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From: Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of
Heritability
Arch Gen Psychiatry. 2009;66(5):467-477. doi:10.1001/archgenpsychiatry.2009.24
Figure Legend:
Average surface with overlaid cortical parcellation labels. Using an automated algorithm, labels were generated for 33 gyral regions
of interest. As an example, an average pial surface for the normal control group is displayed here, with the group's average cortical
parcellations overlaid.
Date of download: 5/13/2017
Copyright © 2009 American Medical
Association. All rights reserved.
From: Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of
Heritability
Arch Gen Psychiatry. 2009;66(5):467-477. doi:10.1001/archgenpsychiatry.2009.24
Figure Legend:
Mean thickness maps for normal controls (NC), patients with schizophrenia (SCZ), and siblings (SIB). For each subject, cortical
thickness values were calculated on a node-by-node basis. Results were then mapped to a mean surface generated based on the
NC group, and average thicknesses for each diagnosis group were calculated. For display purposes, average thickness maps were
imported into SUMA (http://afni.nimh.nih.gov/afni/suma) and overlaid on the NC's average surface. Mean thickness maps for each
diagnosis group were similar both to each other Copyright
and the maps
reported
byMedical
Von Economo. Purple represents areas of highest
© 2009
American
Date
of download:
5/13/2017
thickness
(>3.5 mm),
whereas red indicates areasAssociation.
of lowest thickness
(<1.5
mm). Results in the corpus callosum and midbrain were
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not meaningful.
From: Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of
Heritability
Arch Gen Psychiatry. 2009;66(5):467-477. doi:10.1001/archgenpsychiatry.2009.24
Figure Legend:
Node-based contrasts of thickness between diagnosis groups. A surface-based general linear model approach was used to contrast
thickness values between diagnosis groups on a node-by-node basis. Thickness values for each subject were mapped to an
average surface of the normal control (NC) group and smoothed using a 10-mm full-width-at-half-maximum gaussian filter. Group
contrasts were then performed, covarying for age and sex. Results were thresholded at P < .05, false discovery rate corrected, and
display images were generated in the same fashion
as Figure
2. American
Between-group
Copyright
© 2009
Medicalcontrasts of thickness revealed widespread
Date
of download:
5/13/2017
reductions
in patients
with schizophrenia (SCZ) compared
with
NCs,
most
pronouncedly in frontal and temporal lobes. Comparison
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of the affected patients with unaffected siblings (SIB) revealed similar, but far less pronounced, reductions. The SIB vs NC contrast
From: Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of
Heritability
Arch Gen Psychiatry. 2009;66(5):467-477. doi:10.1001/archgenpsychiatry.2009.24
Figure Legend:
Average thickness distributions and heritability results for selected frontal regions. Thickness was also analyzed on a regionwide
basis using automated cortical parcellations. Here, results are displayed for the 3 frontal regions in which patient thicknesses were
most reduced. Red circles show the distribution of average thicknesses for subjects in each region, and error bars show the mean
and standard deviation. Lines connect patients with schizophrenia (SCZ) expressing each phenotype (ie, having scaled volumes
>1.5 SDs from the mean in the direction of our hypothesis)
their
unaffected
siblings (SIB). Solid lines represent cases where the
Copyright © to
2009
American
Medical
Date
of download:
5/13/2017
SIB also
expressed
the phenotype, whereas dotted
lines
indicate
cases
where
Association. All rights reserved.the SIB did not. According to Risch λ tests (λ s), SIB
showed heritability for thickness reductions in the left hemisphere for all 3 regions. NC indicates normal controls.
From: Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of
Heritability
Arch Gen Psychiatry. 2009;66(5):467-477. doi:10.1001/archgenpsychiatry.2009.24
Figure Legend:
Average thickness distributions and heritability results for selected temporal regions. Similar to Figure 4, thickness distribution and
heritability results are displayed for superior temporal gyrus, as well as regions of the medial temporal lobe (parahippocampal gyrus
and entorhinal cortex), in which affected patients (SCZ) did not significantly differ from normal controls (NC). Red circles show the
distribution of average thicknesses for subjects in each region, and error bars show the mean and standard deviation. Lines connect
SCZ expressing each phenotype (ie, having scaled
volumes
>1.5American
SDs from
the mean in the direction of our hypothesis) to their
Copyright
© 2009
Medical
Date
of download:
unaffected
siblings5/13/2017
(SIB). Solid lines represent cases
where
the
SIB
also
expressed
the phenotype, whereas dotted lines indicate
Association. All rights reserved.
cases where the SIB did not. Risch λ tests (λ ) revealed heritability for thickness reductions in left superior temporal gyrus, left