Download APPROXIMATE EQUIVALENT OPIOID DOSES

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

Document related concepts
no text concepts found
Transcript 
TAPENTADOL DOSE CONVERSION CHART
Doses in this conversion chart are approximate equivalent doses only. Caution is always necessary. It should be noted that these equivalent doses relate to
analgesic equivalence and not opioid equivalence due to the dual mechanism of action of tapentadol (mu-opioid receptor agonist and noradrenaline reuptake
inhibitor). When converting from one strong opioid to another it is important to: take account of the clinical condition of the patient; consider a dose reduction;
review after 24 hours and titrate accordingly.
Route of administration
Oral
Drug
Equivalent Doses
Morphine
total daily dose
Tapentadol(1)
total daily dose
Oxycodone
total daily dose
40mg<=>
80mg<=>
120mg<=>
160mg<=>
200mg<=>
100mg<=>
200mg<=>
300mg<=>
400mg<=>
500mg<=>
20mg<=>
40mg<=>
60mg<=>
80mg<=>
100mg<=>
(1) Tapentadol m/r is restricted to patients unable to tolerate morphine m/r under the direction of the Pain Clinic. Total daily doses of tapentadol greater than
500mg have not been studied and are therefore not recommended.
Opioid Formulations and Strengths
Preparations
Liquid
Morphine (oral)
10mg/5mL oral solution
Tapentadol (oral)
100mg/5mL concentrated oral solution
Immediate Release
Modified Release
10mg, 20mg, 50mg tablets
12-hourly tablets: 5mg, 10mg, 15mg,
30mg, 60mg, 100mg,
200mg
Oxycodone (oral)
5mg/5mL oral solution
10mg/1mL concentrated oral solution
Not recommended - 50mg and 75mg tablets are
available but not approved by SMC.*
5mg, 10mg, 20mg capsules
12-hourly tablets: 50mg, 100mg, 150mg, 200mg,
250mg
12-hourly tablets: 5mg, 10mg, 15mg, 20mg,
30mg, 40mg, 60mg, 80mg, 120mg
12-hourly suspension (sachet of granules
to mix with water): 20mg, 30mg, 60mg,
100mg, 200mg
*Tapentadol immediate release can only be used under specialist direction where an Individual Patient Treatment Request (IPTR) has been approved.
Caution: tapentadol immediate-release tablets do not allow an appropriate breakthrough dose at total daily doses of tapentadol below 300mg.
Reference: Personal communication. Grunenthal Ltd. 18/10/11.
Related documents