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DATE PREPARED:
9/26/02
Name:
Edward Robert Smith
Office Address:
ACC3
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114
E:Mail:
[email protected]
FAX:
617-726-4814
Place of Birth:
Newton, MA, USA
Education:
1992
1996
B.A.
M.D.
Dartmouth College
Columbia University
Intern in General Surgery
Resident in Neurosurgery
Massachusetts General Hospital
Massachusetts General Hospital
Postdoctoral Training:
1996-1997
1997-2003
Licensure and Certification:
1999-present
Registered Physician by the Commonwealth of Massachusetts Board of Registration in
Medicine (License # 161140, exp. 4/18/2004)
Academic Appointments:
1996-2002
2003-2003
Clinical Fellow in Surgery
Instructor in Neurosurgery
Harvard Medical School
Harvard Medical School
Hospital or Affiliated Institution Appointments:
1996-2002
2002-2003
2003-present
Clinical Fellow in Surgery
Assistant in Neurosurgery
Instructor in Neurosurgery
Professional Societies:
Congress of Neurological Surgeons
American Association of Neurological Surgeons
American College of Surgeons
American Society for Gene Therapy
American Medical Association
Massachusetts Medical Society
Alpha Omega Alpha
Sigma Xi Scientific Society
Awards and Honors:
Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
2002
2002
2000
2000
2000
1999-2001
1996
1994
1992-1993
1991-1992
Congress of Neurological Surgeons Synthes Basic Science Award
American Association of Neurological Surgeons/Congress of Neurological
Surgeons Mayfield Basic Science Award
American College of Surgeons - Massachusetts Chapter Annual Meeting Best
Resident Presentation Award
American Association of Neurological Surgeons/Congress of Neurological
Surgeons Tumor Meeting Best Resident Paper Award
New England Neurosurgical Society Best Resident Presentation Award
American Brain Tumor Association Post-Doctoral Fellowship Award
"Characterizing the Interaction Between Oncolytic Viruses and Tumors"
National Institutes of Health Student Research Grant
“Advanced Glycation Endproducts in Neurovascular Disease”
American Cancer Society/Columbia-Presbyterian Cancer Center Research Grant
“bcl-2 and Apoptosis in Prostate Cancer”
Honors Research Program in Physiology
College of Physicians & Surgeons, Columbia University
Presidential Scholar Research Grant
Dartmouth College
Peer Reviewed Publications:
Smith ER, Chapman PH, Ogilvy CS (2002) Far posterior subtemporal approach to the dorsolateral brainstem and
tentorial ring: Technique and clinical experience (Neurosurgery, in press)
Smith ER, Carter BS, Ogilvy CS (2002) Proposed Use of Prophylactic Decompressive Craniectomy in Poor Grade
Aneurysmal Subarachnoid Hemorrhage Patients Presenting with Associated Large Sylvian Hematomas
(Neurosurgery, 2002 July 51(1):117-124)
Dreibelbis JE, Brown RH Jr, Pastuszak KA, Smith ER, Kaplan PL, Cudkowicz ME. (2002) Disease course unaltered
by a single intracisternal injection of BMP-7 in ALS mice. (Muscle & Nerve 2002 Jan;25(1):122-3)
Smith ER, Ott M, Wain J, Louis DN, Chiocca EA (2002) Massive Growth of a Meningioma into the Brachial Plexus
and Thoracic Cavity after Intraspinal and Supraclavicular Resection: A Case Report and Review of the Literature.
(Journal of Neurosurgery 2002 Jan;96(1 Suppl):107-11.)
Wade-Martins R, Smith ER, Tyminski E, Chiocca EA, Saeki Y (2001) An infectious transfer and expression system
for genomic DNA loci in human
and mouse cells. (Nature Biotechnology, 2001 Nov;19(11):1067-70.)
Gupta A, Smith ER, Velez SJ, (1993) Synaptic repression at the crayfish
neuromuscular junction II. Evidence for calcium involvement. ( Journal of
Neurobiology 1993, 24(8): p. 999-1007.)
Book Chapters and Review Articles:
Smith ER, Amin-Hanjani S (2002) Diagnosis and management of elevated intracranial pressure (UpToDate, Rose,
BD (Ed), UpToDate, Wellesley, MA, in press)
Smith ER, Butler WE, Ogilvy CS (2002) Surgical approaches to vascular anomalies of the child’s brain (Current
Opinion in Neurology, 2002, Apr. 15(2): 165-171 )
Smith ER, Chiocca EA, (2000) Oncolytic viruses as novel anticancer agents: turning one scourge against another.
(Expert Opinion on Investigational Drugs 2000 9(2): p. 311-327.)
Abstracts and Presentations:
Smith ER, Aghi M, Sharpless N, Chiocca EA (2002) Functional Analysis of Cell Cycle Regulatory Pathways
Utilizing Oncolytic Viruses. To be presented at the 2002 Congress of Neurological Surgeons Annual Meeting,
Philadelphia, PA, September 21-26, 2002.
Smith ER , Butler WE, Barker FG (2002) Mortality After Ventriculoperitoneal Shunt Procedures: Relation to
Hospital and Surgeon Volume. Presented at the New England Neurosurgical Society Meeting, Newport, RI.
Septermber 13, 2002.
Smith ER, Cheng T, Scadden D, Chiocca EA (2002) Demonstration of Increased Frequency of Cells Expressing a
Neuronal Phenotype in the Injured Spinal Cord after Intravascular Transplantation with Bone Marrow Cells. Oral
presentation at the Proceedings of the 5th Annual Meeting of the American Society of Gene Therapy, Boston, MA,
June 8, 2002.
Smith ER, Chiocca EA (2002) Increased Frequency of Cells Expressing a Neuronal Phenotype in the Injured Spinal
Cord after Intravascular Transplantation with Bone Marrow Cells. Oral presenatation at The 18th Annual Meeting of
the AANS/CNS Section on Section on Disorders of the Spine and Peripheral Nerves, in Lake Buena Vista
(Orlando), FL, February 27 - March 2, 2002.
Smith ER, Chapman PH, Ogilvy CS (2002) Far Posterior Subtemporal Approach to the Dorsolateral Brainstem and
Tentorial Ring: Technique and Clinical Experience. Poster presentation at the AANS/CNS Section on
Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology in Addison
(Dallas), TX, February 3-6, 2002.
Smith ER, Carter BS, Ogilvy CS (2001) Aneurysm Clipping and Hemicraniectomy for Patients in Poor Neurologic
Condition After Subarachnoid Hemorrhage. Oral Presentation at the American College of Surgeons Annual
Meeting, New Orleans, LA.
Smith ER, Chapman PH, Ogilvy CS (2001) Far Posterior Subtemporal Approach to the Dorsolateral Brainstem and
Tentorial Ring: Technique and Clinical Experience. Presented at the New England Neurosurgical Society Meeting,
Stockbridge, MA.
Wade-Martins R, Smith ER, Tyminski E, Chiocca EA, Saeki Y (2001) Phenotype Correction by Infectious Delivery
of Large (>100 kb) Genomic DNA Transgenes. Oral Presentation, Abstract 379; Proceedings of the 4th Annual
Meeting of the American Society of Gene Therapy, Seattle, WA.
Smith ER, Louis DN, Chiocca EA, (2001) The Use of Oncolytic Viruses for Functional Analysis of Human Brain
Tumors. Abstract 330; Proceedings of the 4 th Annual Meeting of the American Society of Gene Therapy, Seattle,
WA.
Smith ER, Louis DN, Chiocca EA (2001) Functional Analysis of Human Brain Tumors Utilizing Oncolytic Viruses.
Presented at the XIV International Conference on Brain Tumor Research and Therapy (Asilomar Conference),
Asheville, NC.
Smith ER, Chiocca EA, (2001) Metastatic Granular Cell Tumor of the Tibial Nerve - A Case Report and Review of
the Literature. Presented at the New England Neurosurgical Society Meeting, Manchester, VT.
Wade-Martins R, Smith ER, Tyminski E, Chiocca EA, Saeki Y (2001) Infectious Delivery Of A Functional 115 Kb
Genomic Transgene. Abstract 138; Proceedings of Gene Therapy: 2001 Keystone Symposium, Snowbird, UT.
Smith ER, Carter BS, Ogilvy CS (2000) Aneurysm Clipping and Hemicraniectomy for Patients in Poor Neurologic Condition
After Subarachnoid Hemorrhage. Presented at the American College of Surgeons Massachusetts Chapter Annual Meeting,
Boston, MA
Smith ER, Carter BS, Ogilvy CS (2000) CT-Angiography, Sylvian Hematoma Removal and Hemicraniectomy can
Facilitate Management of Patients Presenting in Poor Grade after MCA Aneurysm Rupture. Presented at the Annual
Congress of Neurologic Surgeons, San Antonio, TX.
Ogilvy CS, Smith ER, (2000) Decompressive Surgery for Refractory Intracranial Hypertension: PointCounterpoint. Presented to the Section on Neurotrauma and Critical Care at the Annual Congress of Neurological
Surgeons, San Antonio, TX.
Smith ER, Ott M, Wain J, Louis D, Chiocca EA, (2000) Massive Growth of a Meningioma into the Brachial Plexus
and Thoracic Cavity after Intraspinal and Supraclavicular Resection: A Case Report and Review of the Literature.
Presented at the New England Neurosurgical Society Meeting, Woods Hole, MA.
Dreibelbis JE, Cudkowicz ME, Pastuszak KA, Smith ER, Kaplan PL, Brown RH, (2000) Intracisternal Injection of
Bone Morphgenetic Protien-7 at Time of Disease Onset Did Not Alter Disease Course in a Transgenic Mouse Model
of Amyotrophic Lateral Sclerosis. Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.
Smith ER, et al., (2000) Replication of Oncolytic Viruses: A Proposed Mechanism of Viral Tumor Selectivity with
Demonstration of Selectivity for Tumor vs. Normal Tissue in Human Brain. Presented at the Annual Meeting of the
American Association of Neurological Surgeons Tumor Symposium, San Francisco, CA.
Smith ER, Carter BS, Ogilvy CS, (2000) CT Angiography, Sylvian Hematoma Removal and Hemicraniectomy can
Facilitate Management of Patients Presenting in Poor Grade after MCA Aneurysm Rupture. Presented at the New
England Neurosurgical Society, Hanover, NH.
Barker FG, Smith ER, (1999) Anterior cervical discectomy with and without fusion: a meta-analysis of the
randomized trials. Presented at the Annual Congress of Neurological Surgeons, Boston, MA.
Carmel P, Smith ER, Grief L, (1993) Preliminary experience with the use of programmable valves in the management of
hydrocephalus. Presented at the Richard Lende Winter Neurosurgical Conference, Snowbird, UT.
Smith ER, Velez SJ, (1992) Calcium ionophore A23187 activates repressed synapses in the crayfish. Presented at the
Society for Neuroscience Annual Meeting.
Freeman MR, Bagli DJ, Guthrie PD, Smith ER, Lamb CC, (1992) Morphologic transformation of prostate epithelial cells is
mediated by extracellular matrix and results in alterations in expression of tissue matrix genes. Presented at the American
Urological Association Annual Meeting.
Invited Speaker:
Smith ER, Chiocca EA (2002) Clinical Case Presentation, Grand Rounds, Massachusetts General Hospital, Boston,
MA, July 25, 2002.
Smith ER, Chiocca EA (2002) Increased Frequency of Cells Expressing a Neuronal Phenotype in the Injured Spinal
Cord after Intravascular Transplantation with Bone Marrow Cells. Grand Rounds, Invited Speaker, Department of
Neurosurgery, University of Rochester, Rochester, NY, June 11, 2002.
Smith ER , Barker FG (2002) Esthesioneuroblastoma. Clinical Neurosurgery Presentation, Invited Speaker,
Department of Neurosurgery, University of Rochester, Rochester, NY, June 11, 2002.
Smith ER , Pfannl, RM, Barker FG (2002) Report of the West Neurosurgical Service, Grand Rounds,
Massachusetts General Hospital, Boston, MA, May 30, 2002.
Smith ER, Carter BS, Ogilvy CS, (2000) CT-Angiography, Sylvian Hematoma Removal and Hemicraniectomy can
Facilitate Management of Patients Presenting in Poor Grade after MCA Aneurysm Rupture. Presented at
Neurosurgery Grand Rounds, September 14th, Massachusetts General Hospital, Boston, MA.
Smith ER, Carter BS, Ogilvy CS, (2000) The Evoloving Role of Craniectomy in Trauma and Subarachnoid
Hemorrhage. Presented at Neurosurgery Grand Rounds, March 9 th, Massachusetts General Hospital, Boston, MA.