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Table A. List of candidate genes identified by literature mining involved in methionine metabolism. Gene Symbol Gene Name Gene Function AHCY S-adenosylhomocysteine hydrolase Hydrolysis of AdoHcy to adenosine and homocysteine BHMT Betaine-homocysteine methyltransferase Conversion of betaine to dimethyl glycine (DMG) in liver and kidney BHMT2 Betaine-homocysteine methyltransferase 2 It catalyzes the transfer of the methyl group from betaine to homocysteine CBS Cystathionine beta-synthase Condensation of homocysteine and serine to form cystathionine ENOSF1 Enolase superfamily member 1 Transferase activity FOLH1/GCPII Folate hydrolase 1 / Glutamate Carboxypeptidase II Glutamate carboxypeptidase activity on different substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate MTHFD1 Methylene-tetra hydrofolate dehydrogenase Conversion of 5, 10-methylene-tetrahydrofolate to5, 10methenyltetrahydrofolate MTHFR Methylenetetrahydrofolate Reductase Conversion of 5, 10-methylene-tetrahydrofolate to 5-methyl-tetrahydrofolate MTR Methyltetrahydrofolatehomocysteine methyltransferase Remethylation of homocysteine to methionine MTRR Methionine synthase reductase Reductive regeneration of cob(I)alamin cofactor required for the maintenance of MTR in a functional state NNMT Nicotinamide N-methyltransferase N-methylation activity using S-adenosyl methionine as the methyl donor PON1 Paraoxonase 1 Hydrolysis of the toxic organo-phosphorus. It also mediate an enzymatic protection of LDL against oxidative modification PON2 Paraoxonase 2 Hydrolytic activity. Antioxidant properties protecting cells from oxidative stress SLC19A1/RFC1 Solute carrier family 19 (folate transporter), member 1 / Reduced-folate carrier 1 5-methyl-tetrahydrofolate internalization in cell SHMT1 Serine Hydroxymethyltransferase 1 Reversible conversion of serine and tetrahydrofolate to glycine and 5, 10methylene tetrahydrofolate TCN2 Transcobalamine II Transport of vitamin B12 TYMS Thymidylate Synthase 5, 10-methylene THF and deoxyuridylate to form dihydro-folate and thymidylate
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