kimes AS, Tabakoff B, ED London (1989): SIDA et troubles du sommeil: effect du
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TH Vu, AD Weissman, ED London (1990): Pharmacological characteristics and distributions of
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ED London, EPM Broussolle, JM Links, DF Wong, NG Cascella, RF Dannals, M Sano, R
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ED London, G Wilkerson, C Ori, AS Kimes (1990): Central action of psychomotor stimulants on
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AS Kimes, JA Bell, ED London (1990): Clonidine attenuates increased brain glucose metabolism
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ED London, NG Cascella, DF Wong, RL Phillips, RF Dannals, JM Links, R Herning, R Grayson,
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JE Henningfield, ED London, NL Benowitz (1990): Arterial-venous differences in plasma
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CR Mantione, S Demirgören, ED London (1990): Specific binding of [3H]-spermidine to
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AD Weissman, EP Broussolle, ED London (1990): In vivo binding of [3H]d-Nallylnormetazocine and [3H]-haloperidol to sigma receptors in the mouse brain. J. Chem.
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MD Majewska, S Demirgören, ED London (1990): Binding of pregnenolone sulfate to rat brain
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RL Phillips, ED London, JM Links, NG Cascella (1990): Program for PET image alignment:
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AD Weissman, MF Casanova, JE Kleinman, ED London, EB de Souza (1990): Selective loss of
cerebral cortical sigma, but not PCP binding sites in schizophrenia. Biol. Psychiatry 29:41-54.
MD Majewska, JA Bell, ED London (1990): Regulation of the NMDA receptor by redox
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SR Cohen, AS Kimes, ED London (1991): Morphine decreases cerebral glucose utilization in
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AS Kimes, ED London, G Szabo, L Raymon, B Tabakoff (1991): Reduction of cerebral glucose
utilization by the HIV envelope glycoprotein gp-120. Exp. Neurol. 112:224-228.
X-Z Wu, JA Bell, CW Spivak, ED London, T-P Su (1991): Electrophysiological and binding
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VL Dawson, TM Dawson, ED London, DS Bredt, SH Snyder (1991): Nitric oxide mediates
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NG Cascella, G Pearlson, DF Wong, EPM Broussolle, C Nagoshi, RA Margolin, ED London
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S Demirgören, MD Majewska, CE Spivak, ED London (1991): Receptor binding and
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AS Kimes, LR Raymon, LT Meltzer, T Heffner, ED London (1991): Cerebral metabolic effects
of 8-ethyl-7, 8-dihydro-1, 3,5-trimethyl-1H-imidazo-[1,2,-c]pyrazolo-[3,4-e]-pyrimidine, a
potential anti-psychotic drug. Drug Dev. Res 24:29-39.
MJ Morgan, AS Kimes, ED London (1992): Possible roles for nitric oxide in AIDS and
associated pathology. Med. Hypothesis 38:189-193.
AS Kimes, WJ Smith, CJ Winchell, ED London (1992): Effects of morphine on the phenotypic
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DK Ingram, P Garofalo, EL Spangler, CR Mantione, I Odano, ED London (1992): Reduced
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AS Kimes, AA Wilson, U Scheffel, BG Campbell, ED London (1992): Radiosynthesis, cerebral
distribution and binding of [125I]1-(p-iodophenyl-3-(1-adamantyl)guanidine ([125I]PIPAG), a
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A della Puppa, AS Kimes, ED London (1993): Dose-dependent effects of d-N-allylnormetazocine
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K Hashimoto, ED London (1993): Further characterization of [3H]ifenprodil binding to 
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JE Henningfield, JM Stapleton, NL Benowitz, RF Grayson, ED London (1993): Higher levels of
nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 33:23-29.
MJ Morgan, NJ Cascella, JM Stapleton, RL Phillips, BCK Yung, DF Wong, EK Shaya, ED
London (1993): Sensitivity to subjective effects of cocaine in drug abusers: Relation to cerebral
ventricle size. Am. J. Psychiatry 150:1712-1717.
AS Kimes, DB Vaupel, ED London (1993): Attenuation of some signs of opioid withdrawal by
inhibitors of nitric oxide synthase. Psychopharmacology 42:521-524.
DB Vaupel, WR Lange, ED London (1993): Effects of verapamil on morphine-induced euphoria,
analgesia and respiratory depression in humans. J. Pharmacol. Exp. Ther. 267:1386-1394.
K Hashimoto, CR Mantione, MR Spada, JL Neumeyer, ED London (1994): Further
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MC Ritz, CR Mantione, ED London (1994): Spermine interacts with cocaine binding sites on
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TP O'Brien, CA Gleason, MD Jones Jr., EJ Cone, ED London, RJ Traystman (1994): Cerebral
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JE Flesher, U Scheffel, ED London, JJ Frost (1994): In vivo labeling of nicotinic cholinergic
receptors in brain with [3H]cytisine. Life Sci. 54:1883-1890.
SL Walsh, SF Gilson, DR Jasinski, JM Stapleton, RL Phillips, RF Dannals, J Schmidt, KL
Preston, R Grayson, GE Bigelow, JT Sullivan, C Contoreggi, ED London (1994): Buprenorphine
reduces cerebral glucose metabolism in polydrug abusers. Neuropsychopharmacology
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RI Herning, BJ Glover, B Koeppl, RL Phillips, ED London (1994): Cocaine-induced increases in
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RL Phillips, R Herning, ED London (1994): Morphine effects on the spontaneous
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A Shimada, EL Spangler, ED London, DK Ingram (1994): Spermidine potentiates dizocilpineinduced impairment of learning performance by rats in a 14-unit T-maze. Eur. J. Pharmacol.
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DK Ingram, EL Spangler, S Iijima, H Ikari, H Kuo, NH Greig, ED London (1994): Rodent
models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the
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Hashimoto K, U Scheffel, ED London (1995): In vivo labeling of sigma receptors in mouse brain
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ED London, U Scheffel, AS Kimes, KJ Kellar (1995): In vivo labeling of nicotinic acetycholine
receptors in brain with [3H]epibatidine. Eur. J. Pharmacol. 278:R1-R2.
DB Vaupel, AS Kimes, ED London (1995): Comparison of 7-nitroindazole with other nitric oxide
synthase inhibitors as attenuators of opioid withdrawal. Psychopharmacology 118:361-368.
JM Stapleton, MJ Morgan, RL Phillips, DF Wong, BCK Yung, EK Shaya, RF Dannals, X Liu,
RL Grayson, ED London (1995): Cerebral glucose utilization in polysubstance abuse.
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X Liu, RL Phillips RL, SM Resnick, VL Villemagne, DF Wong, JM Stapleton, ED London
(1995): Magnetic resonance imaging reveals no ventriculomegaly in polydrug abusers. Acta
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RL Phillips, CY Chen, DF Wong, ED London (1995): An improved method to calculate cerebral
metabolic rates for glucose using PET. J. Nucl. Med. 36:1668-1679.
DB Vaupel, AS Kimes, ED London (1995): Nitric oxide synthase inhibitors: Preclinical studies of
potential use for treatment of opioid addiction. Neuropsychopharmacology 13:315-322.
JA Bell, C Beglan, ED London (1995): Interaction of ascorbic acid with the neurotoxic effects of
NMDA and sodium nitroprusside. Life Sci. 58:367-371.
H Takahashi, JR Kirsch, K Hashimoto, ED London, R Koehler, RJ Traystman (1995): PPBP [4phenyl-l-(4-phenylbutyl) piperidine], a potent sigma--receptor ligand, decreases brain injury after
transient focal ischemia in cats. Stroke 26:1676-1682.
A Horti, Ravert HT, London ED, Dannals RF (1996): Synthesis of a radiotracer for studying
nicotinic acetylcholine receptors: (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl-7azabiocyclo[2.2.1]heptane. J. Label Compds. Radiopharm. 38: 355-366.
T Matsunaga, AG Mukhin, ED London (1996): Regionally distinct stoichiometry for N-methylD-aspartate receptor domains in brain. Neuroreport 7:833-837.
RD Kusztos, DK Ingram, EL Spangler, ED London (1996): Effects of aging and chronic
nimodipine on hippocampal binding of [3H]CGS 19755. Neurobiol. Aging 17(3): 453-457.
S Grant, ED London, DB Newlin, VL Villemagne, X Liu, C Contoreggi, RL Phillips, AS Kimes,
A Margolin (1996): Activation of memory circuits during cue-elicited cocaine craving. Proc.
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VL Villemagne, RL Phillips, X Liu, SF Gilson, RF Dannals, DF Wong, PJ Harris, M Ruff, C
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complex. J. Nucl. Med. 37:1177-1180.
H Takahashi, JR Kirsch, K Hashimoto, ED London, RC Koehler, RJ Traystman (1996): PPBP[4Phenyl-l-l(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats.
Stroke 27:2120-2123.
R Soria, JS Stapleton, SF Gilson, A Sampson-Cone, JE Henningfield, ED London (1996):
Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers.
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JL Musachio, A Horti, ED London, RF Dannals (1997): Synthesis of a radioiodinated analog of
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M Kassiou, HT Ravert, WB Mathews, JL Musachio, ED London, RF Dannals (1997): Synthesis
of 3-[(1-[11C]methyl-2(S)-pyrrolidinyl)methoxy]pyridine and 3-[1-[11C]methyl-2-(R)pyrrolidinyl)-methoxy]pyridine: Radioligands for in vivo studies of neuronal nicotinic
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DB Vaupel, AS Kimes, ED London (1997). Further in-vivo studies on attenuating morphine
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JL Musachio, V Villemagne, U Scheffel, M Stathis, P Finley, A Horti, ED London, RF Dannals
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acetylcholine receptors. Synapse 26:392-399.
JM Stapleton, MJ Morgan, X Liu, BC-K Yung, RL Phillips, DF Wong, EK Shaya, RF Dannals,
ED London (1997): Cerebral glucose utilization is reduced in second test session. J. Cereb. Blood
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MI Davila-Garcia, JL Musachio, DC Perry, Y Xiao, A Horti, ED London, RF Dannals, KJ Kellar
(1997): [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic
receptors. J. Pharmacol. Exp. Ther. 282:445-451.
RL Phillips, ED London (1997): Simplified calculation of MRglc using PET. J. Nucl. Med.
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A Horti, U Scheffel, M Stathis, P Finley, HT Ravert, ED London, RF Dannals (1997): Fluorine18-FPH for PET imaging of nicotinic acetylcholine receptors. J. Nucl. Med. 38:1260-1265.
A Mukhin, ES Kovaleva, ED London (1997): Two affinity states of NMDA recognition sites:
Modulation by cations. J. Pharmacol. Exp. Ther. 282:945-954.
A Shimada, A Mukhin, DK Ingram, ED London (1997). N-methyl-D-aspartate receptor binding
in brains of rats at different ages. Neurobiol. Aging 18:329-33.
E Koylu, S Demirgören, ED London, S Pogun (1997). Sex difference in up-regulation of nicotinic
acetylcholine receptors in rat brain. Life Sci. 61:PL185-190.
H Takahashi, RJ Traystman, K Hashimoto, ED London, JR Kirsch (1997): Postischemic brain
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X Liu, JL Musachio, HN Wagner, Jr., T Mochizuki, RF Dannals, ED London (1997). External
monitoring of cerebral nicotinic acetylcholine receptors in living mice. Synapse 24:378-380.
VL Villemagne, A Horti, U Scheffel, HT Ravert, P Finley, D Clough, ED London, HN Wagner
Jr., RF Dannals (1997): Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an
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NJ Alkayed, I Harukuni, AS Kimes, ED London, RJ Traystman, PD Hurn (1998): Gender-linked
brain injury in experimental stroke. Stroke 29:159-166.
X Liu, JA Matochik, JL Cadet, ED London (1998): Smaller volume of prefrontal lobe in polysubstance abusers: A magnetic resonance imaging study. Neuropsychopharmacology 18:243-252.
DK Ingram, EL Spangler, RC Meyer, ED London (1998): Learning in a 14-unit T-maze is
impaired in rats following systemic treatment with N-nitro-L-arginine. Neurobiol.
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RC Meyer, ED Spangler, N Patel, ED London, DK Ingram (1998): Impaired learning in a 14-unit
T-maze by 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, is attenuated by the nitric
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DK Ingram, EL Spangler, H Kametani, RC Meyer, ED London (1998): Intracerebroventricular
injection of N-nitro-L-arginine in rats impairs learning in a 14-unit T-maze. Neurobiol.
Aging 341:11-16.
AG Horti, AO Koren, HT Ravert, JL Musachio, WB Mathews, ED London, RF Dannals (1998):
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X Liu, DB Vaupel, S Grant, ED London (1998): Effect of cocaine-related environmental stimuli
on the spontaneous electroencephalogram in polydrug abusers. Neuropsychopharm. 19:10-17.
M Kassiou; UA Scheffel, HT Ravert, WB Mathews, JL Musachio; ED London, RF Dannals
(1998): Pharmacological evaluation of [11C]A-84543: an enantio-selective ligand for in vivo
studies of neuronal nicotinic acetylcholine receptors. Life Sci. 63:PL13-8.
K Bolla, JL Cadet, ED London (1998): The neuropsychiatry of chronic cocaine abuse. J.
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DB Vaupel, AG Mukhin, AS Kimes, AG Horti, AO Koren, ED London (1998): In vivo studies
with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. Neuroreport 9: 2311-2317.
AO Koren, AG Horti, AG Mukhin, D Gündisch, AS Kimes, RF Dannals, ED London: 2-, 5- and
6-Halo-3-(2(S)-azetidinylmethoxy)pyridines (1998): Synthesis, affinity for nicotinic acetylcholine
receptors, and molecular modeling. J. Med. Chem. 41:3690-3698.
AG Horti, U Scheffel, AO Koren, HT Ravert, WB Mathews, JL Musachio, PA Finley, ED
London, RF Dannals (1998): 2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic
acetylcholine receptors. J. Nucl. Med. Biol. 25:599-603.
AG Horti, U Scheffel, AS Kimes, JL Musachio, HT Ravert, WB Mathews, Y Zhan, PA Finley,
ED London, RF Dannals (1998): Synthesis and evaluation of N-[11C]methylated analogs of
epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine
receptors. J. Med. Chem. 41:4199-4206.
SI Chefer, AG Horti, KS Lee, AO Koren, DW Jones, J Gorey, JM Links, AG Mukhin, DR
Weinberger, ED London (1998): In vivo imaging of brain nicotinic acetylcholine receptors
with 5-[123I]iodo-A-85380 using single photon emission computed tomography. Life Sci.
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PM Sanchez-Roa, HW Wagner Jr., VL Villemagne, ED London, JR Lever (1998): Effects of
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simple probe. Eur. J. Pharmacol. 358:207-11.
A Bhardwaj, M Sawada, ED London, RC Koekler, RJ Traystman, JR Kirsch (1998): Potent
sigma1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-Daspartate-evoked nitric oxide production in vivo. Stroke 29:2404-11.
AS Kimes, R Maldonado E Ambrosio GF Koob, ED London (1998): Cerebral glucose
metabolism during opioid withdrawal following methylnaloxonium injection into the locus
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I Harukuni. Bhardwaj A. Traystman RJ. Crain B. London ED. Kirsch JR (1998): Neuroprotection
from focal ischemia by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is dependent on treatment
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AG Horti, AO Koren, KS Lee, AG Mukhin, DB Vaupel, AS Kimes, M Stratton, ED London
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ED Morris, SI Chefer, MA Lane, RF Muzic Jr., DF Wong, RF Dannals, JA Matochik, AA Bonab,
VL Villemagne, SJ Grant, DK Ingram, GS Roth, ED London (1999): Loss of D2 receptor binding
with age in rhesus monkeys: Importance of correction for differences in striatal size. J. Cereb.
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Sihver W, KJ Fasth, AG Horti, AO Koren, M Bergström, L Lu, G Hagberg, H Lundqvist, RF
Dannals, ED London, A Nordberg, and B Långström (1999): Synthesis and characterization of
binding of 5-[76Br]-bromo-3-[[2(S)-azetidinyl]methoxy]pyridine, a novel nicotinic acetylcholine
receptor ligand, in rat brain. J. Neurochem. 73:1264-1272.
SI Chefer, AG Horti, AO Koren, D Gündisch, JM Links, V Kurian, RF Dannals, AG Mukhin, ED
London (1999): 2-[18F]F-A-83580: a PET radioligand for 42 nicotinic acetylcholine receptors.
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R Rusa, N Alkayed, B Crain, R Traystman, A Kimes, ED London, J Klaus, PD Hurn (1999): 17Estradiol reduces stroke injury in estrogen-deficient female animals. Stroke 30:1665-70.
D Gündisch, ED London, P Terry, GR Hill, AG Mukhin (1999): High affinity binding of [3H]epibatidine to rat brain membranes. Neuroreport 10:1631-1636.
KR Bonson, SJ Grant, JM Links, ED London (2000): Validation of an analytic method of
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G Bartzokis, PH Lu, M Beckson, R Rapoport, S Grant, EJ Wiseman, ED London (2000):
Abstinence from cocaine reduces high-risk responses on a gambling task.
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U Scheffel, AG Horti, AO Koren, HT Ravert, JP Banta, PA Finley, ED London, RF Dannals
(2000): 6-[18F] Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptor. Nucl.
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AG Mukhin, D Gündisch, AG Horti, AO Koren, G Tamagnan, AS Kimes, J Chambers, DB
Vaupel, SI King, MR Picciotto, RB Innis, ED London (2000): 5-Iodo-A-85380, an 42 subtypeselective ligand for nicotinic acetylcholine receptors. Mol. Pharmacol. 57:642-649.
AO Koren, AG Horti, AG Mukhin, D Gündisch, RF Dannals, ED London (2000): Synthesis and
initial in vitro characterization of 6-[18F]fluoro-3-(2(s)-azetidinylmethoxy)-pyridine, a highaffinity radioligand for central nicotinic acetylcholine receptors. J. Labelled Compd. Radiopharm.
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S Grant, C Contoreggi, ED London (2000): Drug abusers show impaired performance in a
laboratory test of decision-making. Neuropsychologia 38: 1180-1187.
II Galynker, S Watras-Ganz, C Miner, RN Rosenthal, DC Desjarlais, BL Richman, ED London
(2000): Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.
Mt. Sinai J Med 67:381-387.
AG Horti, SI Chefer, AG Mukhin, AO Koren, D Gündisch, JM Links, V Kurian, RF Dannals, ED
London (2000): 6-[18F]-fluoro-A-85380, a novel radioligand for in vivo imaging of central
nicotinic acetylcholine receptors. Life Sci. 67:463-469.
DB Newlin, CJ Wong, JM Stapleton, and ED London (2000): Intravenous cocaine decreases
cardiac vagal tone, vagal index (derived in Lorenz space), and heart period complexity
(approximate entropy) in cocaine abusers. Neuropsychopharmacology 23:560-8.
JA Matochik, SI Chefer, MA Lane, RI Woolf, ED Morris, DK Ingram, GS Roth, ED London
(2000): Age-related decline in striatal volume in monkeys as measured by magnetic resonance
imaging, Neurobiol. Aging 21:591-598.
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LG Sharpe, NS Pilotte, TS Shippenberg, CB Goodman, ED London (2000): Autoradiographic
evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor
expression in limbic regions of the rat brain, Synapse 37:292-297.
S Pogun, S Demirgören, D Taskiran, L Kanit, O Yilmaz, EO Koylu, B Balkan, ED London
(2000): Nicotine modulates nitric oxide in rat brain. Eur. Neuropsychopharmacol. 10:463-472.
Yilmaz, O., Kanit, L., Okur, B.E., London, E. D., Pogun, S. (2000): Nitric oxide synthetase
inhibition hinders facilitation of active avoidance learning by nicotine in rats. Behav. Pharmacol.
11:505-510.
M Ernst, JA Matochik, SJ Heishman, JD Van Horn, PH Jons, JE Henningfield, ED London
(2001): Effect of nicotine on brain activation during performance of a working memory task.
Proc. Nat. Acad. Sci. USA. 98:4728-4733.
M Ernst, SJ Heishman, L Spurgeon, ED London (2001): Smoking history and nicotine effects on
cognitive performance. Neuropsychopharmacology 25:313-319.
MZ Mintzer, RR Griffiths, C Contoreggi, AS Kimes, ED London, M Ernst (2001): Effects of
triazolam on brain activity during episodic memory encoding: a PET study.
Neuropsychopharmacology 25:744-756.
KR Bonson, SJ Grant, CS Contoreggi, JM Links, J Metcalfe, HL Weyl, V Kurian, M Ernst,
ED London (2002): Neural systems and cue-induced cocaine craving. Neuropsychopharmacology
26: 376-386.
M Ernst, K Bolla, M Mouratidis, C Contoreggi, JA Matochik, V Kurian, J-L Cadet, AS Kimes,
ED London (2002): Decision-Making in a risk-taking task: A PET study.
Neuropsychopharmacology 26: 682-691.
M Fujita, JP Seibyl, DB Vaupel, G Tamagnan, M Early, SS Zoghbi, RM Baldwin, AG Horti, AO
Koren, AG Mukhin, S Khan, A Bozkurt, AS Kimes, ED London, RB Innis (2002): Whole-body
biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in
healthy human subjects. Eur. J. Nucl. Med. 29:183-190.
AL Brody, MA Mandelkern, ED London, AR Childress, GS Lee, RG Bota, ML Ho, S Saxena,
LR Baxter, D Madsen, ME Jarvik (2002): Brain metabolic changes during cigarette craving.
Arch. Gen. Psychiatry 59:1162-72.
M Ernst, SJ Grant, ED London, CS Contoreggi, AS Kimes, L Spurgeon (2003): Decision-making
in adolescents with behavior disorders and adults with substance abuse. Am. J. Psychiatry 160:
33-40.
JE Rose, FM Behm, EC Westman, RJ Mathew, ED London, TC Hawk, TG Turkington, RE
Coleman (2003): PET studies of the influences of nicotine on neural systems in cigarette smokers.
Am. J. Psychiatry 160:323-33.
DB Vaupel, SR Tella, DL Huso, AG Mukhin, I Baum, ED London, AO Koren, AS Kimes
(2003): Pharmacology, toxicology, and radiation dosimetry evaluation of [123I]5-I-A-85380, a
radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans.
Drug Dev. Res. 58: 149-168.
JM Stapleton, SF Gilson, DF Wong, VL Villemagne, RF Dannals, RF Grayson, JE Henningfield,
ED London (2003): Intravenous nicotine reduces cerebral glucose metabolism: a preliminary
study. Neuropsychopharmacology 28:765–772.
KI Bolla, DA Eldreth, ED London, KA Kiehl, M. Mouratidis, C Contoreggi, JA Matochik, V
Kurian, J-L Cadet, AS Kimes, FR Funderburk, M Ernst (2003): Orbitofrontal cortex dysfunction
in abstinent cocaine abusers performing a decision-making task: NeuroImage 19:1085-1094.
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SI Chefer, ED London, AO Koren, OA Pavlova, V Kurian, AS Kimes, AG Horti, AG Mukhin
(2003): Graphical analysis of 2-[18F]fluoro-A85380 binding to nicotinic acetylcholine receptors
in rhesus monkey brain. Synapse 48:25-34.
AS Kimes, AG Horti, ED London, SI Chefer, C Contoreggi, M Ernst, P Friello, AO Koren, V
Kurian, J Matochik, O Pavlova, D Vaupel, AG Mukhin (2003): 2-[18F]F-A85380: PET imaging
brain nicotinic acetylcholine receptors and whole body distribution in humans.
FASEB J 10:1331-1333.
JA Matochik, ED London, DA Eldreth, J Cadet, KI Bolla (2003): Frontal cortical tissue
composition in abstinent cocaine abusers: a magnetic resonance imaging study. NeuroImage 19:
1095-1102.
X Liu, AO Koren, SK Yee, RN Pechnick, RE Poland, ED London (2003): Self-administration of
5-Iodo-A 85380, a 2-selective nicotinic receptor ligand, in operantly trained rats. NeuroReport,
14:1503-1505.
M Ernst, AS Kimes, ED London, JA Matochik, D Eldreth, S Tata, C Contoreggi, M Leff, K Bolla
(2003): Neural substrates of decision-making in attention-deficit hyperactivity disorder. Am. J.
Psychiatry 160:1061-1070.
MK Leff, ET Moolchan, BA Cookus, L Spurgeon, LA Evans, ED London, A Kimes, JR
Schroeder, M Ernst (2003): Predictors of smoking initiation among at risk youth: a controlled
study. J. Child & Adolescent Substance Abuse 13(1):59-75.
E Rotheram-Fuller, S Shoptaw, SM Berman, ED London (2003): Impaired performance in a test
of decision-making by opiate-dependent tobacco smokers. Drug Alcohol Depend. 73:79-86.
M Fujita, M Ichise, CH van Dyck, SS Zoghbi, G Tamagnan, AG Mukhin, A Bozkurt, N Seneca,
D Tipre, CC DeNucci, H Iida, DB Vaupel, AG Horti, AO Koren, AS Kimes, ED London, JP
Seibyl, RM Baldwin, RB Innis (2003): Quantification of nicotinic acetylcholine receptors in
human brain using [123I]5-I-A-85380 SPET. Eur. J. Nucl. Med. Mol. Imaging 30:1620-1629.
AL Brody, RE Olmstead, ED London, J Farahi, JH Meyer, P Grossman, GS Lee, J Huang, E
Hahn, MA Mandelkern (2004): Smoking-induced ventral striatal dopamine release. Am. J.
Psychiatry 161:1211-1218.
ED London, SL Simon, SM Berman, MA, Mandelkern, AM Lichtman, J Bramen, AK Shinn, K
Miotto, J Learn, Y Dong, JA Matochik, V Kurian, T Newton, R Woods, R Rawson, W Ling
(2004): Mood disturbances and regional cerebral metabolic abnormalities in recent
methamphetamine abusers. Arch. Gen. Psychiatry 61:73-84.
JA Matochik, SI Chefer, MA Lane, GS Roth, JA Mattison, ED London, DK Ingram (2004): Agerelated decline in striatal volume in rhesus monkeys: assessment of long-term calorie restriction.
Neurobiol. Aging 25:193-200.
AL Brody, MA Mandelkern, ME Jarvik, GS Lee, EC Smith, JC Huang, RG Bota, G Bartzokis,
ED London (2004): Differences between smokers and non-smokers in regional gray matter
volumes and densities. Biol. Psychiatry 55:77-84.
AL Brody, MA Mandelkern, G Lee, E Smith, M Sadeghi, S Saxena, M Jarvik, ED London
(2004): Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in
bupropion-treated smokers: a preliminary study. Psychiatry Res. Neuroimaging 130:269-281.
P Thompson, KM Hayashi, SL Simon, JA Geaga, MS Hong, Y Sui, JY Lee, AW Toga, W Ling,
ED London (2004): Structural abnormalities in the brains of human subjects who use
methamphetamine. J. Neurosci. 24:6028-6036.
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KI Bolla, M Ernst, KA Kiehl, M Mouratidis, DA Eldreth, C Contoreggi, JA Matochik, V Kurian,
JL Cadet, AS Kimes, FR Funderburk, ED London (2004): Prefrontal cortical dysfunction in
abstinent cocaine abusers. J Neuropsych. & Clin. Neurosci. 16: 456-464.
DB Vaupel, S Tella, D Huso, V Wagner III, A Mukhin, S Chefer, A Horti, E London, A Koren, A
Kimes (2005): Pharmacological and toxicological evaluation of 2-F-A-85380, a ligand for
imaging cerebral nicotinic acetylcholine receptors with positron emission tomography. J.
Pharmacol. Exp. Ther. 312: 355-365.
D Gündisch, AO Koren, AG Horti, OA Pavlova, AS Kimes, AG Mukhin, ED London (2005): In
vitro characterization of 6-[18F]fluoro-A-85380, a novel high-affinity ligand for α4β2 nicotinic
acetylcholine receptors. Synapse 55:89-97.
DH Fishbein, DL Eldreth, C Hyde, JA Matochik, ED London, C Contoreggi, V Kurian AS
Kimes, A Breeden, S Grant (2005): Risky decision-making and the anterior cingulate cortex in
abstinent drug abusers and nonusers. Cogn. Brain Research 23:119-136.
MJ Bauer, ED London, SM Berman, N Rasgon, MA Frye, LL Altshuler, MA Mandelkern, J
Bramen, B. Voytek, R Woods, JC Mazziotta, PC Whybrow (2005): Supraphysiological doses of
levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol.
Psychiatry 10:456-469.
JA Matochik, ED London, BO Yildiz, M Ozata, S Caglayan, AM DePaoli, M Wong, J Licinio
(2005): Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J
Clin. Endocr. & Metab. 90:2851-2854.
JR Monterosso, AR Aron, X Cordova, J Xu, ED London (2005). Deficits in response inhibition
associated with chronic methamphetamine abuse. Drug Alcohol Depend. 79:273-277.
DH Fishbein, C Hyde, DL Eldreth, ED London, JA Matochik, M Ernst, N Isenberg, S Steckley, B
Schech, A Kimes (2005). Cognitive performance and autonomic reactivity in abstinent drug
abusers and nonusers. Exp Clin Psychopharmacol. 13:25-40.
J Xu, A Mendrek, MS Cohen, J Monterosso, P Rodriquez, SL Simon, A Brody, M Jarvik, CP
Domier, R Olmstead, M Ernst, ED London (2005): Brain activity in cigarette smokers
performing a working memory task: Effects of smoking. Biol. Psychiatry 58:143-150.
B Voytek, SM Berman, BD Hassid, SL Simon, MA Mandelkern, AL Brody, J Monterosso, W
Ling, ED London (2005). Differences in regional brain metabolism associated with marijuana
abuse in methamphetamine abusers. Synapse 57:113-115.
ED London, SM Berman, BT Voytek, SL Simon, J Monterosso, JA Geaga, MS Hong, KM
Hayashi, PM Thompson, MA Mandelkern, AL Brody, RA Rawson and W Ling (2005): Cerebral
metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers.
Biol. Psychiatry 58: 770-778.
A Mendrek, J Monterosso, SL Simon, M Jarvik, A Brody, R Olmstead, CP Domier, MS Cohen,
M Ernst, ED London (2006): Working memory in cigarette smokers: comparison to non-smokers
and effects of abstinence. Addictive Behaviors, 31: 833-844.
LJ Cohen, E Gertmenian-King, L Kunik, C Weaver, ED London, I Galynker (2005). Personality
measures in former heroin users receiving methadone or in protracted abstinence from opiates.
Acta Psychiatrica Scand. 112:149-158.
DP Eisenberg, ED London, JA Matochik, S Derbyshire, LJ Cohen, M Steinfeld, II. Galynker
(2005). Education-associated cortical glucose metabolism during sustained attention.
NeuroReport 16:1473-1476.
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SL Obrzut, AO Koren, MA Mandelkern, AL Brody, CK Hoh, ED London (2005): Whole-body
radiation dosimetry of 2-[18F]fluoro-A-85380 in human PET imaging studies. Nucl. Med.
Biol.32: 869-874.
AL Brody, MA Mandelkern, ED London, RE Olmstead, J Farahi, D Scheibal, J Jou, V Allen, E
Tiongson, SI Chefer, AO Koren, AG Mukhin (2006): Cigarette smoking saturates brain α4β2
nicotinic acetylcholine receptors. Arch. Gen. Psychiatry 63: 907-915.
AL Brody, MA Mandelkern, RE Olmstead, D Scheibal, E Hahn, S Shiraga, E Zamora-Paja, J
Farahi, S Saxena, ED London, JT McCracken (2006): Gene variants of the brain dopamine
reward pathway determine smoking-induced dopamine release in the ventral caudate/nucleus
accumbens. Arch. Gen. Psychiatry 63: 808-816.
M Ernst, DA Luckenbaugh, ET Moolchan, M Leff, R Allen, N Eshel, ED London, A Kimes
(2006). Behavioral predictors of substance use initiation in adolescents with and without
attention-deficit/hyperactivity disorder. Pediatrics 117 (6): 2030-2039.
J Prosser, LJ Cohen, M Steinfeld, D Eisenberg, ED London, II Galynker (In press 2006)
Neuropsychological functioning in opiate dependent subjects receiving and following methadone
maintenance treatment. Drug Alcohol Depend.
JK Staley, S Krishnan-Sarin, KP Cosgrove, E Krantzler, E Frohlich, E Perry, J Dubin, E Brenner,
RM Baldwin, GD Tamagnan, JP Seibyl, ED London, S O’Malley and CH van Dyck (2006).
Human tobacco smokers have higher β2* nicotinic acetylcholine receptors during early
abstinence. J. Neurosci. 26: 8707-8714.
J Monterosso, CP Domier, G Ainslie, J Xu, X Cordova, ED London (In press 2006)
Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects
performing a parametric delay-discounting task. Human Brain Mapping.
DF Wong, H Kuwabara, D Schretlen, K Bonson, Y Zhou, A Nandi, J Brasic, A Kimes, A Kumar,
C Contoreggi , J Links , M Ernst , O Rousset, S Zukin, A Grace, C Rohde, D Jasinski, ED
London (In press 2006). Increased occupancy of dopamine receptors in human striatum during
cue-elicited cocaine craving. Neuropsychopharmacology.
J Xu, A Mendrek, MS Cohen, J Monterosso, S Simon, M Jarvik, R Olmstead, AL Brody, M
Ernst, ED London (In press 2006). Effect of cigarette smoking on prefrontal cortical function on
nondeprived smokers performing the Stroop task. Neuropsychopharmacology.
Chapters and Reviews:
1.
JT Coyle, P Campochiaro, ED London (1978): Neurotoxic action of kainic acid in the developing
rat striatum. In: Maturation of Biochemical Neurotransmission, A Vernadakis, E Giacobini, G
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JT Coyle, ED London, K Biziere, Zaczek (1979): Kainic acid neurotoxicity: Insights into the
pathophysiology of Huntington's disease. Adv. in Neurol. Vol. 23: Huntington’s Disease, TN
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JT Coyle, J Slevin, ED London, K Biziere, J Collins (1981): Characterization of neuronal
recognition sites for [3H]kainic acid. In: Psychopharmacology and Biochemistry of
Neurotransmitter Receptors RW Olsen, HI Yamamura, E Usdin, eds. Raven Press, New York,
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SI Rapoport, M Ohata, ED London (1981): Cerebral blood flow and glucose utilization following
opening of the blood-brain barrier and during maturation of the rat brain. Fed. Proc. 40:23222334.
SI Rapoport, ED London (1982): Brain metabolism during aging of the rat and dog - Implications
for brain function in man during aging and dementia. In: Aging, Vol. 18: Neural Aging and its
Implications in Neurological Pathology RD Terry, CL Bolis, G Toffano, eds. Raven Press, New
York, pp. 79-88.
SI Rapoport, R Duara, ED London, RA Margolin, M Schwartz, N Cutler, M Partanen, NL
Shinowara (1983): Glucose metabolism of the aging nervous system. In: Aging Vol. 22: Aging
the Brain, D Samuel, S Algeri, S Gershon, VE Grimm, G Toffano, eds. Raven Press, New York,
pp 111-121.
MJ Ball, H Mersky, M Fisman, IM Fyfe, H Fox, RDT Cape, SB Waller, ED London (1983):
Hippocampal morphometry in Alzheimer dementia: Implications for neurochemical hypotheses.
In: Banbury Report Vol. 15: Biological Aspects of Alzheimer's Disease, R Katzman, ed. Cold
Spring Harbor Laboratories, Cold Spring Harbor, pp. 45-57.
ED London, SI Rapoport (1983): Cerebral glucose utilization in the aging rat and beagle:
Implications for human brain metabolism during aging and dementia. In: Atherosclerotic Brain
Disease. New Trends in Prevention and Treatment of Atherosclerosis, G Crepaldi, R Fellin, AG
Olsson, G Toffano, eds. Raven, New York, pp. 45-52.
ED London (1984): Metabolism of the brain: A measure of cellular function in aging. In: Aging
and Cell Function, JE Johnson, ed. Plenum, New York, pp. 187-210.
M Dam, SI Rapoport, ED London (1984): Aging and cholinergic system: A 2-deoxyglucose study
in the rat brain. In: Monogr. Neural Sciences Vol. 11: Effects of Aging on Regulation of Cerebral
Blood Flow and Metabolism, C Fieschi, GL Lenzi, CW Loeb, eds. Karger, New York, pp. 62-67.
R Duara, ED London, and SI Rapoport (1985): Changes in structure and energy metabolism of
the aging brain. In: Handbook of the Biology of Aging 2nd edition, CE Finch, E Schneider, eds.
Van Nostrand Reinhold Company, New York, pp. 595-616.
ED London, M Szikszay, M Dam (1986): Metabolic mapping of the cerebral effects of abused
drugs. NIDA Res. Monogr. 67:26-35.
London ED (1986): Reversal of cerebral metabolic deficits in rodent models for aging and
Alzheimer's disease. In: Alzheimer's and Parkinson's Diseases: Strategies in Research and
Development, A Fisher, I Hanin & C Lachman, eds. Plenum, New York, pp. 407-417.
ED London, AD Weissman, RJ Fanelli, G Wilkerson, EP Broussolle, JH Jaffe (1986): Mapping
the cerebral distributions of action of euphoriant drugs. Clin. Neuropharm. 9: Suppl. 4:208-210.
ED London, SB Waller (1986): Relationships between choline acetyltransferase and muscarinic
binding in aging rodent brain and in Alzheimer's disease. In: Dynamics of Cholinergic Function I
Hanin, ed. Plenum, New York, pp 215-224.
JE Henningfield, JH Jaffe, ED London (1987): Nicotine reward: Studies of abuse liability and
physical dependence potential. In: Brain Reward Systems and Abuse, J Engel, L Oreland, eds.
Raven Press, New York, pp. 147-164.
ED London, R Fanelli, M Szikszay, D Jasinski (1987): Effects of opioid analgesics on local
cerebral glucose utilization. NIDA Res. Monogr. 75: 379-381.
M Szikszay, FR Snyder, ED London (1987): Effects of morphine and calcium antagonists on
plasma glucose in male rats. NIDA Res. Monogr. 75: 382-384.
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SB Waller, ED London (1987): Noninvasive diagnostic techniques to study age-related cerebral
disorders. In: Psychogeriatrics: An International Handbook, M Bergener, ed. Springer, New
York, pp. 172-193.
ED London, M Dam, AD Weissman (1987): Different patterns of cerebral glucose utilization
produced by phencyclidine and d-N-allylnormetazocine. In: Sigma and Phencyclidine-like Compounds as Molecular Probes in Biology, EF Domino, J-M Kamenka, eds. NPP Books, pp. 297307.
Submitted chapter, "Distribution & cerebral metabolic effects of nicotine" in CE Koop (1988):
The Health Consequences of Smoking: Nicotine Addiction, a report of the Surgeon General. U.S.
Govt. Printing Office, Washington, DC.
T-P Su, ED London, JH Jaffe (1989): Steroid binding at  "opioid" receptor: Response to a
technical comment. Science 246:1635-1638.
ED London (1990): Effects of nicotine on cerebral metabolism. In: The Biology of Nicotine
Dependence, Ciba Foundn. Symp. #152, G Bock, J Marsh, eds. Wiley, Chichester, pp. 131-146.
ED London (1990): Glucose metabolism: An index of nicotine action in the brain. In: Proc.
International Symposium on Nicotine. Advances in Pharmacological Sciences, A Adlkofer, ed.
Birkhauser Verlag, Basel, pp. 239-248.
ED London, VL Dawson, CR Mantione (1990): Specific binding sites for polyamines in
mammalian brain. In: NMDA Related Agents: Biochemistry Pharmacology and Behavior, T
Nabeshima, T Kameyama, EF Domino, eds. NPP Books, Ann Arbor, MI, pp. 71-78.
T-P Su, X-Z Wu, CE Spivak, ED London, JA Bell (1990): Binding studies on intact NCB-20
cells suggest receptor multiplicity: 1 and 2. In: NMDA Related Agents: Biochemistry
Pharmacology and Behavior, T Nabeshima, T Kameyama, EF Domino, eds. NPP Books, Ann
Arbor, MI,. 227-234.
ED London, MJ Morgan, RL Phillips, JM Stapleton, NG Cascella, DF Wong (1991): Mapping
the metabolic correlates of drug-induced euphoria. NIDA Res. Monogr. 105:54-60.
ED London, MJ Morgan (1993): Positron emission tomography studies on the acute effects of
psychoactive drugs on brain metabolism and mood. In: Imaging Drug Action in the Brain, ED
London, ed. CRC Press, Boca Raton, FL, pp 265-280.
ED London, SR Zukin (1993): Sigma receptors, PCP receptors and the developing nervous
system. In: Receptors in the Developing Nervous System, Volume 2: Neurotransmitters IS
Zagon, PJ McLaughlin, eds. Chapman & Hall, London, pp 215-230.
ED London: Studies of receptors and metabolic responses to  ligands in the brain (1993): NIDA
Res. Monogr. 133:55-68.
ED London (1993): Seeing the brain: The role of PET, autoradiography, and other imaging
techniques. In: Biomedical Approaches to Illicit Drug Demand Reduction, CR Hartel, ed. Proc.
Int. Res. Conf., Sea Island, GA, Feb. 24-26, 1992, NIDA, NIH Pub. No. 93-3698, pp. 235-241.
K Hashimoto, ED London (1994): Imaging Sigma Receptors and Cerebral Responses to Sigma
Drugs. In: Sigma Receptors, Y. Itzhak, ed. Academic Press, Miami, FL, pp. 225-242.
ED London (1994): Positron emission tomography in studies of drug abuse. NIDA Res. Monogr.
138:15-24.
DK Ingram, EL Spangler, S Iijima, H Kuo, EL Bresnahan, NH Greig, and ED London (1994):
New pharmacological strategies for cognitive enhancement using a rat model of age-related
memory impairment. Ann. N.Y. Acad. Sci. 717:16-32.
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K Hashimoto, ED London (1994): Specific binding sites for polyamines in brain. In:
Neuropharmacology of Polyamines, CJ Carter, ed. Academic Press, London, pp. 155-165.
ED London (1994): Patterns of nicotine action in the brain. Tobacco Control 3:101.
MJ Morgan, ED London (1995): The use of positron emission tomography to study the acute
effects of addictive drugs on cerebral metabolism. In: Sites of Drug Addiction in the Human
Brain, A Biegon, ND Volkow, eds. CRC Press, Boca Raton, FL, pp. 159-172.
ED London (1995): Brain metabolism in substance abusers. NIDA Res. Monogr. 152(1)
Problems of Drug Dependence 1994: Proc. 56th Annual Scientific Meeting, College on Problems
of Drug Dependence, Inc.
DB Vaupel, AS Kimes, and ED London (1995): Attenuation of opioid withdrawal:
Pharmacological profiles of nitric oxide synthase inhibitors. NIDA Res. Monogr. 153(2): 103.
X Liu, RL Phillips, SM Resnick, DF Wong, JM Stapleton, VL Villemagne, and ED London
(1995): No evidence for ventriculomegaly in polysubstance abusers: A volumetric magnetic
resonance imaging study. NIDA Res. Monogr. 153(2): 209.
ED London, A Mukhin (1995): Polyamines as endogenous modulators of the N-methyl-Daspartate receptor. Ann. N.Y. Acad. Sci. 757:430-438.
ED London (1995): Mapping the cerebral metabolic responses to nicotine. In: Brain Imaging of
Nicotine and Tobacco Smoking, EF Domino, ed. NPP Books Inc., Ann Arbor, MI, pp 153-166.
ED London, S Grant, D Newlin (1995): Identifying the substrates in brain that underlie cocaine
craving. NIH Catalyst May/Jun. pp. 10,11,22.
ED London, AS Kimes, DB Vaupel (1995): Inhibitors of nitric oxide synthase and the opioid
withdrawal syndrome. NIDA Res. Monogr. 147:170-181.
JM Stapleton, ED London (1995): Imaging techniques: visualizing the living brain. In:
Encyclopedia of Drugs & Alcohol Vol 2, JH Jaffe, ed. Macmillan, New York, NY, pp. 573-576.
ED London, SJ Grant, MJ Morgan, SR Zukin (1996): Neurobiology of drug abuse. In:
Neuropsychiatry: A Comprehensive Textbook, BS Fogel, RB Schiffer, SM Rao, eds. Baltimore
MD, Williams & Wilkins, pp 635-678.
ED London, JM Stapleton, RL Phillips, SJ Grant, VL Villemagne, X Liu, R Soria (1996) PET
studies of cerebral glucose metabolism: Acute effects of cocaine and long-term deficits in brains
of drug abusers. NIDA Res. Monogr. 163: 146-158.
DK Ingram, A Shimada, A Mukhin, ED London (1996): Evaluating the glutamate hypothesis of
geriatric memory impairment: Focus on hippocampal NMDA receptors. Perspect. Brain Aging
Res. 1:30-35.
FJ Vocci; ED London (1997): Assessment of neurotoxicity from potential medications for drug
abuse: ibogaine testing and brain imaging. Ann. NY Acad. Sci. 820:29-39; discussion 39-40.
M Ernst, ED London (1997): Brain imaging studies of drug abuse: Therapeutic implications.
Semin. Neurosci. 9:120-130.
ED Morris, Chefer SI, ED London (1998): Limitations of binding potential as a measure of
receptor function. A two-point correction for the effects of mass. In Quantitative Functional Brain
Imaging with Positron Emission Tomography, RE Carson, P Herscovitch, ME DaubeWitherspoon, eds. Academic Press, San Diego, CA, pp. 407-413.
M Ernst, ED London (1998): More ethical challenges: commentary on Fischman and Johanson's
ethical and practical issues involved in behavioral pharmacology research that administers drugs
of abuse to human volunteers. Behav. Pharmacol. 9(7): 499-501.
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London, KR Bonson, M Ernst, S Grant (1999): Brain imaging studies of cocaine abuse:
implications for medication development. Critical Reviews in Neurobiology 13(3): 227-242.
ED London, KR Bonson, S Grant (1999): Brain imaging to develop treatments for drug abuse.
Paradigm Magazine 4 (3):14-18. Quest Publishing Company.
ED London and FJ Vocci (2000): Neurosciences II – Biomarkers for alcohol and drug abuse. In
Biomarkers and Surrogate Endpoints: Clinical Research and Applications. Proceedings of the
NIH-FDA conference held on 15-16 April 1999 in Bethesda, MD. GJ Downing, ed., Elsevier,
Amsterdam and New York, pp. 119-131.
W Sihver, A Nordberg, B Långström, AG Mukhin, AO Koren, AS Kimes, ED London (2000):
Development of ligands for in vivo imaging of cerebral nicotinic receptors. Behav. Brain
Research 113(1-2): 143-57.
ED London, M Ernst, S Grant, K Bonson, A Weinstein (2000): Orbitofrontal Cortex and Human
Drug Abuse: Functional Imaging. Cerebral Cortex 10:334-342.
SI Chefer, A Mukhin, AG Horti, AOKoren, OA Pavlova, V Kurian, M Stratton, AS Kimes, ED
London (2000). 2-[18F]Fluoro-A-85380: A novel PET ligand for nicotinic acetylcholine receptors.
Proc. Int. Conf Mathematics and Engineering Techniques in Medicine and Biological Sciences
(METMBS’00) 2: 409-415, F. Valafar, ed. CSREA Press, Las Vegas, NV.
AG Mukhin, SI Chefer, AG Horti, AO Koren, DB Vaupel, D Gündisch, OA Pavlova, M Stratton,
V Kurian, AS Kimes, ED London (2000): Radiohalogenated analogues of A-85380 as potential
ligands for in vivo monitoring of the 42 nicotinic receptor alteration in Alzheimer’s disease.
Proc. Int. Conf Mathematics and Engineering Techniques in Medicine and Biological Sciences
(METMBS’00) 2: 429-435, F. Valafar, ed. CSREA Press, Las Vegas, NV.
DK Ingram, S Chefer, J Matochik, TD Moscrip, J Weed, GS Roth, ED London, MA Lane (2001):
Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies.
Ann. NY Acad. Sci. 928:316-326.
SR Cherry, ED London, YC Tai, LA Fairbanks (2001): Development of a molecular imaging
laboratory at the Sepulveda VA vervet research center. 2001 ONDCP International Technology
Symposium Proc. 1:33-39, Jun 25-28, San Diego, CA.
AS Kimes, SI Chefer, DB Vaupel, O Pavlova; AO Koren; C Contoreggi, ED London, A Mukhin
(2001): PET imaging of nicotine acetylcholine receptors. A method to test hypotheses on the role
of nAChRs in facilitating drug-abusing behavior. ONDCP International Technology Symposium
Proc. 1:140-149, Jun 25-28, San Diego, CA.
DH Fishbein, C Hyde, ED London, J Matochik, M Ernst, N Isenberg, B Schech, A Kimes (2001):
Cognitive and physiological differences between abstinent drug abusers and controls. 2001
ONDCP Int’l. Technology Symposium Proceedings 1:158-175, Jun 25-28, San Diego, CA.
CJ Endres, AS Dogan, JR Brasic, Y Zhou, J Hilton, ED London, and DF Wong (2002):
Comparison between bolus and infusion [11C]raclopride delivery for the quantification of
dopamine release. In Brain Imaging Using PET M Senda, Y Kimura, P Herscovitch, eds.
Elsevier, Amsterdam, pp.71-75.
JL Obert, ED London, RA Rawson (2002): Incorporating brain research findings into standard
treatment: an example using the Matrix Model. J. Substance Abuse Treatment. 23:107-113.
RD Mayfield, RL Popp, TK Machu, SJ Grant, MJ Morgan, SR Zukin, ED London (2003):
Neurobiology of drug abuse. In Fogel BS, Schiffer RB, and Rao SM, editors. Neuropsychiatry,
2nd ed. Baltimore MD, Williams & Wilkins, pp. 840-892.
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M Bauer, ED London, DHS Silverman, N Rasgon, J Kirchheiner, PC Whybrow (2003): Thyroid,
brain and mood modulation in affective disorder: Insights from molecular research and functional
brain imaging. Pharmacopsychiatry: 36 Suppl 3: S215-S221.
K Baicy, CE Bearden, J Monterosso, AL Brody, AJ Isaacson, ED London (2005): Common
Substrates of dysphoria in stimulant drug abuse and primary depression: Therapeutic Targets.
Int. Rev. Neurobiol. 65:117-145.
K Baicy, ED London (In press 2006). Corticolimbic dysregulation and chronic methamphetamine
abuse. Addiction.
Curriculum Vitae - Edythe D. London, Ph.D.
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Abstracts:
1.
ED London, JW Hauswirth, FD Kundig, PP Nair (1972): Dependence of heme biosynthesis on
vitamin E status and age -- modulation by phenobarbital. Fed. Proc. 31:713.
2.
ED London, GG Buterbaugh (1975): Convulsant thresholds in developing rats: Effect of
tetrabenazine. Fed. Proc. 34:624.
3.
ED London, FJ Vocci, GG Buterbaugh (1977): Age-dependent modification of the maximal
electroshock convulsive threshold by central monoamine reduction in rats. Pharmacologist 19:14.
4.
ED London, JT Coyle (1977): Pharmacologic augmentation of acetylcholine levels in kainatelesioned rat striatum. Soc. Neurosci. Abstr. 3:41.
5.
ED London, JT Coyle (1978): Characterization of a CNS binding site for the neurotoxin kainic
acid. Fed. Proc. 37:907.
6.
ED London, LW Harris, WC Heyl, JT Coyle (1978): Effect of Deanol in kainate-lesioned rat
striatum: Anomaly in the radioenzymatic assay of acetylcholine. Pharmacologist 20:247.
7.
ED London, N Klemm, JT Coyle (1979): Phylogenetic distribution of [3H]-kainic acid receptor
binding sites in neural tissue. Soc. Neurosci. Abstr. 5:407.
8.
ED London, S Nespor, L Moore, P Mahone, SI Rapoport (1979): Age-dependent changes in local
cerebral glucose utilization. Age 2:131.
9.
ED London, G Schattschneider, HI Yamamura, JT Coyle (1980): Decreased kainic acid binding
sites in Huntington's diseased brain. Fed. Proc. 39:388.
10.
D Dow-Edwards, JM Peterson, P Mahone, SI Rapoport, ED London (1980): Effect of
oxotremorine, a muscarinic agonist, on local cerebral glucose utilization in the rat. Soc. Neurosci.
Abstr. 6:769.
11.
AS Garden, M Ohata, SI Rapoport, ED London (1980): Age-associated decrease in local cerebral
glucose utilization (LCGU) in the Beagle. Soc. Neurosci. Abstr. 6:768.
12.
M Ohata, U Sundaram, WR Fredericks, ED London, SI Rapoport (1980): Age-associated
alterations in regional cerebral blood flow in the Fischer-344 rat. Soc. Neurosci. Abstr. 6:768.
13.
NL Shinowara, SI Rapoport, MJ Hoover, ED London (1980): Changes in retinal morphology and
local glucose utilization (LGU) in 1 to 34 month old Fischer-344 rats. Soc. Neurosci. Abstr.
6:346.
14.
SI Rapoport, WR Fredericks, D Dow-Edwards, ED London (1980): Increased local cerebral
glucose utilization (LCGU) following opening of the blood-brain barrier by hypertonic arabinose
infusion or by acute hypertension. Soc. Neurosci. Abstr. 6:829.
15.
ED London, JM Palacios, SI Rapoport, MJ Kuhar (1980): Local cerebral glucose utilization
following systemic administration of GABAergic agonist and antagonist drugs. Soc. Neurosci.
Abstr. 6:7.
16.
ED London, M Ohata, SI Rapoport (1980): Local cerebral glucose utilization and regional blood
flow during development, maturation and aging of the Fischer-344 rat. Gerontologist 20:(5)
Suppl. II: 252.
17.
ED London, S Nespor, SI Rapoport (1980): Age-associated decreases in local cerebral glucose
utilization. In: Neural Regulatory Mechanisms During Aging ed. by RC Adelman, G Baker, V
Cristofalo, J Roberts. Alan R Liss, Inc. New York, pp. 193-194.
Curriculum Vitae - Edythe D. London, Ph.D.
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NL Shinowara, MJ Hoover, SI Rapoport, ED London (1980): Comparison of retinal changes in
morphology and glucose utilization in aging Fisher-344 rats. In: Neural Regulatory Mechanisms
During Aging ed. by RC Adelman, G Baker, V Cristofalo, J Roberts. Alan R Liss, Inc. New
York, pp. 191-192.
M Dam, H Holloway, P Mahone, D Dow-Edwards, ED London (1981): Oxotremorine increases
glucose utilization in the Papez circuit. Trans. Am. Soc. Neurochem. 12:141.
ED London, M Dam, J Palacios, M Kuhar, S Rapoport (1981): Relation of metabolic drug
responses to receptor distribution. Trans. Am. Soc. Neurochem. 12:141.
ED London, M Ohata, SI Rapoport (1981): Cerebral glucose utilization during aging of the rat
and dog: Implications for brain metabolism in man during aging and dementia. Eur.
Atherosclerosis Group Spring meeting "Atherosclerotic Brain Disease" May 26-27, Padova, Italy.
SI Rapoport, ED London, H Takei, M Ohata (1981): Cerebral metabolism and blood flow during
aging of the Fischer-344 rat. Symposium on Physiological and Pathophysiological Aspects of the
Aging Brain, Jul 9-11, Heidelberg, Germany.
SB Waller, DK Ingram, MA Reynolds, ED London (1981): Neurochemical changes as a function
of genotype and age in mice. Soc. Neurosci. Abstr. 7:186.
H Takei, WR Fredericks, ED London, SI Rapoport (1981): Cerebral blood flow and cerebral
metabolic rates for oxygen, glucose and carbon dioxide in Fischer-344 rats of different ages. Soc.
Neurosci. Abstr. 7:369.
SB Waller, DK Ingram, MA Reynolds, ED London (1982): Changes in neurotransmitter synthetic
enzymes as a function of genotype and age. Age 4:143.
DK Ingram, ED London, MA Reynolds, SB Waller, CL Goodrick (1982): Differential effects of
age on motor performance in two inbred mouse strains. Age 4:138.
GS Sundaram, S Manimekalai, RS London, MA Reynolds, ED London (1982): Age effects on
plasma and lipoprotein cholesterol and related enzymes in the rat. Age 4:150.
ED London, P Mahone, SI Rapoport, M Dam (1982): Effect of age on oxotremorine-induced
stimulation of local cerebral glucose utilization. Fed. Proc. 41:1323.
R Duara, RA Margolin, EA Robertson-Tchabo, ED London, M Schwartz, JW Renfrew, R
Kessler, L Sokoloff, DH Ingvar, SI Rapoport (1982): Regional cerebral glucose utilization in
healthy men at different ages. Neurology 32:A166-A167.
SB Waller, ED London (1982): Increased Vmax for choline acetyltransferase in brain regions of
aged C57BL/6J mice. Fed. Proc. 41:1308.
M Dam, SI Rapoport, ED London (1982): Dose-dependent stimulation of local cerebral glucose
utilization by physostigmine. Fed. Proc. 41:1308.
ED London, SI Rapoport, M Dam (1982): Effect of age on oxotremorine-induced stimulation of
local cerebral glucose utilization. 10th Aharon Katzir-Katchalski Conference on Aging of the
Brain. Mantua, March 26-29.
P Helén, ED London (1982): Muscimol-scopolamine interactions in the rat brain: A study with
[14C]2-deoxy-D-glucose. Soc. Neurosci. Abstr. 8:579.
SB Waller, ED London (1982): Kinetic studies of choline acetyltransferase and muscarinic
receptor binding in aged C57BL/6J mice. Soc. Neurosci. Abstr. 8:518.
ED London, M Dam (1982): Stimulation of local cerebral glucose utilization in the rat visual
system by physostigmine. Soc. Neurosci. Abstr. 8:775.
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London, SI Rapoport, M Dam (1982): Age-related decrease in oxotremorine-induced
stimulation of local cerebral glucose utilization. In: Energy Transduction and Neuro-transmission,
ed. by G Benzi, AM Giuffrida Stella, H S Bachelard, A Agnoli. Fondazione Int. Menarini,
Milano, p. 214.
MJ Ball, H Merskey, M Fisman, I Fyfe, H Fox, R Cape, S Waller, ED London (1983):
Hippocampal morphometry and chemistry in Alzheimer's dementia. J. Neuropathol. Exp. Neurol.
42:335.
ED London, M McKinney, M Dam, JT Coyle (1983): Decreased cortical glucose utilization after
ibotenate lesion of the rat globus pallidus: Effect of oxotremorine. Pharmacologist 25:626.
SB Waller, MJ Ball, ED London (1983): Choline acetyltransferase and muscarinic binding in
Alzheimer's diseased brain. Pharmacologist 25:626.
ED London, DK Ingram, SB Waller (1983): Effects of dietary restriction on neurotransmitter
synthetic enzymes and muscarinic binding in aging rat brain. Soc. Neurosci. Abstr. 9:98.
SB Waller, MJ Ball, ED London (1983): Choline acetyltransferase and muscarinic binding in
regions of normal and Alzheimer's diseased brains. Soc. Neurosci. Abstr. 9:1052.
AM Lowy, DS Olton, DK Ingram, SB Waller, MS Reynolds, ED London (1983): Age and
neurochemical correlates of behavioral rigidity in rats. Soc. Neurosci. Abstr. 9:96.
DE Bernstein, D Olton, D Ingram, S Waller, M Reynolds, ED London (1983): Performance of
young and aged mice in an eight arm radial maze and neurochemical correlates. Soc. Neurosci.
Abstr. 9:98.
SI Rapoport, R Duara, ED London (1983): Brain metabolism in the aging Fischer-344 rat.
Continuing Medical Education, Syllabus & Scientific Proceedings in Summary Form, Am.
Psychiatric Assoc. April, p. 237.
MJ Ball, H Merskey, M Fishman, R Cape, H Fox, I Fyfe, S Waller, ED London (1983):
Hippocamp-al analysis in Alzheimer's disease: Chemical and morphometric changes. Can. J.
Neurol. Sci. 10:156.
ED London, SB Waller (1983): Choline acetyltransferase (CAT) and muscarinic binding in aged
rat and mouse brain. Age 6:133.
D Bernstein, DS Olton, DK Ingram, SB Waller, MA Reynolds, ED London (1983): Radial maze
performance in young and aged mice: A behavioral and neurochemical analysis. Age 6:134.
A Lowy, D Olton, D Ingram, S Waller, MA Reynolds, ED London (1983): Performance of young
and aged rats in a T-maze: Behavioral-neurochemical correlates. Age 6:134.
ED London, SB Waller (1983): Relations between choline acetyltransferase and muscarinic
binding in aging and Alzheimer's disease. Int. Conf. on Dynamics of Cholinergic Function
Oct 30 - Nov 4, Oglebay, West Virginia.
MJ Ball, M Fisman, H Merskey, I Fyfe, H Fox, S Waller, ED London (1983): Correlative study
of chemical and morphometric changes in hippocampi in Alzheimer dementia. Gerontologist
23:247.
RC Walovitch, ED London (1984): Naloxone selectively increases local cerebral glucose
utilization in rats. Fed. Proc. 43:741.
ED London, SB Waller, JK Wamsley (1984): Autoradiographic localization of [3H] nicotine
binding sites in the rat brain. Soc. Neurosci. Abstr. l0: 556.
RC Walovitch, ED London (1984): Acute Hydergine treatment selectively increases local
cerebral glucose utilization in rats. Soc. Neurosci. Abstr. l0: 541.
Curriculum Vitae - Edythe D. London, Ph.D.
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PM Wise, IR Cohen-Becker, NG Weiland, RC Walovitch, ED London (1984): Age effects and
circadian periodicity in local cerebral glucose utilization in ovariectomized female rats. Soc.
Neurosci. Abstr. 10:449.
JE Johnson, J White, A Hervonen, R Walovitch, ED London (1984): Effects of subchronic
morphine treatment on the fine structure of the rat superior cervical ganglion. Soc. Neurosci.
Abstr. 10:164.
RF Mervis, S Moroi, ED London, DK Ingram (1984): Effect of dietary restriction on dendritic
spines in aging rat neocortex. Age 7:144.
ED London, RC Walovitch (1984): Enhanced local glucose utilization in many subcortical
regions of the rat brain following acute co-dergocrine treatment. International symposium: New
Experimental Findings on Hydergine (Sandoz), Paris, Oct 29.
ED London, RC Walovitch (1985): Pharmacological treatment of cerebral metabolic deficits in
rodent models for aging and Alzheimer's disease. OHOLO Biol. Conf., Mar 24-27, Eilat, Israel.
M Selmanoff, RC Walovitch, GE Walker, ED London (1985): Effects of hyperprolactinemia on
plasma prolactin and glucose and on local cerebral glucose utilization. Proc. 67th Annual Meeting
Endocr. Soc., p. 42.
M Szikszay, G Benedek, ED London (1985): Physiological interactions of morphine and
diltiazem in rats. Soc. Neurosci. Abst. 11:1071.
RC Walovitch, MK Selmanoff, F Snyder, ED London (1985): Increases in median eminence
glucose utilization and suppression of plasma prolactin levels by naloxone in rats. Soc. Neurosci.
Abst. 11:1197.
JA Bell, AS Kimes, ED London (1985): Local stimulation of glucose utilization in the spinal cord
during naloxone-precipitated opioid abstinence. Soc. Neurosci. Abst. 11:1070.
ED London, RJ Connolly, M Szikszay, JK Wamsley, M Dam (1985): Distribution of cerebral
metabolic effects of nicotine in the rat. Soc. Neurosci. Abst. 11:654.
AS Kimes, RC Walovitch, ED London (1985): Quantitation of local cerebral glucose utilization
during opioid dependence and naloxone- precipitated withdrawal. Soc. Neurosci. Abstr. 11:1151.
PM Wise, ED London, IR Cohen-Becker, NG Weiland (1985): Circadian rhythm of local cerebral
glucose utilization (LCGU) in estradiol-treated ovariectomized rats: Effects of age. Soc.
Neurosci. Abstr. 11:951.
M Dam, R Connolly, G Wilkerson, ED London (1985): Effects of nicotine on glucose utilization
in the rat brain visual system. Soc. Neurosci. Abstr. 11:231.
SB Waller, MJ Ball, MA Reynolds, ED London (1986): Muscarinic binding and choline
acetyltransferase activity in postmortem brains of demented patients. 1st Canadian Symposium on
the Organic Dementias, June, London, Ontario.
G Wilkerson, M Risner, S Goldberg, ED London (1986): Effects of cocaine on local cerebral
glucose utilization in the rat. Trans. Am. Soc. Neurochem. 17:161.
P Wise, E London, I Cohen-Becker, N Weiland (1986): Effect of estradiol on local cerebral
glucose utilization in ovariectomized rats. Deutsche Geselschaft fur Endokrinologie 30.
Symposion 12. bis 15. Marz, Munchen.
ED London, RJ Fanelli, M Szikszay, DR Jasinski (1986): Local cerebral glucose utilization in the
rat following administration of opioid analgesics. Int. Narcotics Res. Conf. July, San Francisco.
M Szikszay, ED London (1986): Interaction of morphine and calcium antagonists on plasma
glucose in male rats. Int. Narcotics Res. Conf. July, San Francisco.
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JE Jaffe, ED London, J Henningfield (1986): Nicotine dependence and psychopharmacology. 3rd
World Cong. on Clin. Pharmacol. & Therapeutics, Stockholm, Jul 27 - Aug 1, Int. Union
Pharmacol., Nordic Pharmacol. Soc. & Swedish Soc. Med. Sciences.
ED London, E Broussolle, M Dam (1986): Acute effects of diazepam on local cerebral glucose
utilization in the rat. Soc. Neurosci. Abstr. 12:178.
E Broussolle, D Wong, ED London (1986): In vivo binding of [3H]l-nicotine in the mouse brain.
Soc. Neurosci. Abstr. 12:1333.
RJ Fanelli, M Szikszay, RC Walovitch, DR Jasinski, ED London (1986): Cerebral glucose
utilization in the rat following administration of opioid analgesics and naloxone. Soc. Neurosci.
Abstr. 12:408.
M Dam, AD Weissman, ED London (1986): Sigma agonist actions on brain local cerebral
glucose utilization by +SKF-10, 047. Soc. Neurosci. Abstr. 12:1410.
M Szikszay, ED London (1986): Capsaicin effect on regional glucose utilization in the rat central
nervous system. Soc. Neurosci. Abstr. 12:957.
AD Weissman, M Dam, ED London (1986): Phencyclidine induces selective changes in brain
glucose utilization. Soc. Neurosci. Abstr. 12:179.
AS Kimes, JA Bell, ED London (1986): Effect of clonidine on cerebral glucose utilization during
naloxone precipitated abstinence in morphine dependent rats. Soc. Neurosci. Abstr. 12:408.
AD Weissman, M Dam, ED London (1986): Differentiation of phencyclidine and sigma effect on
local cerebral glucose utilization in rats. Pharmacologist 28:224.
G Wilkerson, ME Risner, SR Goldberg, ED London (1986): Effects of l-cocaine on local cerebral
glucose utilization in the rat. Pharmacologist 28:236.
G Wilkerson, ED London (1987): (+) 3,4-Methylenedioxymethamphetamine (MDMA) effects on
cerebral glucose utilization in the rat. Fed. Proc. 511:404.
AD Weissman, KL Marquis, JE Moreton, ED London (1987): Effects of self-administered
phencyclidine on regional brain uptake of 2-deoxy-D-[l-14C]glucose. Fed. Proc. 511:404.
AS Kimes, JA Bell, ED London (1987): Interaction between the effects of naloxone-precipitated
morphine-withdrawal and clonidine on cerebral glucose utilization. J. Neurochem. 48:S94.
ED London, E Broussolle, J Links, D Wong, R Dannals, H Wagner, L Rippetoe, B Holicky, R
Herning, W Pickworth, J Toung, J Jaffe (1987): Morphine effect on brain metabolism in
postaddicts. Am. Psychiatric Assoc. 140th Annual Meeting May 9-15, Chicago IL.
AD Weissman, T-P Su, JC Hedreen, DL Price, ED London (1987): Sigma receptors demonstrated
in human postmortem brains. Neuroscience Suppl. 22:S85.
E Broussolle, ED London, J Links, D Wong, R Dannals, H Wagner, L Rippetoe, B Holicky, R
Herning, W Pickworth, F Snyder, N Cascella, J Toung, JH Jaffe (1987): Morphine decreases
regional cerebral glucose utilization in human postaddicts. J. Nucl. Med. 28:1074.
ED London, M Dam, A Weissman (1987): Different patterns of cerebral glucose utilization
produced by phencyclidine and (+)N-allylnormetazocine. 2nd US-French Sponsored Int. Seminar
on Sigma Opioid/PCP-like Compounds as Molecular Probes in Biology, Ann Arbor MI.
ED London, Broussolle, E, J Links, DF Wong, RF Dannals, HN Wagner Jr., LR Rippetoe, B
Holicky, RI Herning, WB Pickworth, FR Snyder, N Cascella, JKT Toung, RA Margolin, JH Jaffe
(1987): Human opioid abusers show regional decreases in cerebral glucose utilization during
morphine euphoria. Soc. Neurosci. Abstr. 13:813.
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C Ori, ED London (1987): Alterations in kappa and mu opioid receptor binding by volatile
anesthetics in vitro. Soc. Neurosci. Abstr. 13:640.
TH Vu, AD Weissman, ED London (1987): Phylogenetic distribution of haloperidol-sensitive
sigma and phencyclidine binding sites in the nervous system. Soc. Neurosci. Abstr. 13:1703.
AD Weissman, EP Broussolle, ED London (1987): In vivo binding of [ 3H] haloperidol and
[3H]d-SKF 10,047 in mouse brain. Soc. Neurosci. Abstr. 13:1130.
G Wilkerson, SR Goldberg, M Risner, ED London (1987): Differential sensitivity to cocaine in
Lewis and Fischer-344 rats as indicated by local cerebral glucose utilization. Soc. Neurosci.
Abstr. 13:1414.
RJ Fanelli, ED London (1987): Effects of chronic nicotine on local cerebral glucose utilization in
the rat. Soc. Neurosci. Abstr. 13:1633.
AS Kimes, WJ Smith, CP Jaffe, ED London (1987): Effects of morphine on the phenotypic
expression of T-lymphocyte cell surface markers in the mouse. Soc. Neurosci. Abstr. 13:1437.
SR Cohen, ED London (1987): The influence of pain and morphine on local cerebral glucose
utilization in the rat. Soc. Neurosci. Abstr. 13:302.
ED London, NG Cascella, DF Wong, M Sano, RF Dannals, J Links, RI Herning, JKT Toung, HN
Wagner Jr., JH Jaffe (1988): Acute cocaine decreases regional cerebral glucose utilization in
human substance abusers. J. Nucl. Med. 29:840.
NG Cascella, ED London, DF Wong, G Pearlson, RF Dannals, J Links, EP Broussolle, HN
Wagner Jr., JH Jaffe (1988): Relation between measures of brain structure and cerebral glucose
utilization in polydrug abusers. J. Nucl. Med. 29:91l.
B Tabakoff, ED London, S Marietta, G Szabo (1988): Peptide-T and VIP effects on brain
metabolism. IV International Conference on AIDS, June 12-16, 1988, Stockholm, Sweden.
E Broussolle, ED London, J Links, DF Wong, RF Dannals, HV Wagner Jr., LR Rippetoe, B
Holicky, R Herning, WB Pickworth, FR Snyder, NG Cascella, JKT Toung, RA Margolin, JH
Jaffe (1988): Human cerebral metabolism decreases during morphine induced euphoria: a PET
study. Eighth European Winter Conf. on Brain Research. Tignes, France, Mar 6-12.
ED London, NG Cascella, DF Wong, M Sano, RF Dannals, J Links, RI Herning, JKT Toung, HN
Wagner Jr., JH Jaffe (1988): Acute cocaine decreases regional cerebral glucose utilization in
human substance abusers. Soc. Neurosci. Abstr. 14:919.
AS Kimes, G Wilkerson, C Ori, ED London (1988): Central action of psychomotor stimulants on
local cerebral glucose utilization in extrapyramidal motor areas. Soc. Neurosci. Abstr. 14:918.
M Sano, N Cascella, B Glover, R Herning, ED London (1988): EEG and subjective responses to
intravenous cocaine in human substance abusers. Soc. Neurosci. Abstr. 14:963.
H Takayama, MD Majewska, ED London (1988): Interactions of allosteric antagonists with
nicotinic acetylcholine recognition sites in brain. Soc. Neurosci. Abstr. 14:230.
F Ford-Rice, A della Puppa, F Snyder, E Cone, ED London (1988): Interactions between
verapamil injection time and morphine effects on physiological parameters in rats. Soc. Neurosci.
Abstr. 14:542.
A della Puppa, JL Cadet, ED London (1988): Glucose utilization in discrete brain areas after
chronic administration of iminodipropionitrile in rats. Soc. Neurosci. Abstr. 14:918.
JA Bell, CE Spivak, T-P Su, ED London (1988): Haloperidol-sensitive, a selective
electrophysiological effect of sigma ligands on NCB-20 cells. Soc. Neurosci. Abstr. 14:1155.
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AD Weissman, MF Casanova, JB Kleinman, ED London, EB de Souza (1988): Regional
differences in PCP and sigma binding in the brains of schizophrenics. Soc. Neurosci. Abstr.
14:104.
RI Herning, BJ Glover, M Sano, N Cascella, R Reddish, E London, JH Jaffe (1988): The cortical
and temporal mapping of EEG changes produced by intravenous cocaine. Soc. Psychophysiol.
Research Oct 19-23, San Francisco.
NG Cascella, DG Wong, G Pearlson, C Nagoshi, ED London (1988): Brain structural
abnormalities differentially correlate with severity of alcohol and opioid abuse. NIDA Res.
Monogr. 90: 374.
SB Waller, MJ Ball, ED London (1989): The neocortical and hippocampal cholinergic nervous
systems in dementia: a neurochemical examination. Ann. Meeting, Am. Geront. Soc., Nov 18-22,
San Francisco.
ED London, JH Jaffe, NG Cascella, M Sano, RI Herning, J Links, D Wong, RF Dannals, R
Grayson, HN Wagner Jr. (1988): Acute cocaine decreases regional cerebral glucose utilization in
human substance abusers. 29th Ann. Meeting Am. Coll. Neuropsychopharmacol. Dec 11-16, San
Juan, PR.
C Ori, ED London (1988): Effetto degli anestetici inalatori protossido d'azoto e alotano sul
sottotipo kappa dei recettori degli oppioidi. XLII Congresso Nazionale SIAARTI Oct 20-23,
Sorrento.
A Della Puppa, AS Kimes, T Vu, ED London (1989): Cerebral metabolic mapping of the effects
of agonists and antagonists for binding sites. Brain 89, ed. by C Fieschi, GL Lenzi. Proc. XIVth
Int.l Symp. on Cerebral Blood Flow and Metabolism. Bologna, Italy, Raven Press, New York.
FY Ford-Rice, MD Majewska, ED London (1989): Effects of in vivo steroid hormone treatment
on sigma receptor binding in the female rat brain. Soc. Neurosci. Abstr.15: 1216.
GR Hill, A della Puppa, ED London (1989): Effects of high-dose d-SKF 10047 on cerebral
metabolism in rats. Soc. Neurosci. Abstr. 15:858.
DF Wong, D Young, LT Young, LE Tune, G Pearlson, E Minkin, C Cidis Meltzer, K Midha, RF
Dannals, HT Ravert, AA Wilson, ED London, HN Wagner Jr., M Casanova, J Kleinman, MJ
Kuhar, A Gjedde (1989): Validation of PET D2 dopamine receptor quantification using
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[11C]NMSP and [ F]haloperidol. Soc. Neurosci. Abstr. 15:1123.
S Demirgören, MD Majewska, HN Wagner, ED London (1989): Binding of pregnenolone sulfate
to rat brain membranes: interaction with the GABAA receptor complex. Soc. Neurosci. Abstr.
15:994.
AS Kimes, G Szabo, ED London, L Raymon, B Tabakoff (1989): Metabolic effects of GP120 in
brain regions rich in VIP receptors. Soc. Neurosci. Abstr. 15:381.
ED London, MD Majewska (1989): Binding of [3H]-mecamylamine to the nicotinic receptor
complex in the rat brain: modulation by ATP. Soc. Neurosci. Abstr. 15:64.
H Takayama, MD Majewska, ED London (1989): ATP: An allosteric modulator of the nicotinic
receptor in brain. Soc. Neurosci. Abstr. 15:64.
MD Majewska, JMH ffrench-Mullen, ED London (1989): Ascorbic acid and glutathione are
antagonists of the NMDA receptor. Soc. Neurosci. Abstr. 15:1167.
A della Puppa, ED London (1989): Cerebral metabolic effects of sigma ligands in the rat. Soc.
Neurosci. Abstr. 15:857.
Curriculum Vitae - Edythe D. London, Ph.D.
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124.
NG Cascella, ED London, M Sano, DF Wong, RI Herning, JM Links (1989): Acute cocaine
reduces brain glucose metabolism in drug users. 142nd Ann. Meeting, Am. Psychiatric Assoc.
May 6-12 San Francisco, CA.
125.
ED London, H Takayama, MD Majewska (1989): [3H]Mecamylamine binding to the nicotinic
receptor complex in the rat brain: Modulation by ATP. Am. Coll. Neuropsychopharmacol. Ann.
Meeting, Dec 9-16, Maui, HI.
MD Majewska, JR ffrench-Mullen, ED London (1989): Ascorbic acid and glutathione are
allosteric antagonists of the NMDA receptor. Am. College Neuropsychopharmacol. Ann.
Meeting, Dec 9-16, Maui, HI.
ED London, NG Cascella, DF Wong, RF Dannals, JH Jaffe, HN Wagner Jr. (1989): Decrease in
brain glucose utilization by cocaine. Am. Psychiatric Assoc. 143rd Ann. Meeting, May 12-17,
1990, New York, NY.
ED London, EP Broussolle, JM Links, D Wong, H Wagner, JH Jaffe (1990): Decreased brain
glucose utilization by morphine. Am. Psychiatric Assoc. 143rd Ann. Meeting May 12-17, New
York, NY.
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X-Z Wu, JA Bell, CE Spivak, ED London, T-P Su (1990): Sigma ligand [3H]-d-SKF-10047
labelled two types of binding sites in intact NCB-20 Cells. FASEB J. 4:A329.
MJ Morgan, NG Cascella, JM Stapleton, EK Shaya, DF Wong, ED London (1990): Relationship
between ventricle/brain ratio, a measure of cerebral atrophy and subjective responses to
intravenous cocaine in human substance abusers. Soc. Neurosci. Abstr. 16:582.
LP Raymon, AS Kimes, LT Meltzer, TG Heffner, ED London (1990): Effects of CI-943, A
potential antipsychotic agent, on cerebral glucose utilization in rats. Soc. Neurosci. Abstr. 16:250.
DB Vaupel, A della Puppa, WR Lange, ED London (1990): Verapamil reduces hypercapnia and
euphoria produced by morphine in humans. Soc. Neurosci. Abstr. 16:928.
MD Majewska, JA Bell, ED London (1990): Redox phenomena modulate function of the NMDA
receptor. Soc. Neurosci. Abstr. 16:464.
SD Demirgören, MD Majewska, ED London (1990): Dehydroepiandrosterone sulfate, a
neurosteroid, binds to rat brain membranes and modulates the function of GABA-A receptors.
Soc. Neurosci. Abstr. 16:691.
CR Mantione, S Demirgören, ED London (1990): Polyamine binding sites on synaptosomal
membranes. Soc. Neurosci. Abstr. 16:540.
AS Kimes, DF Wong, ED London (1990): Use of mecamylamine (MEC) and lobeline (LOB) to
estimate nonspecific binding of radiolabeled nicotine (NIC) in vivo. Soc. Neurosci. Abstr. 16:684.
DF Wong, R Gibson, ED London, HD Burns, E Shaya, RF Dannals, HT Ravert, AA Wilson, HN
Wagner Jr. (1990): In vivo studies of receptors with radiolabeled haloperidol. Soc. Neurosci.
Abstr. 16:1140.
ED London, NG Cascella, JS Stapleton, R Phillips, M Morgan, DF Wong (1991): Brain
metabolism and drug-induced euphoria. Am. Psychiat. Assoc. 144rd Ann. Meeting, May 11-16,
New Orleans.
ED London (1990): Acute effects of cocaine on cerebral glucose metabolism in substance
abusers. Am. Coll. Neuropsychopharmacol. Ann. Meeting, Dec 9-14, San Juan, PR.
ED London (1990): Sigma receptor deficits in schizophrenia: Postmortem studies suggest a
potential for PET diagnosis. Am. Coll. Neuropsychopharmacol. Ann. Meeting, Dec 9-14, San
Juan, PR.
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London, CR Mantione (1991): Ligand-binding studies of polyamine receptors in the brain.
IBRO Third World Congress Workshop Montreal, Canada (unpublished abstract).
BCK Yung, JM Stapleton, RL Phillips, MJ Morgan, NG Cascella, JH Jaffe, DF Wong, ED
London (1991): Subjective responses to cocaine and brain metabolism. J. Cerebral Blood Flow
Metab. 11:S392.
JM Stapleton, BCK Yung, ML Spurgeon, MJ Morgan, RL Phillips, NG Cascella, JH Jaffe, DF
Wong, ED London (1991): Brain metabolism and psychological parameters in substance abusers.
J. Cereb. Blood Flow Metab. 11:391.
RI Herning, BJ Glover, B Koeppl, R Reddish, ED London (1991): Effects of cocaine withdrawal
on the CNS: EEG, evoked potential and performance measures. Biol. Psychiatry 29:191.
DF Wong, R Gibson, HD Burns, RF Dannals, E Shaya, ED London, N Brenner, AA Wilson, HT
Ravert, C Chen, E Minkin, HN Wagner, Jr. (1991): In vivo imaging of sigma receptors in
primate brain. J. Nucl. Med. 32:1071.
ED London, JM Stapleton, BCK Yung, RL Phillips, MJ Morgan, NG Cascella, DF Wong, JH
Jaffe (1991): Effects of acute cocaine on cerebral glucose utilization in human polydrug abusers:
relations between regional metabolism and subjective responses. NIDA Res. Monogr. 119:220.
ED London, J Stapleton, B Yung, RL Phillips, MJ Morgan, NG Cascella, DF Wong, JH Jaffe
(1991): Effects of intravenous cocaine on cerebral glucose utilization in human polydrug abusers:
relations between regional metabolism and subjective responses. Symposium on Nuclear Imaging
in Drug Discovery, Development and Approval, Jun 17-19, Baltimore, MD.
JM Stapleton, BCK Yung, ML Spurgeon, MJ Morgan, RL Phillips, NG Cascella, JH Jaffe, DF
Wong (1991): Personality characteristics in substance abuse and relationship to physiological
parameters in human subjects. Am. Psychological Assoc. 99th Annual Convention Aug 16-20,
San Francisco, CA, (unpublished abstract).
P Garofalo, D Ingram, E Spangler, I Odano, CR Mantione, ED London (1991): Possible
interaction of cholinergic and glutaminergic systems in age-associated memory impairment. 4th
Int. Cong. Int. Assoc. Biomed. Gerontol, Jun 26-29, Ancona, Italy, (unpublished abstract).
VL Dawson, TM Dawson, ED London, DS Bredt, SH Snyder (1991): Glutamate neurotoxicity is
mediated by nitric oxide. Soc. Neurosci. Abstr. 17:7
DK Ingram, P Garofalo, EL Spangler, C Mantione, I Odano, ED London (1991): Aging
Increases dizocilpine-induced learning impairment and decreases hippocampal and striatal
NMDA receptor concentrations in rats. Soc. Neurosci. Abstr. 17:368.
RD Kusztos, CR Mantione, ED London (1991): Interactions of polyamines with the nicotinic
acetylcholine receptor in rat brain. Soc. Neurosci. Abstr. 17:1524.
AS Kimes, DB Vaupel, M Bruckner, ED London (1991): Nitroarginine, a nitric oxide synthase
inhibitor, attenuates morphine withdrawal. Soc. Neurosci. Abstr. 17:538.
ED London, CR Mantione (1991): Ligand-binding studies of polyamine receptors in rat brain.
Third French-U.S. Seminar Multiple Sigma and PCP Receptor Ligands: Mechanisms for
Neuromodulation and Protection, Sept , Montpellier, France (unpublished abstract).
CR Mantione, VL Dawson, ED London (1991): [3H]-Spermidine labels multiple polyamine
receptor sites in brain. Trans. Am. Soc. Neurochem. 22:222.
AS Kimes, B Hope, K Rasmussen, ED London (1992): Opioid withdrawal, from DNA to the
human addict. Winter Conf. on Brain Res. Steamboat Springs, CO (unpublished abstract).
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London (1991): Steroid binding at  receptors: A link between the brain and the endocrine
and immune systems. Colloquium on Ageing, Istituto Scientifico Roussel Italia, Oct 24-25,
Rome, Italy.
ED London (1991): Imaging with positron emission tomography to investigate drug action. Am.
College of Neuropsychopharmacol. Annual Meeting (ACNP) Dec 9-13, San Juan, PR.
ED London, EB de Souza, SW Tam, WD Bowen, AS Basile (1991): Sigma Receptors:
Biochemistry, physiology and clinical potential. Am. Coll. Neuropsychopharmacology Ann.
Meeting Dec 9-13, San Juan, PR.
JM Stapleton, ML Spurgeon, M Morgan, B Yung, RL Phillips, NG Cascella, JH Jaffe, DF Wong,
ED London (1991): Psychological characteristics and cerebral glucose metabolism in substance
abusers & control subjects. Am. Coll. Neuropsychopharm. Ann. Mtg., Dec 9-13, San Juan, PR.
ED London (1992): Effects of acute exposure to drugs of abuse on regional brain metabolism.
Am. Coll. Nuclear Physicians 18th Ann. Meeting, San Diego CA, Mar 1-5.
DB Newlin, CJ Wong, RP Waits, JM Stapleton, ED London (1992): Tachycardia from
intravenous nicotine is mediated vagally in human subjects Comm. Problems Drug Dependence
Ann. Meeting, Jun 20-25, Keystone, CO.
J Stapleton, J Henningfield, DF Wong, R Phillips, R Grayson, R Dannals, ED London (1993):
Nicotine reduces cerebral glucose utilization in humans. NIDA Res. Monogr. 132:106.
JI Szekely, ED London (1992): Drug addiction and functional preponderance of the kappa opioid
system: A hypothesis. Comm. Problems Drug Dependence Ann. Mtg., Jun 20-25, Keystone, CO.
AS Kimes, ED London (1992): Attenuation of opioid withdrawal by inhibitors of nitric oxide
synthase. Pharmacologist 34:209.
SL Walsh, JM Stapleton, KL Preston, JT Sullivan, RF Dannals, RF Grayson, RL Phillips, GE
Bigelow, DR Jasinski, ED London (1992): Acute effects of buprenorphine on cerebral glucose
utilization in human substance abusers. Soc. Neurosci. Abstr. 18:371.
RD Kusztos, DK Ingram, JA Joseph, EL Spangler, ED London (1992): [3H]CGS 19755 binding
to NMDA receptors in rat hippocampus: Effects of age and chronic nimodipine. Soc. Neurosci.
Abstr. 18:1435.
K Hashimoto, CR Mantione, M Spada, JL Neumeyer, ED London (1992): Subcellular
distribution of [3H] ifenprodil binding in rat brain. Soc. Neurosci. Abstr. 18:1155.
DB Vaupel, WR Lange, ED London (1992): Verapamil potentiates morphine analgesia and
reduces euphoria in humans. Soc. Neurosci. Abstr. 18:687.
JM Stapleton, JE Henningfield, DF Wong, RL Phillips, SF Gilson, RF Grayson, FR Dannals, ED
London (1992): Effects of nicotine on cerebral metabolism and subjective responses in human
volunteers. Soc. Neurosci. Abstr. 18:1074.
DK Ingram, E Spangler, D Roberts, S Iijima, ED London (1992): Nitric oxide synthase inhibition
by Nw-nitro-l-arginine impairs learning of rats in a 14-unit t-maze. Soc. Neurosci. Abstr.
18:1220.
DL Frankenfield, JM Stapleton, R Stauffer, ED London, WR Lange (1992): Profound
bradyarrhythmia following nicotine administration. 27th Ann. ASHP Midyear Clin. Meeting Dec
6-10, Orlando, FL.
RL Phillips, C Chen, DF Wong, JM Stapleton, ED London (1993): Modeling the plasma cerebral
metabolic rate for glucose. Soc. Nucl. Med. 34:40P
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J Flesher, U Scheffel, ED London, JJ Frost (1993): In vivo labeling of nicotinic cholinergic
receptors in brain using [H-3]cytisine. Soc. Nucl. Med. 34:199P.
X Liu, RL Phillips, DF Wong, RN Bryan, ED London (1993): Brain structure and
neuropsychological performance of substance abusers: A preliminary magnetic resonance
imaging study. Abstr. Soc. Neurosci. 19:380.
AS Kimes, R Maldonado, GF Koob, E Ambrosio, ED London (1993): Injections of
methylnaloxonium into the locus coeruleus produce cerebral hypermetabolism in morphinedependent rats. Abstr. Soc. Neurosci. 19:1022.
K Hashimoto, ED London (1993): Characterization of [3H] 4-phenyl-1-(4-phenylbutyl)piperidine binding in rat brain: Abstr. Soc. Neurosci. 19:1155.
DK Ingram, E Spangler, D Roberts, H Kametani, ED London (1993): Intraventricular injection
of N-nitro-L-arginine impairs learning of rats in a 14-unit t-maze. Abstr. Soc. Neurosci.
19:1390.
A Mukhin, E Kovaleva, ED London (1993): Effect of mono-, di- and polyvalent cations on
3
NMDA sensitive [ H]CGP-39653 binding in rat brain membranes. Abstr Soc. Neurosci.. 19:1784.
K Hashimoto, ED London (1993): Further characterization of [3H]ifenprodil binding to sigma
sites. J. Cereb. Blood Flow Metab. 13 (Suppl). 630.
ED London (1993): Drug effects on cerebral metabolism and blood flow. Am. Psychiatric Assoc.
May 21-26, 1994, Philadelphia, PA
ED London (1993): Brain metabolism in substance abusers. Am. Psychiatric Assoc. May 21-26,
1994, Philadelphia, PA.
K Hashimoto, ED London (1993): Further characterization of [3H]ifenprodil binding to sigma
sites. XVIth Int’l Symposium on Cerebral Blood Flow & Metab. May 22-28, Sendai, Japan.
DB Vaupel, WR Lange, ED London (1993): Verapamil potentiates morphine analgesia and
reduces euphoria in humans. Comm. Problems of Drug Dependence Jun 12-17, Toronto, Canada.
VL Villemagne, S Gilson, AS Kimes, RL Phillips, DF Wong, X Liu, P Bridge, PJ Harris, RF
Dannals, M Ruff, C Pert, HN Wagner Jr., ED London (1994): Effects of peptide T on cerebral
glucose metabolism in AIDS dementia complex (ADC) studied by positron emission tomography
(PET) and [F-18] FDG. Soc. Nucl. Med. 35S: 118P
DB Vaupel, WR Lange, ED London (1994): Verapamil potentiates morphine analgesia and
reduces euphoria in human subjects. NIDA Res. Monogr. 141:80.
ED London, DB Vaupel, AS Kimes (1994): Inhibitors of nitric oxide synthase as potential
treatments for opioid withdrawal. Regul. Pept. 54:165.
T Matsunaga, A Mukhin, ED London (1994): NMDA receptor domains: Regional variation in
the densities and proportions of binding sites. Soc. Neurosci. Abstr. 20:491.
A Shimada, EL Spangler, ED London, DK Ingram (1994): Spermidine potentiates dizocilpineinduced learning impairment in a 14-unit T-maze to demonstrate polyamine modulation of
NMDA receptor. Soc. Neurosci. Abstr. 20:1019.
AS Kimes, DB Vaupel, ED London (1994): Comparison of the attenuation of the opioid
withdrawal syndrome by 7-nitroindazole, a brain-specific nitric oxide synthase inhibitor, with that
of other nitric oxide synthase inhibitors. Soc. Neurosci. Abstr. 20:1675.
ED London, AG Mukhin (1994): Polyamines as endogenous modulators of NMDA receptor and
other ligand-gated ion channels. NY Acad. Sci. May 25-28, 1994, Washington, DC.
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AG Mukhin, T Matsunaga, ED London (1994): Effect of anions on [3H]CGP 39653 binding to
NMDA receptors in brain. XIXth Coll. Int. Neuro-Psychopharm. Jun 27-Jul 1, Washington, DC.
AS Kimes, DB Vaupel, ED London (1994): Comparison of the attenuation of opioid withdrawal
by nitric oxide synthase inhibitors. IUPHAR, Symposium entitled Nitric Oxide in the Nervous
System, Jul 22-24, Montreal, Canada.
H Takahashi, JR Kirsch, K Hashimoto, ED London, RC Kohler, RJ Traystman (1994): PPBP [4Phenyl-l-(4-phenylbutyl)piperidine], a potent -receptor ligand, decreases brain injury following
transient focal ischemia in cats. Am. Soc. Anesthesiol. Oct 15-19, San Francisco, CA.
S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi,
Arthur Margolin, ED London (1994): Cerebral glucose metabolism during cocaine craving: A
PET FDG study. Am. Coll. of Neuropsychopharmacology (ACNP), Dec 12-16, San Juan, PR.
B Vaupel, AS Kimes, and ED London (1995): Attenuation of opioid withdrawal:
pharmacological profiles of nitric oxide synthase inhibitors. NIDA Res. Monogr. 153:103.
X Liu, RL Phillips, SM Resnick, DF Wong, JM Stapleton, VL Villemagne, ED London (1995):
Volume of lateral ventricles in polysubstance abusers: A nuclear magnetic resonance imaging
study. NIDA Res. Monogr. 153:209.
S Grant, D Newlin, VL Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi,
ED London (1995): Cocaine craving: a PET FDG study. Soc. Nucl. Med. 36:43P. Jun 15,
Minneapolis, MN.
RL Phillips, JM Links, AS Kimes, SJ Grant, ED London (1995): Modeling of FDG concentration
in venous plasma to assay cerebral gluclose metabolism by PET. Soc. Nucl. Med. 36:82P. Jun 15,
Minneapolis, MN.
U Scheffel, K Kellar, A Kimes, M Kuhar, ED London (1995): In vivo labeling of nicotinic
choliner-gic receptors in brain using [H-3]epibatidine. Soc. Nucl. Med. 36:253P. Jun 15,
Minneapolis, MN.
U Scheffel, FI Carroll, JA Kepler, GF Taylor, M Stathis, ED London (1995): In vivo labeling of
nicotinic acetylcholine receptors with (+)- and (-)H-3-norchloro-epibatidine. Soc. Nucl. Med.
36:253P. Jun 15, Minneapolis, MN.
AS Kimes, U Scheffel, KJ Kellar, ED London (1995): Radiolabeled epibatidine: Promising ligand
for in vivo imaging of central nicotinic acetylcholine receptors. Soc. Neurosci. Abstr. 21:10.
S Pögun, E Koylu, S Demirgören, ED London (1995): Gender differences in neuronal nicotinic
receptors and the effects of chronic nicotine administration and nicotine withdrawal in rats. Soc.
Neurosci. Abstr. 21:11.
A Shimada, ED London, A Mukhin, EL Spangler, DK Ingram (1995): Polyamine modulation of
NMDA receptors as a strategy for cognitive enhancement in aged rats. Soc. Neurosci. Abstr.
21:198.
DB Vaupel, ED London (1995): Varying intravenous rates of morphine administration affects
subjective responses of experienced heroin users. Soc. Neurosci. Abstr. 21:728.
S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, C Contoreggi, ED London
(1995): Cerebral glucose metabolism during cocaine craving: a PET FDG study. Soc. Neurosci.
Abstr. 21:1956.
T Matsunaga, A Shimada, AG Mukhin, DK Ingram, SR Zukin, J Kleinman, M Casanova, ED
London (1995): NMDA receptor domains in postmortem brains of schizophrenic patients. Soc.
Neurosci. Abstr. 21:2125.
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H Takahashi, JR Kirsch, K Hashimoto, ED London, RJ Traystman (1995): The sigma ligand (+)pentazocine decreases brain injury following transient focal ischemia in rat. 21st Int’l Joint
Conference on Stroke and Cerebral Circulation Jan 25-27, San Antonio, TX.
H Takahashi, JR Kirsch, K Hashimoto, ED London, RC Koehler, RJ Traystman (1995): A sigmareceptor ligand decreases brain injury following transient focal ischemia in cat. 20th Int’l Joint
Conference on Stroke and Cerebral Circulation Feb 9-11, Charleston, SC.
S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi, A
Margolin, ED London (1995): Stimulation of regional cerebral glucose metabolism by cocainerelated cues: A brain img. study. Comm. Problems Drug Dependence, Jun 10-15, Scottsdale, AZ.
RL Phillips, JM Links, ED London (1995): Modeling the concentration of FDG in arterial plasma
to calculate cerebral glucose metabolism by single- and multi-scan methods. XVIIth Int’l
Symposium on Cerebral Blood Flow and Metabolism, BRAIN 95 Jul 2-6, Cologne, GE.
H Takahashi, J Kirsch, K Hashimoto, ED London, RJ Traystman (1995): PPBP [4-phenyl-1-(4phenylbutyl)piperidine], a potent  receptor ligand, decreases brain injury following transient
focal ischemia in rats. Ann. Am. Assoc. Anesthesiol. Oct 21-25, Atlanta, GA.
X Liu, M Takagishi, SM Resnick, JL Cadet, RN Bryan, DF Wong, ED London (1996): Regional
cerebral volumes and asymmetries in polydrug abusers: A volumetric magnetic resonance
imaging study. NIDA Res. Monogr. 162:196.
JL Musachio, U Scheffel, M Stathis, V Villemagne, P Finley, A Horti, AS Kimes, ED London, M
Davila-Garcia, KJ Kellar, RF Dannals (1996): Synthesis of [I-125/I-123]-IPH: A radiolabeled
analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors. J. Nucl. Med. 37:6P.
VL Villemagne, A Horti, U Scheffel, HT Ravert, P Finley, ED London, RF Dannals (1996):
Imaging nicotinic acetylcholine receptors in baboon brain by PET. J. Nucl. Med. 37:192P.
AG Horti, HT Ravert, WB Mathews, JL Musachio, A Kimes, ED London, RF Dannals (1996):
Synthesis of high specific activity carbon-11 N-methylated analogs of epibatidine for imaging. J.
Nucl. Med. 37:192P.
DB Vaupel, AS Kimes, ED London (1996): Inhibition of constitutive but not inducible nitric
oxide synthase attenuates signs of morphine withdrawal. Soc. Neurosci. Abstr. 22:1162.
M Takagishi, AS Kimes, ED London (1996): Effects of low dose mecamylamine on regional
cerebral glucose metabolism in rats receiving chronic nicotine. Soc. Neurosci. Abstr. 22:165.
FJ Vocci, ED London (1996): Assessment of neurotoxicity caused by drugs of abuse and
potential treatment agents. Current and Emerging Technologies in Monitoring Brain Structure
and Function Mar 28-29, Bethesda, MD. (unpublished abstract)
S Grant, D Newlin, V Villemagne, R Phillips, X Liu, A Kimes, C Contoreggi, A Margolin, ED
London (1996): Activation of a cortical memory circuit is related to cue-elicited cocaine craving:
A positron emission tomographic study. Cognitive Neurosci. Soc. 3rd Ann. Meeting, Mar 31 Apr 2, San Francisco, CA.
E London, S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, C Contoreggi, A
Margolin (1995): Cocaine-related cues elicit craving and activate cortical circuits relevant to
episodic memory. Soc. Biol. Psychiatry, 51st Ann. Convention & Sci. Prog., May 1-5, 1996, New
York, NY.
F Yokoi, P Finley, M Stathis, A Chen, M Master, U Scheffel, ED London, DF Wong (1996):
Effects of saffan and isoflurane on [H3]-raclopride and [H3] NMSP binding in mouse brain. Soc
Nucl. Med. 43rd Ann. Meeting Jun 3-6, Denver, CO.
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A Horti, U Scheffel, RF Dannals, M Stathis, PA Finley, HT Ravert, ED London (1996): [18F]-(+)exo-2-(2-fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane, a radioligand for in vivo labeling and
imaging of central nicotinic acetylcholine receptors. Soc Nucl. Med. 43rd Ann. Meeting, Jun 3-6,
Denver, CO.
E London, S Grant (1996): Positron emission tomographic studies of cerebral glucose metabolism
in stimulant and opiate addiction. XXth CINP Congress Jun 23-27, Melbourne, Australia.
ED Morris, CA Heidbreder, TS Shippenberg, M Ernst, BT Christian, ED London (1996): Can
positron emission tomography detect changes in intrasynaptic dopamine? Computer stimulations
can optimize the experimental design. Abstr. Soc Neurosci., Nov 16-21, Washington, DC.
X Liu, JA Matochik, JL Cadet, ED London (1996): Reduced volume of prefrontal lobe in
polysubstance abusers: A magnetic resonance imaging study. Abstr. Soc. Neurosci., Nov 16-21,
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MI Davila-Garcia, JL Musachio, DC Perry, Y Xiao, A Horti, ED London, RF Dannals, KJ Kellar
(1996): [125I]-IPH, an epibatidine analog binds with high affinity to neuronal nicotinic receptors.
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ED London, S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, C Contoreggi, A
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prefrontal cortex and medial temporal lobe. NIDA Res. Monogr. 174:119
AG Horti, AO Koren, U Scheffel, AS Kimes, HT Ravert, WB Mathews, JL Musachio, PA Finley,
Y Zhan, ED London, RF Dannals (1997): [18F]-2-Fluoro-5-(2(s)-azetidinylmethoxy)-pyridine, a
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ED Morris, SI Chefer, ED London (1997): A two-scan graphical method to correct estimates of
binding potential for the effects of mass of injected ligand. J. Nucl. Med. Abstr. 44:93P.
SI Chefer, ED Morris, DF Wong, DK Ingram, G Roth, M Lane, RF Muzic Jr., S Grant, L Weyl, J
Matochik, V Villemagne, F Yokoi, RF Dannals, ED London (1997): Considerations for
measuring dopamine binding potential with PET in the striata of primates smaller than humans. J.
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F Yokoi, S Szymanski, SJ Offord, G Grunder, AS Dogan, HT Ravert, RF Dannals, ED London,
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acetylcholine receptors in human brain: A PET comparison. J. Nucl. Med. Abstr. 44:289P.
A Bhardwaj, JR Kirsch, RC Koehler, ED London, and RJ Traystman (1997): The sigma ligand
(+)-pentazocine attenuates N-methyl-D-aspartate enhanced striatal nitric oxide production in
vivo. 22nd Int. Joint Conf. on Stroke and Cerebral Circulation, Feb 6-8, Anaheim, CA.
M Kassiou, UA Scheffel, HT Ravert, WB Mathews, JL Musachio, ED London, RF Dannals
(1997): [11C]A-84543. An enantioselective ligand for in vivo studies of neuronal nicotinic
acetylcholine receptors. 44th Annual Soc. Nucl. Med., Jun 1-5, San Antonio, TX.
DB Newlin, S Grant, B Vaupel, L Xiang, ED London (1997): Is craving for cocaine an acquired
state and/or a trait? Coll. Problems Drug Depend., Jun 14-19, Nashville, TN.
S Grant, C Contoreggi, ED London (1997): Drug abusers show impaired performance on a test of
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AO Koren, AG Horti, A Kimes, U Scheffel, HT Ravert, ED London, RF Dannals (1997):
Synthesis and evaluation of benzo analogs of epibatidine as potential nAChR ligands for PET
studies. XIIth Int. Symposium on Radiopharmaceutical Chem. Jun 15-19, Uppsala, Sweden. J.
Labelled Comp. Radiopharm. 40:518
C Loc'h, M Kassiou, JL Musachio, C Coulon, M Ottaviani, M Bottlaender, ED London, RF
Dannals, B Maziere (1997): [76Br]-BrPH: A radiobrominated analog of epibatidine for studies of
nicotinic acetylcholine receptors using PET. XIIth Int. Symposium on Radiopharmaceutical
Chemistry. Jun 15-19, Uppsala, Sweden. J. Labelled Comp. Radiopharm. 40:519-521.
ED Morris, ED London, SI Chefer (1997): Limitations of binding potential as a clinical measure
of receptor function: Susceptibility to Mass. Brain ’97 Jun 20-22, Bethesda, MD.
ED Morris, RF Muzic Jr., SI Chefer, AA Bonab, ED London (1997): Partial volume significantly
affects binding potential estimates in primates. Brain ’97 Jun 20-22, Bethesda, MD.
RL Phillips, SJ Grant, ED London (1997): Controlling for subject motion during measurement of
rCMRglc using FDG-PET. Brain ’97 Jun 20-22, Bethesda, MD.
C Loc'h, M Bottlaender, M Kassiou, JL Musachio, ED London, RF Dannals, B Maziere (1997):
Evaluation of a Br-76 analog of epibatidine for PET imaging of nicotinic acetylcholine receptors.
Eur. Assoc. of Nucl. Med. Aug 23-27, Glasgow, Scotland. Eur. J. Nucl. Med.
DB Vaupel, X Liu, SR Grant, ED London (1997): Effect of cocaine-related environmental stimuli
on the spontaneous electroencephalogram in polydrug abusers. Abst. Soc. Neurosci. 23:314.6, p.
804.
ED Morris, SI Chefer, RF Muzic Jr., AA Bonab, ED London (1997): Can PET measure receptor
binding potential accurately in the primate striatum? An investigation of partial volume effects
using computer simulations. Abstr. Soc. Neurosci. 23:208.3, p. 532.
SG Grant, C Contoreggi, ED London (1997): Drug abusers show impaired performance on a test
of orbitofrontal function. Abstr. Soc. Neurosci. 23:754.12, p. 1943.
M Bottlaender, C Loc’h, M Kassiou, C Ottaviani, C Coulon, B Tavitian, ED London, JL
Musachio, RF Dannals, B Maziere. In vivo PET study of nicotinic acetylcholine receptors
(nAChRs) with [Br-76] bromoepibatidine. Abstr. Soc. Neurosci. 23:154.13, p. 382.
GR Hill, M Kassiou, L-I, Tsao, TP Su, RF Dannals, L Sharpe, ED London (1997):
1-[(N,N-dimethylamino)methyl]-2-(3,4-dichlorophenylacetamide)-1,2,3,4-tetrahydroisoquinoline
binding to  opioid receptor subtypes. Abstr. Soc. Neurosci. 23:1549.10, p. 397.
M Ernst, JA Matochik, SJ Heishman, R Soria, PH Jons, T Zeffiro, ED London (1997): Cognitive
activation in nicotine withdrawal. Abstr. Soc. Neurosci. 23:103.5, p. 257.
II Galynker, ED London, S Ganz, RN Rosenthal: Methadone maintenance and regional cerebral
glucose metabolism in opiate abusers (1997): A positron emission tomographic study. Consensus
Development Conf. on Effective Medical Treatment of Heroin Addiction, Nov 19, Bethesda, MD.
ED London, S Grant, K Bonson, X Liu, DB Vaupel, J Matochik (1997): Cerebral metabolism
during cue-elicited cocaine craving. 36th Am. Coll. Neuropsychopharmacol. Ann. Meeting, Dec.
8-12, Kamuela, HI.
AO Koren, AG Horti, AG Mukhin, D Gündisch, AS Kimes, WB Pickworth, RF Dannals, ED
London (1998): Synthesis and evaluation of halogenated analogs of A-85380 as ligands for
nicotinic acetylcholine receptors. Soc Neurosci Abstr. 24(1): 85.
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U Scheffel, JL Musachio, AG Horti, M Kassiou, P Finley, Y Zhan, HT Ravert, WB Mathews, ED
London, RF Dannals (1998). In vivo evaluation of new high affinity radioligands for imaging
central nicotinic acetylcholine receptors. Eur. J. Nucl. Med. 25:854
AG Mukhin, D Gündisch, AG Horti, AO Koren, AS Kimes, DB Vaupel, ED London (1998): 5Iodo-A85380 - a novel highly selective ligand for α4β2 subtype of nicotinic acetylcholine
receptors. Soc Neurosci Abstr. 24(1): 85.
SI Chefer, AG Horti, KS Lee, AO Koren, DW Jones, JG Gorey, JM Links, AG Mukhin, DR
Weinberger, ED London (1998): In vivo imaging of brain nicotinic acetylcholine receptors with
5-[123I] iodo-A-85380 using single photon emission computed tomography. Soc. Neurosci. Abstr.
24: 89.
AS Kimes, DB Vaupel, AG Mukhin, JK Chambers, AG Horti, AO Koren, TD Foster, ED London
(1998): Ex vivo and in vitro autoradiographic analysis of nicotinic acetylcholine receptors
(nAChRs) using 5-[125I]-iodo-A-85380. Soc. Neurosci. Abstr. 24(1): 90.
DB Vaupel, AG Mukhin, AS Kimes, AG Horti, AO Koren, ED London (1998): [125I]-Iodo-A85380: Evaluation as a radiotracer for the in vivo imaging of nicotinic acetylcholine receptors
(nAChRs) in the mouse. Soc. Neurosci. Abstr. 24(1): 90.
KR Bonson, SJ Grant, ED London (1998): Validation of an analytic method of calculating
cerebral glucose metabolism using PET. Soc. Neurosci. Abstr. 24(1): 428.
M Ernst, PH Jons, JA Matochik, JD Van Horn, SJ Heishman, JE Henningfield, ED London
(1998): Nicotine and cerebral blood flow during a working memory task. Soc. Neurosci. Abstr.
24(1): 753.
GR Hill, AS Kimes, TD Foster, JA Bell, A Cho, W Ling, ED London (1998): Acute and chronic
effects of methamphetamine on cerebral glucose metabolism. Soc. Neurosci. Abstr. 24(1): 994.
JA Matochik, SI Chefer, ED Morris, MA Lane, DK Ingram, GS Roth, ED London (1998): Agerelated decline in striatal volume in monkeys as measured by MRI. Soc. Neurosci. Abstr. 24(1):
999.
D Gündisch, AG Mukhin, PD Terry, ED London (1998): Evaluation of high affinity [3H]epibatidine binding in rat brain. Soc. Neurosci. Abstr. 24(2): 1341.
JR Kirsch, A Bhardwaj, ED London, RC Koehler, RJ Traystman (1998): Potent 1-receptor
ligand 4-phenyl-1-(4-phenyl) piperidine (PPBP), modulates basal and N-methyl-D-aspartateevoked nitric oxide production in vivo. Soc. Neurosci. Abstr. 24(2): 2063.
ED London (1998): What can brain imaging tell us about the mind and soul? Next Med
Conference: The End of Health Care, Jan 27-29, San Diego, CA.
JE Rose, FM Behm, EC Westman, MP Johnson, JE Bates, RJ Mathew, ED London, RE Coleman,
S Hamblen, TC Hawk, T Turkington (1998): Acute effects of nicotine on regional and global
cerebral blood flow. Soc. Res. Nicotine and Tobacco. Symposium - Brain Imaging of Nicotine
and Tobacco Smoking, Mar 27-29, New Orleans, LA.
ED London, M Ernst, JM Stapleton, SJ Heishman, JE Henningfield (1998): Nicotine and
functional brain imaging studies: metabolic effects in rats and humans and blood flow during
cognitive activation. Soc. Res. Nicotine and Tobacco. Symposium - Brain Imaging of Nicotine
and Tobacco Smoking, Mar 27-29, New Orleans, LA.
M Ernst, SJ Heishman, PH Jons, L Spurgeon, JE Henningfield, ED London (1998): Effects of
nicotine on cognitive performance in smokers and nonsmokers. Soc. Res. Nicotine and Tobacco.
Symposium - Brain Imaging of Nicotine and Tobacco Smoking, Mar 27-29, New Orleans, LA.
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M Ernst, PH Jons, JA Matochik, JD Van Horn, SJ Heishman, ED London (1998): Efffect of
nicotine withdrawal on cerebral blood flow during a working memory task. Cogn. Neurosci, Apr.,
San Francisco, CA.
ED Morris, SI Chefer, MA Lane, RF Muzic, DF Wong, RF Dannals, JA Matochik, AA Bonab,
VL Villemagne, SJ Grant, DK Ingram, GS Roth, ED London (1998): Effect of age on D2
dopamine receptor binding measured with 11-C raclopride and PET in Rhesus monkeys. Partial
volume correction reduces the apparent rate of decline with age. Soc. Nucl. Med. 45th Annual
Meeting Jun 7-11, Toronto, Canada.
M Ernst, BA Cookus, S Grant, ED London (1998): Neurocognitive performance in adolescents:
Predictors for later substance abuse? Am. Acad. Child & Adolescent Psychiatry, 45th Annual
Meeting, Nov, Anaheim, CA.
BA Cookus, M Ernst, ED London (1998): Neurocognitive performance in adolescent at risk for
substance abuse. Am. Acad. Child & Adolescent Psychiatry, 45th Ann. Mtg., Nov, Anaheim, CA.
ED Morris, AA Bonab, SI Chefer, ED London (1998): Comparison of quantitative measures of
neurotransmitter changes based on PET: A simulation study. Functional Neuroreceptor Mapping
of Living Brain, Jun 12-14, Ann Arbor, MI.
E Rubin, R Van Heertum, ED London, R Foltin, N Nunes, HD Kleber, MW Fischman (1998):
PET rCBF studies of single and multiple dose cocaine. 60th Ann. Meeting, Coll. Problems Drug
Depend., Jun 13-18, Scottsdale, AZ.
D.B. Vaupel, X. Liu, S. Grant, ED London (1998): Effects of cocaine-related environmental
stimuli on the spontaneous EEG and craving in polydrug abusers. 60th Ann. Meeting, Coll.
Problems Drug Depend., Jun 13-18, Scottsdale, AZ.
AD Kalechstein, TF Newton, W Melega, ED London, A Cho, W Ling: Neuropsychological
correlates of methamphetamine dependence (1998): 60th Ann. Meeting, Coll. Problems Drug
Depend., Jun 13-18, Scottsdale, AZ.
R Rusa, NJ Alkayed, RJ Traystman, J Klaus, AS Kimes, ED London, BJ Crain, PD Hurn (1998):
Estrogen replacement therapy is neuroprotective in experimental stroke. 7th Int. Symp.
Pharmacol. Cerebral Ischemia, Jul 27-29, Marburg, GE.
ED London, S Chefer, AO Koren, D Gündisch, AG Mukhin, AG Horti (1998): Halogenated
derivatives of A-85380 for noninvasive imaging of nicotinic receptors in brain. 37th Annual Meeting,
Am. Coll. Neuropsychopharmacol., Dec. 14-18, Las Croabas, PR.
JE Rose, FM Behm, T Turkington, EC Westman, RE Coleman, ED London, RJ Mathew (1998):
Nicotine and mecamylamine effects on regional cerebral blood flow. 37th Ann. Meeting, Am.
Coll. of Neuropsychopharmacol. Dec 14-18, Las Croabas, Puerto Rico.
M Ernst, PH Jons, JA Matochik, JD Van Horn, SJ Heishman, JE Henningfield, ED London
(1998): Nicotine and cerebral blood flow during a working memory task. 37th Ann. Meeting,
Am. Coll. Neuropsychopharmacol. Dec 14-18, Las Croabas, Puerto Rico.
AM Weinstein, S Grant, K Bonson, J Links, ED London (1998): Continuous performance task
during cue-elicited craving: Can cocaine abusers divide their attention? 37th Ann. Meeting, Am.
Coll. Neuropsychopharmacol. Dec 14-18, Las Croabas, Puerto Rico.
ED London, JK Chambers, SI Chefer, TD Foster, D Gündisch, AG Horti, DW Jones, JG Gorey,
KS Lee, JM Links, AO Koren, AG Mukhin, PD Terry, DB Vaupel, DR Weinberger (1998): 5[123I]Iodo-A-85380: A promising radiotracer for SPECT imaging of nicotinic acetylcholine
receptors. NIH Research Festival, Bethesda, MD Oct 6-9.
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AM Weinstein, S Grant, K Bonson, J Links, C Contoreggi, ED London (1999): Brain activation
during presentation of cocaine-related cues and performance of an attentional task: Divided
attention in cocaine abusers Continuous performance task during cue-elicited craving: Can
cocaine abusers divide their attention. J. Psychopharamcol. Supplement A to Vol. 13(3): A56.
JA Matochik, SI Chefer, MA Lane, RI Woolf, DK Ingram, GS Roth, ED London (1999): Striatal
volume in Rhesus monkeys undergoing dietary caloric restriction. Soc. Neurosci. Abstr. 25:29.
I Harukuni, A Bhardwaj, AB Shaivitz, AC DeVries, ED London, PD Hurn, RJ Traystman, JR
Kirsch (1999): Potent 1-receptor ligand, PPBP [4-phenyl-1-(4-Pphenylbutyl) piperidine] affords
neuroprotection from focal ischemia and prolonged reperfusion. Soc. Neurosci. Abstr. 25:583.
M Ernst, SJ Heishman, PH Jons, L Spurgeon, JE Henningfield, ED London (1999): Cognitive
performance and nicotine. Soc. Neurosci. Abstr. 25:629.
AO Koren, D Gündisch, AG Horti, AG Mukhin, ED London (1999): 6-[18F] F-A-85380 - a novel
PET ligand for the 42 subtype of nicotinic acetylcholine receptors: in vitro characterization. Soc.
Neurosci. Abstr. 25:978.
AG Horti, S Chefer, U Scheffel, AO Koren, AG Mukhin, JM Links, D Gündisch, V Kurian, P
Finley, RF Dannals, ED London (1999): 6-[18F] F-A-85380, a novel tracer for the nicotinic
acetylcholine receptor. Soc. Neurosci. Abstr. 25:978.
SI Chefer, AG Horti, AO Koren, D Gündisch, JM Links, V Kurian, AG Mukhin, ED London
(1999): 2-[18F]Fluoro-A-85380: A PET radioligand for the 42 nicotinic acetylcholine receptors.
Soc. Neurosci. Abstr. 25:979.
SJ Grant, KR Bonson, CC Contoreggi, ED London (1999): Activation of the ventromedial
prefrontal cortex correlates with gambling task performance: A FDG-PET study. Soc. Neurosci.
Abstr. 25:1551.
AL Brody, LR Baxter, ED London, MA Mandelkern, S Alborzian, DC Madsen, ME Jarvik
(1999): Brain metabolic changes during cigarette craving. Soc. Neurosci. Abstr. 25:1637.
O Yilmaz, L Kanit, BE Okur, ED London, S Pogun (1999): Nitric oxide mediates facilitation of
active avoidance learning by nicotine in rats. Soc. Neurosci. Abstr. 25:2153.
M Ernst, PH Jons, JA Matochik, JD Van Horn, SJ Heishman, JE Henningfield, ED London
(1999): Nicotine effects on cerebral blood flow during a working memory task. Soc. Res.
Nicotine and Tobacco, 5th Annual Meeting Mar 5-7, San Diego, CA.
DB Vaupel, SI Chefer, D Gündisch, AG Horti, AS Kimes, JM Links, AO Koren, AG Mukhin,
ED London (1999): Imaging nicotinic acetylcholine receptors using 5-[123/125I]-Iodo-A-85380.
Soc. Res. Nicotine and Tobacco, 5th Annual Meeting Mar 5-7, San Diego, CA.
JE Rose, FM Behm, EC Westman, T Turkington, RE Coleman, RJ Mathew, ED London (1999):
Nicotine and mecamylamine effects on regional cerebral blood flow. Soc. Research on Nicotine
and Tobacco, Annual Meeting Mar 5-7, San Diego, CA.
AG Mukhin, SI Chefer, AG Horti, AO Koren, D Gündisch, AS Kimes, DB Vaupel, J Matochik,
ED London (1999): Radiohalogenated analogues of A-85380, novel ligands for imaging the 42
subtype of nicotinic receptors. Neuronal Nicotinic Receptors – Their Functional Role in CNS
Disorders with Focus on New Therapeutic Implications, May 27-29.
AG Horti, S Chefer, AG Mukhin, AO Koren, JM Links, D Gündisch, V Kurian, RF Dannals, ED
London (1999): Imaging nicotinic acetylcholine receptors with 6-[18F]FA, an analog of A-85380
for use with PET. 46th Annual Meeting, Society of Nucl. Med., Jun 6-10.
Curriculum Vitae - Edythe D. London, Ph.D.
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U Scheffel, AG Horti, AO Koren, HT Ravert, JP Banta, PA Finley, ED London, RF Dannals
(1999): Radiosynthesis and in vivo evaluation of 6-[18F] FA, a novel tracer for the nicotinic
acetylcholine receptor. 13th Int. Symp. Radiopharmaceutical Chem., Jun 27 - Jul. 1.
AO Koren, AG Horti, A Mukhin, D Gündisch, RF Dannals, ED London (1999): Synthesis and in
vitro characterization of 6-[18F]-fluoro-3-(2(S)-azetidinylmethoxy)pyridine, a high-affinity
radioligand for central nicotinic acetylcholine receptors. 13th Int. Symp. Radiopharmaceutical
Chem., Jun 27 - Jul 1, St. Louis, MO.
SI Chefer, KR Bonson, AS Kimes, A Mukhin, ED London (1999): Using samples of venous
blood to calculate metabolic rates for glucose with PET and FDG in Rhesus monkeys. High
Resolution Imaging in Small Animals with PET, MR and Other Modalities, Sept 27-29,
Amsterdam, Netherlands.
SI Chefer, AG Horti, AO Koren, D Gündisch, AG Mukhin, RF Dannals, ED London (1999):
2-[18F]Fluoro-A-85380: A novel ligand for imaging 42 subtype of nicotinic receptors.
Functional Imaging in Drug Discovery and Development, Sept 30 - Oct 1, Paris, France.
M Robinson, BA Cookus, L Spurgeon, ED London, M Ernst (1999): Executive function in
adolescents at risk for substance abuse. 46th Ann. Meeting, Am. Acad. Child & Adolescent
Psychiatry. Oct, Chicago, Illinois.
BA Cookus, M Robinson, L Spurgeon, S Grant, ED London, M Ernst (1999): Neurocognitive
tasks as potential predictors of vulnerability to substance abuse. 46th Ann. Meeting, Am. Acad.
Child & Adolescent Psychiatry. Oct, Chicago, Illinois.
E Rubin, ED London, E Nunes, R Van Heertum, V Furman, M Fischman (1999): Placebo effects
on regional brain perfusion in cocaine-dependent humans: recruitment of multiple cognitive
substrates. Am. Coll. Neuropsychopharmacol., Ann. Mtg., Dec, Acapulco, Mexico.
AS Kimes, D Vaupel, D Huso, A Mukhin, A Horti, A Koren, I Baum, ED London (1999):
Pharmacological effects of 2-fluoro and 5-iodo derivatives of A-85380, potential radiotracers for
imaging nicotinic acetylcholine receptors. Am. Coll. Neuropsychopharmacol, Ann. Meeting. Dec,
Acapulco, Mexico.
II Galynker, Y Itskovich, K Nikiforov, E Klein, S Acker, J Matochik, E London (2000): Deviant
sexual arousal in pedophilia: A PET study. Am. Psychiatric Assoc. May 13-18, Chicago, IL.
M Ernst, K Bolla, C Contoreggi, M Mouratidis, V Kurian, J-L Cadet, AS Kimes, ED London
(2000): Pattern of brain activation during a gambling task. Annual Meeting, Cogn. Neurosci.
Soc., Apr 9-11.
AG Mukhin, SI Chefer, AO Koren, O Pavlova, AG Horti, DB Vaupel, D Gundisch, V Kurian, M
Stratton, AS Kimes, ED London (2000): Imaging Brain 42 nicotinic receptors with
radiohalogenated analogs of A-85380 and quantitation of the ligand-receptor interaction in vivo.
Abstr. Soc. Neurosci. 26:24.
M Ernst, K Bolla, M Mouratidis, FR Funderburk, V Kurian, JL Cadet, C Contoreggi, AS Kimes,
ED London (2000): Brain activation during performance of a gambling task. Abstr. Soc.
Neurosci. 26:549.
M Ernst, SJ Heishman, L Spurgeon, ED London (2000): Smoking history and nicotine effects on
cognitive performance. Soc. Res. Nicotine and Tobacco. February, Richmond, VA.
OA Pavlova, D Gündisch, AO Koren, AG Horti, SI Chefer, AS Kimes, AG Mukhin, ED London
(2000): In vitro characterization of 2-[18F]F-A-85380, a novel PET ligand for 42 nicotinic
receptors. Abstr. Soc. Neurosci. 26:627. Nov 4-9, New Orleans, LA.
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AO Koren, SI Chefer, AO Pavlova, AG Horti, DB Vaupel, AS Kimes, ED London, AG Mukhin
(2000): 5-iodo-6-fluoro-A-85380, a novel ligand for nicotinic acetylcholine receptors: initial in
vitro and in vivo characterization. Abstr. Soc. Neurosci. 26:627. Nov 4-9, New Orleans, LA.
DB Vaupel, D Huso, S Tella, A Horti, A Koren, I Baum, ED London, AS Kimes (2000): Acute
toxicity and safety studies of 5-I-A-85380 and 2-F-A-85380, new radiotracers for imaging
nicotinic acetylcholine receptors (NACHRS). Abstr. Soc. Neurosci. 26:627. Nov 4-9, New
Orleans, LA.
SI Chefer, AG Mukhin, AO Pavlova, AO Koren, AG Horti, V Kurian, ED London, AS Kimes
(2000): In vivo measurement of the density of nicotinic receptor with 2-[18F]Fluoro-A-85380 by
PET. Abstr. Soc. Neurosci. 26:628. Nov 4-9, New Orleans, LA.
KR Bonson, SJ Grant, CS Contoreggi, JM Links, J Metcalfe, HL Weyl, V Kurian, M Ernst, ED
London (2000): Neural systems and cue-induced cocaine craving. Abstr. Soc. Neurosci. 26:1279.
Nov 4-9, New Orleans, LA.
KI Bolla, M Ernst, M Mouratidis, FR Funderburk, JA Matochik, V Kurian, J Bragg, JL Cadet, AS
Kimes, ED London (2000): Reduced brain activation in chronic cocaine abusers during
performance on the Stroop color-word interference task. Abstr. Soc. Neurosci. 26:1305.
E London, W Ling, R Rawson, R Woods, M Mandelkern, K Miotto, S Simon, S Berman, T
Newton, J Matochik, J Mogy, A Hayrapetian, A Shinn, V Kurian, J Mazziotta (2000): Cerebral
metabolic deficits in abstinent methamphetamine abusers. Abstr. Soc. Neurosci. 26:1322.
JA Matochik, SI Chefer, MA Lane, DK Ingram, GS Roth, ED London (2000): Age-related
changes in brain white matter volume in the rhesus monkey. Abstr. Soc. Neurosci. 26(2): 2300.
MS Cohen, T Allison, DC Madsen, ME Jarvik, R Olmstead, and ED London (2000): fMRI of
cigarette smoking: a method and preliminary results. Intl. Soc. Magnetic Resonance in Med.,
Annual Meeting Apr 1-7, Denver, CO.
SI Chefer, AG Mukhin, AG Horti, AO Koren, O Pavlova, V Kurian, M Stratton, ED London, AS
Kimes (2000): Characterization of 2-[18F]-Fluoro-A-85380 binding in vivo by PET. 3rd Int.
Neuroreceptor Mapping Symposium Jun 9-11, New York, NY.
AG Mukhin, S Chefer, A Horti, A Koren, D Vaupel, D Gündisch, O Pavlova, V Kurian, AS
Kimes, ED London (2000): Radiohalogenated analogs of A-85380: Potential ligands for mapping
42 nicotinic receptors in human brain. 3rd Int. Neuroreceptor Mapping Symp. Jun 9-11, New
York, NY.
MZ Mintzer, M Ernst, RR Griffiths, C Contoreggi, J Matochik, A Kimes, ED London (2000):
Effects of triazolam on brain activity during episodic memory encoding. 41st Ann. Meeting Soc.
Psychonomics. New Orleans, LA, November.
M Ernst, SJ Heishman, L Spurgeon, ED London (2000): Nicotine effects on cognitive
performance in smokers, ex-smokers, and never-smokers. Coll. Problems Drug Depend., Ann.
Meeting, Jun 18, San Juan, PR.
E Rotheram-Fuller, ED London, S Shoptaw, S Berman (2000): Associations between cognitive
task performance and illicit substance use and tobacco use. Coll. Problems Drug Depend., Ann.
Meeting. Jun 18, San Juan, PR.
ED London, K Miotto, S Simon, Y Dong, A Shinn, S Berman, M Mandelkern, J Matochik, V
Kurian, J Hoffs, R Rawson, and W Ling (2000). Cognitive deficits and correlated abnormalities
of regional cerebral glucose metabolism in methamphetamine abusers. Am. Coll.
Neuropsychopharmacol., 39th annual meeting, Dec. 11-15, San Juan, PR.
Curriculum Vitae - Edythe D. London, Ph.D.
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ED London, MS Cohen, M Ernst, D Madsen, R Olmstead, M Jarvik (2000): Effects of nicotine
and smoking on cognitive activation. Am. Coll. Neuropsychopharmacol., 39th annual meeting,
Dec 11-15, San Juan, PR.
I Galynker, J Matochik, M Ernst, R Rosenthal, E London (2000): Regional cerebral glucose
metabolism in patients removed from opiate replacement therapy. Am. Coll.
Neuropsychopharmacol., 39th annual meeting, Dec. 11-15, San Juan, PR.
ED London, A Mukhin, A Horti, A Koren, D Gündisch, J Matochik, S Chefer, A Kimes, B
Vaupel (2000): Radiohalogenated analogues of A-85380 for imaging of cerebral nicotinic
receptors. Soc. Res. Nicotine and Tobacco, Feb. 18-20, Arlington, VA.
SI Chefer, AG Mukhin, AG Horti, AO Koren, AS Kimes, ED London (2000): 2-[18F]Fluoro-A85380: a novel PET ligand for nicotinic acetylcholine receptors. Mathematics and Engineering
Techniques in Medicine and Biol. Science, Jun 26-29, Las Vegas, NV.
AG Mukhin, SI Chefer, AG Horti, AO Koren, DB Vaupel, D Gündisch, OI Pavlova, V Kurian,
AS Kimes, ED London (2000): Radiohalogenated analogues of A-85380 as potential ligands for
in vivo monitoring of 42 nicotinic receptor alterations in Alzheimer’s disease. Mathematics and
Engineering Techniques in Medicine and Biol. Science, Jun 26-29, Las Vegas, NV.
M Ernst, K Bolla, C Contoreggi, M Mouratidis, J Matochik, V Kurian, M Leff, J-L Cadet, ED
London, AS Kimes (2001): Imaging risk-taking in attention deficit hyperactivity disorder. Cogn.
Neurosci. Soc., March, New York, NY.
AG Mukhin, ED London, AO Koren, OA Pavlova, SI Chefer, AG Horti, LL Brown, AS Kimes
(2001): Development of PET ligands for imaging 42 nicotinic receptors in human brain: status
quo and prospects. Abstr. Soc. Neurosci. 27:621.
M Fujita, RB Innis, JP Seibyl, DB Vaupel, G Tamagnan, SS Zoghbi, RM Baldwin, AG Horti, AO
Koren, AG Mukhin, S Khan, A Bozkurt, AS Kimes, ED London (2001): Whole-body
biodistribution, radiation absorbed dose and brain SPECT imaging with [I-123] 5-I-A-85380 in
healthy human subjects. Abstr. Soc. Neurosci. 27:621.
Y Dong, S Simon, S Berman, M Mandelkern, JA Matochik, V Kurian, R Woods, JC Mazziotta, R
Rawson, ED London, W Ling (2001): Partial recovery in cerebral metabolism during early
abstinence from methamphetamine abuse. Abstr. Soc. Neurosci. 27:900.
OA Pavlova, A Koren, A Horti, D Gündisch, ED London, A Kimes A Mukhin (2001): Effect of
temperature on interaction between ligands and 42 nicotinic receptors. Soc. Neurosci. Abstr.
27:1275.
SI Chefer, AG Mukhin, AG Koren, AG Horti, OA Pavlova, J Matochik, V Kurian, EF Domino,
AS Kimes, ED London (2001): Binding of 2-[18F]Fluoro-A-85380 to 42 nicotinic
acetylcholine receptors (NACHRS) in hemiparkinsonian monkeys 10-12 years after MPTP
treatment. Soc. Neurosci. Abstr. 27:1993.
S Pogun, S Demirgoren, M Sahiner, ED London (2001): Sex differences in the effects of nicotine
on dopamine (DA) and DA metabolite levels in rat nucleus accumbens. Soc. Neurosci. Abstr.
27: 377.11.
ED London, S Simon, Y Dong, K Miotto, A Shinn, S Berman, M Mandelkern, J Matochik, V
Kurian, R Rawson, W Ling (2001): Cognitive deficits and correlated abnormalities of regional
cerebral glucose metabolism in methamphetamine abusers. Drug Alcohol Depend. 63: S93. Jun
16-21, Scottsdale, AZ.
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M Ernst, B Cookus, J Schroeder, L Spurgeon, L Evans, E London, A Kimes, M Leff, R Spencer
(2001): Onset of substance use in 3–year prospective follow up study of adolescents at risk for
substance abuse. Drug Alcohol Depend. 63:S44. Jun 16-21, Scottsdale, AZ.
MK Leff, L Spurgeon, L Evans, B Cookus, E Moolchan, ED London, A Kimes, M Ernst (2001):
Smoking initiation among youth at risk for substance use disorder. Drug Alcohol Depend.
63:S89.
E Rotheram-Fuller, S Shoptaw, S Berman, ED London, M Mandelkern (2001): Selective frontal
lobe deficits associated with illicit substance and tobacco use. Drug Alcohol Depend. 63: S135.
Jun 16-21, Scottsdale, AZ.
B Vaupel, R Innis, E London, A Koren, A Horti, A Mukhin, M Fujita, S Chefer, G Tamagnan, J
Staley, J Seibyl, D Huso, S Tella, A Kimes (2001): 5-I-A-85380, a new radiotracer for imaging
nicotinic receptors, has a margin of safety that should make it an acceptable imaging agent for
human SPECT studies. Drug Alcohol Depend. 63:S163.
DF Wong, C Endres, J Brasic, O Gay, M Ernst, D Schretlen, K Bonson, AS Kimes, ED London
(2001): Changes in intrasynaptic dopamine induced by cocaine-related cues. Drug Alcohol
Depend. 63:S172.
SL Simon, S Glynn, R Rawson, W Ling, E London (2001): Working memory associated with
lateralization of inferior frontal cortex in normal and substance abusing participants. Cogn.
Neurosci. Soc., Mar 25-27, New York, NY.
M Bauer, ED London, N Rasgon, S Berman, M Mandelkern, M Frye, L Altshuler, AK Shinn, PC
Whybrow (2001): Effects of supraphysiological thyroxine (T4) on cerebral glucose metabolism in
bipolar depression: findings from a positron emission tomographic study. Am. Psychiatric Assoc.,
May 5-10, New Orleans, LA.
AL Brody, ED London, M Barsom, MA Manelkern, LR Baxter, AR Childress, ME Jarvik (2001):
Brain metabolic correlates of increased urge to smoke. Am. Psychiatric Assoc., May 5-10, New
Orleans, LA.
ED London (2001): Imaging brain dysfunction in substance abuse. Am. Psychiatric Assoc., May
5-10, New Orleans, LA.
M Bauer, ED London, N Rasgon, S Berman, M Mandelkern, M Frye, L Altshuler, AK Shinn, M
Gitlin, PC Whybrow (2001): Effects of supraphysiological thyroxine (T4) on cerebral glucose
metabolism in bipolar depression: Findings from a positron emission tomographic study. 4th Intl.
Conf. on Bipolar Disorder. June, Pittsburgh, PA.
KI Bolla, M Ernst, M Mouratidis, J Matochik, C Contoreggi, V Kurian, JL Cadet, AS Kimes, D
Eldreth, ED London (2001): Reduced cerebral blood flow in anterior cingulate cortex (ACC)
during stroop performance in chronic cocaine users. Human Brain Mapping, Jun 10-14,
Brighton, UK.
C Endres, S Dogan, J Brasic, Y. Zhou, J Hilton, ED London, DF Wong (2001): Comparison
between bolus and infusion [11C]raclopride delivery for the quantification of dopamine release
associated with craving for cocaine. J. Cerebral Blood Flow Metabol. 21:Suppl. 1, 540.
Y Dong, E. London et al. Cerebral metabolic deficits and time-related changes in early abstinent
methamphetamine abusers. J. Cerebral Blood Flow Metabol. 21:Suppl. 1 (Brain 01 and Human
Brain Mapping 01. June 10-14, Brighton, UK)
SR Cherry, ED London, LA Fairbanks (2001): Development of a molecular imaging center at the
Sepulveda VA Vervet Research Center. ONDCP Intl. Tech. Symp. Jun 25-28, San Diego, CA.
Curriculum Vitae - Edythe D. London, Ph.D.
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M Ernst, M Leff, J Schroeder, E Moolchan, E London, A Kimes (2001): Smoking initiation
among youth at risk for substance abuse. Nicotine & Tobacco Res. 4:243-244. Sep 19-22, Paris,
France.
M Ernst, K Bolla, M Mouratidis, C Contoreggi, S Tata, JL Cadet, AS Kimes, ED London (2001):
ADHD: Cingulate Dysfunction. Abst. Soc. Neurosci. 10.2.
ED London, Y Dong, SL Simon, S Berman, A Shinn, M Mandelkern, AM Lichtman, J Matochik,
V Kurian, R Woods, JC Mazziotta, R Rawson, W Ling (2001): Brain metabolism during early
abstinence from methamphetamine abuse. Am. Coll. Neuropsychopharmacol., annual meeting,
Dec 8-13, Waikoloa, HI.
M Bauer, E London, N Ragson, S Berman, M Frye, J Mazziotta, L Altshuler, P Whybrow (2001):
Effects of supraphysiological doses of l-thyroxine on regional brain metabolism in bipolar
disorder: results of a FDG-PET study. Am. Coll. Neuropsycopharmacol., annual meeting, Dec. 813, Waikaloa, HI.
AL Brody, ED London, G Bartzokis, LA Fairbanks, G Lee, ME Jarvik (2001): Regional Brain
Volume Differences With Age Between Heavy Cigarette Smokers and Nonsmokers. Am. Coll.
Neuropsychopharmacol., annual meeting, Dec. 8-13, Waikoloa, HI.
M Ernst, KI Bolla, ED London, C Contoreggi, AS Kimes, J-L Cadet, M Leff (2001): Decisionmaking in ADHD: A PET study. Am. Coll. Neuropsychopharmacol., annual meeting, Dec. 13,
Waikoloa, HI.
AO Koren, SI Chefer, AG Mukhin, OA Pavlova, AG Horti, DB Vaupel, ED London, AS Kimes
(2001): 5-Iodo-6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine, a novel PET radioligand for
nicotinic acetylcholine receptors: synthesis and initial evaluation. 14th Int. Symp.
Radiopharmaceutical Chem., Interlaken, Switzeralnd, Jun. 10-15.
AS Kimes, AG Horti, C Contoreggi, SI Chefer, V Kurian, P Friello, DB Vaupel, AO Koren, M
Ernst, JA Matochik, OA Pavlova, A Hall, ED London, AG Mukhin (2002): Imaging Human
42 nicotinic acetylcholine receptors. Drug Alcohol Depend. 66:S94.
DB Vaupel, E London, A Horti, A Koren, A Mukhin, S Chefer, O Pavlova, D Huso, S Tella, A
Kimes (2002): 2[F-18]F-A-85380 acquires Phase I approval as a radiotracer for imaging
alpha4beta2 nicotinic receptors in human PET studies. Drug Alcohol Depend. 66: S187.
AS Kimes, AG Horti, C Contoreggi, SI Chefer, V Kurian, P Friello, DB Vaupel, AO Koren, M
Ernst, JA Matochik, OA Pavlova, A Hall, ED London, AG Mukhin (2002): Imaging human 42
nicotinic acetylcholine receptors. Drug Alcohol Depend. 66:S704.
AS Kimes, AG Horti, C Controeggi, SI Chefer, V Kurian, P Friello, DB Vaupel, AO Koren, M
Ernst JA Matochik, OA Pavlova, A Hall, ED London, AG Mukhin (2002): Imaging human
nicotinic receptors. Soc. Res. Nicotine and Tobacco, Feb. 20-23, Savannah, GA.
M Leff, J Schroeder, E Moolchan, S Tata, A Kimes, E London, M Ernst (2002): Smoking
initiation in adolescents with and without ADHD. Children and Adults with AttentionDeficit/Hyperactivity Disorder (CHADD) Conference. Mar 9, University of Loyola, CA.
SL Simon, S Glynn, M Mandelkern, A Lichtman, R Rawson, ED London (2002): Changes in
cognition and cerebral glucose metabolism during 5 weeks of abstinence from chronic
methamphetamine. Cogn. Neurosci. Soc., Apr 14-16, San Francisco, CA.
ED London, S Simon, Y Dong, S Berman, A Shinn, M Mandelkern, JA Matochik, V Kurian, R
Woods, JC Mazziotta, R Rawson, W Ling (2002): Brain metabolism during early abstinence for
methamphetamine abuse. Am. Psychiatric Assoc., May 18 – 23, Philadelphia, PA.
Curriculum Vitae - Edythe D. London, Ph.D.
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I Galynker, CR Miner, DC Des Jarlais, JA Matochik, C Contoreggi, AS Kimes, M Ernst, RN
Rosenthal, ED London, C Weaver, EC Gertmenian-King, V Kurian (2002): Differences in
cerebral glucose metabolism in patients on and off opiate replacement therapy. Am. Psychiatric
Assoc., May 18 – 23, Philadelphia, PA.
M Fujita, CH Van Dyck, M Ichise, SS Zoghbi, G Tamagnan, A Bozkurt, N Seneca, AG Mukhin,
DB Vaupel, AG Horti, AO Koren, AS Kimes, ED London, JP Seibyl, RM Baldwin, RB Innis
(2002): Quantification of brain nicotinic acetylcholine receptors in humans using 123 I-5-A85380. Soc. Nucl. Med., 49th annual meeting, June 15-19, Los Angeles, CA.
AS Kimes, AG Horti, C Contoreggi, SI Chefer, V Kurian, P Friello, DB Vaupel, AO Koren, M
Ernst, JA Matochik, O A Pavlova, ED London, AG Mukhin (2002): Imaging Human 42
Nicotinic Receptors with PET. Soc. Nucl. Med., 49th annual meeting, June 15-19, Los Angeles,
CA.
ED London, Y Dong, SL Simon, S Berman, AK Shinn, M Mandelkern, AM Lichtman, J
Matochik, V Kurian, R Woods, JC Mazziotta, R Rawson, W Ling (2002): Regional cerebral
metabolism in methamphetamine users. XXIII CINP Congress. Jun 23 –27, Montreal, Canada.
AG Mukhin, SI Chefer, AG Horti, C Contoreggi, V Kurian, P Friello, M Ernst, JA Matochik, A
Hall, DB Vaupel, OA Pavlova, AO Koren, ED London, AS Kimes (2002): PET imaging of 42
nicotinic acetylcholine receptors in human brain with 2-[18F]fluoro-A-85380: comparison of
receptor binding and pharmacokinetics in humans and nonhuman primates. Neuroreceptor
Mapping Meeting, July 19-21, Oxford UK.
KI Bolla, D Eldreth, ED London, C Mouratidis, M Ernst (2002): Decision making and
orbitofrontal cortex function in cocaine abusers – A PET 15O Study. Intl’ Neuropsychiatric
Assoc., 4th Intl’ Cong. Neuropsychiatry. Sept. 4 – 7, Buenos Aries, Argentina.
A Mendrek, SL Simon, MS Cohen, ME Jarvik, RE Olmstead, AL Brody, M Ernst, ED London
(2002): Effects of smoking history and nicotine withdrawal on cognitive function. Natl.
Conference on Tobacco or Health. Nov 19 – 21, San Francisco, CA.
ED London, SL Simon, A Mendrek, J Learn, MS Cohen, AL Brody, RO Olmstead, M Ernst, M
Jarvik (2002): Differences between smokers and nonsmokers in tests of selective attention and
working memory: effects of abstinence and cigarette smoking. Tobacco-Related Disease
Research Program Annual Investigator’s Meeting. Dec 4 – 5, San Jose, CA.
J Licinio, JA Matochik, S Caglayan, M Ozata, AJ Wagner, A DePaoli, I Alvarado, M Wong, ED
London (2002): Human leptin replacement treatment and brain structure in leptin-deficient adults.
Soc. Neurosci. Abstr. 124.5.
AS Kimes, A Mukhin, SI Chefer, P Friello, A Horti, C Contoreggi, M Ernst, J Matochik, O
Pavlova, ED London, A Koren, A Hall, V Kurian, K Demuth, DB Vaupel (2002): Imaging
Human 42 nicotinic acetylcholine receptors with PET and 2[18F]-Fluoro-A-85380. Soc.
Neurosci. Abstr. 238.13.
ED London, JA Matochik, SL Simon, A Brody (2002): Age-dependence of cerebral tissue
composition in methamphetamine abusers and healthy control subjects. Soc. Neurosci. Abstr.
401.15.
M Ernst, K Bolla, AS Kimes, ED London, JA Matochik, D Eldreth, S Tata, C Contoreggi, M Leff
(2002): Decision-making in ADHD: A PET study. Soc. Neurosci. Abstr. 578.19.
SI Chefer, AG Horti, JA Matochik, AW Hall, OA Pavlova, V Kurian, EF Domino, AS Kimes,
ED London, AG Mukhin (2002): Striatal dopaminergic abnormalities in hemiparkinsonian
monkeys 10 – 12 years after MPTP treatment. Soc. Neurosci. Abstr. 788.
Curriculum Vitae - Edythe D. London, Ph.D.
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SI Chefer, AG Mukhin, AO Koren, AS Kimes, OA Pavlova, JA Matochik, V Kurian, EF
Domino, AG Horti, ED London (2002): Striatal 42 nicotinic acetylcholine receptors in the
MPTP model of Parkinson’s disease: PET study with 2-[18F]fluoro-A-85380. Neuroreceptor
Mapping Meeting.
AL Brody, ED London, MA Mandelkern, S Alborzian, LR Baxter, DC Madsen, MA Jarvik
(2002): Cue-induced craving for cigarettes: PET studies of regional brain function. Am. Coll.
Nueropsychopharmacol., annual meeting, Dec. 8-12, San Juan, PR
M Fujita, C van Dyck, M Ichise, S Zoghbi, G Tamagnan, A Bozkurt, N Seneca, A Mukhin, B
Vaupel, A Horti, A Koren, S Khan, M Early, AS Kimes, ED London, J Seibyl, R Baldwin, R
Innis (2003): Whole body biodistribution, radiation-absorbed dose, and brain SPECT imaging
with [I-123]5-I-A-85380 in healthy human subjects. Neuroreceptor Mapping Meeting.
D Fishbein, ED London, C Hyde, J Matochik, D Eldreth, A Breedan, C Contoreggi, V Kurian, B
Schech (2003): Neuroimaging of cognitive and physiological differences between abstinent drug
abusers and nonusers. Cognitive Neurosci. Meeting, March 30-April 1, New York, NY.
W Gottdiener, JA Matochik, LJ Cohen, ED London, AS Kimes, C Contereggi, V Kurian, E
Gertmenian-King, II Galynker (2003): Relative glucose metabolism and post-acute opiate
withdrawal. Am. Psychiatric Assoc. Conf., May 19, San Francisco, CA.
S Simon, S Berman, B Voytek, J Dacey, W Ling, ED London: (2003): Deficits in reasoning and
correlated abnormalities of regional cerebral glucose metabolism in methamphetamine abusers.
Cognitive Neurosci. Meeting, March 30 - April 1, New York, NY.
DF Wong, JS Lee, Y Zhou, J Brasic, A Maini, H Kuwabara, AS Kimes, M Ernst, D Schretlen, D.
Jasinski, ED London (2003): Intrasynaptic dopamine release and cocaine craving induced by
video/audio cues. Coll. Problems Drug Depend., 65th annual meeting, June 14-19, Bal Harbour,
FL.
DF Wong, JS Lee, A Maini, Y Zhou, H Kuwabara, C Endres, J Brasic, S Dogan, D Schretlen, M
Alexander, A Kimes, M Ernst, D Jasinski, ED London, and S Zukin (2003): Cue-induced cocaine
craving and dopamine release: methodology and correlates. Soc. Nucl. Med., June 21 – 25, New
Orleans, LA.
SI Chefer, ED London, A Kimes, O Pavlova, A Horti, AO Koren, EF Domino, AG Mukhin: 2[18F]-Fluoro-A-85380 (2003): A new tool for quantitation of nicotinic acetylcholine receptors in
vivo. 10th Ann. Int. Conf. In Vivo Methods Monitoring Molecules in Neurosci., Jun 24-27,
Stockholm, Sweden.
DF Wong, JS Lee, Y Zhou, C Endres, A Maini, J Brasic, H Kuwabara, S Dogan, M Alexander, C
Contoreggi, A Kimes, D, Schretlen, M Ernst, D. Jasinski, SR Zukin, ED London (2003):
Approaches to quantifying dopamine release by cue-induced cocaine craving. BrainPET –3. Jul 1.
KI Bolla, DA Eldreth, ED London, C Mouratidis, M Ernst (2003): Decision-making and
prefrontal lobe funcition in cocaine abusers. Int. Neuropsychology Soc. July 16 – 19, Berlin,
Germany.
Kate Baicy B.S., Bradley T. Voytek B.A., Sara L. Simon Ph.D., Edythe D. London Ph.D.,
Department of Psychiatry and Biobehavioral Science (2003): Memory and hippocampal
metabolism of recently abstinent methamphetamine abusers. STTP, The Josiah Brown Res. Fair.
July 31, UCLA Health Sciences.
AO Koren, DP Holschneider, AV Hirsivara, JM Maarek, J Yang, J Harimoto, MA Madelkern,
OU Scremin, ED London (2003): Constraint-free functional neuroimaging with positron emission
tomography in rats. Abstr. Soc. Neurosci. 21.2.
Curriculum Vitae - Edythe D. London, Ph.D.
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AS Kimes, SI Chefer, JA Matochik, OA Pavlova, CS Contoreggi, AF Horti, V Kurian, BD
Vaupel, P Friello, AO Koren, M Ernst, ED London, AG Mukhin (2003): Quantitation of human
cerebral nicotinic acetylcholine receptors with 2-[18F]Fluoro-A-85380 and PET. Abstr. Soc.
Neurosci. 232.9.
SL Simon, SM Berman, BL Voytex, J Dacey, W Ling, J Xu, ED London (2003): Deficits on
complex cognitive tasks and correlated regional cerebral glucose metabolism in
methamphetamine abusers. Abstr. Soc. Neurosci. 962.18.
PM Thompson, KM Hayashi, MS Hong, DH Herman, SL Simon, AW Toga, ED London (2003):
Methamphetamine-induced deficits in the human hippocampus detected using novel
computational anatomical mapping algorithms and MRI. Abstr. Soc. Neurosci. 135.2.
BT Voytek, S Berman, SL Simon, W Ling, K Hayashi, ED London (2003): Differences in
regional brain function due to marijuana use by methamphetamine abusers. Abstr. Soc. Neurosci.
449.11.
JE Bramen, Z Bilusic, DC Madsen, RE Olmstead, ED London, ME Jarvik, MS Cohen (2003):
Brain responses to naturalistic tobacco smoking. Abstr. Soc. Neurosci. 559.1.
ED London, J Xu, A Mendrek, MS Cohen, M Jarvik, SL Simon, AL Brody, R Olmstead, J
Monterosso, M Ernst (2003): Regional brain activation during performance of a working memory
task by cigarette smokers and nonsmokers. Abstr. Soc. Neurosci. 559.2.
DH Fishbein, DL Eldreth, C Hyde, ED London, A Breeden, S Grant, AS Kimes, C Contoreggi,
JA Matochik (2003): Functional neuroanatiomical substrates of risky decision-making in drug
abusers. Abstr. Soc. Neurosci. 111.12.
DF Wong, JS Lee, H Kuwabara, Y Zhou, J Brasic, A Maini, AS Kimes, C Contoreggi, M Ernst,
D Schretlen, D Jasinski, S Zukin, ED London (2003): Cocaine craving induced by video/audio
cues and intrasynaptic dopamine release. Washington, DC: Society for Neuroscience, Nov. 8-12,
New Orleans, LA.
London, Edythe D. (2003): Neural Substrates of Dysphoric Mood in Addiction: Targets of
Medications for Substance Abuse Disorders. Am. Coll. Neuropsychopharmacol., annual meeting,
Dec 7-11, San Juan PR.
ED London, J Xu, PF Rodriguez, A Mendrek, MS Cohen, SL Simon, AL Brody, R Olmstead,
ME Jarvik, J Monterosso, M Ernst (2003): More task-related cortical activity in cigarette smokers
than in nonsmokers performing a working memory task. Am. Coll. Neuropsychopharmacol.,
annual meeting, Dec 7-11, San Juan PR.
A Brody, RE Olmstead, MA Mandelkern, GS Lee, J Huang, E Hahn, ED London (2003):
Smoking-Induced Ventral Striatal Dopamine Release. Am. Coll. Neuropsychopharmacol., annual
meeting, Dec 7-11, San Juan PR.
M Bauer, ED London, N Rasgon, BM Steven, MA Frye, L Altshuler, MA Mandelkern, R Woods,
JC Mazziotta, PC Whybrow (2003): Supraphysiological Doses of Levothyroxine Alter Regional
Cerebral Metabolism in Bipolar Depression. Am. Coll. Neuropsychopharmacol., annual meeting,
Dec 7-11, San Juan PR.
ED London, J Xu, P Rodriguez, A Mendrek, M Cohen, S Simon, A Brody, R Olmstead, M
Jarvik, M Ernst (2004): Greater cortical activation during performance of a working memory task
by smokers than nonsmokers. Soc. Res. Nicotine & Tobacco, 10th annual meeting, Feb. 18-21,
Scottsdale, AZ.
ED London, J Xu, PF Rodriguez, A Mendrek, MS Cohen, SL Simon, AL Brody, ME Jarvik, J
Monterosso, M Ernst (2004): Greater task-related cortical activity in cigarette smokers than in
Curriculum Vitae - Edythe D. London, Ph.D.
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nonsmokers performing a working memory task. Coll. Problems Drug Depend., annual meeting,
June 12-17, San Juan, PR.
BT Voytek, S Berman, SL Simon, W Ling, ED London (2004): Differences in cerebral
metabolism but not cognitive performance due to marijuana use by methamphetamine abusers.
Coll. Problems Drug Depend., annual meeting, June 12-17, San Juan, PR.
A Mendrek, J Monterosso, M. Jarvik, A Brody, MS Cohen , R Olmstead, M Ernst, SL Simon, ED
London (2004): Working memory impairments are associated with chronic smoking and
withdrawal. Coll. Problems Drug Depend., annual meeting, June 12-17, San Juan, PR.
SL Simon, S Berman, J. Dacey, W Ling, R Rawson, ED London (2004): Logical reasoning in
methamphetamine abusers during the first month of abstinence. Coll. Problems Drug Depend.,
annual meeting, June 12-17, San Juan, PR.
DF Wong, Kuwabara, W Ye, A Kumar, Y Zhou, M Alexander, J Brasic, M Thomas, M Maris, D
Schretlen, E London, D Jasinski (2004): Cocaine craving correlates with psychostimulant induced
dopamine release and dopamine transporters. Coll. Problems Drug Depend., annual meeting,
June 12-17, San Juan, PR.
JK Staley, S Krishnan-Sarin, SO Malley, E Kranztler, RM Baldwin, G Tamagnan, JP Seibyl, ED
London, CH Van Dyck (2004): I-123]5-IA-85830 SPECT imaging of cerebral beta2 nicotinic
acetylcholine receptors in human subjects who smoke tobacco smokers. Coll. Problems Drug
Depend., annual meeting, June 12-17, San Juan, PR.
PM Thompson, KM Hayashi, SL Simon, JA Geaga, MS Hong, Y Sui, JY Lee, AW Toga, W
Ling, ED London (2004): Detection & mapping of abnormal brain structure in methamphetamine
users. 10th Ann. Meeting, Org. Human Brain Mapp. Jun 13-17, Budapest, Hungary.
ED London (2004): Brain Function and Methamphetamine Dependence. Am. Psychological
Assoc. July 28-Aug 1, Honolulu, HI.
P Rodriguez, J Xu, A Mendrek, MS Cohen, SL Simon, AL Brody; R Olmstead, ME Jarvik, J
Monterosso, ED London (2004): Effective Connectivity of fMRI Activity Related to the N-Back
Task in Cigarette Smokers and Nonsmokers. Cogn. Neurosci. Meeting. Apr., San Francisco, CA.
JK Staley, S Krishnan-Sarin, E Kranztler, E Frohlich, S O’Malley, K Cosgrove, RM Baldwin,
GD Tamagnan, JP Seibyl, P Jatlow, ED London, CH vanDyck (2004): [I-123] 5-IA-85380
SPECT imaging of β2 nicotinic acetylcholine receptors in tobacco smokers. Soc. Neurosci., Oct.
23-27, 2004, San Diego, CA.
J Xu, J Monterosso, A Mendrek, PF Rodriguez, AL Brody, MS Cohen, SL Simon, R Olmstead,
ME Jarvik, M Ernst, ED London (2004): Cortical activation and deactivation when healthy
nonsmokers perform a working memory task. Soc. Neurosci., Oct. 23-27, San Diego, CA.
ED London, J Xu, RF Rodriguez, A Mendrek, MS Cohen, J Monterosso, SL Simon, AL Brody, R
Olmstead, M Jarvik, M Ernst (2004): Smoking and task-related brain activity after overnight vs.
brief abstinence in smokers. Soc. Neurosci., Oct. 23-27, San Diego, CA.
JJ Lin, N Salamon, AD Lee, RA Dutton, JA Geaga, KM Hayashi, ED London, AW Toga, J
Engel, PM Thompson (2004): Mapping of neocortical gray matter loss in patients with mesial
temporal lobe epilepsy with hippocampal sclerosis. Soc. Neurosci., Oct. 23-27, San Diego, CA.
KM Hayashi, PM Thompson, SL Simon, JA Geaga, MS Hong, Y Sui, JY Lee, AW Toga, W
Ling, ED London (2004): Mapping abnormal brain structure associated with methamphetamine
abuse. Soc. Neurosci., Oct. 23-27, San Diego, CA.
ED London, S Berman, B Voytek, SL Simon, JR Monterosso, JA Geaga, M Hong, KM Hayashi,
PM Thompson, MA Mandelkern, AL Brody, RA Rawson, W Ling (2004): Cerebral metabolic
Curriculum Vitae - Edythe D. London, Ph.D.
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dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Am. Coll.
Neuropsychopharmacol., 43rd annual meeting, Dec. 12-16, San Juan, PR.
AL Brody, MA Mandelkern, D Scheibal, E Hahn, H-W Lee, E Zamora-Paja, J Farahi, ED
London, JT McCracken (2004): Genetic variants in the alpha4 subunit of nAChR and in COMT
predict smoking-induced dopamine release in mesolimbic reward pathways. Am. Coll.
Neuropsychopharmacol., 43rd annual meeting, Dec. 12-16, San Juan, PR.
S Saxena, G Eda, S Chang, J O’Neill, SK Baker, KM Maidment, JM Schwartz, ED London
(2004): Rapid effects of intensive cognitive-behavioral therapy on brain glucose metabolism in
obsessive-compulsive disorder. Am. Coll. Neuropsychopharmacol., 43rd annual meeting, Dec. 1216, San Juan, PR.
I Galynker, JA Matochik, LJ Cohen, KS Alane, V Kurian, C Contoreggi, M Ernst, RN Rosenthal,
ED London (2004): Regional brain metabolism and negative affect in opiate abusers receiving or
removed from long-term methadone maintenance. Am. Coll. Neuropsychopharmacol., 43rd
annual meeting, Dec. 12-16, San Juan, PR.
D Eldreth, D Fishbein, C Hyde, J Matochik, S Grant, ED London (2005): Neural substrates of
deficits in emotional perception in abstinent drug abusers. Cogn. Neurosci. Soc.
DP Eisenberg, JA Matochik, ED London, S Derbyshire, LJ Cohen, M.Steinfeld, II Galynker
(2005). Association of education with regional cortical glucose metabolism during a continuous
performance task. American Psychiatric Association Annual Meeting May 21-26, Atlanta,
Georgia.
SL Obrzut, AO Koren, ED London, AL Brody, CK Hoh, MA Mandelkern (2005) 2-[18F]F-A85380 Whole-body dosimetry in human pet imaging studies. Soc. Nuclear Medicine Annual
Meeting; June 18-20, Toronto, Canada
AB Brody, MA Mandelkern, ED London, RE Olmstead, J Farahi, D Scheibal, J Jou, V Allen, E
Tiongson, SI Chefer, AO Koren, EA Stein, AG Mukhin (2005). Cigarette smoking leads to
enormous occupancy of 42* nicotinic acytylcholine receptors: new insight on the role of these
receptors in nicotine dependence. Abstr. Soc. Neurosci. , Nov. 12-16, Washington, DC.
D Payer, R Albistegui-DuBois, J Xu, JR Monterosso, T Fong MS Cohen, ED London (2005).
Deficits in corical activation associated with emotion recognition and processing in
methamphetaime abusers. Abstr. Soc. Neurosci., Nov. 12-16, Washington, DC.
JR Monterosso, CP Domier, X Cordova, J Xu, T Fong, ED London (2005). Differences in
behavioral and neural activity between methamphetamine abusers and control subjects
performing a delay discounting task. Abstr. Soc. Neurosci., Nov. 12-16, Washington, DC.
J Xu, A Mendrek, MS Cohen, J Monterosso, CP Domier, SL Simon, A Brody, M Jarvik, M Ernst,
ED London (2005). Effects of cigarette smoking on brain activity of smokers performing the
Stroop task. Abstr. Soc. Neurosci., Nov. 12-16, Washington, DC.
ED London, G Bartzokis, BD Hassid, D Payer, J Monterosso, B Voytek (2005). Greater agerelated brain atrophy in methamphetamine abusers than in healthy comparison subjects. Abstr.
Soc. Neurosci., Nov. 12-16, Washington, DC.
ED London, J Xu, A Mendrek, MS Cohen, J Monterosso, P Rodriguez, S Simon, A Brody, M
Jarvik, CP Domier, R Olmstead, M Ernst (2005). Brain activity in cigarette smokers performing
a working memory task: effect of smoking abstinence and acute smoking. Investigator Meeting,
Tobacco-Related Disease Research Program of Univ. CA, Oct. 11, L.A., CA.
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JR Monterosso, X Cordova, J Xu, M Cohen, ED London (2005). The effect of imminent
smoking opportunity on craving and neural activity. Investigator Meeting, Tobacco-Related
Disease Research Program of Univ. CA, Oct. 11, L.A., CA..
J Xu, A Mendrek, MS Cohen, J Monterosso, CP Domier, SL Simon, A Brody, M Jarvik, M
Ernst, ED London (2005). Effects of cigarette smoking on brain activity in smokers performing
the stroop task. Investigator Meeting, Tobacco-Related Disease Research Program of Univ. CA,
Oct. 10 – 11, L.A., CA.
CP Domier, A Mendrek, J Monterosso, S Simon, A Brody, M Jarvik, R Olmstead, M Ernst, ED
London (2005). Performance of Stroop Tasks by Smokers and Nonsmokers: Do Cigarette
Smoking and Withdrawal Affect Selective Attention? Investigator Meeting, Tobacco-Related
Disease Research Program of Univ. CA, Oct. 11, L.A., CA.
ED London, SM Berman, JR Monterosso, T Newton, T Fong, SL Simon, PM Thompson, KM
Hiyashi, AL Brody, MA Mandelkern, W Ling, R Rawson (2005). Brain Imaging Reveals
Corticolimbic Dysregulation in Methamphetamine Abusers. ACNP – JSNP Joint Symposium, Dec.
11 – 15, Waikoloa, Hawaii.
AL Brody, MA Mandelkern, RE Olmstead, D Scheibal, E Hahn, J Jou, H-W Lee,E Zamora-Paja,
J Farahi, ED London, JT McCracken (2005). Genetic variants of the dopamine transporter,
DRD4, and COMT predict smoking-induced dopamine release in the ventral striatum.Investigator
Meeting, Tobacco-Related Disease Research Program of Univ. CA, Oct. 11, L.A., CA.
B Lee, ED London, JD Jentsch (2005): Blockade of D2/D3 dopamine receptors selectively
impairs reversal learning, but not new learning, in monkeys performing a visual discrimination
task. Am. Coll. of Neuropsychopharmacol. 44th Ann. Mtg., Dec. 11-15, Waikoloa, HI.
M Bauer, ED London, SM Berman, N Rasgon, MA Mandelkern, B Voytek, PC Whybrow (2005).
Regional cerebral metabolism and anxiety symptoms in bipolar depression: Effects of
levothyroxine. Am. Coll. of Neuropsychopharmacol. 44th Ann. Mtg., Dec. 11-15, Waikoloa, HI.
SM Berman, J Bueller, B Suyenobu, ED London, L Chang, BD Naliboff, EA Mayer (2005):
Irritable bowel syndrome and increased anxiety in healthy females, but not in healthy males, is
associated with increased size of midbrain region activated during inescapable pain. Am. Coll. of
Neuropsychopharmacol. 44th Ann. Mtg., Dec. 11-15, Waikoloa, HI.
AL Brody, MA Mandelkern, RA Olmstead, J Jou, E Tiangson, V Allen, D Scheibal,, ED London,
ST Tiffany, MS Cohen (2006): Neural substrates of resisting the urge to smoke. Soc. Res.
Nicotine and Tobacco 11th Ann. Mtg., Feb. 15-18, Orlando, Florida.
ED London, J Monterosso, T Mann, A Ward, G Ainslie, J Xu, A Brody, S Engel, M Cohen
(2006): Neural activation during smoking self-control: fMRI assay. Coll. Problems Drug Depend.
68th Ann. Mtg. Jun 17-22, Scottsdale, AZ.
CP Domier, J Monterosso, ED London (2006): Performance of Stroop tasks by smokers and nonsmokers: Do cigarette smoking and withdrawal affect selective attention?. Coll. Problems Drug
Depend. 68th Ann. Mtg. Jun 17-22, Scottsdale, AZ.
J Monterosso, G Ainslie, ED London (2006): Delay discounting based on activation in the ventral
striatum. Coll. Problems Drug Depend. 68th Ann. Mtg. Jun 17-22, Scottsdale, AZ.
S Chefer, A Kimes, E Domino, ED London, A Mukhin (2006): Estimations of D2-like dopamine
receptor occupancy by dopamine in the MPTP primate model of Parkinson’s disease.
Neuroreceptor Mapping Conference July 6-8, Copenhagen, Denmark.
ED London, J Xu, CP Domier (2006): Brain Imaging Studies of Cognitive Performance in
Smokers. Soc. Res. on Nicotine and Tobacco September 23-26, Kusadasi, Turkey.
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K Baicy, JR Monterosso, ED London (2006): Methamphetamine dependence and deficient
regulation of negative emotion. Soc. Neurosci., October 14-18, Atlanta, GA.
SM Berman, B Voytek, MA Mandelkern, BD Hassid, JR Monterosso, K Miotto, W Ling, ED
London (2006): Changes in cerebral glucose metabolism during the first month of abstinence
from chronic methamphetamine abuse. Soc. Neurosci., October 14-18, Atlanta, GA.
J Xu, JR Monterosso, TW Fong, ED London (2006): Abnormal brain activation of
methamphetamine abusers performing the N-Back working memory task. Soc. Neurosci.,
October 14-18, Atlanta, GA.
B Lee, SM Groman, ED London, JD Jentsch (2006): Dissociable contributions of dopamine
receptor subtypes to visual discrimination learning and reversal in monkeys. Soc. Neurosci.,
October 14-18, Atlanta, GA.
J O’Neill, JR Monterosso, M Walker, ED London (2006): 1H MRSI brain findings in chronic
methamphetamine abuse. Soc. Neurosci., October 14-18, Atlanta, GA.
AL Brody, MA Mandelkern, ED London, RE Olmstead, JE Rose, AG Mukhin (2006): Regular,
but not de-nicotininzed, cigarettes saturate α4β2 nicotinic acetylcholine receptors. Am. Coll. of
Neuropsychopharmacol. 45th Annual Meeting, Dec. 3-7, Hollywood, FL.
RM Bilder, DS Parker, N Brown, D Kalar, F Sabb, D Glahn, C Bearden, R Poldrack, D Shattuck,
TD Cannon, ED London, N Freimer, A Toga (2006): Cognitive Phenomics: Informatics
Strategies for Schizophrenia Research. Intl Congress on Schizophenia Research. Mar 2007,
Colorado Springs, CO.
J Xu, JR Monterosso, CP Domier, AL Brody, and ED London (2006): Gender Differences in the
Effects of Abstinence from Smoking and Relief Due to Smoking on Measures of Negative
Emotional States. Soc. Res. Nicotine and Tobacco 13th Annual Meeting. Feb 21-24, 2007,
Austin, TX.
A Azizian, JR Monterosso, SL Simon, AL Brody and ED London (2006): Selective Attention of
Smokers and Nonsmokers as Measured by the d2 Test of Attention. Soc. Res. Nicotine and
Tobacco 13th Annual Meeting. Feb 21-24, 2007, Austin, TX.